The Use Of Tissue Engineering To Fabricate Perfusable 3d Brain Microvessels,
2021
Rowan University
The Use Of Tissue Engineering To Fabricate Perfusable 3d Brain Microvessels, Kalpani N Udeni Galpayage Dona, Jonathan Franklin Hale, Tobi Salako, Akanksha Anandanatarajan, Kiet A Tran, Brandon J Deore, Peter Galie, Servio Heybert Ramirez, Allison Michelle Andrews
Henry M. Rowan College of Engineering Departmental Research
Tissue engineering of the blood-brain barrier (BBB) in vitro has been rapidly expanding to address the challenges of mimicking the native structure and function of the BBB. Most of these models utilize 2D conventional microfluidic techniques. However, 3D microvascular models offer the potential to more closely recapitulate the cytoarchitecture and multicellular arrangement of in vivo microvasculature, and also can recreate branching and network topologies of the vascular bed. In this perspective, we discuss current 3D brain microvessel modeling techniques including templating, printing, and self-assembling capillary networks. Furthermore, we address the use of biological matrices and fluid dynamics. Finally, key challenges …
Data-Driven Design Of Energy-Shaping Controllers For Swing-Up Control Of Underactuated Robots,
2021
Boise State University
Data-Driven Design Of Energy-Shaping Controllers For Swing-Up Control Of Underactuated Robots, Wankun Sirichotiyakul, Aykut C. Satici
Mechanical and Biomedical Engineering Faculty Publications and Presentations
We propose a novel data-driven procedure to train a neural network for the swing-up control of underactuated robotic systems. Our approach is inspired by several recent developments ranging from nonlinear control theory to machine learning. We embed a neural network indirectly into the equations of motion of the robotic manipulator as its control input. Using familiar results from passivity-based and energy-shaping control literature, this control function is determined by the appropriate gradients of a neural network, acting as an energy-like (Lyapunov) function. We encode the task of swinging-up robotic systems through the use of transverse coordinates and goal sets; which …
Wearable Knee Assistive Devices For Kneeling Tasks In Construction,
2021
Rutgers University - New Brunswick/Piscataway
Wearable Knee Assistive Devices For Kneeling Tasks In Construction, Siyu Chen, Duncan Stevenson, Shuangyue Yu, Monika Mioskowska, Jingang Yi, Hao Su, Mitja Trkov
Henry M. Rowan College of Engineering Departmental Research
Construction workers regularly perform tasks that require kneeling, crawling, and squatting. Working in awkward kneeling postures for prolonged time periods can lead to knee pain, injuries, and osteoarthritis. In this paper, we present lightweight, wearable sensing and knee assistive devices for construction workers during kneeling and squatting tasks. Analysis of kneeling on level and slopped surfaces (0, 10, 20 degs) is performed for single- and double-leg kneeling tasks. Measurements from the integrated inertial measurement units are used for real-time gait detection and lower-limb pose estimation. Detected gait events and pose estimation are used to control the assistive knee-joint torque provided …
Ionizable Lipid Nanoparticles For In Utero Mrna Delivery.,
2021
Rowan University
Ionizable Lipid Nanoparticles For In Utero Mrna Delivery., Rachel S. Riley, Meghana V Kashyap, Margaret M Billingsley, Brandon White, Mohamad-Gabriel Alameh, Sourav K Bose, Philip W Zoltick, Hiaying Li, Rui Zhang, Andrew Y Cheng, Drew Weissman, William H Peranteau, Michael J Mitchell
Henry M. Rowan College of Engineering Departmental Research
Clinical advances enable the prenatal diagnosis of genetic diseases that are candidates for gene and enzyme therapies such as messenger RNA (mRNA)-mediated protein replacement. Prenatal mRNA therapies can treat disease before the onset of irreversible pathology with high therapeutic efficacy and safety due to the small fetal size, immature immune system, and abundance of progenitor cells. However, the development of nonviral platforms for prenatal delivery is nascent. We developed a library of ionizable lipid nanoparticles (LNPs) for in utero mRNA delivery to mouse fetuses. We screened LNPs for luciferase mRNA delivery and identified formulations that accumulate within fetal livers, lungs, …
Characterization & Calibration Of Foresight Ice,
2021
Western University
Characterization & Calibration Of Foresight Ice, Hareem Nisar, Terry M Peters, Elvis C.S. Chen
Robarts Imaging Publications
No abstract provided.
