Statistics and Probability Commons^™

Targeted Maximum Likelihood Method For Repeated Measures Semiparametric Regression: Discovery For Transcription Factor Activity, Catherine Tuglus, Mark J. Van Der Laan

U.C. Berkeley Division of Biostatistics Working Paper Series

In longitudinal and repeated measures data analysis, often the goal is to determine the effect of a treatment or aspect on a particular outcome (e.g. disease progression). We consider semiparametric repeated measures regression model, where the parametric component models effect of the variable of interest and any modification by other covariates. The expectation of this parametric component over the other covariates is a measure of variable importance. Here we present a targeted maximum likelihood estimator of the finite dimensional regression parameter, which is easily estimated using standard software for generalized estimating equations. The targeted maximum likelihood method provides double robust …

Graphical Procedures For Evaluating Overall And Subject-Specific Incremental Values From New Predictors With Censored Event Time Data, Hajime Uno, Tianxi Cai, Lu Tian, L. J. Wei

Harvard University Biostatistics Working Paper Series

No abstract provided.

Collaborative Targeted Maximum Likelihood For Time To Event Data, Ori M. Stitelman, Mark J. Van Der Laan

U.C. Berkeley Division of Biostatistics Working Paper Series

Current methods used to analyze time to event data either, rely on highly parametric assumptions which result in biased estimates of parameters which are purely chosen out of convenience, or are highly unstable because they ignore the global constraints of the true model. By using Targeted Maximum Likelihood Estimation one may consistently estimate parameters which directly answer the statistical question of interest. Targeted Maximum Likelihood Estimators are substitution estimators, which rely on estimating the underlying distribution. However, unlike other substitution estimators, the underlying distribution is estimated specifically to reduce bias in the estimate of the parameter of interest. We will …

Doubly Regularized Reml For Estimation And Selection Of Fixed And Random Effects In Linear Mixed-Effects Models, Sijian Wang, Peter Xuewin Song, Ji Zhu

The University of Michigan Department of Biostatistics Working Paper Series

The linear mixed effects model (LMM) is widely used in the analysis of clustered or longitudinal data. In the practice of LMM, the inference on the structure of the random effects component is of great importance, not only to yield proper interpretation of subject-specific effects but also to draw valid statistical conclusions. This task of inference becomes significantly challenging when a large number of fixed effects and random effects are involved in the analysis. The difficulty of variable selection arises from the need of simultaneously regularizing both mean model and covariance structures, with possible parameter constraints between the two. In …

Multilevel Sparse Functional Principal Component Analysis, Chong-Zhi Di, Ciprian M. Crainiceanu

Johns Hopkins University, Dept. of Biostatistics Working Papers

The basic observational unit in this paper is a function. Data are assumed to have a natural hierarchy of basic units. A simple example is when functions are recorded at multiple visits for the same subject. Di et al. (2009) proposed Multilevel Functional Principal Component Analysis (MFPCA) for this type of data structure when functions are densely sampled. Here we consider the case when functions are sparsely sampled and may contain as few as 2 or 3 observations per function. As with MFPCA, we exploit the multilevel structure of covariance operators and data reduction induced by the use of principal …

A New Class Of Dantzig Selectors For Censored Linear Regression Models, Yi Li, Lee Dicker, Sihai Dave Zhao

Harvard University Biostatistics Working Paper Series

No abstract provided.

Statistical Power Analysis Using Sas And R, Peter Osmena

Statistics

Statistical power is something that has to be considered when designing an experiment. The power is used to determine the usefulness of the test. In this paper the concept of power and what it is will be discussed. A general ANOVA test and a Chi Squared test will be discussed in greater depth. Computers make these power calculations relatively easy to compute, considering they are used right. SAS and R both have the capabilities to make these calculations for a different variety of tests. Calculating power for a general ANOVA test and a Chi Squared test using these programs are …

Monopoly, Regulation, And Innovation, Matt Bogard

Economics Faculty Publications

Recently the Justice department has started investigations into alleged anti-trust violations by Monsanto. This has helped fuel a lot of already hyped discontent with one of the world’s leaders in innovative solutions for sustainable agriculture. This article discusses how the regulatory environment could possibly have contributed to more concentration and power in the biotech industry. Increasing regulation would likely have the opposite effect of creating a level playing field in the agriculture industry. From AgWeb, March 27,2010 http://www.agweb.com/blog/Economic_Sense_190/Monopoly_Regulation__and_Innovation_10771/

Software Internationalization: A Framework Validated Against Industry Requirements For Computer Science And Software Engineering Programs, John Huân Vũ

Master's Theses

View John Huân Vũ's thesis presentation at http://youtu.be/y3bzNmkTr-c.

In 2001, the ACM and IEEE Computing Curriculum stated that it was necessary to address "the need to develop implementation models that are international in scope and could be practiced in universities around the world." With increasing connectivity through the internet, the move towards a global economy and growing use of technology places software internationalization as a more important concern for developers. However, there has been a "clear shortage in terms of numbers of trained persons applying for entry-level positions" in this area. Eric Brechner, Director of Microsoft Development Training, suggested …

Culture, Acculturation, And Social Capital: Latinos And Use Of Mental Health Services, Edward Mcfield Jr.

