Digital Commons Network^™

Single‐Use Versus Multiple‐Use Endotracheal Suction Catheters In Mechanically Ventilated Patients: A Feasibility Randomised Controlled Trial, Mohamed H. Eid, Kevin Hambridge, Patricia Schofield, Jos M. Latour

School of Nursing and Midwifery

BackgroundIn resource-limited settings, single-use open endotracheal suction catheters are commonly used multiple times. The current evidence of this practice on ventilator-associated pneumonia (VAP) among mechanically ventilated patients remains unclear.AimThe aim of this study was to test the feasibility of single-use and multiple-use endotracheal suction catheters flushed with chlorhexidine versus standard care (multiple-use endotracheal suction catheters flushed with normal saline) to reduce VAP in resource-limited intensive care units (ICUs) and evaluate study methods for designing a future definitive randomised controlled trial (RCT).Study DesignA three-armed feasibility RCT was conducted in three ICUs at a university hospital in Egypt.ResultsSixty mechanically ventilated patients were …

2026 Spring Convocation Program, Morehead State University. Office Of Communications & Marketing.

Communications and Marketing Publications Archive

The 2026 Morehead State University Convocation Program from January 7, 2026.

Enhanced Confocal Microscopy With Physics-Guided Autoencoders Via Synthetic Noise Modeling, Shyam Pokharel

All Publications

We present a Physics-guided deep learning framework to address common limitations in Confocal Laser Scanning Microscopy (CLSM), including diffraction-limited resolution, noise, and under sampling due to low laser power conditions. The optical system’s point spread function and primary CLSM image degradation mechanisms, namely photon shot noise, dark current noise, motion blur, speckle noise, and under sampling are explicitly incorporated into the model as physics-based constraints. A convolutional autoencoder is trained with a custom loss function that integrates these optical degradation processes, ensuring that the reconstructed images adhere to physical image formation principles. The model is evaluated on simulated CLSM datasets …

Embedding Interprofessional Education In Pediatric Clerkships: Lessons From Nebraska’S Tracking Infant Progress Statewide (Tips) Program, Grace E. Berentson, Liliana Bronner, Paige Hardy, Neil Kalsi, Brianna Brei, Kerry Miller

Posters and Presentations: Munroe-Meyer Institute

Background: NICU graduates experience disproportionate developmental and health challenges. Their families face barriers to equitable care including access to coordinated follow-up services. Traditional medical education rarely exposes students to authentic interprofessional models of care that address these inequities. The Tracking Infant Progress Statewide (TIPS) program provides developmental, social, and medical follow-up for NICU graduates across Nebraska, bringing together physicians, nurse practitioners, child developmental specialists, and nurses in a single family-centered visit. Embedding third-year medical students into this setting models collaborative practice, builds understanding of interprofessional competencies, and fosters awareness of systemic inequities affecting NICU families. This innovative curricular approach differs …

Banking On Jarkesy, Jacob Cunningham, Todd Phillips

Duke Law Journal Online

The 150-year-old bank regulatory system is under threat. Following the Supreme Court’s landmark decision in Jarkesy, bankers have filed numerous lawsuits challenging the ability of the federal bank regulatory agencies to adjudicate cases in non-Article III tribunals. But unlike the agencies tasked with enforcing the securities, antitrust, and consumer protection laws, the banking regulators lack statutory authority to file cases in federal court. A decision invalidating their in-house adjudicative authority strips of them of any forum in which to file enforcement actions.

This essay argues that these lawsuits should fail. Because the Seventh Amendment jury trial right exempts “public rights,” …

Wcu Digital Commons Accessibility Statement, Julia Doelling

Policy Library

No abstract provided.

The Virtual Kitchen Challenge-Version 2: Validation Of A Digital Assessment Of Everyday Function In Older Adults, Marina Kaplan, Moira Mckniff, Stephanie M. Simone, Molly B. Tassoni, Katherine Hackett, Sophia Holmqvist, Rachel E. Mis, Kimberly Halberstadter, Riya Chaturvedi, Melissa Rosahl, Giuliana Vallecorsa, Mijail Serruya, Deborah A. G. Drabick, Takehiko Yamaguchi, Tania Giovannetti

Department of Medicine Faculty Papers

BACKGROUND: Conventional methods of functional assessment include subjective self- or informant report, which may be biased by personal characteristics, cognitive abilities, and lack of standardization (eg, influence of idiosyncratic task demands). Traditional performance-based assessments offer some advantages over self- or informant reports but are time-consuming to administer and score.