Implementation Of Microfluidic Mixers For The Optimization Of Polymeric, Gold, And Perovskite Nanomaterials Synthesis,
2021
Cleveland State University
Implementation Of Microfluidic Mixers For The Optimization Of Polymeric, Gold, And Perovskite Nanomaterials Synthesis, Alexa Roberts
ETD Archive
I would like to thank Dr. Chandra Kothapalli for the opportunity to participate in this research project and the continuous guidance he has given me in all aspects of the lab work. I would like to acknowledge the entire Chemical and Biomedical Engineering Department for their assistance throughout the program, for partially supporting my tuition and stipend through teaching assistantships, and the opportunities to present and discuss my research project with other interested students and faculty. I would like to acknowledge Dr. Petru Fodor and Dr. Geyou Ao for their support as members of my defense committee. Additionally, I would …
Calvin Engineering Lab Development,
2021
Calvin University
Calvin Engineering Lab Development, Christopher Hartemink
Summer Research
The project was selected was a robotic hand that has a variety of unique and interesting inputs. These demonstrations would follow and in class project of small groups designing a simple artificial hand from basic crafting materials such as cardboard, strings, straws, and glue. These interesting inputs included a mechanical measurement, muscle signals measurement, and neurological signal measurement. Effort was primarily focused on the neurological measurement in the form of electroencephalogram (EEG). The selected design was based on simple electrical components and an Arduino. This was done to show students the applications of components experienced throughout their classes at Calvin.
Co2 Biocapture By Scenedesmus Sp. Grown In Industrial Wastewater,
2021
Tecnologico de Monterrey
Co2 Biocapture By Scenedesmus Sp. Grown In Industrial Wastewater, Itzel Y. López-Pacheco, Eduardo Israel Castillo-Vacas, Lizbeth Castañeda-Hernández, Angie Gradiz-Menjivar, Laura Isabel Rodas-Zuluaga, Carlos Castillo-Zacarías, Juan Eduardo Sosa-Hernández, Damià Barceló, Hafiz M.N. Iqbal, Roberto Parra-Saldívar
Panhandle Research and Extension Center
Greenhouse gases (GHG) emissions are widely related to climate change, triggering several environmental problems of global concern and producing environmental, social, and economic negative impacts. Therefore, global research seeks to mitigate greenhouse gas emissions. On the other hand, the use of wastes under a circular economy scheme generates subproducts from the range of high to medium-value, representing away to help sustainable development. Therefore, the use of wastewater as a culture medium to grow microalgae strains that biocapture environmental CO2, is a proposal with high potential to reduce the GHG presence in the environment. In this work, Scenedesmus sp. …
The Advanced Applications For Optical Coherence Tomography In Skin Imaging,
2021
Wayne State University
The Advanced Applications For Optical Coherence Tomography In Skin Imaging, Qiuyun Xu
Wayne State University Dissertations
Optical coherence tomography (OCT), based on the principle of interferometry, is a fast and non-invasive imaging modality, which has been approved by FDA for dermatologic applications. OCT has high spatial resolution up to micrometer scale compared to traditional ultrasound imaging. In addition, OCT can provide real-time cross-sectional images with 1 to 2 mm penetration depth, which makes it an ideal imaging technique to assess the skin micro-morphology and pathology without any tissue removal. Many studies have investigated the possibilities of using OCT to evaluate dermatologic conditions, such as skin cancer, dermatitis, psoriasis, and skin damages. Hence, OCT has tremendous potential …
Multiparametric Quantitative Acoustic Imaging Of Cervical Remodeling During Pregnancy,
2021
Wayne State University
Multiparametric Quantitative Acoustic Imaging Of Cervical Remodeling During Pregnancy, Yan Yan
Wayne State University Dissertations
