Life Sciences | Open Access Articles | Digital Commons Network™

Nf-Kappab Signaling Pathways In Mammalian And Insect Innate Immunity, Neal S. Silverman, Tom Maniatis

Neal Silverman

In this review, we discuss recent advances in understanding the signaling pathways in mammalian and Drosophila innate immunity, with emphasis on the mechanisms by which NF-kappaB/Rel family proteins are activated.

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Hormonal Regulation Of The Humoral Innate Immune Response In Drosophila Melanogaster, Thomas Flatt, Andreas Heyland, Florentina Rus, Ermelinda Porpiglia, Chris Sherlock, Rochele Yamamoto, Alina Garbuzov, Subba R. Palli, Marc Tatar, Neal S. Silverman

Neal Silverman

Juvenile hormone (JH) and 20-hydroxy-ecdysone (20E) are highly versatile hormones, coordinating development, growth, reproduction and aging in insects. Pulses of 20E provide key signals for initiating developmental and physiological transitions, while JH promotes or inhibits these signals in a stage-specific manner. Previous evidence suggests that JH and 20E might modulate innate immunity, but whether and how these hormones interact to regulate the immune response remains unclear. Here we show that JH and 20E have antagonistic effects on the induction of antimicrobial peptide (AMP) genes in Drosophila melanogaster. 20E pretreatment of Schneider S2 cells promoted the robust induction of AMP genes, …

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Consent To The Use Of Stored Dna For Genetics Research: A Survey Of Attitudes In The Jewish Population, Marc D. Schwartz, Karen H. Rothenberg, Linda Joseph, Judith Benkendorf, Caryn Lerman

Karen H. Rothenberg

No abstract provided.

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Judging Genes: Implications Of The Second Generation Of Genetic Tests In The Courtroom, Diane E. Hoffmann, Karen H. Rothenberg

Karen H. Rothenberg

The use of DNA tests for identification has revolutionized court proceedings in criminal and paternity cases. Now, requests by litigants to admit or compel a second generation of genetic tests – tests to confirm or predict genetic diseases and conditions – threaten to affect judicial decision-making in many more contexts. Unlike DNA tests for identification, these second generation tests may provide highly personal health and behavioral information about individuals and their relatives and will pose new challenges for trial court judges. This article reports on an original empirical study of how judges analyze these requests and uses the study results …

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Social Implications Of Genetic Testing, Karen H. Rothenberg

Karen H. Rothenberg

This paper examines the social implications of predictive genetic testing and its impact on the insurance industry. Although the Human Genome Project has the potential to improve the health of our nation, it also may serve as a means of highlighting genetic differences among individuals and ethnic groups. Thus, if we are to reach the full promise of the Project, society must address the public's fears of genetic discrimination in insurance and employment context. Following an analysis of state and federal legislation on genetic privacy and discrimination, the paper concludes with a challenge to the insurance industry to work with …

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Genetic Information And The Workplace: Legislative Approaches And Policy Challenges, Karen H. Rothenberg, Barbara Fuller, Mark Rothstein, Troy Duster, Mary Jo Ellis Kahn, Rita Cunningham, Beth Fine, Kathy Hudson, Mary-Claire King, Patricia Murphy, Gary Swergold, Francis Collins

Karen H. Rothenberg

No abstract provided.

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The Scarlet Gene: Behavioral Genetics, Criminal Law, And Racial And Ethnic Stigma, Karen H. Rothenberg, Alice Wang

Karen H. Rothenberg

Imagine that a scientist from the state university asks you and your family to participate in a study on a particular gene variant associated with alcoholism. The project focuses on your ethnic group, the Tracy Islanders, who have a higher incidence of alcoholism, as well as a higher incidence of the gene variant, than the general population. You will not be informed whether you have the gene variant, but your participation in the study might help scientists develop drugs to help individuals control their addiction to alcohol. You have a family history of alcoholism, and you are concerned that your …

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When Should Judges Admit Or Compel Genetic Tests?, Diane E. Hoffmann, Karen H. Rothenberg

Karen H. Rothenberg

No abstract provided.