OBJECTIVE: This study aims to evaluate the validity and reliability of the Virtual Kitchen Challenge-Version 2 (VKC-2), an objective, standardized, and highly efficient alternative to current functional assessments for older adults across the spectrum of cognitive aging, from preclinical to mild dementia.

METHODS: A total of 236 community-dwelling, diverse older adults …

Leveraging Wastewater Resource Recovery To Reduce Landfill Organic Loading: Process Modeling, Environmental, And Economic Impact Assessment, Ahmed I. Yunus, Arjun T. Ramshankar, Zainab O. Akinsemoyin, Thomas Igou, Ameet Pinto, George Fu, Yongsheng Chen, Joe F. Bozeman Iii

Civil Engineering & Construction: Faculty Publications

No abstract provided.

Ai Companions And Adolescent Social Relationships: Benefits, Risks, And Bidirectional Influences, Xiaoran Sun, Yunqi Wang, Brandon Mcdaniel

Health Services and Informatics Research

AI companions (AI-Cs)—rapidly emerging conversational agents built on large language models that can provide personalized humanlike companionship—create unprecedented opportunities for adolescents to form emotional bonds with nonhuman entities during a critical period for social development. In this article, we discuss the interplay between adolescents' use of AI-Cs and their social relationships based on theoretical hypotheses driving research on digital communication and adolescent well-being. We explore the benefits and risks of AI-Cs to social development based on the stimulation hypothesis and the displacement hypothesis: AI-Cs can provide safe spaces for identity exploration and emotional expression, potentially building skills that transfer to …

Wikipedia And Archival Internships: Preparing Memory Workers For Inclusive Practice, April K. Anderson-Zorn

Faculty and Staff Publications – Milner Library

Archival internships guided by the Rayfield Archives offer opportunities for future archivists, public historians, and other memory workers to gain hands-on experience working with historical records and their communities. Along with archival processing, exhibit curation, and metadata, interns can also learn to create authoritative Wikipedia entries for underrepresented members of the ISU community. From its early, grant-funded stages in 2020 to its current iteration as an interactive, guided project, the Wikipedia internship at the Rayfield Archives prepares students for inclusive practice in memory work in the classroom and the field.

Experimental And Simulation Analysis For Different Pot-In-Pot Indirect Heating Scenarios For Cooking Applications, Pamella K. Kajumba, Jimmy Chaciga, Denis Okello, Karidewa Nyeinga

Tanzania Journal of Science

The paper presents simulation and experimental results to demonstrate heat transfer performance during cooking that can be practical in pot-in-pot arrangements for indirect cooking/heating. The cases included single pots, pot-in-pot with oil, and pot-in-pot with no oil. The aim was to optimize the heat transfer through conduction and the cooking process for a recently developed small-scale sensible heat storage system integrated with a cooking unit. Cooking experiments reported were carried out using an electric hot plate with a power rating of 1.8 kW, 220V. Temperature measurements were recorded using a TC-08 data logger. The heating rates were analyzed for the …

Appropriate Wireless Technology For Blue Data Communication To Enhance Artisanal Fishery, Abdi T. Abdalla, Eva Shayo, Angelina Misso, Baraka Maiseli, Kwame S. Ibwe, Narriman Jiddawi, Moses Ismail

Tanzania Journal of Science

The paper examines the development of a system architecture to support smart fishing. This includes the establishment of a blue data center, which would allow government agencies and research institutions to access fisheries data. The goal is to provide policymakers with the tools they need to efficiently manage artisanal fisheries resources. The architecture also incorporates wireless communication components that are suitable for small-scale fishers in remote areas. The study delves into the selection of appropriate wireless communication technology for transmitting fishing data to the communication center. Factors such as coverage range, data rates, and cost implications are taken into consideration. …

Qualitative And Numerical Observations Into The Career Trajectories Of Early Career Academics: A Mathematical Model Approach, Oluwatayo M. Ogunmiloro

Tanzania Journal of Science

This study develops and analyzes a mathematical model that describes the interplay among different researcher groups within academia by focusing on how variables such as mentorship, access to funding, and academic peer influence affect the career trajectories of early-career, experienced, redundant, and successful researchers. Using stability theory and relevant theorems of differential equations, this study ensures the existence, uniqueness, positivity, and boundedness of the model's solutions. Additionally, the model’s equilibrium states, are analyzed to determine the local asymptotic stability. Numerical simulations using the Runge-Kutta fourth-order (RK4) method, implemented in Python, are performed to illustrate issues related to career growth within …

Re: Comment Letter For Draft Clark Tailings Consolidated Waste Management Area (Ctcwma) 2024 Data Summary Report (Dated October 15, 2025), Emma Rott

Silver Bow Creek/Butte Area Superfund Site

No abstract provided.

