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The Thermodynamics Of Fluid-Phase Benzene Via Molecular Simulation, John L. Tatarko 2010 Cleveland State University

The Thermodynamics Of Fluid-Phase Benzene Via Molecular Simulation, John L. Tatarko

ETD Archive

Accurate values for thermodynamic properties throughout the fluid phase are a requirement for the design of separation processes. To date, very few pure substances have been completely characterized because of time and monetary constraints. Low cost computing power now permits complete determination of the thermodynamic properties of pure substances via molecular simulation. Molecular simulation is computational statistical mechanics. Benzene is an important industrial chemical and pharmaceutical precursor. It is the prototypical, symmetric, hexagonal molecule and is an ideal candidate for molecular simulation. The molecular models of three researchers in the field are submitted for Monte Carlo simulation in the virtual ...


Directional Solidification Of Al - 7 Wt Si Alloy, Ravi Shanker Rajamure 2010 Cleveland State University

Directional Solidification Of Al - 7 Wt Si Alloy, Ravi Shanker Rajamure

ETD Archive

Al - 7 wt Si alloy has been directionally solidified from an aluminum single crystal seed with its [100] orientation parallel to the growth direction with a positive thermal gradient of 40 K/cm and over the range of growth speeds. Growth speed dependence of primary Dendrite Spacing and Primary Dendrite trunk Diameter has been analyzed during the step increase and step decrease in the growth speeds. Frequency distribution of Nearest Neighbor dendrites obtained from the statistical analysis shows the hexagonal distribution of dendrites. The interdendritic convection was present in the form of transverse macrosegregation and non uniform distribution of dendrites ...


Characterizing The Controlled Release Of Glial Cell-Line Derived (Gdnf) Neurotrophic Factor From Encapsulated Schwann Cells, Kristy Broadrick 2010 Wayne State University

Characterizing The Controlled Release Of Glial Cell-Line Derived (Gdnf) Neurotrophic Factor From Encapsulated Schwann Cells, Kristy Broadrick

Wayne State University Theses

ABSTRACT

CHARACTERIZING THE CONTROLLED RELEASE OF GDNF IN SCHWANN CELLS

by

KRISTY BROADRICK

May 2010

Advisor: Dr. Pamela VandeVord

Major: Biomedical Engineering

Degree: Masters of Science

Controlled expression of glial cell line derived neurotrophic factor (GDNF) can be integrated in the development of a system for repair of injured peripheral nerves. This delivery strategy was demonstrated via inducible GDNF from microencapsulated cells in barium alginate. The Schwann cell line RT4-D6P2T was initially modified utilizing an ecdysone-based stable transfection system to produce RT4-GDNF cells. During construct preparation, it was found that C6 cells (where GDNF cDNA was isolated) make three GDNF ...


Implementation Of Risk Management In The Medical Device Industry, Rachelo Dumbrique 2010 San Jose State University

Implementation Of Risk Management In The Medical Device Industry, Rachelo Dumbrique

Master's Theses

This study looks at the implementation and effectiveness of risk management (RM) activities in the medical device industry. An online survey was distributed to medical device professionals who were asked to identify RM-related activities performed during the device life cycle. RM activities and techniques included Establishing Risk Acceptance Criteria, Hazard Identification, Human Factors/Usability, Fault Tree Analysis (FTA), Design Failure Mode and Effects Analysis (DFMEA), Process Failure Mode and Effects Analysis (PFMEA), Hazard and Operability Study (HAZOP), Hazard Analysis and Critical Control Point (HACCP), Risk Benefit Analysis, and Risk Assessment of Customer Complaint. Devices were identified by type (therapeutic, surgical ...


Presencia De La Facultad De Ciencias De La Salud De La Universidad De La Salle En La Problemática Visual Del País Y América Latina, Martha Fabiola Rodríguez 2010 Universidad de La Salle, Bogotá

Presencia De La Facultad De Ciencias De La Salud De La Universidad De La Salle En La Problemática Visual Del País Y América Latina, Martha Fabiola Rodríguez

Ciencia y Tecnología para la Salud Visual y Ocular

No abstract provided.


