Biomedical Engineering and Bioengineering Commons^™

Biom/Biol 4110: The Science Of Medicine (Syllabus), Bradford D. Pendley

Biomedical Engineering Syllabi Archive

Course Description: Integration of fundamental principles from physics, chemistry, biology and mathematics, and applications of these principles to solve problems in medicine.

Engr 1010: Engineering Problem Solving (Syllabus), Stephen Strain

Biomedical Engineering Syllabi Archive

Course Description: Introduction to the methods of engineering problem solving. Application of mathematical concepts to solve engineering problems.

Biom 3110(Honors): Medical Physiology (Syllabus), Bradford D. Pendley

Biomedical Engineering Syllabi Archive

Course Description: Basic principles of human physiology and how these are applied in medicine and biomedical engineering problem and devices; physiological principles using appropriate mathematical and engineering models to construct an understanding of how the body works as an integrated system.

Biom 4906: Tissue Engineering (Syllabus), Gary L. Bowlin

Biomedical Engineering Syllabi Archive

Course Description: To study the design, development, and implantation of tissue engineered components. Analysis of the basis for cell growth and differentiation, control of tissue development (in vivo & in vitro), models for tissue engineering, and transplantation of engineered cells and tissues. The emphasis of these analyses will be focused on the cardiovascular system (blood vessels and cardiac prostheses), musculoskeletal system (Bone, cartilage, and tendons), and skin.

Biom 4801/6801: Introduction To Medical Imaging (Syllabus), Aaryani Sajja

Biomedical Engineering Syllabi Archive

Course Description: This course will introduce fundamentals of the four most-important clinical medical imaging modalities: X-ray, Radionuclide, Ultrasound, and MRI. The primary focus is on the physical principles, instrumentation methods, imaging algorithms, and clinical applications of each imaging modality.

Engr 1009: Preparation For Engineering Problem Solving (Syllabus), Stephen Strain

Biomedical Engineering Syllabi Archive

Course Description: Applications of algebra and trigonometry to engineering problems. Accelerated preparation for an engineering or technology major.

Patient-Specific Cardiovascular Superelastic Niti Stents Produced By Laser Powder Bed Fusion, Valentina Finazzi, Francesca Berti, Roger J. Guillory Ii, Lorenza Petrini, Barbara Previtali, Ali Gökhan Demir

Michigan Tech Publications, Part 1

To date, there is a general lack of customizability within the selection of endovascular devices for catheter-based vascular interventions. Laser powder bed fusion (LPBF) has been flexibly exploited to produce customized implants using conventional biomedical alloys for orthopedic and dental applications. Applying LPBF for cardiovascular applications, patient-specific stents can be produced with small struts (approximately 100-300 µm), variable geometries, and clinically used metals capable of superelastic behaviour at body temperature (eg. equiatomic nickel-titanium alloys, NiTi). Additionally, the growing availability and use of patient-specific 3D models provides a unique opportunity to outline the necessary manufacturing process that would be required for …

The Role Of Pro-Longevity Micrornas In Aging, Sarah Noureddine

Electronic Theses and Dissertations, 2020-2023

Cellular senescence, a hallmark of aging, has been implicated in the pathogenesis of many major age-related disorders, including atherosclerosis, metabolic disease, and neurodegenerative disorders such as Alzheimer's disease (AD). AD is characterized by increased cognitive impairment and treatment options available provide minimal disease attenuation. Additionally, diagnostic methods for AD are not conclusive with definitive diagnoses requiring postmortem brain evaluations. Therefore, miRNAs, a class of small, non-coding RNAs, have garnered attention for their ability to regulate a variety of mRNAs and their potential to serve as both therapeutic targets and biomarkers of disease. Several miRNAs have already been implicated with AD …

Comparing Symbolic And Connectionist Algorithms For Correlating The Age Of Healthy Children With Sigma-Lognormal Neuromuscular Parameters, Zigeng Zhang, Christian O'Reilly, Rejean Plamondon

Publications

It is important to accurately evaluate the motor control maturity to help physicians diagnose delayed or abnormal motor development in children. Traditionally, it has been challenging to design assessment methods that are practical and accurate at the same time. This study aims to develop an effective algorithm to predict motor control maturity based on the Kinematic Theory of rapid human movements. We used handwritten pen strokes made on an electronic tablet by 513 children (5.5 to 13 years of age). We considered two types of movements: a single stroke and a triangle drawing test. For the analysis, Sigma-Lognormal parameters were …

