Biomedical Devices and Instrumentation Commons^™

Prosthetic Thumb, Allison M. Sigdestad, Sahil Sharma, Cale Foreman

Biomedical Engineering

The Prosthetic Thumb Project is a senior design project completed by Biomedical Engineering Undergraduate students at California Polytechnic State University. This senior design project is aimed at designing a prosthetic thumb for a Cal Poly Pomona student who lost their thumb in an accident last year. The patient has ultimately lost between 30-40% of functionality of his left hand, and so we would like to give him that mobility back. Originally, the patient was worried about having a prosthesis, and wanted something more stagnant that would resemble the look of the thumb he lost. However, after working with him, we …

Esophageal Temperature Mapping And Monitoring Sheath, Nicole M. Rogers, Hillary Johnson, Alexander Silva

Biomedical Engineering

The purpose of this document is to provide a product development summary for an accessory device that joins an esophageal temperature probe and a mapping catheter together to be used during cardiac ablation. Catheter ablation therapy is performed in the left atrium, utilizing extremely hot or cold temperatures to create scar tissue and treat atrial fibrillation and other arrhythmias. The close positioning of the left atria adjacent to the esophagus presents a large risk as the extreme temperatures used during ablation can lead to esophageal damage or fistulas. This device is designed to integrate correlate data from the temperature probe …

Housecalls Mobile: Virtual Stethoscope/Otoscope, Julia Kelley, Cullen Mcgee, Eduardo Uribe-Saldana

Biomedical Engineering

At the start of the project, our initial deliverables were to add a low cost camera into virtual otoscope and to add a pediatric attachment to the stethoscope. However, about half way through the first quarter (1.5 months into the project), our deliverables changed to the following: to design a housing unit for the selected otoscope camera and to increase battery life to allow for 12+ battery life. To accomplish our deliverables, we divided up the responsibilities as follows: One person headed the mechanical design, one person headed the electrical design, and one person served as a liaison between the …

Pulsed Electrical Field Ablation Modulation, Camille Lousie Dozois, Jason Tyler Arias, Courtnee Lin Madsen

Biomedical Engineering

This document comprises the steps taken by the senior project team to create a Proof-of-Concept Review for a Variable Pulsed Electric Field Ablation Catheter. First, the team did a significant amount of background research on related literature to better understand the current status of the project topic. After sufficient background information was obtained, project objectives and deliverables were finalized. Once customer requirements and the indications for use were completed, engineering specifications for the product and project were documented. All key customer requirements and engineering specs were related to the variable pulse functionality, maneuverability, as well as overall dimensioning of the …

Artificial Kidney And Hemodialysis, Zhongping Huang

Physics & Engineering Faculty Publications

No abstract provided.

Effect Of Tio2 Doping On Degradation Rate, Microstructure And Strength Of Borate Bioactive Glass Scaffolds, Romina Shafaghi, Omar Rodriguez, Sunjeev Phull, Emil H. Schemitsch, Paul Zalzal, Stephen D. Waldman, Marcello Papini, Mark R. Towler

Chemical and Biochemical Engineering Faculty Research & Creative Works

A titanium-containing borate glass series based on the system (52-X) B₂O₃–12CaO–6P₂O₅–14Na₂O–16ZnO-XTiO₂ with X varying from 0, 5 and 15 mol% of TiO2 incorporated, identified as BRT0, BRT1 and BRT3, respectively, were used in this study. Scaffolds (pore sizes, 165–230 μm and porosity, 53.51–69.51%) were prepared using a polymer foam replication technique. BRT3 scaffolds exhibited higher compressive strength (7.16 ± 0.22 MPa) when compared to BRT0 (6.02 ± 0.47 MPa) and BRT1 (5.65 ± 0.28 MPa) scaffolds with lower, or no, TiO₂ content. The solubility of the scaffolds decreased …

Experimental And Computational Tools For Single Cell Analysis In Cancer Diagnostics, Manibarathi Vaithiyanathan

LSU Doctoral Dissertations

Substantial evidence shows that cellular heterogeneity commonly exists within an isogenic or clonal population. Whether in isolation or caused through a combination of the above events, cellular heterogeneity can dramatically influence cellular decision making and cell fate, however, this can be masked by the average response from a population. One approach to solve this issue is to analyze a population at the individual cell level. The goal of this work is to develop high-throughput experimental and computational platforms to screen and quantify single cancer cells for specific intracellular enzyme activities. An interdisciplinary approach was taken to 1) better understand the …

