Statistical Models Commons^™

Gene Set Testing By Distance Correlation, Sho-Hsien Su

Graduate Theses and Dissertations

Pathways are the functional building blocks of complex diseases such as cancers. Pathway-level studies may provide insights on some important biological processes. Gene set test is an important tool to study the differential expression of a gene set between two groups, e.g., cancer vs normal. The differential expression of a gene set could be due to the difference in mean, variability, or both. However, most existing gene set tests only target the mean difference but overlook other types of differential expression. In this thesis, we propose to use the recently developed distance correlation for gene set testing. To assess the …

Quantifying The Simultaneous Effect Of Socio-Economic Predictors And Build Environment On Spatial Crime Trends, Alfieri Daniel Ek

Graduate Theses and Dissertations

Proper allocation of law enforcement agencies falls under the umbrella of risk terrainmodeling (Caplan et al., 2011, 2015; Drawve, 2016) that primarily focuses on crime prediction and prevention by spatially aggregating response and predictor variables of interest. Although mental health incidents demand resource allocation from law enforcement agencies and the city, relatively less emphasis has been placed on building spatial models for mental health incidents events. Analyzing spatial mental health events in Little Rock, AR over 2015 to 2018, we found evidence of spatial heterogeneity via Moran’s I statistic. A spatial modeling framework is then built using generalized linear models, …

A Management Strategy Evaluation Of The Impacts Of Interspecific Competition And Recreational Fishery Dynamics On Vermilion Snapper (Rhomboplites Aurorubens) In The Gulf Of Mexico, Megumi C. Oshima

Dissertations

In the Gulf of Mexico (GOM), Vermilion Snapper (Rhomboplites auroruben), are believed to compete with Red Snapper directly for prey and habitat. The two species share similar diets and have significant spatial overlap in the Gulf. Red Snapper are thought to be the dominate competitor, forcing Vermilion Snapper to feed on less nutritious prey when local resources are depleted. In addition to ecological pressures, GOM Vermilion Snapper support substantial commercial and recreational fisheries. Over the past decade, recreational landings have steadily increased, reaching a historical high in 2018. One cause may be stricter regulations for similar target species such as …

Statistical Approaches Of Gene Set Analysis With Quantitative Trait Loci For High-Throughput Genomic Studies., Samarendra Das

Electronic Theses and Dissertations

Recently, gene set analysis has become the first choice for gaining insights into the underlying complex biology of diseases through high-throughput genomic studies, such as Microarrays, bulk RNA-Sequencing, single cell RNA-Sequencing, etc. It also reduces the complexity of statistical analysis and enhances the explanatory power of the obtained results. Further, the statistical structure and steps common to these approaches have not yet been comprehensively discussed, which limits their utility. Hence, a comprehensive overview of the available gene set analysis approaches used for different high-throughput genomic studies is provided. The analysis of gene sets is usually carried out based on …

Incorporating Shear Resistance Into Debris Flow Triggering Model Statistics, Noah J. Lyman

Master's Theses

Several regions of the Western United States utilize statistical binary classification models to predict and manage debris flow initiation probability after wildfires. As the occurrence of wildfires and large intensity rainfall events increase, so has the frequency in which development occurs in the steep and mountainous terrain where these events arise. This resulting intersection brings with it an increasing need to derive improved results from existing models, or develop new models, to reduce the economic and human impacts that debris flows may bring. Any development or change to these models could also theoretically increase the ease of collection, processing, and …

Development Of A Statistical Model To Predict Materials’ Unit Prices For Future Maintenance And Rehabilitation In Highway Life Cycle Cost Analysis, Changmo Kim, Ghazan Khan, Brent Nguyen, Emily L. Hoang

