Statistics and Probability Commons^™

Geometric Framework For Evaluating Rare Variant Tests Of Association, Keli Liu, Shannon Fast, Matthew Zawistowski, Nathan L. Tintle

Faculty Work Comprehensive List

The wave of next-generation sequencing data has arrived. However, many questions still remain about how to best analyze sequence data, particularly the contribution of rare genetic variants to human disease. Numerous statistical methods have been proposed to aggregate association signals across multiple rare variant sites in an effort to increase statistical power; however, the precise relation between the tests is often not well understood. We present a geometric representation for rare variant data in which rare allele counts in case and control samples are treated as vectors in Euclidean space. The geometric framework facilitates a rigorous classification of existing rare …

Optimal Methods For Using Posterior Probabilities In Association Testing, Keli Liu, Alexander Luedtke, Nathan L. Tintle

Faculty Work Comprehensive List

Objective: The use of haplotypes to impute the genotypes of unmeasured single nucleotide variants continues to rise in popularity. Simulation results suggest that the use of the dosage as a one-dimensional summary statistic of imputation posterior probabilities may be optimal both in terms of statistical power and computational efficiency; however, little theoretical understanding is available to explain and unify these simulation results. In our analysis, we provide a theoretical foundation for the use of the dosage as a one-dimensional summary statistic of genotype posterior probabilities from any technology. Methods: We analytically evaluate the dosage, mode and the more general set …

The Association Of Diet And Physical Activity With Stroke Mortality Results From The Adventist Health Study-1, Tahereh Zamansani

Loma Linda University Electronic Theses, Dissertations & Projects

Stroke is one of the leading causes of death and disability, with major global public health implications. Stroke ranks No. 4 among all causes of death, behind heart disease, cancer, and chronic lower respiratory disease (CLRD). Stroke accounts for almost 1 of every 18 deaths in the United States. Women accounted for 60.6% of stroke deaths. Death certificate data show that the mean age at stroke death was 79.6 years; males had a younger mean age (76.3) than females.

There is still a great scientific uncertainty among researchers and epidemiologists about the magnitude of any preventive effect, mechanisms of action …

Environmentally Friendly Sizing Agent From Corn Distillers Dried Grains, Yue Zhang

College of Education and Human Sciences: Dissertations, Theses, and Student Research

Distillers dried grains (DDGS), the coproducts of corn ethanol production, were used as a textile sizing agent on cotton, polyester and polyester/cotton blends in an effort to find inexpensive and biodegradable alternatives to sizing agents such as poly(vinyl alcohol) that are currently used. Although DDGS is an inexpensive, biodegradable and abundant co-product, it has limited industrial applications. DDGS is a mixture of carbohydrates, proteins and oil which are used as sizing agents or as size additives. The effects of DDGS extraction conditions on sizing evaluation parameters such as fiber adhesion, film properties, viscosity and fabric abrasion were studied in comparison …

Characterizations Of Certain Recently Introduced Distributions, Gholamhossein Hamedani

Mathematics, Statistics and Computer Science Faculty Research and Publications

Various characterizations of the Beta Weibull Geometric distribution of Bidram et al. (2011), the New Generalized Exponential distribution of Bidram et al. (2012), and the Gamma Exponentiated Weibull distribution of Pinho et al. (2012) are presented. These characterizations are based on: (i) a simple relationship between two truncated moments (ii) certain functions of the nth order statistic, and (iii) certain functions of the 1st order statistics.

Does The Sat Predict Academic Achievement And Academic Choices At Macalester College?, Jing Wen

Mathematics, Statistics, and Computer Science Honors Projects

This paper examines the predictive power of the Scholastic Aptitude Test (SAT) for Macalester students’ college success and academic choices. We use linear regression to study whether the SAT can predict students’ first year or four-year grades. Using Kullback-Leibler divergence and classification trees, we also examine the SAT’s predictive ability for other aspects of students’ academic experience, for example, major selection, or academic division of study. After controlling for major and course level, we find that the SAT does not explain a large proportion of the variability in Macalester students’ college success. However, the SAT does provide some useful information …

