Statistics and Probability Commons^™

Healthcare Outcomes And Resource Utilization Associated With Neonatal Hypoglycemia: Analysis Of Data From The Hcup Kid’S Inpatient Database, Brook T. Alemu

Health Services Research Dissertations

Neonatal hypoglycemia is the most common metabolic abnormality in infants and is associated with neurological damage and death. The risk of developing hypoglycemia among infants born from diabetic mothers is even higher. Although much work has been performed addressing issues for treatment and care, research related to neonatal hypoglycemia has been focused on the clinical or individual level risk factors. Contextual risk factors such as hospital characteristics, neighborhood economic status, and regional variations were not considered in earlier studies. Additionally, although healthcare resources utilization of hypoglycemia has been adequately addressed in the adult population, this topic has not been studied …

Emergency Diesel-Electric Generator Set Maintenance And Test Periodicity, Stephen John Fehr

Engineering Management & Systems Engineering Theses & Dissertations

Manufacturer and industry recommendations vary considerably for maintenance and tests of emergency diesel-electric generator sets in emergency standby duty. There is little consistency among generator sets of similar technology, and manufacturers and their representatives often provide contradictory guidance. As a result, periodicity of emergency diesel-electric generator set maintenance and tests varies considerably in practice. Utilizing the framework proposed and tested by Fehr (2014), this research developed a parametric regression survival model of the reliability of modern diesel-electric generator sets in emergency standby duty as a function of maintenance, age, and cumulative run hours. A survival regression technique leveraging Cox’s (1972) …

Estimation Of A Noisy Subordinated Brownian Motion Via Two-Scales Power Variations, José E. Figueroa-López, Kiseop Lee

Mathematics Faculty Research

High frequency based estimation methods for a semiparametric pure-jump subordinated Brownian motion exposed to a small additive microstructure noise are developed building on the two-scales realized variations approach originally developed by Zhang et al. (2005) for the estimation of the integrated variance of a continuous Itô process. The proposed estimators are shown to be robust against the noise and, surprisingly, to attain better rates of convergence than their precursors, method of moment estimators, even in the absence of microstructure noise. Our main results give approximate optimal values for the number K of regular sparse subsamples to be used, which is …

Statistical Analysis And Modeling Of Ovarian And Breast Cancer, Muditha V. Devamitta Perera

USF Tampa Graduate Theses and Dissertations

The objective of the present study is to investigate key aspects of ovarian and breast cancers, which are two main causes of mortality among women. Identification of the true behavior of survivorship and influential risk factors is essential in designing treatment protocols, increasing disease awareness and preventing possible causes of disease. There is a commonly held belief that African Americans have a higher risk of cancer mortality. We studied racial disparities of women diagnosed with ovarian cancer on overall and disease-free survival and found out that there is no significant difference in the survival experience among the three races: Whites, …

Investigating The Student Enrollment Decision At Wku, Alec Brown

Mahurin Honors College Capstone Experience/Thesis Projects

The purpose of this research is to investigate the relationships between the enrollment decision of first-time, first-year students admitted to Western Kentucky University and the amount of financial aid awarded, as well as demographic information. The Division of Enrollment Management provided a SAS dataset containing various information about all WKU students admitted in 2013, 2014, and 2015. Additionally, information about the 2016 class of admitted students was provided. The data has been analyzed in SAS Enterprise Miner. We performed analysis using decision tree modeling and logistic regression modeling. Results of these two procedures indicated the importance of credit hours earned …

Comparison Of Adaptive Randomized Trial Designs For Time-To-Event Outcomes That Expand Versus Restrict Enrollment Criteria, To Test Non-Inferiority, Josh Betz, Jon Arni Steingrimsson, Tianchen Qian, Michael Rosenblum

Johns Hopkins University, Dept. of Biostatistics Working Papers

Adaptive enrichment designs involve preplanned rules for modifying patient enrollment criteria based on data accrued in an ongoing trial. These designs may be useful when it is suspected that a subpopulation, e.g., defined by a biomarker or risk score measured at baseline, may benefit more from treatment than the complementary subpopulation. We compare two types of such designs, for the case of two subpopulations that partition the overall population. The first type starts by enrolling the subpopulation where it is suspected the new treatment is most likely to work, and then may expand inclusion criteria if there is early evidence …

