Biomedical Devices and Instrumentation Commons^™

Tmtt Chimera Valve Attachment Process, Paulina Nguyen, Devin Debouk, Tamar Kazazian, Noah Thompson

Biomedical Engineering

No abstract provided.

Non-Invasive Peripheral Venous And Arterial Line Air Detector For Embolization Prevention, Alexandria Kwong, Kevin Shu, Dylan Meinster

Biomedical Engineering

The scope of this project includes designing a non-invasive bubble detector for peripheral venous and arterial lines. For minimally invasive cardiac procedures, arterial and venous access is necessary for these procedures as is constant flow through the tubing to prevent clotting and to administer drugs. Air bubbles are common in these lines and can be consequential if enough air is introduced into the human system. Air embolisms are the most common and relevant issues during these procedures. The goal of this device is to create an attachable detector for air bubbles in saline that can also terminate flow and alert …

Surf Sled, Marius Jatulis, Arthur Zaayer, Griffin O'Malley, Jose Covarrubias

Mechanical Engineering

This Final Design Review document outlines the process by which we designed and built a surfboard sled, nicknamed the “Beachin’ Buggy”, for the AmpSurf program. The document describes the goals and services that AmpSurf provides for those living with disabilities, and the current methods that volunteers use to transport people from to beach to the water and onto a surfboard. It then identifies the need for a new system for beach-to-water transportation, along with all specifications, constraints, and goals for the system. Background research will be introduced to relate similar products to this project, and their relevant features and parameters …

Concussion Detection Device, Jenna C. Sussex, Mark B. Edin, Bianca X. Aleman

Biomedical Engineering

No abstract provided.

D.I.Y. Clean Hood, Samuel G. Porter, Ryan E. Shimogaki, Ryan S. Staples

Biomedical Engineering

The DIY Clean Hood is a low-cost, sterile, and accessible scientific workspace intended for installation in the BioElectroFluidics Lab of California Polytechnic State University’s (San Luis Obispo) Biomedical Engineering Department (BMED), under the sponsorship of Dr. Benjamin Hawkins, PhD. As normal Clean Hood, Biosafety Cabinets, and the like are generally too expensive for a university, a competitive solution to an expensive problem can assist research students and professors alike continue their own work with an inexpensive yet effective environment.

Specific design elements that the customer requirements entailed for the project include a low-particle-count air filtration system, positive pressure air flow …

Sandy Feet, Garrett E. Herbst, Jacqueline Chuang, Jerin T. Brust, Parker S. Duncan

General Engineering

Sgt. Brady is a former armed forces member with a transtibial amputation. He walks on sand frequently for work and leisure, but experiences severe pain and inconvenience because his current prosthesis is not meant for use on sand. Sand Foot V2 is a prosthesis that allows Sgt. Brady to walk on sand for long periods of time without issue.

The Effect Of Distal Core Flattening And Heat Treatment On 304 Stainless Steel Guide Wires, Andrew Spencer Yap, Bryce Eric Veit, Matthew Frederick Lopez Villena

Materials Engineering

The mechanical response of 304 stainless steel guide wires due to different temper conditions and amounts of flattening is to be explored in this project. For this specific project, there is no public literature on the mechanical properties of guide wires with the above conditions through tensile testing or Turns to Failure Testing. To address this, the project with Abbott Vascular will measure the mechanical properties of guide wires using the aforementioned factors. Due to a lack of previous literature on this research topic, there are no quantitative goals for the project, however, any new research compiled in this area …

Prosthetic Foot Shell, Ql+, Kathryn Victoria Versteeg, Jackson A. Tucker, Ethan William Frey

Mechanical Engineering

This final design review includes an overview of our project and the steps we have taken to create our final product. We discuss the background research conducted, including various products like the foot shell we are trying to design and its related patents, along with similar past senior projects. As our product is considered a medical device, there are also certain standards that we must comply with. After determining our problem statement, we established what we believe to be the wants and needs of our user. These wants and needs were converted into specifications for our design, with durability as …