Estrabismos Convergentes Y Divergentes En Niños, Luisa Fernanda Figueroa O., Yolanda López Aguirre 2010 Universidad de La Salle, Bogotá

Estrabismos Convergentes Y Divergentes En Niños, Luisa Fernanda Figueroa O., Yolanda López Aguirre

Ciencia y Tecnología para la Salud Visual y Ocular

En la valoración visual del paciente pediátrico es indispensable determinar el alineamiento ocular, para poder así descartar estrabismos que generan además de ambliopía, pérdida de la visión binocular. La endotropia se considera como el tipo más frecuente de estrabismo en los niños, responsable de más del 50% de las desviaciones, cuyo manejo puede ser quirúrgico o con prescripción óptica de acuerdo a su origen. Las exodesviaciónes son poco frecuentes antes de los 6 meses, generalmente inician de manera intermitente y se vuelven constantes, están asociadas a insuficiencia de convergencia y correspondencia sensorial anómala; dependiendo de su magnitud y permanencia se ...


Modeling Changes In Biomass Composition During Microwave-Based Alkali Pretreatment Of Switchgrass, Deepak R. Keshwani, Jay J. Cheng 2010 University of Nebraska-Lincoln

Modeling Changes In Biomass Composition During Microwave-Based Alkali Pretreatment Of Switchgrass, Deepak R. Keshwani, Jay J. Cheng

Biological Systems Engineering: Papers and Publications

This study used two different approaches to model changes in biomass composition during microwave-based pretreatment of switchgrass: kinetic modeling using a time-dependent rate coefficient, and a Mamdani-type fuzzy inference system. In both modeling approaches, the dielectric loss tangent of the alkali reagent and pretreatment time were used as predictors for changes in amounts of lignin, cellulose, and xylan during the pretreatment. Training and testing data sets for development and validation of the models were obtained from pretreatment experiments conducted using 1–3% w/v NaOH (sodium hydroxide) and pretreatment times ranging from 5 to 20 min. The kinetic modeling approach ...


Efecto De Lentes Con Tinte Gris 2, Amarillo 2 Y Ámbar En La Atención En Niños De Quinto Grado, Sergio Ramírez González, Elizabeth Casillas Casillas, Jaime Bernal Escalante 2010 Universidad Autónoma de Aguascalientes (México)

Efecto De Lentes Con Tinte Gris 2, Amarillo 2 Y Ámbar En La Atención En Niños De Quinto Grado, Sergio Ramírez González, Elizabeth Casillas Casillas, Jaime Bernal Escalante

Ciencia y Tecnología para la Salud Visual y Ocular

Objetivo: determinar si existe un cambio en la atención con el uso de lentes con tinte gris 2, amarillo 2 y ámbar. Metodología: se realizó un estudio observacional, comparativo, transversal en la ciudad de Aguascalientes, México a 120 estudiantes (60 niños y 60 niñas) de quinto grado de educación básica; la muestra no probabilística por conveniencia se subdividió en niños con y sin signos de problemas de atención a criterio de los profesores. Se realizaron pruebas sin lentes y, posteriormente, con el uso de lentes con cada tipo de tinte para determinar la velocidad y el tipo de procesamiento; las ...