Development Of A Single Use Device Intended To Wash Blood Clot Debris From A Stent Retriever In The Operating Room, Shane Diller

Theses and Dissertations

Ischemic stroke is a life-threatening condition that requires immediate surgical intervention to remove the blood clot that is lodged in the blood vessels of the brain. Mechanical thrombectomy, performed by an endovascular surgeon, involves inserting a stent retriever, which deploys distally and attempts to capture the clot when dragged backwards. A complication prevalent in 50% - 67% of cases is that the blood clot is only partially removed and clings to the mesh framework of the stent. The operating surgeon must either clean the debris from the stent retriever, to be reinserted or throw the stent retriever away and open …

Assessment Of White Matter Hyperintensity, Cerebral Blood Flow, And Cerebral Oxygenation In Older Subjects Stratified By Cerebrovascular Risk, Ahmed A. Bahrani

Theses and Dissertations--Biomedical Engineering

Objective: Cerebrovascular disease (CVD) is the fifth most common cause of mortality in the United States. Diagnosis of CVD at an early stage is critical for optimal intervention designed to prevent ongoing and future brain injury. CVD is commonly associated with abnormalities of the cerebral microvasculature leading to tissue dysfunction, neuronal injury and death, and resultant clinical symptoms, which in turn, further impacts cerebral autoregulation (CA). This series of studies aims to test the hypothesis that white matter hyperintensities (WMH) and cerebral hemodynamics (quantified by magnetic resonance imaging (MRI) and an by innovative hybrid near-infrared diffuse optical instrument) can be …

Noncontact Multiscale Diffuse Optical Imaging Of Deep Tissue Hemodynamics In Animals And Humans, Siavash Mazdeyasna

Theses and Dissertations--Biomedical Engineering

Blood flow (BF) impacts the delivery of oxygen and nutrients to tissues and the removal of metabolic byproducts from tissues. Imaging of BF distributions helps characterize many diseases associated with tissue hypoxia/ischemia. The purpose of this study was to develop and validate a novel, noninvasive, noncontact, high-density camera-based speckle contrast diffuse correlation tomography (scDCT) device for use in both animal and human studies. The scDCT uses a galvo-mirror to remotely deliver the focused point near-infrared light to source positions and a sensitive 2D camera to quantify spatial diffuse speckle fluctuations, resulting from the movement of red blood cells in deep …

3d Printing Of Iron Oxide Incorporated Polydimethylsiloxane Soft Magnetic Actuator, Rasoul Bayaniahangar

Dissertations, Master's Theses and Master's Reports

Soft actuators have grown to be a topic of great scientific interest recently. As the fabrication of soft actuators with conventional microfabrication methods are tedious, expensive, and time consuming, employment of 3-D printing fabrication methods appears promising as they can simplify fabrication and reduce the production cost. Complex structures can be fabricated with 3-D printing such as helical coils can achieve actuation performances that otherwise would not be possible with simpler geometries. In this thesis development of soft magnetic helical coil actuators of iron-oxide embedded polydimethylsiloxane (PDMS) was achieved with embedded 3-D printing techniques. Composites with three different weight ratios …

The Tera Multi Terrain Mobility Aid Chassis, Colton Kemp, Daniel Nicoll, Ibrahim Suleiman, Mohammad Alyami

Williams Honors College, Honors Research Projects

The natural environment poses a significant number of obstacles and dynamic settings that makes mobility difficult for those with physical and mobility impairments. To approach this problem, a suspension was designed using inspiration from the early Mars rovers developed by NASA for traversing the varied Martian landscape. The course of the project followed the direction of a start-up through problem identification, early design generation and review, and final design production. The project outcome, through client request and proven market research, aimed to produce a multi-terrain wheelchair. The final product is a kinematic body with mobile front “legs” and a rotational …

Prosthetic Hand, Nicholas Damiani, Eric Rassavong, John Zolton

Williams Honors College, Honors Research Projects

Development of a prosthetic hand for an above-the-wrist amputee. The hand will provide flexion and extension of the wrist, fingers and thumb. The device will be customized for each individual by utilizing an medical imaging of the amputation side stump and the normal arm/wrist as the input. An integral hand/wrist and socket will be 3D printed, and actuators will be mounted to the prosthetic to provide motion. The wrist will be a mirror-image of the normal hand. Materials utilized will be selected based on the medical image intensity for different tissue types (cartilage, bone, skin, fat, etc.) and will simulate …