Septal Closure Device, Olivia N. Welch, Hillal H. Jarrar, Kai Harrison

Biomedical Engineering

The septal closure device was designed to seal defects in the atrial septum. To fully seal an atrial defect, the device was designed to consist of two circular seals to cover the defect in both the right and left atria, attached with a central rod. The materials were chosen for compressibility (for ease of insertion), biocompatibility, and tissue ingrowth. A CAD model was drafted in SolidWorks. Key customer requirements include ease of implantation (specifications: adjustable sizing and clear directions for use), physician controlled (specifications: short implantation time and compatibility with current catheter/scope techniques), and a long lifetime (specifications: materials that …

The Role Of Poly(Methyl Methacrylate) In Management Of Bone Loss And Infection In Revision Total Knee Arthroplasty: A Review, Leyla Hasandoost, Omar Rodriguez, Adel Alhalawani, Paul Zalzal, Emil H. Schemitsch, Stephen D. Waldman, Marcello Papini, Mark R. Towler

Chemical and Biochemical Engineering Faculty Research & Creative Works

Poly (methyl methacrylate) (PMMA) is widely used in joint arthroplasty to secure an implant to the host bone. Complications including fracture, bone loss and infection might cause failure of total knee arthroplasty (TKA), resulting in the need for revision total knee arthroplasty (rTKA). The goals of this paper are: (1) to identify the most common complications, outside of sepsis, arising from the application of PMMA following rTKA, (2) to discuss the current applications and drawbacks of employing PMMA in managing bone loss, (3) to review the role of PMMA in addressing bone infection following complications in rTKA. Papers published between …

Control And Locomotion Of Inertially And Magnetically Actuated Multi-Scale Robotic Systems, Ehab Al Khatib

Mechanical Engineering Research Theses and Dissertations

In this research, two actuation systems were introduced, inertial and magnetic actuation. In the inertial actuation, the robot used the transfer of momentum to navigate, and this momentum could be generated by spinning masses and wheels. Recent studies in our System Laboratory proved that a wide range of inertially actuated locomotion systems could be generated. This can be achieved by using a family tree approach, starting from a very simple system, and progressively evolving it to more complex ones. The motion diversity of these robots inspired us to extend their locomotion from a macro scale to millimeter and micro scales. …

Wearable Blood Pressure Device For Detection Of Orthostatic Hypotension, Mariam Hafez

Honors Scholar Theses

Orthostatic hypotension may be described as an inevitable response from the body in the form of a drop in blood pressure after changing positions. This quick drop in blood pressure can cause a syncopal episode, often injuring victims. There are limitations in the currently used cuff-type blood pressure sensor, which is used in healthcare settings, in that it does not continuously measure blood pressure. This research project developed a wearable device that measures heart rate variability (HRV) to detect changes in blood pressure using the correlation between the two measurements. The instrumentation was developed and included a commercially available pulse …

A Microfluidic Platform For High-Throughput Screening Of Aquaporin Performance, Adriana Del Pino Herrera, Jordan Hoydick, Rachel Rauh, Elyssa El-Hajj, Madison Burchfield

Undergraduate Research and Scholarship Symposium

Aquaporins are a family of small integral membrane proteins that transport water across cell membranes in response to osmotic gradients. They facilitate fluid secretion and absorption across epithelial surfaces in kidney tubules, exocrine glands, and gastrointestinal tract. Here, we describe a novel microfluidic method to evaluate and screen for aquaporin-based transmembrane permeability in mammalian cells. A microfluidic device was designed and fabricated for the encapsulation of single mammalian and yeast cells in micron-sized droplets. For this purpose, Chinese Hamster Ovarian (CHO) cells were used. CHO cells express AQP1 (aquaporin-1) homologous to human kidney aquaporins. The cells were cultivated and exposed …

Heel Down And Toe-Off Time Measured With Ultrasonic Doppler System And Force Plate Sensor, Sabin Timsina

Honors Theses

Collie Box is a medical device that measures the gait parameters of the person walk- ing in front of it. This device uses the Ultrasonic Doppler system to extract the heel-contact and toe-off times of a person walking within the range of 2-10 meters. These times are used to determine the leg’s swing phase and double stance times. The ultrasonic transducer of 10mm diameter is driven at 40kHz. At the time of the heel-contact and toe-off, foot velocity is zero while the torso part of the human body is still in motion. The wide directivity of 10mm diameter ultrasonic transducer …