Mineta Transportation Institute

The main objectives of this study are to investigate the trends in primary pavement materials’ unit price over time and to develop statistical models and guidelines for using predictive unit prices of pavement materials instead of uniform unit prices in life cycle cost analysis (LCCA) for future maintenance and rehabilitation (M&R) projects. Various socio-economic data were collected for the past 20 years (1997–2018) in California, including oil price, population, government expenditure in transportation, vehicle registration, and other key variables, in order to identify factors affecting pavement materials’ unit price. Additionally, the unit price records of the popular pavement materials were …

Statistical Methods With A Focus On Joint Outcome Modeling And On Methods For Fire Science, Da Zhong Xi

Electronic Thesis and Dissertation Repository

Understanding the dynamics of wildfires contributes significantly to the development of fire science. Challenges in the analysis of historical fire data include defining fire dynamics within existing statistical frameworks, modeling the duration and size of fires as joint outcomes, identifying the how fires are grouped into clusters of subpopulations, and assessing the effect of environmental variables in different modeling frameworks. We develop novel statistical methods to consider outcomes related to fire science jointly. These methods address these challenges by linking univariate models for separate outcomes through shared random effects, an approach referred to as joint modeling. Comparisons with existing …

Stochastic Analysis And Statistical Inference For Seir Models Of Infectious Diseases, Andrés Ríos-Gutiérrez, Viswanathan Arunachalam, Anuj Mubayi

Annual Symposium on Biomathematics and Ecology Education and Research

No abstract provided.

Stochastic Modeling Of Ovarian Follicle Growth In Adult Female Rats, Zhaozhi Li

Annual Symposium on Biomathematics and Ecology Education and Research

No abstract provided.

Statistical Modeling Of Private Sector Participation In Disaster Risk Reduction Data, Wupeng Yin

FIU Electronic Theses and Dissertations

The impacts of disaster on the private sector are inevitable, but their risks can be managed and reduced by preventively evaluative measures. Disaster risk reduction index (DRRI) and Disaster Experience (DE) variables were investigated in a survey study in six Western Hemisphere cities within the private sector of various business sizes. Our thesis built and evaluated 16 predictive models of DRRI with 36 categorical predictors and N = 1162 observations. Four statistical methods for linear regression and five for classification as well as seven machine learning methods were utilized. We also used stepwise selection and regulation methods for variable selection. …

Applying The Data: Predictive Analytics In Sport, Anthony Teeter, Margo Bergman

Access*: Interdisciplinary Journal of Student Research and Scholarship

The history of wagering predictions and their impact on wide reaching disciplines such as statistics and economics dates to at least the 1700’s, if not before. Predicting the outcomes of sports is a multibillion-dollar business that capitalizes on these tools but is in constant development with the addition of big data analytics methods. Sportsline.com, a popular website for fantasy sports leagues, provides odds predictions in multiple sports, produces proprietary computer models of both winning and losing teams, and provides specific point estimates. To test likely candidates for inclusion in these prediction algorithms, the authors developed a computer model, and test …

Interval Estimation Of Proportion Of Second-Level Variance In Multi-Level Modeling, Steven Svoboda

The Nebraska Educator: A Student-Led Journal

Physical, behavioral and psychological research questions often relate to hierarchical data systems. Examples of hierarchical data systems include repeated measures of students nested within classrooms, nested within schools and employees nested within supervisors, nested within organizations. Applied researchers studying hierarchical data structures should have an estimate of the intraclass correlation coefficient (ICC) for every nested level in their analyses because ignoring even relatively small amounts of interdependence is known to inflate Type I error rate in single-level models. Traditionally, researchers rely upon the ICC as a point estimate of the amount of interdependency in their data. Recent methods utilizing an …

Cost Estimating Using A New Learning Curve Theory For Non-Constant Production Rates, Dakotah Hogan, John J. Elshaw, Clay M. Koschnick, Jonathan D. Ritschel, Adedeji B. Badiru, Shawn M. Valentine

Faculty Publications

Traditional learning curve theory assumes a constant learning rate regardless of the number of units produced. However, a collection of theoretical and empirical evidence indicates that learning rates decrease as more units are produced in some cases. These diminishing learning rates cause traditional learning curves to underestimate required resources, potentially resulting in cost overruns. A diminishing learning rate model, namely Boone’s learning curve, was recently developed to model this phenomenon. This research confirms that Boone’s learning curve systematically reduced error in modeling observed learning curves using production data from 169 Department of Defense end-items. However, high amounts of variability in …

A Differential Geometry-Based Machine Learning Algorithm For The Brain Age Problem, Justin Asher, Khoa Tan Dang, Maxwell Masters

The Journal of Purdue Undergraduate Research

No abstract provided.

