Utility Of Ultrasound/Photoacoustic Imaging For Accurate Catheter Tracking And Temperature Monitoring During Endovenous Laser Ablation,
2017
Wayne State University
Utility Of Ultrasound/Photoacoustic Imaging For Accurate Catheter Tracking And Temperature Monitoring During Endovenous Laser Ablation, Ayushi Jharia, Keerthana Palani, Yan Yan
Research Opportunities for Engineering Undergraduates (ROEU) Program 2016-17
Laser ablation is a treatment method that uses light energy through a catheter inserted into a vein to induce localized heat to close the diseased blood vessels. Ultrasound (US) imaging has been used for catheter visualization and tracking. US has limitations for tracking the accurate location of the fiber tip inside small perforating veins such as angular dependency and comet tail artifacts. We propose a robust and accurate method for fiber tip tracking using combined US and Photoacoustic (PA) imaging to overcome the existing limitations.
Surface Enabled Lab-On-A-Chip (Loc) Device For Protein Detection And Separation,
2017
Michigan Technological University
Surface Enabled Lab-On-A-Chip (Loc) Device For Protein Detection And Separation, Zhichao Wang
Dissertations, Master's Theses and Master's Reports
Sensitive and selective chemical/biological detection/analysis for proteins is essential for applications such as disease diagnosis, species phenotype identification, product quality control, and sample examination. Lab-on-a-chip (LOC) device provides advantages of fast analysis, reduced amount of sample requirements, and low cost, to magnificently facilitate protein detection research. Isoelectric focusing (IEF) is a strong and reliable electrophoretic technique capable of discerning proteins from complex mixtures based on the isoelectric point (pI) differences. It has experienced plenty of fruitful developments during previous decades which has given it the capability of performing with highly robust and reproducible analysis. This progress has made IEF devices …
Oxygen Transport In Carotid And Stented Coronary Arteries,
2017
Technological University Dublin
Oxygen Transport In Carotid And Stented Coronary Arteries, Eoin A. Murphy
Doctoral
Oxygen deficiency, known as hypoxia, in arterial walls has been linked to increased intimal hyperplasia, which is the main adverse biological process causing in-stent restenosis. Stent implantation can have significant effects on the oxygen transport into the arterial wall. Helical flow has been theorised to improve the local haemodynamics and the oxygen transport within stented arteries. In this study an advanced oxygen transport model was developed to assess different stent designs. This advanced oxygen transport model incorporates both the free and bound oxygen contained in blood and includes a shear-dependent dispersion coefficient for red blood cells. In two test cases …
Design Of A Fine-Needle Aspiration Biopsy Device For Thyroid Nodules,
2017
Andrews University
Design Of A Fine-Needle Aspiration Biopsy Device For Thyroid Nodules, Troy Furst, Christa Spieth, Gunnar Lovhoiden, Michael Spieth
Posters, Presentations, and Papers
While other devices currently exist to assist in FNA biopsies, none remove the repetitive whole wrist or arm movements needed to collect the sample.
