Development Of A Targeted Drug Delivery System For Intracranial Atheroslerotic Disease,
2022
University of South Dakota
Development Of A Targeted Drug Delivery System For Intracranial Atheroslerotic Disease, Kirby Fuglsby
Dissertations and Theses
Intracranial atherosclerotic disease (ICAD) remains a leading cause of ischemic events such as stroke. However, the use of drug coated balloons (DCBs) containing paclitaxel (PAT) in the brain vasculature remains limited. This is the result of several factors including particulate shed from polymer excipients, PAT toxicity, and poor blood-brain barrier (BBB) permeability of PAT. Therefore, there is a need for novel PAT and excipient formulations for balloon coatings to improve delivery of PAT to the arterial wall in ICAD while reducing off target drug effects and particulate shed. GM1 has previously been shown to cross the BBB and have high …
Probing The Effect Of Hyperglycemia On Endothelial Force Generation And Transmission,
2022
University of Central Florida
Probing The Effect Of Hyperglycemia On Endothelial Force Generation And Transmission, Jovani J. Gutierrez
Honors Undergraduate Theses
This thesis intends to utilize biomechanics to study the endothelial biomechanical response in a static hyperglycemic microenvironment. Hyperglycemia is a diabetic condition with abnormally high levels of glucose in the bloodstream. The effects of hyperglycemia over time lead to vascular complications resulting in patients being more prone to cardiovascular diseases. Current studies have focused on the molecular mechanisms affected by hyperglycemia; however, the mechanical mechanisms by which hyperglycemia causes vascular structural and functional changes are understudied. Therefore, to study the effects of hyperglycemia in the endothelium, Human Umbilical Vein Endothelial Cells (HUVEC) were cultured under three glucose conditions: normal glucose …
Design And Development Of Medical Devices For Multifaceted Applications,
2022
University of Central Florida
Design And Development Of Medical Devices For Multifaceted Applications, Madisyn Messmore
Honors Undergraduate Theses
The fields of biotechnology and biomedical sciences are rapidly evolving and involve the constant growth of knowledge. As a consequence, engineering design has to also remain at the cutting edge in order to not inhibit the growth of these fields. This study focuses on engineering design and analysis as it pertains to the field of biotechnology, at every step of the engineering process. More specifically, how the engineering design and analysis approach can assist in solving medical problems relating to bone diseases and biomaterials. The first part of the study focuses on a project to design and manufacture a novel …
Electrode Evaluation And Electrocortical Dynamics Of Adapting To Small Perturbations During Treadmill Walking,
2022
University of Central Florida
Electrode Evaluation And Electrocortical Dynamics Of Adapting To Small Perturbations During Treadmill Walking, Jinfeng Li
Electronic Theses and Dissertations, 2020-2023
Mobile brain-body imaging (MoBI) seeks to understand human brain and body dynamics during movement and locomotor tasks such as walking with perturbations that challenge balance and lead to adaptation of walking behavior. In this dissertation, I evaluated the long-term electromyography (EMG) recording performance of dry epidermal electrodes for measuring electrical muscle activity. I also evaluated the relationships between the signals recorded from the two sides of dual-sided electroencephalography (EEG) electrodes, a recent advancement in EEG electrode design for measuring electrical brain activity. Last, I investigated adaptation of brain and body responses to small and frequent perturbations during treadmill walking while …
Biom 1720: Introduction To Biomedical Engineering Tools (Syllabus),
2022
University of Memphis
Biom 1720: Introduction To Biomedical Engineering Tools (Syllabus), Stephen Strain
Biomedical Engineering Syllabi Archive
Course Description: Use of computer tools for data analysis, presentation, documentation; introduction to programming; individual and group design projects.
Biom 4730 / Mech 4365: Biomaterials (Syllabus),
2022
University of Memphis
Biom 4730 / Mech 4365: Biomaterials (Syllabus), Joel D. Bumgardner
Biomedical Engineering Syllabi Archive
Course Description: Synthetic materials and their interaction with the physiological environment; methods to design and study materials that are compatible with natural tissue.