Part I - Ai And Data As Medical Devices, W. Nicholson Price Ii

Other Publications

It may seem counterintuitive to open a book on medical devices with chapters on software and data, but these are the frontiers of new medical device regulation and law. Physical devices are still crucial to medicine, but they – and medical practice as a whole – are embedded in and permeated by networks of software and caches of data. Those software systems are often mindbogglingly complex and largely inscrutable, involving artificial intelligence and machine learning. Ensuring that such software works effectively and safely remains a substantial challenge for regulators and policymakers. Each of the three chapters in this part examines …

An Investigation Into The Plate Fixation For Periprosthetic Femoral Fractures, Xiang Chen

Electronic Theses and Dissertations

Periprosthetic femoral fractures are the third most reason for reoperation after the total hip arthroplasty with an incident rate of approximately 6%. The Vancouver type B periprosthetic femoral fractures account for over 70% of all cases, while the sub-type B1 fracture (when the total hip stem is stable) has remained a clinical challenge due to incidences of severe complications after the standard plate-screw fixation. To seek biomechanically sound fixations for the Vancouver type B1 fracture, this dissertation developed a combined modeling and testing framework to investigate the efficacy of fixation for a Vancouver type B1 fracture using different construct lengths …

Multimodal Ultrasound Imaging For Improved Metastatic Lymph Node Detection, Sidhartha Jandhyala

Dartmouth College Ph.D Dissertations

Head and neck squamous cell carcinoma (HNSCC) is the sixth most common cancer worldwide and is complex in nature due to the variety of organs located in the head and neck region. Knowing the metastatic state of the lymph nodes is paramount in accurately staging and treating HNSCC patients. Currently, metastatic lymph node detection involves the use of magnetic resonance imaging and/or x-ray computed tomography, followed by biopsies for histological confirmation. The main diagnostic criteria is the size of the nodes; however, current imaging methods are not 100% accurate due natural lymph node variability. Ultrasound imaging is able to provide …

Load Sharing Assessment Of Osseoligamentous Structures Within A Thoracic Spine Segment During Surgical Release, Michael Polanco, James Bennett, Austin Tapp, Michel Audette, Stacie Ringleb, Sebastian Bawab

Electrical & Computer Engineering Faculty Publications

Spinal surgical procedures often require release of intervertebral discs and ligaments to optimally achieve postural correction on a patient-specific basis. In this paper, a T7-T8 Finite Element (FE) model is utilized to examine internal load sharing during resection steps performed in a Ponte osteotomy. The FE model was rotated bidirectionally along three anatomical planes using an externally applied moment. In each step, the Ranges of Motion (RoM), Instantaneous Centers of Rotation (ICR), and forces from ligaments, discs, facet, and costovertebral joints were calculated. The product of each component’s force and the distance between the ICR and their position were used …

Reconstruction Of Vectorcardiogram From Standard 12-Lead Electrocardiogram Using Convolutional Neural Network, Tanawan Tearwattanarattikal

Chulalongkorn University Theses and Dissertations (Chula ETD)

No abstract provided.

Effects Of Thai Silk Fibroin Content On Properties Of Bioactive Glass-Silk Fibroin Hybrid Scaffolds, Ayuth Vejpongsa

Chulalongkorn University Theses and Dissertations (Chula ETD)

Hybrid scaffolds of bioactive glass (BG) and silk fibroin (SF) were fabricated. 70S30C (70% mol Si, 30% mol Ca) BG is a ceramic biomaterial with natural bone bonding and osteoconductivity potentials. SF is a natural polymer from the silk cocoon of bombyx mori with many desirable properties for tissue engineering applications. Hybridisation between these two biomaterials could mitigate the brittle characteristic of ceramic, enabling the scaffold to resist cyclic load better. This study varied the ratio between BG and SF (BG:SF; 100:0, 95:5, 90:10, 85:15, 80:20, 0:100) and characterized the scaffolds, noting the difference between the scaffolds as a result …