Judging The Neonatal Abstinence Syndrome Assessment Tools To Guide Future Tool Development: The Use Of Clinimetrics As Opposed To Psychometrics, Philip M. Westgate, Enrique Gomez-Pomar

Biostatistics Faculty Publications

In the face of the current Neonatal Abstinence Syndrome (NAS) epidemic, there is considerable variability in the assessment and management of infants with NAS. In this manuscript, we particularly focus on NAS assessment, with special attention given to the popular Finnegan Neonatal Abstinence Score (FNAS). A major instigator of the problem of variable practices is that multiple modified versions of the FNAS exist and continue to be proposed, including shortened versions. Furthermore, the validity of such assessment tools has been questioned, and as a result, the need for better tools has been suggested. The ultimate purpose of this manuscript, therefore, …

Dietary Inflammatory Index And Colorectal Cancer Risk – A Meta-Analysis, Nitin Shivappa, Justyna Godos, James R. Hébert, Michael David Wirth, Gabriele Piuri, Attilio Speciani, Giuseppe Grosso

Faculty Publications

Diet and chronic inflammation of the colon have been suggested to be risk factors in the development of colorectal cancer (CRC). The possible link between inflammatory potential of diet, measured through the Dietary Inflammatory Index (DII®), and CRC has been investigated in several populations across the world. The aim of this study was to conduct a meta-analysis on studies exploring this association. Data from nine studies were eligible, of which five were case-control and four were cohort studies. Results from meta-analysis showed a positive association between increasing DII scores, indicating a pro-inflammatory diet, and CRC. Individuals in the highest versus …

Prevention Of Renal Apob Retention Is Protective Against Diabetic Nephropathy: Role Of Tgf-Β Inhibition, Patricia G. Wilson, Joel C. Thompson, Meghan S. Yoder, Richard Charnigo, Lisa R. Tannock

Internal Medicine Faculty Publications

Animal studies demonstrate that hyperlipidemia and renal lipid accumulation contribute to the pathogenesis of diabetic nephropathy (DN). We previously demonstrated that renal lipoproteins colocalize with biglycan, a renal proteoglycan. The purpose of this study was to determine whether prevention of renal lipid (apoB) accumulation attenuates DN. Biglycan-deficient and biglycan wild-type Ldlr^−/− mice were made diabetic via streptozotocin and fed a high cholesterol diet. As biglycan deficiency is associated with elevated transforming growth factor-β (TGF-β), in some experiments mice were injected with either the TGF-β-neutralizing antibody, 1D11, or with 13C4, an irrelevant control antibody. Biglycan deficiency had no significant effect …

Randomized Trial Of Interventions To Improve Childhood Asthma In Homes With Wood-Burning Stoves, Curtis W. Noonan, Erin O. Semmens, Paul Smith, Solomon W. Harrar, Luke Montrose, Emily Weiler, Marcy Mcnamara, Tony J. Ward

Statistics Faculty Publications

BACKGROUND: Household air pollution due to biomass combustion for residential heating adversely affects vulnerable populations. Randomized controlled trials to improve indoor air quality in homes of children with asthma are limited, and no such studies have been conducted in homes using wood for heating.

OBJECTIVES: Our aims were to test the hypothesis that household-level interventions, specifically improved-technology wood-burning appliances or air-filtration devices, would improve health measures, in particular Pediatric Asthma Quality of Life Questionnaire (PAQLQ) scores, relative to placebo, among children living with asthma in homes with wood-burning stoves.

METHODS: A three-arm placebo-controlled randomized trial was conducted in homes with …

Heterogeneity Aware Random Forest For Drug Sensitivity Prediction, Raziur Rahman, Kevin Matlock, Souparno Ghosh, Ranadip Pal

Department of Statistics: Faculty Publications

Samples collected in pharmacogenomics databases typically belong to various cancer types. For designing a drug sensitivity predictive model from such a database, a natural question arises whether a model trained on diverse inter-tumor heterogeneous samples will perform similar to a predictive model that takes into consideration the heterogeneity of the samples in model training and prediction. We explore this hypothesis and observe that ensemble model predictions obtained when cancer type is known out-perform predictions when that information is withheld even when the samples sizes for the former is considerably lower than the combined sample size. To incorporate the heterogeneity idea …

Prevalence And Trends In Transmitted And Acquired Antiretroviral Drug Resistance, Washington, Dc, 1999-2014., Annette M Aldous, Amanda D Castel, David M Parenti

Epidemiology Faculty Publications

Background

Drug resistance limits options for antiretroviral therapy (ART) and results in poorer health outcomes among HIV-infected persons. We sought to characterize resistance patterns and to identify predictors of resistance in Washington, DC.