Transdermal Drug Delivery Systems: Analysis Of Adhesion Failure,
2022
Wright State University
Transdermal Drug Delivery Systems: Analysis Of Adhesion Failure, Zachary Brooks, Tushar Goswami, Amy Neidhard-Doll, Tarun Goswami
Biomedical, Industrial & Human Factors Engineering Faculty Publications
The most critical component of the TDDS is the adhesive, which is responsible for the safety, efficacy and quality of the patch. For drug delivery to successfully occur, the patch must adhere to the surface of the contact area. If a patch has inadequate adhesion, it is likely to fall off before the entire delivery period has been satisfied, leading to risks for the patient and others who may encounter the patch. Despite the critical concerns associated with the adhesive properties of the patches, the adhesion quality and failure mechanisms have not been fully studied. If certain molecules encounter the …
Retrospective Evaluation And Framework Development Of Bone Anisotropic Material Behavior Compared With Elastic, Elastic-Plastic, And Hyper-Elastic Properties,
2022
Wright State University
Retrospective Evaluation And Framework Development Of Bone Anisotropic Material Behavior Compared With Elastic, Elastic-Plastic, And Hyper-Elastic Properties, Farah Hamandi, James T. Tsatalis, Tarun Goswami
Biomedical, Industrial & Human Factors Engineering Faculty Publications
The main motivation for studying damage in bone tissue is to better understand how damage develops in the bone tissue and how it progresses. Such knowledge may help in the surgical aspects of joint replacement, fracture fixation or establishing the fracture tolerance of bones to prevent injury. Currently, there are no standards that create a realistic bone model with anisotropic material properties, although several protocols have been suggested. This study seeks to retrospectively evaluate the damage of bone tissue with respect to patient demography including age, gender, race, body mass index (BMI), height, and weight, and their role in causing …
Reciprocal Regulation Of Transketolase-Like 1 And Hypoxia-Inducible Factor 1 Alpha In Metabolic Reprogramming And Growth Of Diffuse Midline Glioma, H3 K27m-Mutant,
2022
Wright State University
Reciprocal Regulation Of Transketolase-Like 1 And Hypoxia-Inducible Factor 1 Alpha In Metabolic Reprogramming And Growth Of Diffuse Midline Glioma, H3 K27m-Mutant, Christopher Andrew Waker
Browse all Theses and Dissertations
Diffuse midline glioma, K27M-mutant (DMG) are intractable brain tumors, primarily occurring in the pediatric and adolescent population. Patients have a median survival of less than one year after diagnosis. A lack of therapeutic targets has been a barrier to improvement in patient survival. Irradiation therapy improves symptoms while chemotherapy and surgical intervention, for the most part, have not yet demonstrated utility for treatment. DMG are characterized by a histone H3 mutation that results in the genome-wide loss of epigenetic-repressive marks on K27 and is associated with the misexpression of genes, like Cancer/Testis antigens. A member of this group, transketolase-like 1 …
Part I - Ai And Data As Medical Devices,
2022
University of Michigan Law School
Part I - Ai And Data As Medical Devices, W. Nicholson Price Ii
Other Publications
It may seem counterintuitive to open a book on medical devices with chapters on software and data, but these are the frontiers of new medical device regulation and law. Physical devices are still crucial to medicine, but they – and medical practice as a whole – are embedded in and permeated by networks of software and caches of data. Those software systems are often mindbogglingly complex and largely inscrutable, involving artificial intelligence and machine learning. Ensuring that such software works effectively and safely remains a substantial challenge for regulators and policymakers. Each of the three chapters in this part examines …