Probability Estimation In Random Forests, Chunyang Li

All Graduate Plan B and other Reports, Spring 1920 to Spring 2023

Random Forests is a useful ensemble approach that provides accurate predictions for classification, regression and many different machine learning problems. Classification has been a very useful and popular application for Random Forests. However, it is preferable to have the probability of a membership rather than the simple knowledge that one belongs to whichever group. Votes and the regression method are current probability estimation methods that have been developed in Random Forests. In this thesis, we introduce two new methods, proximity weighting and the out-of-bag method, trying to improve the current methods. Several different simulations are designed to evaluate the new …

Enhancement Of Random Forests Using Trees With Oblique Splits, Andrejus Parfionovas

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

Statistical classification is widely used in many areas where there is a need to make a data-driven decision, or to classify complicated cases or objects. For instance: disease diagnostics (is a patient sick or healthy, based on the blood test results?); weather forecasting (will there be a storm tomorrow, based on today's atmospheric pressure, air temperature, and wind velocity?); speech recognition (what was said over the phone, based on the caller's voice level and articulation); spam detection (can the unsolicited commercial e-mails be identified by their content?); and so on.

Classification trees …

Development Of Novel Methods To Minimize The Impact Of Sequencing Errors In The Next-Generation Sequencing Data Analysis, Xiaofeng Zheng

Dissertations and Theses (Open Access)

Next-generation sequencing (NGS) technology has become a prominent tool in biological and biomedical research. However, NGS data analysis, such as de novo assembly, mapping and variants detection is far from maturity, and the high sequencing error-rate is one of the major problems. .

To minimize the impact of sequencing errors, we developed a highly robust and efficient method, MTM, to correct the errors in NGS reads. We demonstrated the effectiveness of MTM on both single-cell data with highly non-uniform coverage and normal data with uniformly high coverage, reflecting that MTM’s performance does not rely on the coverage of the sequencing …

Integrative Biomarker Identification And Classification Using High Throughput Assays, Pan Tong

Dissertations and Theses (Open Access)

It is well accepted that tumorigenesis is a multi-step procedure involving aberrant functioning of genes regulating cell proliferation, differentiation, apoptosis, genome stability, angiogenesis and motility. To obtain a full understanding of tumorigenesis, it is necessary to collect information on all aspects of cell activity. Recent advances in high throughput technologies allow biologists to generate massive amounts of data, more than might have been imagined decades ago. These advances have made it possible to launch comprehensive projects such as (TCGA) and (ICGC) which systematically characterize the molecular fingerprints of cancer cells using gene expression, methylation, copy number, microRNA and SNP microarrays …

Robust And Efficient Regression, Qi Zheng

All Dissertations

This dissertation aims to address two problems in regression
analysis. One problem is the model selection and robust parameter estimation in high dimensional linear regressions. The other is concerning developing a robust and efficient estimator in nonparametric regressions.
In Chapter 1, we introduce the robust and efficient regression analysis, discuss those two interesting problems and our motivations, and present several exciting results.
We propose a novel robust penalized method for high dimensional linear regression in Chapter 2. Asymptotic properties are established and a data-driven procedure is developed to select adaptive penalties. We show it is the very first estimator to …

Patients With Disabilities As Teachers (P-Dat) Training In Medical Education, Rebecca Royce-Hickey Do, Sweety Jain Md, Susan E. Hansen Ma, Nyann Biery Ms

Department of Family Medicine

No abstract provided.

Level Crossing Times In Mathematical Finance, Ofosuhene Osei

Electronic Theses and Dissertations

Level crossing times and their applications in finance are of importance, given certain threshold levels that represent the "desirable" or "sell" values of a stock. In this thesis, we make use of Wald's lemmas and various deep results from renewal theory, in the context of finance, in modelling the growth of a portfolio of stocks. Several models are employed .

Statistical Algorithms For Optimal Experimental Design With Correlated Observations, Chang Li

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

The first part of my dissertation demonstrates that a modified simulated annealing algorithm can successfully determine highly efficient D-optimal designs for second order polynomial regression for a variety of correlated error structures.