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Cancer Genetic Susceptibility Testing: Ethical And Policy Implications For Future Research And Clinical Practice, Benjamin S. Wilfond, Karen H. Rothenberg, Elizabeth J. Thomson, Caryn Lerman

Karen H. Rothenberg

No abstract provided.

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Toward A Framework Of Mutualism: The Jewish Community In Genetics Research, Karen H. Rothenberg, Amy B. Rutkin

Karen H. Rothenberg

No abstract provided.

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Tree Mortality Following Prescribed Fire And A Storm Surge Event In Slash Pine (Pinus Elliottii Var. Densa) Forests In The Florida Keys, Usa, Jay P. Sah, Michael S. Ross, James R. Snyder, Danielle E. Ogurcak

Department of Earth and Environment

In fire-dependent forests, managers are interested in predicting the consequences of prescribed burning on postfire tree mortality. We examined the effects of prescribed fire on tree mortality in Florida Keys pine forests, using a factorial design with understory type, season, and year of burn as factors. We also used logistic regression to model the effects of burn season, fire severity, and tree dimensions on individual tree mortality. Despite limited statistical power due to problems in carrying out the full suite of planned experimental burns, associations with tree and fire variables were observed. Post-fire pine tree mortality was negatively correlated with …

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Graduate Education In Research Ethics For Scientists And Engineers: Final Report, Jorge Ferrer-Negron, William Frey, Efrain O'Neill-Carrillo, Didier Valdes, Carlos Rios-Valazquez

Ethics in Science and Engineering National Clearinghouse

No abstract provided.

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Smokejumper Obituary: Ladendorff, Edmund (Missoula 1946), National Smokejumper Association

Smokejumper Obituaries

No abstract provided.

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Nina Cross, Nina Cross, Institute Of Child Nutrition

Oral History Project (all interviews)

Evelina (Nina) Cross received her PhD from Texas Woman’s University and then joined the faculty at Louisiana State University. While at LSU, she taught and directed the dietetic internship. Her research and many of her publications were in the area of school food service. In addition, she served three years as the first National Food Service Management Institute Scholar. During this time she worked with the research arm of the Institute to develop a financial model for school food service. Since retirement from LSU, Dr. Cross has worked with both the Louisiana and Mississippi Departments of Education to offer continuing …

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Actions Of Octocoral And Tobacco Cembranoids On Nicotinic Receptors, P. A. Ferchmin, Oné R. Pagán, Henning Ulrich, Ada C. Szeto, Richard M. Hann, Vesna A. Eterović

Biology Faculty Publications

Nicotinic acetylcholine receptors (AChRs) are pentameric proteins that form agonist-gated cation channels through the plasma membrane. AChR agonists and antagonists are potential candidates for the treatment of neurodegenerative diseases. Cembranoids are naturally occurring diterpenoids that contain a 14-carbon ring. These diterpenoids interact with AChRs in complex ways: as irreversible inhibitors at the agonist sites, as noncompetitive inhibitors, or as positive modulators, but no cembranoid was ever shown to have agonistic activity on AChRs. The cembranoid eupalmerin acetate displays positive modulation of agonist-induced currents in the muscle-type AChR and in the related gamma-aminobutyric acid (GABA) type A receptor. Moreover, cembranoids display …

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Protein Rrcovered From Oyster Wash Water By Ultrafiltration And Their Utilization As Oyster Sauce Through Fermentation, Chyuan-Yuan Shiau, Tuu-Jyi Chai

Journal of Marine Science and Technology

The use of ultrafiltration to recover proteins from oyster wash water was found to increase the protein concentration by 18 folds. The concentrations of total suspended solids and chemical oxygen demand in the permeate were reduced by 98 and 47%, respectively. Fermentation was a good method to improve the flavor of the retentate from ultrafiltration. The increase in concentrations of extractive-N, free amino acids and small peptides supported the idea that the fermentation process with Koji (cultured with Aspergillus oryzae) could accelerate the hydrolysis of the recovered protein. The Koji fermented juice was made into oyster sauce, which was accepted …