Read My Lips: No New Constructs! Construct Proliferation As A Threat To The Future Of I-O Psychology, Nathan A. Bowling, Valerie I. Sessa, Jonathan A. Shaffer, George C. Banks

Department of Psychology Faculty Scholarship and Creative Works

Industrial and organizational (I-O) psychology recognizes dozens of different constructs, including several individual differences, environmental variables, job attitudes, and work-related behaviors. It is, of course, necessary to retain a variety of constructs in order to adequately capture the complexities, subtleties, and diversity of work-related phenomena. But do the many constructs recognized by I-O psychologists all serve a useful purpose? Or has our field been too eager to welcome redundant, unnecessary constructs into the fold? And if I-O psychology has embraced too many unnecessary constructs, then what—if anything—should we do about it? In the current focal article, we first discuss when …

Health Impacts Of Migration And Policy On The Iranian Diaspora, Jihye Lee, Mitra Naseh, Sahar Badiezadeh, Sarvenaz Taridashti, Erick Da Luz Scherf

Department of Psychology Faculty Scholarship and Creative Works

Migration is shaped by a complex interplay of political, economic, and social factors that drive individuals to seek stability and better prospects abroad. Since the 1979 Islamic Revolution, Iran has experienced significant emigration of its highly educated population, driven by political instability, economic challenges, and restrictive societal norms. This study explores how U.S. immigration policies affect the health and well-being of highly educated Iranian immigrants, with particular attention given to the impact of nationality-based restrictions on psychosocial outcomes. Using a phenomenological approach, we analyzed in-depth interviews with 40 participants to examine the lived experiences of highly educated Iranian immigrants in …

Powering Up Clinical Scholarship In Evidence-Based Practice For Nurse Residents, Evelyn Wang

HSLIC Faculty and Staff Instructional Resources

This Nurse Residency Evidence-Based Practice workshop introduces core concepts of clinical scholarship for nurse residents, emphasizing how to turn clinical questions into structured literature searches and use HSLIC resources to support scholarly projects. Topics include framing answerable clinical questions (e.g., PICOT), navigating key clinical information tools (PubMed, CINAHL, PsycINFO, EMBASE, ClinicalKey, UpToDate), applying practical literature search techniques (Boolean operators, truncation, wildcards, proximity operators, subject headings), documenting basic search strategies, accessing full text (LibKey Nomad, proxy authentication, interlibrary loan and document delivery), and a brief introduction to critical appraisal tools and publishing supports available through HSLIC.

Employment Stability And Security Of Low-Wage Workers In The United States, Mathieu Despard, Guangli Zhang, Stephen Roll

Center for Social Development Research

One quarter of workers in the United States make $35,000 or less, and nearly half of these are between 35 and 64 years old. Forty percent are caring for children in the home. As temporary and gig working arrangements become increasingly common, this brief explores the stability of work and income for low-wage workers. The analyses draw upon data from the Workforce Economic Inclusion and Mobility survey administered to a nationally representative sample of U.S. workers earning less than 250% of the federal poverty line. The findings from this work have direct implications for employment practices and labor policies.

Characterization Of Inflammatory Pseudotumors In A Large Animal Model Of Liver Cancer, Erik N K Cressman, Samantha Hicks, Natalie W Fowlkes, Danielle L Stolley, Maria Sophia Stenkamp

Faculty, Staff and Student Publications

Background: The development of relevant and robust large animal models of hepatocellular carcinoma is needed to test new therapeutic strategies for this disease. Transgenic approaches hold promise in addressing this complex problem. One such model, the Oncopig, has been reported to develop tumors of up to 4 cm in diameter within 7-14 days at sites of in situ vector inoculation. However, the resulting lesions reportedly contained an extensive inflammatory component that has not been evaluated in detail.

Methods: Herein, we describe our results from multiparametric characterization of the lesions generated using liver biopsy cores incubated in vector solution and replaced …

The Effect Of Exercise On Cognitive Function In The Elderly, Anna Petersen

Advocate GME

No abstract provided.