Methods

We analyzed resistance in the DC Cohort, a longitudinal study of HIV-infected persons in care in Washington, DC. We measured cumulative drug resistance (CDR) among participants with any genotype between 1999 and 2014 (n = 3411), transmitted drug resistance (TDR) in ART-naïve persons (n = 1503), and acquired drug resistance (ADR) in persons with genotypes before and after ART initiation (n = 309). Using logistic regression, …

How Singapore Investors Can Profit From Unstructured Data, Clarence Goh

Research Collection School Of Accountancy

Data that is collected in the business environment can be structured or unstructured. In general, structured data refers to information which is highly organised and which can easily be stored in rows and columns within database systems. On the other hand, unstructured data does not have a strict data structure, and is also not organised in a pre-defined manner.

A Geometric Derivation Of The Irwin-Hall Distribution, James E. Marengo, Lucas Stefanic, David L. Farnsworth

Articles

The Irwin-Hall distribution is the distribution of the sum of a finite number of independent identically distributed uniform random variables on the unit interval. Many applications arise since round-off errors have a transformed Irwin-Hall distribution and the distribution supplies spline approximations to normal distributions. We review some of the distribution’s history. The present derivation is very transparent, since it is geometric and explicitly uses the inclusion-exclusion principle. In certain special cases, the derivation can be extended to linear combinations of independent uniform random variables on other intervals of finite length.The derivation adds to the literature about methodologies for finding distributions …

Influence Of Scaling Up Nutrition Education Towards Knowledge And Attitude Of Students At Santa Elisabeth Medan School Of Health Sciences, Rani Gartika Holivia Silalahi, Yesschi Anggraeni Tambunan

Kesmas

Tingginya angka pernikahan pada usia remaja yang disertai dengan rendahnya pengetahuan tentang pola asuh merupakan salah satu pemicu terjadinya masalah gizi. Remaja merupakan orang tua masa depan. Tujuan penelitian ini untuk mengetahui pengaruh pendidikan 1.000 hari pertama kehidupan terhadap pengetahuan dan sikap mahasiswi Sekolah Tinggi Ilmu Kesehatan Santa Elisabeth Medan tahun 2016. Penelitian ini menggunakan kuasi eksperimental dengan desain one group pre- dan post test. Metode pengambilan sampel dengan metode purposive sampling sebanyak 115 mahasiswi tingkat III program studi Diploma III Kebidanan. Pendidikan dilakukan di kelas sebanyak 4 kali dalam 2 minggu dengan menggunakan metode mengajar dan diskusi. Penelitian ini …

The Profile And Determinant Factors Of Quality Of Life In Patients With Diabetic Neuropathy, Rizaldy Taslim Pinzon, Kadek Sinthia Grahita Adnyana, Marta Lisnawati Zalukhu

Kesmas

Neuropati merupakan salah satu komplikasi tersering pada diabetes melitus (DM). Neuropati dapat memengaruhi kualitas hidup, derajat kesehatan, maupun tingkat ekonomi. Oleh karena itu, penting untuk mengetahui kualitas hidup pasien DM dengan neuropati beserta dampak yang ditimbulkannya terlebih dahulu agar mendapatkan penanganan yang tepat demi meningkatkan kualitas hidup pasien. Penelitian ini bertujuan untuk mengetahui profil kualitas hidup pasien DM dengan neuropati. Penelitian ini merupakan studi observasional menggunakan Short Form 8 (SF-8) Health Survey Standard Indonesia terhadap pasien diabetes melitus dengan neuropati yang diambil secara konsekutif pada bulan Maret hingga Agustus 2016 di Poli Saraf Rumah Sakit Bethesda, Yogyakarta. Terdapat 57 subjek …

Level Of Exposure Of Childhood Tuberculosis With Adult Pulmonary Tuberculosis Household Contacts, Al Asyary, Tris Eryando, Purwantyastuti Purwantyastuti, Purnawan Junadi, Carol Clark, Edwin Van Teijlingen