A Wireless, Passive Sensor For Measuring Temperature At Orthopedic Implant Sites For Early Diagnosis Of Infections,
2017
Michigan Technological University
A Wireless, Passive Sensor For Measuring Temperature At Orthopedic Implant Sites For Early Diagnosis Of Infections, Salil Sidharthan Karipott
Dissertations, Master's Theses and Master's Reports
Sensorized implants with embedded wireless, passive temperature sensors were developed for early detection of implant-associated infections. The operation principle of the sensor is based on the hypothesis that infections can lead to an increase in local temperature prior to the rise of body temperature. The sensor was an inductive capacitive (LC) circuit that has been used for monitoring of different parameters wirelessly, often in difficult to access environments. The sensor was fabricated on to an interference screw, which is used for tendon and ligament reconstruction surgeries. In this project, a sensorized interference screw was designed and fabricated by accommodating an …
Implantable Wireless Sensor Networks: Application To Measuring Temperature For In Vivo Detection Of Infections,
2017
Michigan Technological University
Implantable Wireless Sensor Networks: Application To Measuring Temperature For In Vivo Detection Of Infections, Praharsh Madappaly Veetil
Dissertations, Master's Theses and Master's Reports
It is has been proven that infection in the body cause a local temperature increase due to localized inflammation. Therefore, a method to provide early diagnostic or long-term tracking of this infection will provide great benefits to patients with diabetic foot ulcers or sickle cell disease, and those receiving hemodialysis where they suffer from a weakened immune system. The goal of this project is to develop an implantable wireless temperature sensor based on a wireless sensor network system for monitoring infections in situ. The analog signals from the thermistors are digitized and wirelessly transmitted to a computer with an ez430-rf2500 …
Formulation And Testing Of Biodegradable Polymeric Coating On Zinc Wires In Cardiovascular Stent Application,
2017
Michigan Technological University
Formulation And Testing Of Biodegradable Polymeric Coating On Zinc Wires In Cardiovascular Stent Application, Avishan Arab Shomali
Dissertations, Master's Theses and Master's Reports
Biodegradable and biocompatible poly (L-lactic-acid) (PLLA) coating was applied on a modified zinc (Zn) substrate by dip coating, with the intent to delay the bio-corrosion and slow the degradation rate of zinc substrate. 3-(Trimethoxysilyl) propyl methacrylate (MPS) was used for modification of the zinc substrate for promoting the adhesion between the metallic substrate and the polymer coating. It is hypothesized that the delay in Zn biodegradation could be useful in the first several weeks to prevent the early loss of mechanical integrity of the endovascular stent and to improve the healing process of the diseased vascular site. The PLLA coating …
Characterization Of Polyurethane For Use As Substrate In Nanofiber Sensor For Biomedical Applications,
2017
The University of Akron
Characterization Of Polyurethane For Use As Substrate In Nanofiber Sensor For Biomedical Applications, Megan Theaker
Williams Honors College, Honors Research Projects
The purpose of this project is to begin to determine properties of polymer nanocomposites that make a suitable substrate for nanofiber sensors. In this work, sensitivity of a sodium ion selective sensor constructed with polyurethane was used as a benchmark for comparison with sensors constructed with nylon-6. The sensors were characterized using contact angle and chronoamperometry. Using an ANOVA analysis, the results showed that the multi-walled carbon nanotube type was a significant factor on sensor response both with and without additional functionalization of the polymer by calixarene. The weight percentage of polyurethane in the electrospinning solution was also statistically significant …
Development Of An Electrospun And 3d Printed Cellular Delivery Device For Dermal Wound Healing,
2017
Virginia Commonwealth University
Development Of An Electrospun And 3d Printed Cellular Delivery Device For Dermal Wound Healing, Ryan M. Clohessy
Theses and Dissertations
The goal of this research was to develop a system of individualized medicine that could be applied to dermal wounds serving as a wound dressing and synthetic extracellular matrix while delivering stem cells to the wound bed. First, fabrication parameters for electrospinning polymer fibers were determined. This involved evaluating fiber morphology with respect to polymer selection and solution concentration. Next, construct fabrication was examined to produce an integrated void space, or cargo area, suitable to maintain stem cells. In vitro studies to ensure stem cell viability and phenotype were conducted, and results supported the notion that cells could be administered …