The uterine cervix plays a central role in the maintenance of pregnancy and the process of parturition. Untimely cervical ripening in early gestation predisposes to preterm labor and delivery, the leading cause of infant mortality worldwide. The current approach to evaluate the status of the cervix relies on digital and sonographic examination, which indicates the morphological changes of the cervix (cervical length). Therefore, assessing cervix tissue composition changes may provide more sensitive evaluations about cervix status beyond cervical length. Photoacoustic (PA) imaging is a relatively new, non-invasive ultrasound (US) based technology that captures acoustic signals emitted by tissue components in …
Targeting T Cell Glycolysis To Mitigate Graft-Versus-Host Disease,
2021
University of Central Florida
Targeting T Cell Glycolysis To Mitigate Graft-Versus-Host Disease, Kevin Ezhakunnel
Honors Undergraduate Theses
Hematological cancers account for nearly ten percent of cancer cases diagnosed annually in the United States. Patients who fail to respond to chemotherapy or radiotherapy must often undergo a bone marrow transplant to treat their malignancy. A significant complication following this procedure is Graft versus Host Disease (GvHD), which occurs when donor T cells mount an immune response against recipient tissues. Immunological research has highlighted the role of aberrant T cell metabolism, specifically a shift toward aerobic glycolysis, as a key driver behind the occurrence of this condition. The transcription factor FoxK1 has been revealed to be a key regulator …
Spectroscopic Investigation Of Radiation-Induced Reoxygenation In Radiation-Resistant Tumors,
2021
University of Arkansas, Fayetteville
Spectroscopic Investigation Of Radiation-Induced Reoxygenation In Radiation-Resistant Tumors, Sina Dadgar, Joel Rodriguez Troncoso, Eric R. Siegel, Natalie Curry, Robert J. Griffin, Ruud P.M. Dings, Narasimhan Rajaram
Biomedical Engineering Faculty Publications and Presentations
Fractionated radiation therapy is believed to reoxygenate and subsequently radiosensitize surviving hypoxic cancer cells. Measuring tumor reoxygenation between radiation fractions could conceivably provide an early biomarker of treatment response. However, the relationship between tumor reoxygenation and local control is not well understood. We used noninvasive optical fiber-based diffuse reflectance spectroscopy to monitor radiation-induced changes in hemoglobin oxygen saturation (sO2) in tumor xenografts grown from two head and neck squamous cell carcinoma cell lines - UM-SCC-22B and UM-SCC-47. Tumors were treated with 4 doses of 2 Gy over 2 consecutive weeks and diffuse reflectance spectra were acquired every day …
A Hybrid Gene Selection Strategy Based On Fisher And Ant Colony Optimization Algorithm For Breast Cancer Classification,
2021
ENSAM, Casablanca, Morocco
A Hybrid Gene Selection Strategy Based On Fisher And Ant Colony Optimization Algorithm For Breast Cancer Classification, Mohammed Hamim, Ismail El Moudden, Mohan D. Pant, Hicham Moutachaouik, Mustapha Hain
EVMS School of Health Professions Faculty Publications
Breast cancer poses the greatest threat to human life and especially to women's life. Despite the progress made in data mining technology in recent years, the ability to predict and diagnose such fatal diseases based on gene expression data still reveals a limited prediction performance, which may not be surprising since most of the genes in expression data are believed to be irrelevant or redundant. The dimensionality reduction process may be considered as a crucial step to analyze gene expression data, as it can reduce the high dimensionality of the breast cancer datasets, which may result into a better prediction …
Biom 1720: Introduction To Biomedical Engineering Tools (Syllabus),
2021
University of Memphis
Biom 1720: Introduction To Biomedical Engineering Tools (Syllabus), Stephen Strain
Biomedical Engineering Syllabi Archive
Course Description: Use of computer tools for data analysis, presentation, documentation; introduction to programming; individual and group design projects.
