Statistics and Probability Commons^™

Developing An Automated Forecasting Framework For Predicting Operation Room Block Time, Azad Sadr Haghighi

Wayne State University Theses

Operating rooms are the most important part of the hospitals, since they have highest influence on financial state of the hospital. Because of high uncertainty in surgery cases demands and their durations, the scheduling of the surgeries becomes a very challenging and critical issue in hospitals. One of the most common approaches to overcome this uncertainty is applying block times which is the time intervals allocated to surgery groups in the hospital. Assigning sufficient amount of the time to each block, is very important, since overestimating lead to wasting resources and on the other hand underestimation causes the overtime staffing …

Bayesian Adaptive Penalized Splines In Nonparametric Regression And In Spectral Time Series Analysis, Luis Angel Mora

Open Access Theses & Dissertations

A Bayesian approach to nonparametric regression using Penalized splines (P-splines) is presented. The approach uses the linear mixed model formulation of P-spines. The usual model assumes a single value for the smoothing parameter controlling the amount of smoothing of the fitted function. The main focus of the Thesis is on spatially adaptive smoothing where the smoothing parameter is a function of the covariate so that different amounts of smoothing are applied in different regions of the covariate. An application to spectral time series analysis will be demonstrated. Markov chain Monte Carlo methods are used to make inference based on the …

Diffuse Optical Measurements Of Head And Neck Tumor Hemodynamics For Early Prediction Of Chemo-Radiation Therapy Outcomes, Lixin Dong

Theses and Dissertations--Biomedical Engineering

Chemo-radiation therapy is a principal modality for the treatment of head and neck cancers, and its efficacy depends on the interaction of tumor oxygen with free radicals. In this study, we adopted a novel hybrid diffuse optical instrument combining a commercial frequency-domain tissue oximeter (Imagent) and a custom-made diffuse correlation spectroscopy (DCS) flowmeter, which allowed for simultaneous measurements of tumor blood flow and blood oxygenation. Using this hybrid instrument we continually measured tumor hemodynamic responses to chemo-radiation therapy over the treatment period of 7 weeks. We also explored monitoring dynamic tumor hemodynamic changes during radiation delivery. Blood flow data analysis …

Multi-State Models For Interval Censored Data With Competing Risk, Shaoceng Wei

Theses and Dissertations--Statistics

Multi-state models are often used to evaluate the effect of death as a competing event to the development of dementia in a longitudinal study of the cognitive status of elderly subjects. In this dissertation, both multi-state Markov model and semi-Markov model are used to characterize the flow of subjects from intact cognition to dementia with mild cognitive impairment and global impairment as intervening transient, cognitive states and death as a competing risk.

Firstly, a multi-state Markov model with three transient states: intact cognition, mild cognitive impairment (M.C.I.) and global impairment (G.I.) and one absorbing state: dementia is used to model …

Empirical Likelihood Confidence Band, Shihong Zhu

Theses and Dissertations--Statistics

The confidence band represents an important measure of uncertainty associated with a functional estimator and empirical likelihood method has been proved to be a viable approach to constructing confidence bands in many cases. Using the empirical likelihood ratio principle, this dissertation developed simultaneous confidence bands for many functions of fundamental importance in survival analysis, including the survival function, the difference and ratio of survival functions, the hazards ratio function, and other parameters involving residual lifetimes. Covariate adjustment was incorporated under the proportional hazards assumption. The proposed method can be very useful when, for example, an individualized survival function is desired …

New Results In Ell_1 Penalized Regression, Edward A. Roualdes

Theses and Dissertations--Statistics

Here we consider penalized regression methods, and extend on the results surrounding the l1 norm penalty. We address a more recent development that generalizes previous methods by penalizing a linear transformation of the coefficients of interest instead of penalizing just the coefficients themselves. We introduce an approximate algorithm to fit this generalization and a fully Bayesian hierarchical model that is a direct analogue of the frequentist version. A number of benefits are derived from the Bayesian persepective; most notably choice of the tuning parameter and natural means to estimate the variation of estimates – a notoriously difficult task for the …

Developments In Nonparametric Regression Methods With Application To Raman Spectroscopy Analysis, Jing Guo

