Statistics and Probability Commons^™

Genome-Wide Analysis Of Alternative Rna Splicing In Children With Acute Myeloid Leukemia (Aml), Xichen Li

Shared Knowledge Conference

The pediatric Acute Myeloid Leukemia (AML) is a high-risk and hard-to-treat childhood cancer that originates in the bone marrow from immature white blood cells. Recently, more and more evidence indicates that aberrant splicing of genes is a common characteristic for AML. Gene expression profiles have proved extremely useful for identifying genes that are associated with clinical characteristics and survival outcome of cancer patients. However, conventional gene expression profiles do not account for the differences observed in expressed isoforms when alternative RNA splicing is analyzed. Alternative RNA splicing can generate dozens of distinct transcripts from individual genes and the expressions of …

Analysis Of Ranked Gene Tree Probability Distributions Under The Coalescent Process For Detecting Anomaly Zones, Anastasiia Kim

Shared Knowledge Conference

In phylogenetic studies, gene trees are used to reconstruct species tree. Under the multispecies coalescent model, gene trees topologies may differ from that of species trees. The incorrect gene tree topology (one that does not match the species tree) that is more probable than the correct one is termed anomalous gene tree (AGT). Species trees that can generate such AGTs are said to be in the anomaly zone (AZ). In this region, the method of choosing the most common gene tree as the estimate of the species tree will be inconsistent and will converge to an incorrect species tree when …

Safety, Tolerability, And Pharmacokinetics Of Long-Acting Injectable Cabotegravir In Low-Risk Hiv-Uninfected Individuals: Hptn 077, A Phase 2a Randomized Controlled Trial., Raphael J Landovitz, Sue Li, Beatriz Grinsztejn, Halima Dawood, Albert Y Liu, Manya Magnus, Mina C Hosseinipour, Ravindre Panchia, Leslie Cottle, Gordon Chau, Paul Richardson, Mark A Marzinke, Craig W Hendrix, Susan H Eshleman, Yinfeng Zhang, Elizabeth Tolley, Jeremy Sugarman, Ryan Kofron, Adeola Adeyeye, David Burns, Alex R Rinehart, David Margolis, William R Spreen, Myron S Cohen, Marybeth Mccauley, Joseph J Eron

Epidemiology Faculty Publications

BACKGROUND: Cabotegravir (CAB) is a novel strand-transfer integrase inhibitor being developed for HIV treatment and prevention. CAB is formulated both as an immediate-release oral tablet for daily administration and as a long-acting injectable suspension (long-acting CAB [CAB LA]) for intramuscular (IM) administration, which delivers prolonged plasma exposure to the drug after IM injection. HIV Prevention Trials Network study 077 (HPTN 077) evaluated the safety, tolerability, and pharmacokinetics of CAB LA in HIV-uninfected males and females at 8 sites in Brazil, Malawi, South Africa, and the United States.

METHODS AND FINDINGS: HPTN 077 was a double-blind, placebo-controlled phase 2a trial. Healthy …

Trends In Obesity And Multimorbidity In Canada., Michael Lebenbaum, Gregory S Zaric, Amardeep Thind, Sisira Sarma

Epidemiology and Biostatistics Publications

Very few studies have examined trends in multimorbidity over time and even fewer have examined trends over time across different body mass index (BMI) groups. Given a general decline in death rates but increased cardiovascular risk factors among individuals with obesity, the trend in the association between obesity and multimorbidity is hypothesized to be increasing over time. The data for our study came from the 1996-97 National Population Health Survey and the 2005 and 2012-13 Canadian Community Health Surveys (N = 277,366 across all 3 surveys). We examined trends in the association between BMI groups and multimorbidity using a logistic …

Development And Internal Validation Of An Aneurysm Rupture Probability Model Based On Patient Characteristics And Aneurysm Location, Morphology, And Hemodynamics, Felicitas J. Detmer, Bong Jae Chung, Fernando Mut, Martin Slawski, Farid Hamzei-Sichani, Christopher Putman, Carlos Jiménez, Juan R. Cebral

Department of Applied Mathematics and Statistics Faculty Scholarship and Creative Works

Purpose: Unruptured cerebral aneurysms pose a dilemma for physicians who need to weigh the risk of a devastating subarachnoid hemorrhage against the risk of surgery or endovascular treatment and their complications when deciding on a treatment strategy. A prediction model could potentially support such treatment decisions. The aim of this study was to develop and internally validate a model for aneurysm rupture based on hemodynamic and geometric parameters, aneurysm location, and patient gender and age. Methods: Cross-sectional data from 1061 patients were used for image-based computational fluid dynamics and shape characterization of 1631 aneurysms for training an aneurysm rupture probability …

Blood Transfusions In Preterm Infants: Changes On Perfusion Index And Intermittent Hypoxemia, Katrina T. Ibonia, Henrietta S. Bada, Philip M. Westgate, Enrique Gomez Pomar, Prasad Bhandary, Abhijit R. Patwardhan, Elie G. Abu Jawdeh

Pediatrics Faculty Publications

BACKGROUND

Red blood cell (RBC) transfusion decreases intermittent hypoxemia (IH) events beyond the first week of life. This benefit may be related to improved perfusion to the respiratory control network. Perfusion index (PI) is a perfusion measure provided by the pulse oximeter. We hypothesized that the benefit in IH after RBC transfusion is associated with an increase in PI. In addition, we assessed the value of PI and clinical measures in predicting the effect of RBC transfusion on IH.