Cambios En El Lag De Acomodación Al Emplear Estímulos Visuales De Diferentes Tamaños, Alejandro León Álvarez, Jorge Mario Estrada Álvarez, Lina Marcela Ortiz, Gloria Alexandra García 2010 Fundación Universitaria del Área Andina

Cambios En El Lag De Acomodación Al Emplear Estímulos Visuales De Diferentes Tamaños, Alejandro León Álvarez, Jorge Mario Estrada Álvarez, Lina Marcela Ortiz, Gloria Alexandra García

Ciencia y Tecnología para la Salud Visual y Ocular

La medición de la respuesta acomodativa (LAG de acomodación) tiene gran importancia clínica, puesto que ayuda en el diagnóstico de las disfunciones del sistema de vergencias y acomodativas. Sin embargo, en la forma como es evaluado clínicamente no se ha estandarizado cuál debe ser el tamaño del objeto que se observa. Objetivo: determinar los cambios en el LAG de acomodación con estímulos de diferentes tamaños. Metodología: se realizó un estudio cuasiexperimental con 134 personas (269 ojos), seleccionadas según el cumplimiento de criterios de inclusión y exclusión, que fueron expuestas a diferentes tamaños de estímulos acomodativos para determinar cambios en la ...


Síndrome De Dispersión Pigmentaria, Marcelo Carrizosa 2010 Universidad de La Salle, Bogotá

Síndrome De Dispersión Pigmentaria, Marcelo Carrizosa

Ciencia y Tecnología para la Salud Visual y Ocular

El síndrome de dispersión pigmentaria es una enfermedad caracterizada por la liberación de pigmento del epitelio pigmentario del iris, que se deposita especialmente en la malla trabecular lo que puede ocasionar una forma temprana de aparición de glaucoma de ángulo abierto; como características especiales, hay pérdida de pigmento del iris, lo cual se puede observar con retroalimentación, huso de Krukemberg como depósito de pigmento en el endotelio corneal y profundidad de la cámara anterior amplia, signos clínicos básicos para el diagnóstico de la patología.


Use Of A 3d Perfusion Bioreactor With Osteoblasts And Osteoblast/Endothelial Cell Co-Cultures To Improve Tissue-Engineered Bone, Matthew J. Barron 2010 Michigan Technological University

Use Of A 3d Perfusion Bioreactor With Osteoblasts And Osteoblast/Endothelial Cell Co-Cultures To Improve Tissue-Engineered Bone, Matthew J. Barron

Dissertations, Master's Theses and Master's Reports - Open

The delivery of oxygen, nutrients, and the removal of waste are essential for cellular survival. Culture systems for 3D bone tissue engineering have addressed this issue by utilizing perfusion flow bioreactors that stimulate osteogenic activity through the delivery of oxygen and nutrients by low-shear fluid flow. It is also well established that bone responds to mechanical stimulation, but may desensitize under continuous loading. While perfusion flow and mechanical stimulation are used to increase cellular survival in vitro, 3D tissue-engineered constructs face additional limitations upon in vivo implantation. As it requires significant amounts of time for vascular infiltration by the host ...


Exploration Of The Role Of Serum Factors In Maintaining Bone Mass During Hibernation In Black Bears, Rachel Marie Bradford 2010 Michigan Technological University

Exploration Of The Role Of Serum Factors In Maintaining Bone Mass During Hibernation In Black Bears, Rachel Marie Bradford

Dissertations, Master's Theses and Master's Reports - Open

Disuse osteoporosis is a condition in which reduced mechanical loading (e.g. bed-rest, immobilization, or paralysis) results in unbalanced bone turnover. The American black bear is a unique, naturally occurring model for the prevention of disuse osteoporosis. Bears remain mostly inactive for up to half a year of hibernation annually, yet they do not lose bone mechanical strength or structural properties throughout hibernation. The long-term goal of this study is to determine the biological mechanism through which bears maintain bone during hibernation. This mechanism could pinpoint new signaling pathway targets for the development of drugs for osteoporosis prevention. In this ...