Upper Extremity Mobility Device, Timothy J. Grassi, Jacob R. Miller

Williams Honors College, Honors Research Projects

The goal of this project was to evaluate a clinical problem, explore possible solutions, and produce a functioning prototype that would conform to all the established guidelines and requirements. The project focused on developing an upper extremity mobility device for a singular client with limited muscle activity in his arms due to childhood polio. Our design process was governed by an adapted form of the FDA Design Control Process, 21 CFR 820.30 [1]. The outcome of this project was a functioning prototype that utilized the concept of a motorized pulley system remote controlled using a key fob. This research project …

A Novel Approach To Mid-Foot Reconstruction Surgery In Patients With Charcot Arthropathy, Jessi Martin, Deborah Falokun

Williams Honors College, Honors Research Projects

This honors project details the design and development of an internal orthopedic implant that surgically corrects the midfoot fracture and subsequent arch collapse in patients with Charcot arthropathy. The client of the project is Dr. David Kay, an orthopedic surgeon with the Crystal Clinic in Akron, Ohio. He presented a problem surrounding surgical implants meant to repair Charcot arthropathy. Implants that repair the midfoot fracture failed at a rate of about 60%. A team of senior biomedical engineering students attending the University of Akron developed a goal to design a new surgical implant that would reduce the failure rate of …

All-Wheel-Ukraine, Sofiya Rakovska, Hannah Mcculloch, Andrey Garasimchuk, Ahmad Alsaihati

Williams Honors College, Honors Research Projects

We are working with a non-profit organization in Ukraine that provides wheelchairs/strollers to families of disables children who cannot afford them. Their current preferred solution is a baby stroller. The organization asked us to create a wheelchair that is cost efficient, light and collapsible to be used for children ages up to thirteen years old. We will be creating an alpha prototype wheelchair by modifying a basic wheelchair that we purchased. This modifications include adding a headrest that is adjustable and provides a sufficient support for children within the age group given to us and diverse levels of disabilities. We …

Lower Extremity Exoskeleton, Kelly Haslett, Jacalyn Everhart

Williams Honors College, Honors Research Projects

Develop a lower extremity device that provides assistance, support, and gait correction for children with cerebral palsy who display crouch gait as a symptom. The device will be designed for children ages 7-12. The device will be adjustable to accommodate varying levels of gait irregularity, weakness and human growth. The device would assist walking and stair climbing by providing bilateral support at hips, knees and ankle joints. The device will be designed for ease of donning and doffing. Battery, drive and control electronics will be designed to reside in a minimalistic backpack (outside the scope of this project).

Artificial Reverse Shoulder Arthroplasty Joint Project, Michael Rosen, Bailei Hoyng

Williams Honors College, Honors Research Projects

This proposed project will be developing an artificial reverse shoulder arthroplasty joint that focuses on improvements to the Zimmer Biomet Comprehensive Reverse System by freating a unique feature, or features, to the humeral component that focuses on the prevention of dislocation by not limiting the range of motion of men from ages 45 to 65 years.

The development of the this project will utilize the Food and Drug Administration (FDA) medical device design process. This project will involve a total of four Biomedical Engineering students from the University of Akron. Two students, Michael and Bailei, are in the Honors college …

Enhancement Of The Syncardia Total Artificial Heart For Pediatric Use, Margaret Clark, Madison Marks

Williams Honors College, Honors Research Projects

Pediatric patients with disorders and diseases of the heart have limited options with regards to implantable devices. Many of these implants are ventricular assist devices, which is not always suitable for a patient. Total artificial hearts (TAHs) have supported many adult patients until transplantation, and we believe that they could do the same for pediatric patients. SynCardia has the only Food and Drug Administration (FDA) approved TAH devices. Since SynCardia is the only company with FDA approved TAHs, we decided to modify the design of the SynCardia TAH for use in pediatric patients without compromising the function of the current …

Mems Biosensor For Water-Immersed Application, Kun-Lin Lee

Dissertations and Theses

Although many air-based sensing mechanisms exist, not all of them can be applied in the water-based environment. In order to obtain a cell-based biosensor, the sensing method needs to be reliable and repeatable in a liquid environment. Therefore, this study is focused on transforming existing air-based sensors to water-immersed applications. This study includes two types of sensors.

First, commercial quartz resonators are used to investigate live-cell activity in water-based toxic solutions. I perform toxicity tests using quartz crystal microbalance (QCM). The QCM used in the study has a resonant frequency of 10 MHz and consists of an AT-cut quartz crystal …