Skintronics: Wireless, Skin-Wearable Electronics For Monitoring Of Electrocardiogram,
2017
Virginia Commonwealth University
Skintronics: Wireless, Skin-Wearable Electronics For Monitoring Of Electrocardiogram, Matthew B. Piper, Woon-Hong Yeo, Yongkuk Lee
Undergraduate Research Posters
The ECGs I micro-fabricate are designed to be flexible, stretchable and wireless circuits that can be applied to the skin directly. The device is encased in a conformal, silicon-like substrate, that allows the ECG to be attached with the electrodes. Each electrode has been previously measured and verified that it will be correctly placed for an accurate reading. Prototyping this ECG/electrode device allows the user to mount the prototype directly to the patient without having to attach and wire ten other electrodes. This prototype solves the issue that comes about when a doctor, nurse or emergency medical technician must attach …
Final Design Report: Polymer Fatigue Characterization Test Method,
2016
California Polytechnic State University, San Luis Obispo
Final Design Report: Polymer Fatigue Characterization Test Method, Wyatt Ayling, Tyler Price, Brandon Stell, Michela Upson
Mechanical Engineering
Polylogix is a team dedicated to the design, build, and testing of a fatigue machine to simulate cyclic loading on a biomedical polymer. This project is sponsored by Endologix, Inc. to provide test data characterizing mechanical material properties of various formulations of polymer used in abdominal aortic aneurysm surgeries. With this project goal, the machine must be able to test the polymer at body conditions; these include a testing temperature of 37°C and a cycling frequency ranging from 1 Hz to 10 Hz. This report proposes the following solution to this design challenge: an AC motor-driven mechanism utilizing a planetary …
Design Of A Flexible Control Platform And Miniature In Vivo Robots For Laparo-Endoscopic Single-Site Surgeries,
2016
University of Nebraska-Lincoln
Design Of A Flexible Control Platform And Miniature In Vivo Robots For Laparo-Endoscopic Single-Site Surgeries, Lou P. Cubrich
Department of Mechanical and Materials Engineering: Dissertations, Theses, and Student Research
Minimally-invasive laparoscopic procedures have proven efficacy for a wide range of surgical procedures as well as benefits such as reducing scarring, infection, recovery time, and post-operative pain. While the procedures have many advantages, there are significant shortcomings such as limited instrument motion and reduced dexterity. In recent years, robotic surgical technology has overcome some of these limitations and has become an effective tool for many types of surgeries. These robotic platforms typically have an increased workspace, greater dexterity, improved ergonomics, and finer control than traditional laparoscopic methods. This thesis presents the designs of both a four degree-of-freedom (DOF) and 5-DOF …
Laboratory Development Of A Self-Powered Fontan For Treatment Of Congenital Heart Disease,
2016
Embry-Riddle Aeronautical University
Laboratory Development Of A Self-Powered Fontan For Treatment Of Congenital Heart Disease, Arka Das
Doctoral Dissertations and Master's Theses
Around 8% of all newborns with a Congenital Heart Defect (CHD) have only a single functioning ventricle. The Fontan operation has served as a palliation for this anomaly for decades, but the surgery entails multiple complications and survival rate is less than 50% by adulthood. A rapidly testable novel alternative is proposed by creating a bifurcating graft, or Injection Jet Shunt (IJS), used to “entrain” the pulmonary flow and thus provide assistance while reducing the caval pressure. A benchtop Mock Flow Loop (MFL) is configured to validate this hypothesis. The MFL is based on a Lumped-Parameter Model (LPM) of the …
A Portable And Automatic Biosensing Instrument For Detection Of Foodborne Pathogenic Bacteria In Food Samples,
2016
University of Arkansas, Fayetteville
A Portable And Automatic Biosensing Instrument For Detection Of Foodborne Pathogenic Bacteria In Food Samples, Zhuo Zhao
Graduate Theses and Dissertations
Foodborne diseases are a growing public health problem. In recent years, many rapid detection methods have been reported, but most of them are still in lab research and not practical for use in the field. In this study, a portable and automatic biosensing instrument was designed and constructed for separation and detection of target pathogens in food samples using nanobead-based magnetic separation and quantum dots (QDs)-labeled fluorescence measurement. The instrument consisted of a laptop with LabVIEW software, a data acquisition card (DAQ), a fluorescent detector, micro-pumps, stepper motors, and 3D printed tube holders. First, a sample in a syringe was …