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Influence Of Surface Currents On Post-Nesting Migration Of Green Sea Turtles Nesting On Wan-An Island, Penghu Archipelago, Taiwan, I-Jiunn Cheng, Yu-Huai Wang

Journal of Marine Science and Technology

The relationships between ambient flows and the migration corridors of green turtles (Chelonia mydas) nesting at Wan-an Island, Penghu Archipelago in Taiwan Strait were determined. Six turtles deployed with Argos-linked satellite tags from 1996 to 2004 were used. The ambient flows were derived from the combination of ship board measurements, a global tidal model, and the geostrophic flows derived from sea surface height anomalies. The results showed that there were, basically, three migrating patterns. Turtles that migrated northeastward rode the main surface currents, traveling 2000 km in a month. The swimming speeds along the track were less than 0.5 m …

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Fleet Dynamic Analysis Of The Taiwan Offshore Trawl Fishery: An Application Of The Sea Surface Temperature Measures, Chin-Hwa Sun, Fu-Sung Chiang

Journal of Marine Science and Technology

The overall goal of this paper is to provide important information documenting and analyzing Taiwan’s trawl fishing fleet activities in the northeastern of Taiwan. Seasonal SST data are used to analyze different seasonal fishing patterns and the density of fleet dynamics of offshore trawl fleet is used to identify five distinct fishing areas (A, B, C, D, and E) in the northeastern of Taiwan. A Wilcoxon sign test is used to examine the variability in the percent of days spent in each fishing area from 1993 to 1996. Results show that a significant portion of trawl vessels have shifted from …

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Inferring Dispersal Of Aquatic Invertebrates From Genetic Variation: A Comparative Study Of An Amphipod (Talitridae Hyalella Azteca) And Mayfly (Baetidae Callibaetis Americanus) In Great Basin Springs, Heather Lynn Stutz

Theses and Dissertations

Whether active or passive, dispersal accompanied by gene flow shapes the population genetics and evolutionary divergence of species. Indirect methods which use genetic markers have the ability to assess effective dispersal—that which resulted in gene flow. My objective was to see if an aquatic insect and an obligate aquatic invertebrate show similar phylogeographic patterns and genetic uniqueness. Hyalella azteca and Callibaetis americanus were collected from 4-5 springs in each of six basins in the Great Basin of western North America. No dispersal or genetic studies of C. americanus have been conducted to date. However, several studies focusing on mtDNA diversity …

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Manifest Greatness Version5 By Marc Guerrero With Tato Malay, Emmanuel Mario B. Santos Aka Marc Guerrero

Emmanuel Mario B Santos aka Marc Guerrero

MANIFEST GREATNESS version5 by Marc Guerrero with Tato Malay

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Smokejumper Obituary: Sullivan, Jerry (North Cascades 1949), National Smokejumper Association

Smokejumper Obituaries

No abstract provided.

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The Danger Signal Adenosine Induces Persistence Of Chlamydial Infection Through Stimulation Of A2b Receptors, Matthew A. Pettengill, Verissa W. Lam, David M. Ojcius

All Dugoni School of Dentistry Faculty Articles

Infections with intracellular bacteria such as chlamydiae affect the majority of the world population. Infected tissue inflammation and granuloma formation help contain the short-term expansion of the invading pathogen, leading also to local tissue damage and hypoxia. However, the effects of key aspects of damaged inflamed tissues and hypoxia on continued infection with intracellular bacteria remain unknown. We find that development of Chlamydia trachomatis is reversibly retarded by prolonged exposure of infected cells to extracellular adenosine, a hallmark of hypoxia and advanced inflammation. In epithelial cells, this effect was mediated by the A2b adenosine receptor, unique in the adenosine receptor …

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Manifest Greatness Version3 By Marc Guerrero With Jay Fajardo, Emmanuel Mario B. Santos Aka Marc Guerrero