Loma Linda University Electronic Theses, Dissertations & Projects

Studies suggest that the prevalence of mental illness in Latinos is similar to that of other groups; however, Latinos are less likely than non-Latino whites to access mental health services, and when they do, the quality of care is poor. To better understand the factors that influence use of mental health services among Latinos, a descriptive, cross-sectional, correlational study was conducted (N= 340; 219 non-consumers and 121 consumers), which examined the association between social capital, acculturation, cultural beliefs or explanatory models of illness, stigma, need, and mental health service use. An innovative integrative model drawing from Andersen's Behavioral …

Targeting The Optimal Design In Randomized Clinical Trials With Binary Outcomes And No Covariate, Antoine Chambaz, Mark J. Van Der Laan

U.C. Berkeley Division of Biostatistics Working Paper Series

This article is devoted to the asymptotic study of adaptive group sequential designs in the case of randomized clinical trials with binary treatment, binary outcome and no covariate. By adaptive design, we mean in this setting a clinical trial design that allows the investigator to dynamically modify its course through data-driven adjustment of the randomization probability based on data accrued so far, without negatively impacting on the statistical integrity of the trial. By adaptive group sequential design, we refer to the fact that group sequential testing methods can be equally well applied on top of adaptive designs. Prior to collection …

Targeted Maximum Likelihood Based Causal Inference, Mark J. Van Der Laan

U.C. Berkeley Division of Biostatistics Working Paper Series

Given causal graph assumptions, intervention-specific counterfactual distributions of the data can be defined by the so called G-computation formula, which is obtained by carrying out these interventions on the likelihood of the data factorized according to the causal graph. The obtained G-computation formula represents the counterfactual distribution the data would have had if this intervention would have been enforced on the system generating the data. A causal effect of interest can now be defined as some difference between these counterfactual distributions indexed by different interventions. For example, the interventions can represent static treatment regimens or individualized treatment rules that assign …

Bio-Creep In Non-Inferiority Clinical Trials, Siobhan P. Everson-Stewart, Scott S. Emerson

UW Biostatistics Working Paper Series

After a non-inferiority clinical trial, a new therapy may be accepted as effective, even if its treatment effect is slightly smaller than the current standard. It is therefore possible that, after a series of trials where the new therapy is slightly worse than the preceding drugs, an ineffective or harmful therapy might be incorrectly declared efficacious; this is known as “bio-creep.” Several factors may influence the rate at which bio-creep occurs, including the distribution of the effects of the new agents being tested and how that changes over time, the choice of active comparator, the method used to model the …

Estimates Of Information Growth In Longitudinal Clinical Trials, Abigail Shoben, Kyle Rudser, Scott S. Emerson

UW Biostatistics Working Paper Series

In group sequential clinical trials, it is necessary to estimate the amount of information present at interim analysis times relative to the amount of information that would be present at the final analysis. If only one measurement is made per individual, this is often the ratio of sample sizes available at the interim and final analyses. However, as discussed by Wu and Lan (1992), when the statistic of interest is a change over time, as with longitudinal data, such an approach overstates the information. In this paper, we discuss other problems that can result in overestimating the information, such as …

Effects Of Socioeconomic Status On Brain Development, And How Cognitive Neuroscience May Contribute To Levelling The Playing Field, Rajeev Raizada, Mark M. Kishiyama

Dartmouth Scholarship

The study of socioeconomic status (SES) and the brain finds itself in a circumstance unusual for Cognitive Neuroscience: large numbers of questions with both practical and scientific importance exist, but they are currently under-researched and ripe for investigation. This review aims to highlight these questions, to outline their potential significance, and to suggest routes by which they might be approached. Although remarkably few neural studies have been carried out so far, there exists a large literature of previous behavioural work. This behavioural research provides an invaluable guide for future neuroimaging work, but also poses an important challenge for it: how …

Research Poster: Hydrological Impacts Of Climate Change On Colorado Basin, Peng Jiang, Zhongbo Yu

2010 Annual Nevada NSF EPSCoR Climate Change Conference

Research poster

Research Poster: An Overview Of Progress In Nsf Epscor Project Entitled, “Reducing Cloud Uncertainties In Climate Models”, Subhashree Mishra, David L. Mitchell, W. Patrick Arnott

2010 Annual Nevada NSF EPSCoR Climate Change Conference

Research poster

Research Poster: Climate Prediction Downscaling Of Temperature And Precipitation In The Great Basin Region, Ramesh Vellore, Benjamin J. Hatchett, Darko Koracin

2010 Annual Nevada NSF EPSCoR Climate Change Conference

Research poster

Applied Statistics: Experience & Cerification In Quality Assurance, Huey D. Dodson

Statistics

The composition of my senior project can be broken down into two parts. The first part of my project, without which the second could not be pursued, involved a 13 week internship at a produce processing facility where I took part in several projects varying in scope and type. The second part was to acquire certification as a Quality Process Analyst from the American Society for Quality.

This document is structured to represent the dichotomous nature of my project; the first section is dedicated to my internship experience, and the second dedicated to the certification examination preparation and completion.

Integer Functions On The Cycle Space And Edges Of A Graph, Dan Slilaty

Mathematics and Statistics Faculty Publications

A directed graph has a natural Z-module homomorphism from the underlying graph’s cycle space to Z where the image of an oriented cycle is the number of forward edges minus the number of backward edges. Such a homomorphism preserves the parity of the length of a cycle and the image of a cycle is bounded by the length of that cycle. Pretzel and Youngs (SIAM J. Discrete Math. 3(4):544–553, 1990) showed that any Z-module homomorphism of a graph’s cycle space to Z that satisfies these two properties for all cycles must be such a map induced from an edge direction …