Comparison Of Particulate Load & Characterization In Drug Coated Balloons,
2022
University of South Dakota
Comparison Of Particulate Load & Characterization In Drug Coated Balloons, Ryan Rykhus
Dissertations and Theses
Peripheral artery disease (PAD) is a disease that affects over 200 million patients worldwide and results in a narrowing of the blood vessels in the lower limbs that is caused by plaque buildup and chronic inflammation. The standard of care for treating this disease is the use of a drug-coated balloon (DCB) to open up the artery through the dilation of the vessel with the balloon and to deliver paclitaxel which prevents the vessel from narrowing after the procedure. In the United States, these DCBs are only approved by the FDA to be used in the artery segments above the …
Characterization Of A Malachite Green Dna Aptamer And Development Of Malachite Green Dna Aptamer Sensor,
2022
University of Central Florida
Characterization Of A Malachite Green Dna Aptamer And Development Of Malachite Green Dna Aptamer Sensor, Martin O'Steen
Electronic Theses and Dissertations, 2020-2023
Hydrogels have been extensively studied for use in applications such as tissue engineering, drug delivery systems, wound dressing, actuators, valves, and sensors in Micromechanical Systems (MEMS), among others. Thermo-responsive hydrogels in particular pose various advantages such as their capability to respond to an external stimulus and reverse the response when the stimulus is removed and the ability to imbibe a significant amount of solvent and increase their volume by over 1000%. Extensive research has been conducted to tune and improve hydrogel's rate and degree of swelling and mechanical properties. Previous work showed that when synthetic clay (Laponite) is cross-linked with …
In Vivo Metabolic Analysis Of The Anticancer Effects Of Plasma-Activated Saline In Three Tumor Animal Models,
2022
Old Dominion University
In Vivo Metabolic Analysis Of The Anticancer Effects Of Plasma-Activated Saline In Three Tumor Animal Models, Miao Qi, Dehui Xu, Shuai Wang, Bing Li, Sansan Peng, Qiaosong Li, Hao Zhang, Runze Fan, Hai-Lan Chen, Michael G. Kong
Bioelectrics Publications
In recent years, the emerging technology of cold atmospheric pressure plasma (CAP) has grown rapidly along with the many medical applications of cold plasma (e.g., cancer, skin disease, tissue repair, etc.). Plasma-activated liquids (e.g., culture media, water, or normal saline, previously exposed to plasma) are being studied as cancer treatments, and due to their advantages, many researchers prefer plasma-activated liquids as an alternative to CAP in the treatment of cancer. In this study, we showed that plasma-activated-saline (PAS) treatment significantly inhibited tumor growth, as compared with saline, in melanoma, and a low-pH environment had little effect on tumor growth in …
Alcohol Increases Lung Angiotensin-Converting Enzyme 2 Expression And Exacerbates Severe Acute Respiratory Syndrome Coronavirus 2 Spike Protein Subunit 1–Induced Acute Lung Injury In K18-Hace2 Transgenic Mice,
2022
Old Dominion University
Alcohol Increases Lung Angiotensin-Converting Enzyme 2 Expression And Exacerbates Severe Acute Respiratory Syndrome Coronavirus 2 Spike Protein Subunit 1–Induced Acute Lung Injury In K18-Hace2 Transgenic Mice, Pavel A. Solopov, Ruben Manuel Luciano Colunga Biancatelli, John D. Catravas
Bioelectrics Publications