Emmanuel Mario B Santos aka Marc Guerrero

MANIFEST GREATNESS version3 by Marc Guerrero with Jay Fajardo

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The Effect Of Heavy Handrail Support On Blood Pressure Response In Normotensive Adults During Treadmill Walking, Kevin Brian Reid

Masters Theses, 2010-2019

Physiological and hemodynamic responses to handrail support during treadmill walking have shown a blunted response when compared to non-handrail support. The effects of treadmill walking, with the inclusion of “heavy” upper limb and torso activation through handrail support is yet unreported. The effect of “heavy” support through side handrail support (SHRS) and front console support (C) versus no handrail support (NHRS) treadmill walking was studied utilizing both slow/low (2.5 mph & 3% elevation) and high/fast (3.5 mph & 11% elevation) energy expenditure levels. Seventeen healthy adults (43.89 +/- 6.07 years) completed trials at both energy expenditure levels incorporating all three …

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The Effects Of Different Doses Of Caffeine On A 40 Kilometer Cycling Time Trial: A Dose-Response Study, Michael Martin

Masters Theses, 2010-2019

Abstract The purpose of this study was to determine the ergogenic response to different caffeine doses of 3 mg/kg and 6 mg/kg consumed by trained cyclists 1 hour prior to a 40 kilometer cycling time trial. It was hypothesized that there would not be a difference in time trial performance following caffeine supplementation of a 3 mg/kg dose as compared to a 6 mg/kg dose. Sixteen male subjects, age 18-40, were initially assessed via a VO2max test on an indoor cycle trainer. Subjects then reported to the lab on 4 separate occasions following a 10 hour fast and a 24 …

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Comparison Of Single-Use And Multiple-Use Electrodes For Sensory, Motor Threshold Amplitudes And Force Production, Lucia Maloy

Theses and Dissertations

Context: Electrodes play an important role in interfacing tissue with electrical stimulation devices. Manufacturers recommend that adhesive metallic mesh cloth electrodes be used no more than 10 times before they are discarded, however, clinically the electrodes are often used up to 30 times. Another concern is sanitation. When electrodes are used on different patients, there is a chance for cross-contamination and bacterial growth on the electrode. Objective: To compare amplitudes of perceived sensation, motor twitch and force produced at specific amplitudes using single-use electrodes that run no risk of cross-contamination, and multiple-use electrodes. Design: Mixed model ANOVA with the subject …

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The Gaas Metagenomic Tool And Its Estimations Of Viral And Microbial Average Genome Size In Four Major Biomes, Florent E. Angly, Dana Willner, Alejandra Prieto-Davo, Robert A. Edwards, Robert Schmieder, Rebecca Vega-Thurber, Dionsios A. Antonopoulos, Katie Barott, Matthew T. Cottrell, Christelle Desnues, Elizabeth A. Dinsdale, Mike Furlan, Matthew Haynes, Matthew R. Henn, Yongfei Hu, David L. Kirchman, Tracey Mcdole, John D. Mcpherson, Folker Meyer, R. Michael Miller, Egbert Mundt, Robert K. Naviaux, Beltran Rodriguez-Mueller, Rick Stevens, Linda Wegley, Lixin Zhang, Baoli Zhu, Forest Rohwer

Department of Biological Sciences

Metagenomic studies characterize both the composition and diversity of uncultured viral and microbial communities. BLAST-based comparisons have typically been used for such analyses; however, sampling biases, high percentages of unknown sequences, and the use of arbitrary thresholds to find significant similarities can decrease the accuracy and validity of estimates. Here, we present Genome relative Abundance and Average Size (GAAS), a complete software package that provides improved estimates of community composition and average genome length for metagenomes in both textual and graphical formats. GAAS implements a novel methodology to control for sampling bias via length normalization, to adjust for multiple BLAST …

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Feature Selection And Classification Of Maqc-Ii Breast Cancer And Multiple Myeloma Microarray Gene Expression Data, Qingzhong Liu, Andrew H. Sung, Zhongxue Chen, Jianzhong Liu, Xudong Huang, Youping Deng