Theses and Dissertations--Epidemiology and Biostatistics

Raman spectroscopy has been successfully employed in the classification of breast pathologies involving basis spectra for chemical constituents of breast tissue and resulted in high sensitivity (94%) and specificity (96%) (Haka et al, 2005). Motivated by recent developments in nonparametric regression, in this work, we adapt stacking, boosting, and dynamic ensemble learning into a nonparametric regression framework with application to Raman spectroscopy analysis for breast cancer diagnosis. In Chapter 2, we apply compound estimation (Charnigo and Srinivasan, 2011) in Raman spectra analysis to classify normal, benign, and malignant breast tissue. We explore both the spectra profiles and their derivatives to …

Nonlinear Hierarchical Models For Longitudinal Experimental Infection Studies, Michael David Singleton

Theses and Dissertations--Epidemiology and Biostatistics

Experimental infection (EI) studies, involving the intentional inoculation of animal or human subjects with an infectious agent under controlled conditions, have a long history in infectious disease research. Longitudinal infection response data often arise in EI studies designed to demonstrate vaccine efficacy, explore disease etiology, pathogenesis and transmission, or understand the host immune response to infection. Viral loads, antibody titers, symptom scores and body temperature are a few of the outcome variables commonly studied. Longitudinal EI data are inherently nonlinear, often with single-peaked response trajectories with a common pre- and post-infection baseline. Such data are frequently analyzed with statistical methods …

Sobriety In Delta Not Sober, Joe Mashburn

Mathematics Faculty Publications

We will show that the space delta not sober defined by Coecke and Martin is sober in the Scott topology, but not in the weakly way below topology.

Estimation And Identification Of Change Points In Panel Models With Nonstationary Or Stationary Regressors And Error Term, Badi H. Baltagi, Chihwa Kao, Long Liu

Center for Policy Research

This paper studies the estimation of change point in panel models. We extend Bai (2010) and Feng, Kao and Lazarová (2009) to the case of stationary or nonstationary regressors and error term, and whether the change point is present or not. We prove consistency and derive the asymptotic distributions of the Ordinary Least Squares (OLS) and First Difference (FD) estimators. We find that the FD estimator is robust for all cases considered.

Unavoidable Minors Of Large 4-Connected Bicircular Matroids, Deborah Chun, Tyler Moss, Dan Slilaty, Xiangqian Zhou

Mathematics and Statistics Faculty Publications

It is known that any 3-connected matroid that is large enough is certain to contain a minor of a given size belonging to one of a few special classes of matroids. This paper proves a similar unavoidable minor result for large 4-connected bicircular matroids. The main result follows from establishing the list of unavoidable minors of large 4-biconnected graphs, which are the graphs representing the 4-connected bicircular matroids. This paper also gives similar results for internally 4-connected and vertically 4-connected bicircular matroids.

Statistics In The Billera-Holmes-Vogtmann Treespace, Grady S. Weyenberg

Theses and Dissertations--Statistics

This dissertation is an effort to adapt two classical non-parametric statistical techniques, kernel density estimation (KDE) and principal components analysis (PCA), to the Billera-Holmes-Vogtmann (BHV) metric space for phylogenetic trees. This adaption gives a more general framework for developing and testing various hypotheses about apparent differences or similarities between sets of phylogenetic trees than currently exists.

For example, while the majority of gene histories found in a clade of organisms are expected to be generated by a common evolutionary process, numerous other coexisting processes (e.g. horizontal gene transfers, gene duplication and subsequent neofunctionalization) will cause some genes to exhibit a …

Preparing Secondary Mathematics Teachers: Focus On Modeling In Algebra, Hyunyi Jung, Alexia Mintos, Jill Newton

Mathematics, Statistics and Computer Science Faculty Research and Publications

This study addressed the opportunities to learn (OTL) modeling in algebra provided to secondary mathematics pre-service teachers (PSTs). To investigate these OTL, we interviewed five instructors of required mathematics and mathematics education courses that had the potential to include opportunities for PSTs to learn algebra at three universities. We also interviewed a group of three to four PSTs at each of the universities. We coded the interview transcripts using an analytic framework developed based on related literature and policy documents. We report the similarities and differences in perspectives among instructors and PSTs related to modeling at each university, along with …

Characterizations Of Gamma Distribution Via Sub-Independent Random Variables, Gholamhossein Hamedani

Mathematics, Statistics and Computer Science Faculty Research and Publications

The concept of sub-independence is based on the convolution of the distributions of the random variables. It is much weaker than that of independence, but is shown to be sufficient to yield the conclusions of important theorems and results in probability and statistics. It also provides a measure of dissociation between two random variables which is much stronger than uncorrelatedness. Inspired by the excellent work of Jin and Lee (2014), we present certain characterizations of gamma distribution based on the concept of sub-independence.