In the second part, I solved weak universal optimal block designs for the nearest neighbor correlation structure and multiple block sizes, for the hub correlation structure with any block size, and for circulant correlation with odd block size.

In the third part, we propose an improved Particle Swarm Optimization (PSO) algorithm with time varying parameters. Then combining the theorem of decision making and PSO, we innovated nested PSO …

Spatially Indexed Functional Data, Oleksandr Gromenko

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

The increased concentration of greenhouse gases is associated with the global warming in the lower troposphere. For over twenty years, the space physics community has studied a hypothesis of global cooling in the thermosphere, attributable to greenhouse gases. While the global temperature increase in the lower troposphere has been relatively well established, the existence of global changes in the thermosphere is still under investigation.

A central difficulty in reaching definite conclusions is the absence of data with sufficiently long temporal and sufficiently broad spatial coverage. Time series of data that cover several decades exist only in a few separated (industrialized) …

Applications Of Bayesian Statistics In Fluvial Bed Load Transport, Mark L. Schmelter

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

The science of fluvial sediment transport studies the processes involved in the movement of river sediments. It is commonly understood that when rivers flood they have a great capacity to move sand, gravel, and even larger cobbles and boulders. This process is not only limited to the big floods that usually attract so much attention, but also the more common river flows play a very important role in forming a river. As engineers and scientists, we like to be able to develop equations and relationships that describe some natural phenomenon—in this case, fluvial sediment transport. While we are able to …

Empirical Properties Of Functional Regression Models And Application To High-Frequency Financial Data, Xi Zhang

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

Functional data analysis (FDA) has grown into a substantial field of statistical research, with new methodology, numerous useful applications and interesting novel theoretical developments. My dissertation focuses on the empirical properties of functional regression models and their application to financial data. We start from testing the empirical properties of forecasts with the functional autoregressive models based on simulated and real data. We define intraday returns and consider their prediction from such returns on a market index. This is an extension to intraday data of the Capital Asset Pricing model. Finally we investigate multifactor functional models and assess their suitability for …

Existence And Multiplicity Results On Standing Wave Solutions Of Some Coupled Nonlinear Schrodinger Equations, Rushun Tian

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

Coupled nonlinear Schrodinger equations (CNLS) govern many physical phenomena, such as nonlinear optics and Bose-Einstein condensates. For their wide applications, many studies have been carried out by physicists, mathematicians and engineers from different respects. In this dissertation, we focused on standing wave solutions, which are of particular interests for their relatively simple form and the important roles they play in studying other wave solutions. We studied the multiplicity of this type of solutions of CNLS via variational methods and bifurcation methods.

Variational methods are useful tools for studying differential equations and systems of differential equations that possess the so-called variational …

A Gaming Application Of The Negative Hypergeometric Distribution, Steven Norman Jones

UNLV Theses, Dissertations, Professional Papers, and Capstones

The Negative Hypergeometric distribution represents waiting times when drawing from a finite sample without replacement. It is analogous to the negative binomial, which models the distribution of waiting times when drawing with replacement. Even though the Negative Hypergeometric has applications it is typically omitted from textbooks on probability and statistics and is not generally known. The main purpose of this thesis is to derive expressions for the mean and variance of a new application of the Negative Hypergeometric to gaming and gambling. Other applications are described as well.

Structured Functional Principal Component Analysis, Haochang Shou, Vadim Zipunnikov, Ciprian Crainiceanu, Sonja Greven

Johns Hopkins University, Dept. of Biostatistics Working Papers

Motivated by modern observational studies, we introduce a class of functional models that expands nested and crossed designs. These models account for the natural inheritance of correlation structure from sampling design in studies where the fundamental sampling unit is a function or image. Inference is based on functional quadratics and their relationship with the underlying covariance structure of the latent processes. A computationally fast and scalable estimation procedure is developed for ultra-high dimensional data. Methods are illustrated in three examples: high-frequency accelerometer data for daily activity, pitch linguistic data for phonetic analysis, and EEG data for studying electrical brain activity …