STUDY DESIGN AND METHODS

We prospectively enrolled infants less than 30 weeks' gestation age. PI and oxygen saturation (SpO₂) …

Statistical Investigation Of Road And Railway Hazardous Materials Transportation Safety, Amirfarrokh Iranitalab

Department of Civil and Environmental Engineering: Dissertations, Theses, and Student Research

Transportation of hazardous materials (hazmat) in the United States (U.S.) constituted 22.8% of the total tonnage transported in 2012 with an estimated value of more than 2.3 billion dollars. As such, hazmat transportation is a significant economic activity in the U.S. However, hazmat transportation exposes people and environment to the infrequent but potentially severe consequences of incidents resulting in hazmat release. Trucks and trains carried 63.7% of the hazmat in the U.S. in 2012 and are the major foci of this dissertation. The main research objectives were 1) identification and quantification of the effects of different factors on occurrence and …

Vpsearch: Achieving Verifiability For Privacy-Preserving Multi-Keyword Search Over Encrypted Cloud Data, Zhiguo Wan, Robert H. Deng

Research Collection School Of Computing and Information Systems

Although cloud computing offers elastic computation and storage resources, it poses challenges on verifiability of computations and data privacy. In this work we investigate verifiability for privacy-preserving multi-keyword search over outsourced documents. As the cloud server may return incorrect results due to system faults or incentive to reduce computation cost, it is critical to offer verifiability of search results and privacy protection for outsourced data at the same time. To fulfill these requirements, we design aVerifiablePrivacy-preserving keywordSearch scheme, called VPSearch, by integrating an adapted homomorphic MAC technique with a privacy-preserving multi-keyword search scheme. The proposed scheme enables the client to …

U.S. College Students’ Social Network Characteristics And Perceived Social Exclusion: A Comparison Between Drinkers And Nondrinkers Based On Pastmonth Alcohol Use, Sara G. Balestrieri, Graham T. Diguiseppi, Matthew Meisel, Melissa A. Clark, Miles Q. Ott, Nancy P. Barnett

Statistical and Data Sciences: Faculty Publications

There is a general perception on college campuses that alcohol use is normative. However, nondrinking students account for 40% of the U.S. college population. With much of the literature focusing on intervening among drinkers, there has been less of a focus on understanding the nondrinker college experience. The current study has two aims: to describe the social network differences between nondrinkers and drinkers in a college setting, and to assess perceived social exclusion among nondrinkers. METHOD:First-year U.S. college students (n = 1,342; 55.3% female; 47.7% non-Hispanic White) were participants in a larger study examining a social network of one college …

Smartphone-Based Prenatal Education For Parents With Preterm Birth Risk Factors, U. Olivia Kim, K. Barnekow, Sheikh Iqbal Ahamed, S. Dreier, C. Jones, M. Taylor, Md Kamrul Hasan, M. A. Basir

Mathematics, Statistics and Computer Science Faculty Research and Publications

Objective

To develop an educational mobile application (app) for expectant parents diagnosed with risk factors for premature birth.

Methods

Parent and medical advisory panels delineated the vision for the app. The app helps prepare for preterm birth. For pilot testing, obstetricians offered the app between 18–22 weeks gestational age to English speaking parents with risk factors for preterm birth. After 4 weeks of use, each participant completed a questionnaire. The software tracked topics accessed and duration of use.

Results

For pilot testing, 31 participants were recruited and 28 completed the questionnaire. After app utilization, participants reported heightened awareness of preterm …

Crustal Seismic Anisotropy Of The Ruby Mountains Core Complex And Surrounding Northern Basin And Range, Justin T. Wilgus

Earth and Planetary Sciences ETDs

Metamorphic core complexes (MCC) are distinctive uplifts that expose deeply exhumed and deformed crustal rocks due to localized extensional deformation. Consequently, their detailed structure provide a window into deep crustal mechanics. The North American Cordillera contains numerous MCC, one of which is the Ruby Mountains core complex (RMCC) located in the highly extended northern Basin and Range. To constrain the extent to which anisotropy below the RMCC deviates from the regional Basin and Range average and test the depth dependence of crustal anisotropy we conduct a radial anisotropy investigation below the RMCC and surrounding northern Basin and Range. Data from …