Thermodynamic Stability Modulates Chaperone-Mediated Disaggregation Of Α-Synuclein Fibrils, Celia Fricke, Antonin Kunka, Rasmus K Norrild, Shuangyan Wang, Thi Lieu Dang, Mohammad Shahnawaz, Susana Aznar, Anne S Wentink, Bernd Bukau, Alexander K Buell

Faculty, Staff and Student Publications

Aggregation of the intrinsically disordered protein alpha-synuclein into amyloid fibrils and their subsequent intracellular accumulation are hallmark features of several neurodegenerative disorders, including Parkinson's disease, for which no curative treatments currently exist. In this study, we investigate the relationship between fibril morphology, thermodynamic stability, and susceptibility to disaggregation by the human chaperone system comprising HSP70, DNAJB1, and Apg2. By varying assembly conditions and incubation times, we generated alpha-synuclein fibrils with diverse morphological and biochemical properties, including a broad range of thermodynamic stabilities, which we quantified using a chemical depolymerization assay. The chaperone system effectively disaggregated three of the four fibril …

Defective Dna Damage Response Is A Targetable Therapeutic Vulnerability In Esr1 Mutant Breast Cancer, Sarah K Herzog, Jessica H Stevens, Guowei Gu, Sandra L Grimm, Kloma Cardoza, Hangqing Lin, Amanda R Beyer, David G Edwards, Derek Dustin, Harry J Yang, Nicole Liang, Ashfia F Khan, Tasneem Bawa-Khalfe, Daniel J Mcgrail, Shiaw-Yih Lin, Cristian Coarfa, Suzanne A W Fuqua

Faculty, Staff and Student Publications

ESR1 mutations are the leading cause of endocrine therapy resistance and progression in ER-positive metastatic breast cancer. ESR1 mutations are detected in ~50% of metastatic breast cancer patients, and identification of effective targeted therapeutics are critically needed. Here, we identified enrichment of dysregulated replication stress and DNA damage responses in multiple ESR1 mutant models. Targeting the replication stress response utilizing checkpoint inhibition in combination with PARP inhibition synergistically suppressed growth, induced cell cycle arrest, and attenuated DNA replication. PARP inhibition blocked metastatic dissemination in vivo and reduced both PARP1 and ER-regulated protein expression. PARP trapping by olaparib treatment with or …

Loss Of Kdm6a-Mediated Genomic Instability And Metabolic Reprogramming Regulates Response To Therapeutic Perturbations In Bladder Cancer, Pratishtha Singh, Ranit D'Rozario, Bidisha Chakraborty, Swadhin Meher, Deblina Raychaudhuri, Yang Li, Jessalyn Hawkins, Yun Xiong, Philip Lorenzi, Padmanee Sharma, Kadir Akdemir, Patrick Pilie, Abhinav K Jain, Byron Hing Lung Lee, Sangeeta Goswami

Faculty, Staff and Student Publications

Mutations in epigenetic regulators are common in bladder cancer, yet their impact on therapeutic responses remains unclear. Here, we identify that loss-of-function mutations in KDM6A, a histone demethylase altered in about 26% of advanced bladder cancers, are associated with poor survival after cisplatin chemotherapy, whereas they correlate with improved outcomes with anti-PD-1 therapy. Using CRISPR-Cas9-engineered murine and human bladder cancer models, we show that KDM6A deficiency increases formation of extrachromosomal circular DNA carrying chemoresistance loci, promoting cisplatin resistance. In parallel, KDM6A loss impairs DNA repair and rewires tumor metabolism, reducing glycolysis and lactate output. This metabolic shift diminishes histone lactylation …

3d Reconstruction Of Spatial Transcriptomics With Spatial Pattern Enhanced Graph Convolutional Neural Network, Chen Tang, Yuansheng Zhou, Xue Xiao, Lei Dong, Lei Yu, Guanghua Xiao

Faculty, Staff and Student Publications

Spatially resolved transcriptomics (SRT) is a promising new technology that enables simultaneous analysis of gene expression and spatial information for biomedical research. However, the existing statistical and deep learning algorithms used for analyzing SRT data rely solely on two-dimensional (2D) spatial coordinates, which limits their ability to accurately identify spatial domains, spatially variable genes (SVGs), cell-to-cell communications, and developmental trajectories in a three-dimensional (3D) spatial manner. To address these limitations, we introduced Spa3D, which utilized the anti-leakage Fourier transform and graph convolutional neural network model to reconstruct 3D-based spatial structures from multiple 2D SRT slices. We demonstrate that Spa3D is …