Kesmas

Tuberkulosis paru (TB) pada anak kian menjadi masalah kesehatan global yang masih terlupakan seiring dengan peningkatan proporsi TB di Indonesia. Penularan penyakit ini di populasi umum seringkali berdampak pada anak, terlebih ketika kontak TB terjadi di rumah tangga. Penelitian ini bertujuan untuk memperoleh faktor protektif sehingga anak tetap sehat meskipun memiliki kontak dengan penderita TB dewasa serumah. Penelitian ini dilakukan dengan pendekatan kasus kontrol pada 132 responden anak yang berasal dari delapan rumah sakit rujukan dan beberapa puskesmas di Provinsi Daerah Istimewa Yogyakarta. Penelitian dilakukan dalam periode Januari hingga Desember 2014 yang hasilnya dianalisis dengan uji bivariat (kai kuadrat) dan …

Influence Of Quality Of Work Life Towards Psychological Well-Being And Turnover Intention Of Nurses And Midwives In Hospital, Indra Wahju Hardjanti, Aryo Dewanto, Noermijati Noermijati

Kesmas

Selama ini perawat telah dilatih untuk memberikan perawatan pasien dan meningkatkan kualitas hidup pasien, namun kualitas kehidupan kerja dan psychological well-being mereka sendiri terabaikan. Rendahnya kualitas kehidupan kerja perawat di rumah sakit menyebabkan tingginya keinginan pindah kerja perawat. Tingginya angka keinginan pindah kerja perawat dan bidan di Rumah Sakit X Malang merupakan masalah yang memerlukan perhatian dari manajemen rumah sakit agar tidak menjadi menyebabkan rendahnya mutu pelayanan kesehatan di rumah sakit. Penelitian ini bertujuan untuk mengetahui hubungan antara kualitas kehidupan kerja, psychological well-being, dan keinginan pindah kerja perawat dan bidan di rumah sakit. Penelitian ini menggunakan desain penelitian kuantitatif korelasional …

Risk Differences Between Elderly Men And Women Toward Doctor-Diagnosed Diabetes Mellitus In Urban Areas In Indonesia: 2013 National Basic Health Research Data, Meiwita Budiharsana

Kesmas

Diabetes melitus (DM) adalah salah satu penyakit tidak menular yang paling umum di Indonesia. DM disebabkan berbagai faktor risiko. Peningkatan prevalensi DM salah satunya disebabkan oleh perubahan gaya hidup di perkotaan. Penelitian ini bertujuan untuk menguji perbedaan prevalensi DM yang didiagnosis dokter pada laki-laki dan perempuan usia 15 tahun keatas yang tinggal di daerah perkotaan di Indonesia. Analisis menggunakan data sekunder Riset Kesehatan Dasar (Riskesdas) 2013 dengan desain studi potong lintang. Total sampel sebanyak 333.731 responden. Metode analisis menggunakan regresi logistik ganda. Hasil menunjukkan bahwa DM yang didiagnosis dokter pada laki-laki dan perempuan usia 15-39 tahun di perkotaan tidak berbeda. …

Bancroftian Filariasis Transmission Parameters After The Fifth Year Of Filiariasis Mass Drug Administration In Pekalongan City, Tutik Ida Rosanti, Sugeng Juwono Mardihusodo, Wayan Artama

Kesmas

Penelitian ini bertujuan untuk mengukur parameter parasitologi (microfilaria rate, kepadatan mikrofilaria), parameter imunologi (antigen prevalence) dan parameter entomologi (infection rate dan infective rate) pada tahun kelima pelaksanaan mass drug administration di Kelurahan Pabean Kota Pekalongan. Penelitian ini merupakan penelitian observasional dengan pendekatan potong lintang yang dilaksanakan pada bulan Juli sampai dengan Agustus 2015 di Kelurahan Pabean Kota Pekalongan. Microfilaria rate dan kepadatan mikrofilaria ditentukan dengan pemeriksaan darah jari pada 313 responden. Antigen prevalence ditentukan dengan mengukur antigen beredar menggunakan metode immunochromatographic test (ICT) Wuchereria bancrofti. Incective rate dan infection rate diukur dengan cara menemukan larva cacing filaria pada nyamuk hasil …