Analysis Of Graded Sensorimotor Rhythms For Brain-Computer Interface Applications,
2021
University of Kentucky
Analysis Of Graded Sensorimotor Rhythms For Brain-Computer Interface Applications, Chase Allen Haddix
Theses and Dissertations--Biomedical Engineering
The emerging field of neural engineering is tasked with applying engineering principles towards understanding neuroscience. A by-product of such a venture has been the development of a class of assistive devices known as brain-computer interfaces (BCIs) which link brain activity to actions performed by external devices. One application of this technology is in the rehabilitative sector for individuals with neuromuscular diseases and disorders. Despite tremendous efforts in the last few decades, a reliable signal that reflects fine motor control has yet to be adequately investigated. This gap in knowledge has limited the potential of BCIs to restore movement and communication. …
Lipid Droplet Membrane Proteome Remodeling Parallels
Ethanol-Induced Hepatic Steatosis And Its Resolution,
2021
VA-Nebraska-Western Iowa Health Care System, University of Nebraska Medical Center
Lipid Droplet Membrane Proteome Remodeling Parallels Ethanol-Induced Hepatic Steatosis And Its Resolution, Carol A. Casey, Terrence M. Donohue Jr., Jacy L. Kubik, Vikas Kumar, Michael J. Naldrett, Nicholas T. Woods, Cole P. Frisbie, Mark A. Mcniven, Paul G. Thomes
Nebraska Center for Biotechnology: Faculty and Staff Publications
Abstract Lipid droplets (LDs) are composed of neutral lipids enclosed in a phospholipid monolayer, which harbors membrane-associated proteins that regulate LD functions. Despite the crucial role of LDs in lipid metabolism, remodeling of LD protein composition in disease contexts, such as steatosis, remains poorly understood. We hypothesized that chronic ethanol consumption, subsequent abstinence from ethanol, or fasting differentially affects the LD membrane proteome content and that these changes influence how LDs interact with other intracellular organelles. Here, male Wistar rats were pair-fed liquid control or ethanol diets for 6 weeks, and then, randomly chosen animals from both groups were either …
Understanding Forearm Muscle Coordination In Children,
2021
University of Central Florida
Understanding Forearm Muscle Coordination In Children, Miguel Gonzalez
Electronic Theses and Dissertations, 2020-2023
A combination of surface electromyography (EMG) and pattern recognition algorithms have led to improvements in the functionality of upper limb prosthetics. This method of control relies on user's ability to repeatedly generate consistent muscle contractions. Research in EMG based control of prosthesis has mainly utilized adult subjects who have fully developed neuromuscular control. Little is known about children's ability to generate consistent EMG signals necessary to control artificial limbs with multiple degrees of freedom. To address this gap, two experiments were designed to validate and benchmark an experimental protocol that quantifies the ability to coordinate forearm muscle contractions in able-bodied …
Biom 2720: Experimental Design And Analysis For Biomedical Engineering (Syllabus),
2021
University of Memphis
Biom 2720: Experimental Design And Analysis For Biomedical Engineering (Syllabus), Stephen Strain
Biomedical Engineering Syllabi Archive
Course Description: Application of probability, statistics, error analysis, uncertainty in design and performance of biomedical engineering experimentation; discussion and evaluation of common experimental designs for medical device development.
Engr 1009: Preparation For Engineering Problem Solving (Syllabus),
2021
University of Memphis
Engr 1009: Preparation For Engineering Problem Solving (Syllabus), Stephen Strain
Biomedical Engineering Syllabi Archive
Course Description: Applications of algebra and trigonometry to engineering problems. Accelerated preparation for an engineering or technology major.
Scalable Approaches For Auditing The Completeness Of Biomedical Ontologies,
2021
University of Kentucky
Scalable Approaches For Auditing The Completeness Of Biomedical Ontologies, Fengbo Zheng
Theses and Dissertations--Computer Science
An ontology provides a formalized representation of knowledge within a domain. In biomedicine, ontologies have been widely used in modern biomedical applications to enable semantic interoperability and facilitate data exchange. Given the important roles that biomedical ontologies play, quality issues such as incompleteness, if not addressed, can affect the quality of downstream ontology-driven applications. However, biomedical ontologies often have large sizes and complex structures. Thus, it is infeasible to uncover potential quality issues through manual effort. In this dissertation, we introduce automated and scalable approaches for auditing the completeness of biomedical ontologies. We mainly focus on two incompleteness issues -- …