Predicting Postoperative Delirium Risk For Intracranial Surgery: A Statistical Machine Learning Approach, Juliet Aygun, Alaina Bartfeld, Sahana Rayan

The Journal of Purdue Undergraduate Research

No abstract provided.

Renewable-Energy Resources, Economic Growth And Their Causal Link, Yiyang Chen

Electronic Thesis and Dissertation Repository

This thesis examines the presence and strength of predictive causal relationship between re-newable energy prices and economic growth. We look for evidence by investigating the cases of Norway, New Zealand, and Canada’s two provinces of Alberta and Ontario. The usual vectorautoregressive model (VAR) and its various improved versions still assume constant parametersover time. We devise a Markov-switching VAR (MS-VAR) model in order to accommodate the observed time-dependent causal relation changes. Our proposed modelling approach is induced by the hidden Markov model methodologies in terms of an online parameter estimationthrough recursive filtering. The parameters of the MS-VAR model are governed by …

A Geochemical And Statistical Investigation Of The Big Four Springs Region In Southern Missouri, Jordan Jasso Vega

MSU Graduate Theses

The Big Four Springs region hosts four major first-order magnitude springs in southern Missouri and northern Arkansas. These springs are Big Spring (Carter County, MO), Greer Spring (Oregon County, MO), Mammoth Spring (Fulton County, AR), and Hodgson Mill Spring (Ozark County, MO). Based on historic dye traces and hydrogeological investigations, these springs drain an area of approximately 1500 square miles and collectively discharge an average of 780 million gallons of water per day. The rocks from youngest to oldest that are found in Big Four Springs region are the Cotter and Jefferson City Dolomite (Ordovician), Roubidoux Formation (Ordovician), Gasconade Dolomite …

D-Vine Pair-Copula Models For Longitudinal Binary Data, Huihui Lin

Mathematics & Statistics Theses & Dissertations

Dependent longitudinal binary data are prevalent in a wide range of scientific disciplines, including healthcare and medicine. A popular method for analyzing such data is the multivariate probit (MP) model. The motivation for this dissertation stems from the fact that the MP model fails even the binary correlations are within the feasible range. The reason being the underlying correlation matrix of the latent variables in the MP model may not be positive definite. In this dissertation, we study alternatives that are based on D-vine pair-copula models. We consider both the serial dependence modeled by the first order autoregressive (AR(1)) and …

Machine Learning Approaches For Improving Prediction Performance Of Structure-Activity Relationship Models, Gabriel Idakwo

Dissertations

In silico bioactivity prediction studies are designed to complement in vivo and in vitro efforts to assess the activity and properties of small molecules. In silico methods such as Quantitative Structure-Activity/Property Relationship (QSAR) are used to correlate the structure of a molecule to its biological property in drug design and toxicological studies. In this body of work, I started with two in-depth reviews into the application of machine learning based approaches and feature reduction methods to QSAR, and then investigated solutions to three common challenges faced in machine learning based QSAR studies.

First, to improve the prediction accuracy of learning …

Lectures On Mathematical Computing With Python, Jay Gopalakrishnan

PDXOpen: Open Educational Resources

This open resource is a collection of class activities for use in undergraduate courses aimed at teaching mathematical computing, and computational thinking in general, using the python programming language. It was developed for a second-year course (MTH 271) revamped for a new undergraduate program in data science at Portland State University. The activities are designed to guide students' use of python modules effectively for scientific computation, data analysis, and visualization.

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