National Survey Of Physical Therapists’ Participation As Health Educators In Physical Activity Promotion Among Older Adults, Casey Nicole Mokres

Walden Dissertations and Doctoral Studies

Physical inactivity among older adults remains a major national and global public health concern linked to preventable morbidity, mortality, and rising healthcare costs. Physical therapists are uniquely positioned to promote physical activity (PA) through health education, yet their engagement in this role is not well defined. This quantitative cross-sectional study examined associations between clinical practice factors—years of experience, board certification status, and practice setting—and three domains of the theoretical domains framework (knowledge, skills, and behavioral regulation) related to PA promotion among older adults. The framework guided identification of behavioral and contextual factors influencing therapists’ delivery of PA promotion interventions. Data …

Coworkers' Lived Experiences Of Being Exposed To Healthcare Professionals Misusing Substances, Juratu Garuba-Agbebaku

Walden Dissertations and Doctoral Studies

Despite the harm of substances, coworkers in hospitals, healthcare facilities, and urgent care centers found themselves among healthcare professionals who misused substances such as alcohol and prescription medication. Grounded in social cognitive theory, the purpose of this qualitative descriptive phenomenological study was to explore the lived experiences of coworkers who have been exposed to healthcare professionals’ substance misuse. The participants consisted of 12 healthcare professionals working in various hospitals, healthcare facilities, and urgent care centers in the United States. Data were collected using semistructured interviews. Through Colaizzi’s seven-step analysis, five themes emerged: (a) emotional experiences, (b) ethical reflections, (c) cognitive …

Social Workers' Perspectives Of Using Teletherapy To Foster Resilience Among Middle-Class Single Black Mothers, Yvonne Judge

Walden Dissertations and Doctoral Studies

Inadequate mental health support, particularly from social workers, disproportionately affects middle-class single Black mothers. Prior studies have examined low-income single mothers’ access to mental health care and the potential of teletherapy as a tool for improving access; however, few have explored how middle-class single Black mothers navigate mental health challenges. Further, there is a lack of research on social workers’ perspectives of using teletherapy to foster resilience among middle-class single Black mothers. This is a critical gap, as social workers play a key role in tailoring mental health interventions. The purpose of this study was to explore social workers’ perspectives …

Staff Education To Expand Clinicians’ Knowledge On The Use Of Depression Screening Tools In A Longterm Care Facility, Abibatu Bakarr Bangai

Walden Dissertations and Doctoral Studies

Depression exists as a common yet often undetected mental health issue which affects many elderly residents who live in long-term care facilities. The combination of multiple depression screening tools with inadequate staff training leads to delayed resident diagnosis and produces variable treatment methods which raises the possibility of negative results for residents. This Doctor of Nursing Practice (DNP) project addressed a practice gap related to inconsistent implementation of the Patient Health Questionnaire–2 (PHQ-2) and Patient Health Questionnaire–9 (PHQ-9) through the development and implementation of an evidence-based staff education intervention in a long-term care setting. The research study worked to improve …

Minority Leaders’ Impact On Corporate Diversity And Organizational Change, Nana Kwasi Amponsah

Walden Dissertations and Doctoral Studies

Workplace diversity continues to face criticism due to the limited representation of minority groups, with little progress made in the corporate sector. Despite corporations’ efforts to increase diversity and inclusion in the workplace, a notable lack of minority leadership persists in upper management roles. The purpose of this explanatory sequential mixed-method study was to explore the factors that affect the selection of minority leaders and how corporate executives utilize diversity, equity, and inclusion (DEI) initiatives to foster significant organizational change, even in the face of ongoing underrepresentation in upper management. Social dominance theory, anti-egalitarianism, and social construction theory grounded this …

Cancer Literacy And Social Determinants Of Health: An Epidemiological Analysis Of Trust, Digital Engagement, And Healthcare Utilization In Cancer Information Seeking, Kimberly Leeann Hazel

Walden Dissertations and Doctoral Studies

The rise of online health information has increased access to cancer resources but also amplified misinformation, creating trust gaps that threaten prevention, treatment, and health equity. This study examined how trust in cancer information sources, online information-seeking, and healthcare perceptions relate among U.S. adults. Guided by the health information seeking behavior, the socioecological model, and the structural influence model of health communication, data from the 2022 Health Information National Trends Survey (N = 6,197) were analyzed with logistic regression, mediation, and moderation modeling, controlling for demographics. Trust in government agencies predicted greater cancer information seeking (odds ratio [OR] = 1.94, …