Psychophysiological Analysis Of A Pedagogical Agent And Robotic Peer For Individuals With Autism Spectrum Disorders.,
2016
University of Louisville
Psychophysiological Analysis Of A Pedagogical Agent And Robotic Peer For Individuals With Autism Spectrum Disorders., Mohammad Nasser Saadatzi
Electronic Theses and Dissertations
Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by ongoing problems in social interaction and communication, and engagement in repetitive behaviors. According to Centers for Disease Control and Prevention, an estimated 1 in 68 children in the United States has ASD. Mounting evidence shows that many of these individuals display an interest in social interaction with computers and robots and, in general, feel comfortable spending time in such environments. It is known that the subtlety and unpredictability of people’s social behavior are intimidating and confusing for many individuals with ASD. Computerized learning environments and robots, however, prepare a predictable, …
Radiation Therapy And Dosing Material Transport Methodology,
2016
University of Nevada, Las Vegas
Radiation Therapy And Dosing Material Transport Methodology, Robert O'Brien
UNLV Theses, Dissertations, Professional Papers, and Capstones
A technique is examined here that utilizes high energy beta decays from a short lived radioisotope to treat medical conditions such as shallow cancerous lesions. A major benefit of beta particle interaction in tissue is a fixed penetration depth for the charged particle, with dose limited to the ultimate range of the beta particle. This method improves on some current techniques of radioactive brachytherapy, where "seeds" are placed inside patients through temporary or permanent implantation in order to kill cancerous cells or inhibit growth of tissue. The use of low energy gamma-rays is the most common method of treatment currently …
The Effects Of Cryopreservation On Human Dental Pulp-Derived Mesenchymal Stem Cells,
2016
University of Nevada, Las Vegas
The Effects Of Cryopreservation On Human Dental Pulp-Derived Mesenchymal Stem Cells, Allison Elaine Tomlin
UNLV Theses, Dissertations, Professional Papers, and Capstones
Many studies have demonstrated clinical applications for the use of dental pulp stem cells (DPSC) for the treatment of various conditions. This has driven medical and scientific interest in the collection, isolation and banking of DPSC tissues for research into these potential therapies. Few studies to date have evaluated the viability of DPSC following long-term cryopreservation. The purpose of this study is to evaluate the effects of cryopreservation on dental pulp-derived stem cells (DPSC) viability over a period of three years. Dental pulp-derived stem cells were isolated and cultured from thirty-one healthy teeth. DPSC isolates were assessed for doubling-time and …
An Emg-Based Patient Monitoring System Using Zynq Soc Device,
2016
University of Nevada, Las Vegas
An Emg-Based Patient Monitoring System Using Zynq Soc Device, Farhad Fallahlalehzari
UNLV Theses, Dissertations, Professional Papers, and Capstones
This thesis describes the design, development, and testing of an EMG-based patient monitoring system using the Zynq device. Zynq is a system on chip device designed by Xilinx which consists of an ARM dual cortex-A9 processor as well as an FPGA integrated into one chip. This work also analyzes the performance of image-processing algorithms on this system and compares that performance to more traditional PC-based systems. Image processing algorithms, such as Sobel edge detection, dilation and erosion, could be used in conjunction with a camera for the patient monitoring purposes. These algorithms often perform sub-optimally on processors because of their …
A Prototype Bioreactor Incubation System Designed To Improve Cell Response Modeling In Microgravity,
2016
University of Alabama in Huntsville
A Prototype Bioreactor Incubation System Designed To Improve Cell Response Modeling In Microgravity, Greg Duke, Ryan Longchamps, Azita Amiri
Von Braun Symposium Student Posters
No abstract provided.
Surface Engineering Of Titanium Alloy To Stimulate The Bone Regeneration,
2016
Tianjin University
Surface Engineering Of Titanium Alloy To Stimulate The Bone Regeneration, Yubin Meng, Zhenduo Cui, Zhaoyang Li, Xue Li, Jin Zhao, Xubo Yuan, Xianjin Yang
The 8th International Conference on Physical and Numerical Simulation of Materials Processing
No abstract provided.