Faculty Publications

Microarray data has a high dimension of variables but available datasets usually have only a small number of samples, thereby making the study of such datasets interesting and challenging. In the task of analyzing microarray data for the purpose of, e.g., predicting gene-disease association, feature selection is very important because it provides a way to handle the high dimensionality by exploiting information redundancy induced by associations among genetic markers. Judicious feature selection in microarray data analysis can result in significant reduction of cost while maintaining or improving the classification or prediction accuracy of learning machines that are employed to sort …

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Manifest Greatness Version2 With Danielle Van Asch-Prevot, Emmanuel Mario B. Santos Aka Marc Guerrero

Emmanuel Mario B Santos aka Marc Guerrero

MANIFEST GREATNESS version2 by Marc Guerrero with Danielle van Asch-Prevot

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Environmental Dna Sequencing Primers For Eutardigrades And Bdelloid Rotifers, Byron J. Adams, Jeremy Whiting, Elizabeth K. Costello, Kristen R. Freeman, Andrew P. Martin, Michael S. Robeson, Steve K. Schmidt

Faculty Publications

Background: The time it takes to isolate individuals from environmental samples and then extract DNA from each individual is one of the problems with generating molecular data from meiofauna such as eutardigrades and bdelloid rotifers. The lack of consistent morphological information and the extreme abundance of these classes makes morphological identification of rare, or even common cryptic taxa a large and unwieldy task. This limits the ability to perform large-scale surveys of the diversity of these organisms. Here we demonstrate a culture-independent molecular survey approach that enables the generation of large amounts of eutardigrade and bdelloid rotifer sequence data directly …

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Full-Text Articles in Life Sciences

Nf-Kappab Signaling Pathways In Mammalian And Insect Innate Immunity, Neal S. Silverman, Tom Maniatis

Neal Silverman

Hormonal Regulation Of The Humoral Innate Immune Response In Drosophila Melanogaster, Thomas Flatt, Andreas Heyland, Florentina Rus, Ermelinda Porpiglia, Chris Sherlock, Rochele Yamamoto, Alina Garbuzov, Subba R. Palli, Marc Tatar, Neal S. Silverman

Neal Silverman

Consent To The Use Of Stored Dna For Genetics Research: A Survey Of Attitudes In The Jewish Population, Marc D. Schwartz, Karen H. Rothenberg, Linda Joseph, Judith Benkendorf, Caryn Lerman

Karen H. Rothenberg

Judging Genes: Implications Of The Second Generation Of Genetic Tests In The Courtroom, Diane E. Hoffmann, Karen H. Rothenberg

Karen H. Rothenberg

Social Implications Of Genetic Testing, Karen H. Rothenberg

Karen H. Rothenberg

Genetic Information And The Workplace: Legislative Approaches And Policy Challenges, Karen H. Rothenberg, Barbara Fuller, Mark Rothstein, Troy Duster, Mary Jo Ellis Kahn, Rita Cunningham, Beth Fine, Kathy Hudson, Mary-Claire King, Patricia Murphy, Gary Swergold, Francis Collins

Karen H. Rothenberg

The Scarlet Gene: Behavioral Genetics, Criminal Law, And Racial And Ethnic Stigma, Karen H. Rothenberg, Alice Wang

Karen H. Rothenberg

When Should Judges Admit Or Compel Genetic Tests?, Diane E. Hoffmann, Karen H. Rothenberg

Karen H. Rothenberg

Cancer Genetic Susceptibility Testing: Ethical And Policy Implications For Future Research And Clinical Practice, Benjamin S. Wilfond, Karen H. Rothenberg, Elizabeth J. Thomson, Caryn Lerman

Karen H. Rothenberg

Toward A Framework Of Mutualism: The Jewish Community In Genetics Research, Karen H. Rothenberg, Amy B. Rutkin

Karen H. Rothenberg

Tree Mortality Following Prescribed Fire And A Storm Surge Event In Slash Pine (Pinus Elliottii Var. Densa) Forests In The Florida Keys, Usa, Jay P. Sah, Michael S. Ross, James R. Snyder, Danielle E. Ogurcak