Influence Of Traumatic Impaction And Pathological Loading On Knee Menisci, Megan Leigh Killian 2010 Michigan Technological University

Influence Of Traumatic Impaction And Pathological Loading On Knee Menisci, Megan Leigh Killian

Dissertations, Master's Theses and Master's Reports - Open

Nearly half of the US population faces the risk of developing knee osteoarthritis (OA). Both in vitro and in vivo studies can aid in a better understanding of the etiology, progression, and advancement of this debilitating disorder. The knee menisci are fibrocartilagenous structures that aid in the distribution of load, attenuation of shock, alignment and lubrication of the knee. Little is known about the biochemical and morphological changes associated with knee menisci following altered loading and traumatic impaction, and investigations are needed to further elucidate how degradation of this soft tissue advances over time. The biochemical response of porcine meniscal ...


Fiabilidad Del Csv 1000 Para Evaluar La Función De Sensibilidad Al Contraste En Infantes Entre Los Siete Y Diez Años, Alejandro León Álvarez, Jorge Mario Estrada Álvarez, Diana del Pilar Quiroz, Diana Marcela Bedoya 2010 Fundación Universitaria del Área Andina Seccional Pereira

Fiabilidad Del Csv 1000 Para Evaluar La Función De Sensibilidad Al Contraste En Infantes Entre Los Siete Y Diez Años, Alejandro León Álvarez, Jorge Mario Estrada Álvarez, Diana Del Pilar Quiroz, Diana Marcela Bedoya

Ciencia y Tecnología para la Salud Visual y Ocular

Objetivo: determinar la concordancia entre observadores para medir la función de sensibilidad al contraste empleando el test CSV 1000E en un grupo de infantes entre los siete a diez años. Metodología: fueron evaluados cincuenta niños (cien ojos) visualmente sanos empleando el CSV 1000E. Cada infante fue evaluado por dos evaluadores el mismo día con una diferencia de 30 minutos entre evaluaciones. Resultados: la curva de sensibilidad al contraste promedio fue normal, aunque superior hacia las frecuencias espaciales altas, al ser comparada con un estudio similar (López, 2003). La concordancia obtenida fue muy pobre –coeficiente de correlación concordancia de Lin (ρc ...


Cambios En La Relación Acomodación Convergencia Ac/A En El Valor De Las Forias Después De Cirugía Refractiva Lasik, Catalina Pérez, Melisanda Tirado, Marcela Camacho 2010 Universidad de La Salle, Bogotá

Cambios En La Relación Acomodación Convergencia Ac/A En El Valor De Las Forias Después De Cirugía Refractiva Lasik, Catalina Pérez, Melisanda Tirado, Marcela Camacho

Ciencia y Tecnología para la Salud Visual y Ocular

Objetivo: determinar cambios significativos de la relación acomodación convergencia (AC/A) y las forias en pacientes antes y después de cirugía refractiva con técnica Lasik. Metodología: se realizó un estudio prospectivo para una muestra poblacional de veinte pacientes (cuarenta ojos) sometidos a cirugía refractiva, evaluados ortópticamente en Optiláser en Bogotá. Se determinó como criterio de inclusión haber sido valorado ortópticamente antes y después de la cirugía refractiva. Se evaluaron condiciones motoras, sensoriales, signos, síntomas, agudeza visual, AC/A, forias con cover test y con varilla de maddox. Resultados: en la medida de las forias se observa qué tanto para Cover ...


Reflections Of College Students Promoting Engineering Through Biomechanical Outreach Activities Indicate Dual Benefits, Kimberly Edginton Bigelow 2010 University of Dayton

Reflections Of College Students Promoting Engineering Through Biomechanical Outreach Activities Indicate Dual Benefits, Kimberly Edginton Bigelow

Mechanical and Aerospace Engineering Faculty Publications

Recent work by the National Academy of Engineering revealed that the public has a poor understanding of what engineers actually do on a day-to-day basis. This issue is compounded for non-traditional fields in engineering, such as biomechanical engineering. This is particularly problematic as such fields could draw interest from students not interested in traditional engineering careers, resulting in increased diversity.