Kumaraswamy-Half-Cauchy Distribution: Characterizations And Related Results, Gholamhossein Hamedani, I. Ghosh

Mathematics, Statistics and Computer Science Faculty Research and Publications

We present various characterizations of a recently introduced distribution (Ghosh 2014), called Kumaraswamy- Half- Cauchy distribution based on: (i) a simple relation between two truncated moments; (ii) truncated moment of certain function of the 1^st order statistic; (iii) truncated moment of certain function of the random variable; (iv) hazard function; (v) distribution of the 1^st order statistic; (vi) via record values. We also provide some remarks on bivariate Gumbel copula distribution whose marginal distributions are Kumaraswamy- Half-Cauchy distributions.

Application Of Loglinear Models To Claims Triangle Runoff Data, Netanya Lee Martin

Masters Theses

"In this thesis, we presented in detail different aspects of Verrall's chain ladder method and their advantages and disadvantages. Insurance companies must ensure there are enough reserves to cover future claims. To that end, it is useful to estimate mean expected losses. The chain ladder technique under a general linear model is the most widely used method for such estimation in property and casualty insurance. Verrall's chain ladder technique develops estimators for loss development ratios, mean expected ultimate claims, Bayesian premiums, and Bühlmann credibility premiums. The chain ladder technique can be used to estimate loss development in cases where data …

Space-Based Relative Multitarget Tracking, Keith Allen Legrand

Masters Theses

"Access to space has expanded dramatically over the past decade. The growing popularity of small satellites, specifically cubesats, and the following launch initiatives have resulted in exponentially growing launch numbers into low Earth orbit. This growing congestion in space has punctuated the need for local space monitoring and autonomous satellite inspection. This work describes the development of a framework for monitoring local space and tracking multiple objects concurrently in a satellite's neighborhood. The development of this multitarget tracking systems has produced collateral developments in numerical methods, relative orbital mechanics, and initial relative orbit determination.

This work belongs to a class …

Uncertainty Quantification Of Turbulence Model Closure Coefficients For Transonic Wall-Bounded Flows, John Anthony Schaefer

Masters Theses

"The goal of this work was to quantify the uncertainty and sensitivity of commonly used turbulence models in Reynolds-Averaged Navier-Stokes codes due to uncertainty in the values of closure coefficients for transonic, wall-bounded flows and to rank the contribution of each coefficient to uncertainty in various output flow quantities of interest. Specifically, uncertainty quantification of turbulence model closure coefficients was performed for transonic flow over an axisymmetric bump at zero degrees angle of attack and the RAE 2822 transonic airfoil at a lift coefficient of 0.744. Three turbulence models were considered: the Spalart-Allmaras Model, Wilcox (2006) k-ω Model, and the …

Steam Flooding Screening And Eor Prediction By Using Clustering Algorithm And Data Visualization, Na Zhang

Masters Theses

"Enhanced Oil Recovery (EOR) techniques are vitally important in the oil industry because these techniques could not only extend the life of wells, but also produce 10% to 30% additional oil from the reservoir. However, selecting the most suitable EOR techniques for unknown reservoirs is not easy for decision making. Based on literature, EOR screening criteria could help to find the best candidates for unknown projects, which is classified into two categories: conventional EOR screening and advanced EOR screening. In this research, an artificial intelligent (AI) method, hierarchical clustering algorithm, is adapted to analyze both steam flooding projects and worldwide …

The Distribution Of Type 1 Diabetes Onset In The United States By Demographic Factors, Margaret Beckstrand

Walden Dissertations and Doctoral Studies

Type 1 diabetes (T1D) is a chronic and lifelong condition, often diagnosed in childhood. Patients with T1D are at elevated risks of associated health complications, comorbidities, and mortality. Occurrence, clinical presentation, and complications related to T1D differ by age of onset, ethnicity, and gender. The last reported population-based estimates regarding the burden of T1D in children using the National Health and Nutrition Examination Survey (NHANES) were published in 2008, and these estimates were not well stratified by age of onset, ethnicity, and gender. The purpose of this study was to examine these demographics within the conceptual framework of the hygiene …