Department of Earth and Environment

Graduate Education In Research Ethics For Scientists And Engineers: Final Report, Jorge Ferrer-Negron, William Frey, Efrain O'Neill-Carrillo, Didier Valdes, Carlos Rios-Valazquez

Ethics in Science and Engineering National Clearinghouse

Smokejumper Obituary: Ladendorff, Edmund (Missoula 1946), National Smokejumper Association

Smokejumper Obituaries

Nina Cross, Nina Cross, Institute Of Child Nutrition

Oral History Project (all interviews)

Actions Of Octocoral And Tobacco Cembranoids On Nicotinic Receptors, P. A. Ferchmin, Oné R. Pagán, Henning Ulrich, Ada C. Szeto, Richard M. Hann, Vesna A. Eterović

Biology Faculty Publications

Protein Rrcovered From Oyster Wash Water By Ultrafiltration And Their Utilization As Oyster Sauce Through Fermentation, Chyuan-Yuan Shiau, Tuu-Jyi Chai

Journal of Marine Science and Technology

Influence Of Surface Currents On Post-Nesting Migration Of Green Sea Turtles Nesting On Wan-An Island, Penghu Archipelago, Taiwan, I-Jiunn Cheng, Yu-Huai Wang

Journal of Marine Science and Technology

Fleet Dynamic Analysis Of The Taiwan Offshore Trawl Fishery: An Application Of The Sea Surface Temperature Measures, Chin-Hwa Sun, Fu-Sung Chiang

Journal of Marine Science and Technology

Inferring Dispersal Of Aquatic Invertebrates From Genetic Variation: A Comparative Study Of An Amphipod (Talitridae Hyalella Azteca) And Mayfly (Baetidae Callibaetis Americanus) In Great Basin Springs, Heather Lynn Stutz

Theses and Dissertations

Manifest Greatness Version5 By Marc Guerrero With Tato Malay, Emmanuel Mario B. Santos Aka Marc Guerrero

Emmanuel Mario B Santos aka Marc Guerrero

Smokejumper Obituary: Sullivan, Jerry (North Cascades 1949), National Smokejumper Association

Smokejumper Obituaries

The Danger Signal Adenosine Induces Persistence Of Chlamydial Infection Through Stimulation Of A2b Receptors, Matthew A. Pettengill, Verissa W. Lam, David M. Ojcius

All Dugoni School of Dentistry Faculty Articles

Manifest Greatness Version3 By Marc Guerrero With Jay Fajardo, Emmanuel Mario B. Santos Aka Marc Guerrero

Emmanuel Mario B Santos aka Marc Guerrero

The Effect Of Heavy Handrail Support On Blood Pressure Response In Normotensive Adults During Treadmill Walking, Kevin Brian Reid

Masters Theses, 2010-2019

The Effects Of Different Doses Of Caffeine On A 40 Kilometer Cycling Time Trial: A Dose-Response Study, Michael Martin

Masters Theses, 2010-2019

Comparison Of Single-Use And Multiple-Use Electrodes For Sensory, Motor Threshold Amplitudes And Force Production, Lucia Maloy

Theses and Dissertations

Department of Biological Sciences

Feature Selection And Classification Of Maqc-Ii Breast Cancer And Multiple Myeloma Microarray Gene Expression Data, Qingzhong Liu, Andrew H. Sung, Zhongxue Chen, Jianzhong Liu, Xudong Huang, Youping Deng

Faculty Publications

Manifest Greatness Version2 With Danielle Van Asch-Prevot, Emmanuel Mario B. Santos Aka Marc Guerrero

Emmanuel Mario B Santos aka Marc Guerrero

Environmental Dna Sequencing Primers For Eutardigrades And Bdelloid Rotifers, Byron J. Adams, Jeremy Whiting, Elizabeth K. Costello, Kristen R. Freeman, Andrew P. Martin, Michael S. Robeson, Steve K. Schmidt

Faculty Publications