To address this, mechanical engineering students taking an elective course, Biomechanical Engineering, were given an outreach assignment to teach at least one individual under the age of 18 about the field of biomechanical engineering through a hands-on activity. Students worked ...


Robust Dynamic Balance Of Ap-1 Transcription Factors In A Neuronal Gene Regulatory Network., Gregory M Miller, Babatunde A Ogunnaike, James S Schwaber, Rajanikanth Vadigepalli 2010 Thomas Jefferson University

Robust Dynamic Balance Of Ap-1 Transcription Factors In A Neuronal Gene Regulatory Network., Gregory M Miller, Babatunde A Ogunnaike, James S Schwaber, Rajanikanth Vadigepalli

Department of Pathology, Anatomy, and Cell Biology Faculty Papers

BACKGROUND: The octapeptide Angiotensin II is a key hormone that acts via its receptor AT1R in the brainstem to modulate the blood pressure control circuits and thus plays a central role in the cardiac and respiratory homeostasis. This modulation occurs via activation of a complex network of signaling proteins and transcription factors, leading to changes in levels of key genes and proteins. AT1R initiated activity in the nucleus tractus solitarius (NTS), which regulates blood pressure, has been the subject of extensive molecular analysis. But the adaptive network interactions in the NTS response to AT1R, plausibly related to the development of ...


Computational Structural Modelling Of Coronary Stent Deployment: A Review, David Martin, Fergal Boyle 2010 Technological University Dublin

Computational Structural Modelling Of Coronary Stent Deployment: A Review, David Martin, Fergal Boyle

Articles

The finite element (FE) method is a powerful investigative tool in the field of biomedical engineering, particularly in the analysis of medical devices such as coronary stents whose performance is extremely difficult to evaluate in vivo. In recent years, a number of FE studies have been carried out to simulate the deployment of coronary stents, and the results of these studies have been utilised to assess and optimise the performance of these devices. The aim of this paper is to provide a thorough review of the state-of-the-art research in this area, discussing the aims, methods and conclusions drawn from a ...


Drug-Eluting Stents For Coronary Artery Disease: A Review, David Martin, Fergal Boyle 2010 Technological University Dublin

Drug-Eluting Stents For Coronary Artery Disease: A Review, David Martin, Fergal Boyle

Articles

Over the past decade the introduction of drug-eluting stents (DESs) has revolutionised the treatment of coronary artery disease. However, in recent years concern has arisen over the long-term safety and efficacy of DESs due to the occurrence of late adverse clinical events such as stent thrombosis. With this concern in mind, research and development is currently centred on increasing the long-term safety and efficacy of DESs. The aim of this paper is to provide a thorough review of currently approved and promising investigational DESs. With dozens of companies involved in the development of new and innovative anti-restenotic agents, polymeric coatings ...


Theoretical Study Of The Pyrolysis Of Methyltrichlorosilane In The Gas Phase. 3. Reaction Rate Constant Calculations, Yingbin Ge, Mark S. Gordon, Francine Battaglia, Rodney O. Fox 2010 Central Washington University

Theoretical Study Of The Pyrolysis Of Methyltrichlorosilane In The Gas Phase. 3. Reaction Rate Constant Calculations, Yingbin Ge, Mark S. Gordon, Francine Battaglia, Rodney O. Fox

Chemical and Biological Engineering Publications

The rate constants for the gas-phase reactions in the silicon carbide chemical vapor deposition of methyltrichlorosilane (Ge, Y. B.; Gordon, M. S.; Battaglia, F.; Fox, R. O. J. Phys. Chem. A 2007, 111, 1462.) were calculated. Transition state theory was applied to the reactions with a well-defined transition state; canonical variational transition state theory was applied to the barrierless reactions by finding the generalized transition state with the maximum Gibbs free energy along the reaction path. Geometry optimizations were carried out with second-order perturbation theory (MP2) and the cc-pVDZ basis set. The partition functions were calculated within the harmonic oscillator ...


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