During the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic, alcohol consumption increased markedly. Nearly one in four adults reported drinking more alcohol to cope with stress. Chronic alcohol abuse is now recognized as a factor complicating the course of acute respiratory distress syndrome. and increasing mortality. To investigate the mechanisms behind this interaction, we developed a combined acute respiratory distress syndrome and chronic alcohol abuse mouse model by intratracheally instilling the S1 subunit of SARS-CoV-2 spike protein (S1SP) in K18-human angiotensin-converting enzyme 2 (ACE2) transgenic mice that express the human ACE2 receptor for SARS-CoV-2 and are kept on an …
The Heat Shock Protein 90 Inhibitor, At13387, Protects The Alveolo-Capillary Barrier And Prevents Hci-Induced Chronic Lung Injury And Pulmonary Fibrosis,
2022
Old Dominion University
The Heat Shock Protein 90 Inhibitor, At13387, Protects The Alveolo-Capillary Barrier And Prevents Hci-Induced Chronic Lung Injury And Pulmonary Fibrosis, Ruben M.L. Colunga Biancatelli, Pavel Solopov, Christiana Dimitropoulou, Betsy Gregory, Tierney Day, John D. Catravas
Bioelectrics Publications
Hydrochloric acid (HCl) exposure causes asthma-like conditions, reactive airways dysfunction syndrome, and pulmonary fibrosis. Heat Shock Protein 90 (HSP90) is a molecular chaperone that regulates multiple cellular processes. HSP90 inhibitors are undergoing clinical trials for cancer and are also being studied in various pre-clinical settings for their anti-inflammatory and anti-fibrotic effects. Here we investigated the ability of the heat shock protein 90 (HSP90) inhibitor AT13387 to prevent chronic lung injury induced by exposure to HCl in vivo and its protective role in the endothelial barrier in vitro. We instilled C57Bl/6J mice with 0.1N HCl (2 µL/g body weight, intratracheally) and …
Flexible Battery-Less Wireless Glucose Monitoring System,
2022
Old Dominion University
Flexible Battery-Less Wireless Glucose Monitoring System, Saikat Banerjee, Gymama Slaughter
Bioelectrics Publications
In this work, a low power microcontroller-based near field communication (NFC) interfaced with a flexible abiotic glucose hybrid fuel cell is designed to function as a battery-less glucose sensor. The abiotic glucose fuel cell is fabricated by depositing colloidal platinum (co–Pt) on the anodic region and silver oxide nanoparticles-multiwalled carbon nanotubes (Ag2O-MWCNTs) composite on the cathodic region. The electrochemical behavior is characterized using cyclic voltammetry and chronoamperometry. This glucose hybrid fuel cell generated an open circuit voltage of 0.46 V, short circuit current density of 0.444 mA/cm2, and maximum power density of 0.062 mW/cm2 at 0.26 V …
The Paradox Of Pulmonary Vascular Resistance: Restoration Of Pulmonary Capillary Recruitment As A Sine Qua Non For True Therapeutic Success In Pulmonary Arterial Hypertension,
2022
Old Dominion University
The Paradox Of Pulmonary Vascular Resistance: Restoration Of Pulmonary Capillary Recruitment As A Sine Qua Non For True Therapeutic Success In Pulmonary Arterial Hypertension, David Langleben, Stylianos E. Orfanos, Benjamin D. Fox, Nathan Messas, Michele Giovinazzo, John D. Catravas
Bioelectrics Publications
Exercise-induced increases in pulmonary blood flow normally increase pulmonary arterial pressure only minimally, largely due to a reserve of pulmonary capillaries that are available for recruitment to carry the flow. In pulmonary arterial hypertension, due to precapillary arteriolar obstruction, such recruitment is greatly reduced. In exercising pulmonary arterial hypertension patients, pulmonary arterial pressure remains high and may even increase further. Current pulmonary arterial hypertension therapies, acting principally as vasodilators, decrease calculated pulmonary vascular resistance by increasing pulmonary blood flow but have a minimal effect in lowering pulmonary arterial pressure and do not restore significant capillary recruitment. Novel pulmonary arterial hypertension …