Characterization Of Photoacoustic Flow Cytometry Signals, Craig Benzinger

Electronic Theses and Dissertations

Photoacoustic flow cytometry has been utilized to clinically determine the presence of melanoma circulating tumor cells (CTCs). Further investigation was conducted into the morphology of detection signals and how they could be manipulated to allow for further classification. Novel features were extracted from waveforms that appear to have strong classification ability. Neural networks were also used to determine classification potential and the creation of feature mapping for future unsupervised classification. Detections were expanded from single waves to a time dependent multiwave event. Waveforms were also determined to be of non-parametric distribution, allowing for classification by neural network but not allowing …

Rapid Antibiotic Susceptibility Testing Platform For Direct Clinical Samples, Terrance Zhang

Honors Scholar Theses

Infectious diseases and septicemia are two of the major causes of death in the U.S., necessitating rapid treatment of septic patients with proper, efficacious antibiotics. Unfortunately, the emergence and spread of multidrug-resistant bacteria are continuously being aggravated by an abuse in antibiotic prescription at a clinical and agricultural level. It is known that antibiotic resistance evolves through the sequential accumulation of multiple mutations in bacteria, which is accentuated by prolonged exposure of bacteria to ineffective antibiotics when implementing traditional septicemia treatment. The goal of this project is to develop a novel, easy-to-use AST platform for rapid antimicrobial susceptibility profiling to …

Contemporary Leadership Theory In Biomedical Engineering, Anna Seifried

Senior Honors Projects

Modern leadership theories have begun to slowly weave their way into technical skill based fields, such as Biomedical Engineering, due to a critical need for effective communication skills.

Effectively and efficiently integrating contemporary leadership techniques into these industries, allows for clear goal setting and increased personal and professional satisfaction for both the customers and faculty.

For my Honors Project, I sought to find pre-existing connections and form new ones between modern leadership theories and the current Biomedical Engineering field. I focused specifically on Prosthetics and Orthopedics, but these theories can be applied to other branches of Biomedical Engineering and extend …

Redesign And Quantitative Assessment Of An Accelerated Venous Valve Fatigue Apparatus, Megan Kueh

Biomedical Engineering Undergraduate Honors Theses

Chronic venous insufficiency (CVI) is a form of cardiovascular disease that is caused when valves in the leg become incompetent. Current treatment methods serve to manage symptoms, but there are currently no ways to treat the underlying cause of CVI. A venous valve prosthetic made from a xenograft of a bovine jugular vein is one possible treatment method currently in the research phase. Prosthetic valves must be tested with an accelerated wear tester prior to approval for clinical testing. Although such testers exist for heart valves, physiological differences between heart and venous valves restrict the use those testers on venous …

A High Frequency Photoacoustic System For Colorectal Cancer Imaging, Kexin Huang

McKelvey School of Engineering Graduate Student Theses & Dissertations

While colorectal cancer is the second largest cause of cancer-related deaths in the United States, early detection is a key factor in its survival rate. Compared to conventional imaging modalities, photoacoustic imaging offers benefits in providing angiographic images which are valuable for early-stage tumor detection. This thesis presents the design of a 32-channel 80 MHz photoacoustic image system, whose relatively high frequency offers particular advantages. The system comprises several modules, including a laser system, ultrasound probe, AD convertor, microcontroller (FPGA), and a computer. The system requires programs for the FPGA and the data receiver on the computer. The data transportation …

Computational Imaging Methods For Analysis Of Datscan Spect Images, Hae Sol Moon

McKelvey School of Engineering Graduate Student Theses & Dissertations

There is an important need to develop biomarkers to improve the diagnosis and assess the severity of Parkinson’s disease (PD). The potential to derive such biomarkers from quantitative dopamine transporter scan (DaT-Scan) single-photon emission computed tomography (SPECT) imaging, in particular the uptake of DaT in the caudate, putamen, and globus pallidus regions, is highly appealing as imaging is non-invasive and DaTScan is already used in the management of patients with PD. However, reliable quantification requires reliable segmentation of these regions in these images. Reliable segmentation is challenging due to the limited spatial resolution and high image noise in SPECT images …