Dna Condensation State Regulates Nuclear Lamina Strain And Cellular Adaptation To Physiological Forces, Brooke E. Danielsson

Theses and Dissertations

The nucleus is the largest and stiffest organelle and is exposed to mechanical forces transmitted through the cytoskeleton from outside the cell, as well as from forces generation within the cell. In recent years, the nucleus has been proposed to act as a cellular mechanosensor, with changes to nuclear shape and architecture playing an important role in how the cell responds to physiological forces. Aberrant forms of the nuclear envelope protein lamin A/C, as well as epigenetic modifications to chromatin, has been shown to modify nuclear stiffness and viscosity, therefore effecting nuclear mechanics and mechanotransduction. Altered nuclear mechanics is associated …

Therapeutic Approaches For Respiratory Distress Syndrome, Franck J. Kamga Gninzeko

Theses and Dissertations

Respiratory distress syndrome (RDS) is characterized by shortness of breath and low oxygen levels. RDS affects the neonatal and adult populations. In the neonatal population, RDS can be classified as NRDS (Neonatal respiratory distress syndrome), while in adults, it is known as ARDS (acute respiratory distress syndrome). This dissertation examines a therapeutic approach to NRDS and a mechanistic approach to ARDS with in vivo and in vitro models of lung injury. NRDS is characterized by a deficiency or lack of surfactant. Surfactant is an essential compound composed of phospholipids and proteins to prevent the lungs from collapsing. There are several …

Modeling Of Patient-Specific Periaortic Mechanics And Pulmonary Artery Hemodynamics Based On Phase-Contrast Magnetic Resonance Imaging Sequences., Johane H. Bracamonte

Theses and Dissertations

Inverse modeling in cardiovascular medicine is a collection of methodologies that can provide non-invasive patient-specific estimations of clinical risk factors using medical imaging as inputs. Its incorporation into clinical practice has the potential to improve diagnosis and treatment planning with low associated risks and costs.

Herein, three different phase contrast magnetic resonance imaging (MRI) modalities were implemented as input data, displacement encoding with stimulated echoes (DENSE MRI) applied, and time-resolved velocity encoding phase-contrast MRI, in 1D and 3D, applied to pulmonary artery (PA) hemodynamics.

A model to account for the effect of periaortic interactions due to static and dynamic structures …

Towards The Systematic Evaluation Of Variable Modes Of Mechanical Conditioning On The Compositional, Microstructural And Mechanical Properties Of Engineered Tissue Vascular Grafts., Sarah Saunders

Theses and Dissertations

Coronary artery bypass surgery (CABG) remains one of the most common cardiac surgical procedures performed worldwide, frequently involving multiple bypasses, and commonly employing the patient’s internal mammary artery, radial artery, or saphenous vein. CABG is often not possible because native vessels were already employed in previous interventions or are diseased themselves. Synthetic vascular grafts are currently integral tools of vascular surgery and have had relative success in large-caliber applications providing substantial benefit to aortic or iliac grafting; however, small diameter (< 6 mm) arterial grafts have not yet translated into clinical effectiveness due to thrombosis and anastomotic intimal hyperplasia. ETVGs present an exciting potential alternative in vascular grafting by offering a blood vessel substitute that could exhibit all the functional characteristics of native vasculature. In addition to relieving supply limitations associated with coronary artery bypass surgery ETVGs are especially ideal for pediatric patients with congenital heart disease who require grafts that grow as they do, eliminating the need for reoccurring invasive surgeries.

Though the role of biomechanics in regulating cellular behavior promoting non-thrombogenicity, vasoactivity, and ECM synthesis and maintenance is well …

Effect Of Viscoelasticity On Cellular Morphology And Activity, Thomas J. Petet Jr

Theses and Dissertations

It has been well established that there is a link between substrate stiffness and cellular activities such as proliferation, migration, and differentiation. Less characterized is the link between the time-dependent viscosity of a substrate with those cellular activities. To explore this, PDMS substrates were created with predictably tunable stiffness and viscosity parameters. A simulated model was also developed in parallel to explore the potential effects of viscosity in a computationally predictive way. It was found that the inclusion of viscosity caused a major paradigm shift to a non-zero substrate equilibrium that was sensitive to increases in the substrate stiffness. Finally, …