In Vitro And In Vivo Correlation Of Skin And Cellular Responses To Nucleic Acid Delivery,
2022
Old Dominion University
In Vitro And In Vivo Correlation Of Skin And Cellular Responses To Nucleic Acid Delivery, M. Bosnjak, K. Znidar, A. Sales Conniff, T. Jesenko, B. Markelc, Nina Semenova, J. Tur, K. Kohena, S. Kranjc Brezar, L. Heller, M. Cemazar
Bioelectrics Publications
Skin, the largest organ in the body, provides a passive physical barrier against infection and contains elements of the innate and adaptive immune systems. Skin consists of various cells, including keratinocytes, fibroblasts, endothelial cells and immune cells. This diversity of cell types could be important to gene therapies because DNA transfection could elicit different responses in different cell types. Previously, we observed the upregulation and activation of cytosolic DNA sensing pathways in several non-tumor and tumor cell types as well in tumors after the electroporation (electrotransfer) of plasmid DNA (pDNA). Based on this research and the innate immunogenicity of …
การสร้างภาพสามมิติของกระดูกต้นขาที่แตกหักจากภาพถ่ายรังสีสองมุมมองด้วยวิธีการเรียนรู้เชิงลึก,
2022
คณะวิศวกรรมศาสตร์
การสร้างภาพสามมิติของกระดูกต้นขาที่แตกหักจากภาพถ่ายรังสีสองมุมมองด้วยวิธีการเรียนรู้เชิงลึก, ดนุพงษ์ บุตรทองคำ
Chulalongkorn University Theses and Dissertations (Chula ETD)
ภาวะกระดูกต้นขาส่วนปลายหักนั้นเป็นภาวะบาดเจ็บที่ค่อนข้างรุนแรง มีสาเหตุจากการบาดเจ็บทั้งภาวะบาดเจ็บจากอุบัติเหตุและการหักผ่านรอยโรค การวินิจฉัยและการวางแผนการผ่าตัดเป็นขบวนการที่สำคัญในการรักษา ซึ่งต้องพึ่งพาการถ่ายภาพรังสีเอกซเรย์และเอกซเรย์คอมพิวเตอร์ อย่างไรก็ตามการถ่ายภาพรังสีเอกซเรย์คอมพิวเตอร์นั้นมีค่าใช้จ่ายมาก ปริมาณรังสีสูง และใช้ระยะเวลาในการถ่ายภาพยาวนานกว่าการถ่ายภาพเอกซเรย์ ดังนั้นการสร้างภาพสามมิติของกระดูกต้นขาที่แตกหักจากถ่ายภาพรังสีเอกซเรย์จึงเป็นที่ต้องการและเป็นโจทย์ปัญหาที่ยังไม่ได้รับการแก้ไข อีกทั้งยังขาดแคลนข้อมูลในการวิจัย งานวิจัยนี้จึงนำเสนอโมเดลสร้างภาพสามมิติของกระดูกต้นขาส่วนปลายที่แตกหักจากภาพถ่ายรังสีสองมุมมอง เพื่อเพิ่มมโนภาพการมองเห็นแบบสามมิติใช้สำหรับการวินิจฉัยและการวางแผนการผ่าตัด โมเดลการสร้างภาพสามมิติได้ประยุกต์ใช้การเรียนรู้เชิงลึกซึ่งเป็นโครงข่ายประสาทเทียมคอนโวลูชันแบบพีระมิด คลาสช่วยฝึกสอนเป็นตัวแทนของบริเวณกระดูกที่แตกหักช่วยสนับสนุนการเรียนรู้รายละเอียดการรอยแตกหักของโมเดล เนื่องจากตัวอย่างภาพสำหรับฝึกสอนมีไม่เพียงพอ เทคนิคตัวอย่างฝึกสอนที่แตกหักจึงถูกพัฒนาขึ้นเพื่อขยายขนาดตัวอย่างสำหรับฝึกสอนและเพื่อเพิ่มความแม่นยำของผลลัพธ์ นอกจากนี้โมดูลสำหรับผสมคุณสมบัติตามแนวแกนจึงถูกพัฒนาขึ้นภายในโมเดลเพื่อเอาชนะปัญหาความคลาดเคลื่อนเชิงมุมระหว่างภาพถ่ายรังสี โมเดลที่นำเสนอสามารถทำงานกับชุดข้อมูลที่มีคลาดเคลื่อนเชิงมุมระหว่างภาพถ่ายรังสีได้ถึง 10 องศา โดยมีค่า mIoU ที่ 0.827±0.083SD. และ mASSD มีค่า 1.043±0.481SD. โมเดลที่นำเสนอให้รูปทรงกระดูกต้นขาและรายละเอียดของรอยแตกหักที่แม่นยำใกล้เคียงกับความเป็นจริง
Universal Design In Bci: Deep Learning Approaches For Adaptive Speech Brain-Computer Interfaces,
2022
Virginia Commonwealth University
Universal Design In Bci: Deep Learning Approaches For Adaptive Speech Brain-Computer Interfaces, Srdjan Lesaja
Theses and Dissertations
In the last two decades, there have been many breakthrough advancements in non-invasive and invasive brain-computer interface (BCI) systems. However, the majority of BCI model designs still follow a paradigm whereby neural signals are preprocessed and task-related features extracted using static, and generally customized, data-independent designs. Such BCI designs commonly optimize narrow task performance over generalizability, adaptability, and robustness, which is not well suited to meeting individual user needs. If one day BCIs are to be capable of decoding our higher-order cognitive commands and conceptual maps, their designs will need to be adaptive architectures that will evolve and grow in …