Modification Of Asphalt Rubber With Nanoclay Towards Enhanced Storage Stability, Song-Yi Park, Minji Kang, Lynne Wilkens, Yurii Shvetsov, Brook Harmon, Nitin Shivappa, Michael Wirth, James R. Hébert, Christopher Haiman, Loïc Le Marchand, Carol Boushey

Faculty Publications

Asphalt rubber (AR), which is prepared by blending crumb rubber and bitumen, provides various advantages, including superior rutting resistance, lower road-tire noise and longer service life. However, contractors have expressed concerns regarding its poor storage stability, which in turn limits its wider application. This study aims to address the storage stability concern by incorporating nano-montmorillonite (nanoclay). Three types of nanoclay were dispersed into hot AR binder by high shear blending. The rheological properties of nanoclay-crumb rubber modifier (CRM)-modified bitumen were evaluated through Superpave performance grade (PG) tests and the storage stability was characterized by measuring the difference in softening points …

Probabilities Involving Standard Trirectangular Tetrahedral Dice Rolls, Rulon Olmstead, Doneliezer Baize

Rose-Hulman Undergraduate Mathematics Journal

The goal is to be able to calculate probabilities involving irregular shaped dice rolls. Here it is attempted to model the probabilities of rolling standard tri-rectangular tetrahedral dice on a hard surface, such as a table top. The vertices and edges of a tetrahedron were projected onto the surface of a sphere centered at the center of mass of the tetrahedron. By calculating the surface areas bounded by the resultant geodesics, baseline probabilities were achieved. Using a 3D printer, dice were constructed of uniform density and the results of rolling them were recorded. After calculating the corresponding confidence intervals, the …

Quantitative Appraisal Of Non-Irrigated Cropland In South Dakota, Shelby Riggs

Honors Program: Senior Projects (Public)

This appraisal attempts to remove subjectivity from the appraisal process and replace it with quantitative analysis of known data to generate a fair market value of the subject property. Two methods of appraisal were used, the income approach and the comparable sales approach. For the income approach, I used the average cash rent for the region, the current property taxes for the subject property, and a capitalization rate based on Stokes' (2018) capitalization rate formula to arrive at my income-based valuation. For the comparable sales approach, I utilized Stokes' (2018) research in optimization modeling to estimate a market value for …

Analysis Of Covariance (Ancova) In Randomized Trials: More Precision, Less Conditional Bias, And Valid Confidence Intervals, Without Model Assumptions, Bingkai Wang, Elizabeth Ogburn, Michael Rosenblum

Johns Hopkins University, Dept. of Biostatistics Working Papers

Covariate adjustment" in the randomized trial context refers to an estimator of the average treatment effect that adjusts for chance imbalances between study arms in baseline variables (called “covariates"). The baseline variables could include, e.g., age, sex, disease severity, and biomarkers. According to two surveys of clinical trial reports, there is confusion about the statistical properties of covariate adjustment. We focus on the ANCOVA estimator, which involves fitting a linear model for the outcome given the treatment arm and baseline variables, and trials with equal probability of assignment to treatment and control. We prove the following new (to the best …

Numerical Study Of Liquid Atomization And Breakup Using The Volume Of Fluid Method In Ansys Fluent, Sai Saran Kandati

LSU Master's Theses

The spherical metal particles produced from the centrifugal atomization process have been the topic of numerous theoretical, experimental and numerical studies from the past few years. This atomization process uses centrifugal force to break-up molten material into spherical droplets, which are quenched into solidified granules by the flow of cold air on the spherical droplets. In the present work, a transient three-dimensional multiphase CFD model is applied to three different materials: Molten slag, aqueous glycerol solution, and molten Ni-Nb to study the influence of the dimensionless parameters on the centrifugal atomization outcome.

Results from numerical experiments indicated that the droplet …

Quantitative Validation Of Simulated Sea Ice Displacements, Bryan R. Mccormick

Mathematics & Statistics ETDs

Accurate simulations of Arctic sea ice are important for forecasting as well as for understanding the global climate. However, quantitative measures for simulation displacements are underutilized. We present five such measures proposed as being useful in the validation of simulated sea ice displacements. Using drifting buoy and satellite measurements of sea ice motion as observation, we apply the metrics in a comparison of observed displacements and predicted displacements from the Arctic sea ice simulation MPM\_ice. We find the metric scores are useful for comparing simulations and observations. The metrics also brought to light problems in the simulation MPM_ice, demonstrating their …

Identifying Key Factors Associated With High Risk Asthma Patients To Reduce The Cost Of Health Resources Utilization, Amani Ahmad

LSU Master's Theses

Asthma is associated with frequent use of primary health services and places a burden on the United States economy. Identifying key factors associated with increased cost of asthma is an essential step to improve practices of asthma management.

The aim of this study was to identify factors associated with over utilization of primary health services and increased cost via claims data and to explore the effectiveness of case management program in reducing overall asthma related cost.

Claims data analysis for Medicaid insured asthma patients in Louisiana was conducted. Asthma patients were identified using their ICD-9 and ICD-10 codes, forward variable …

Using Cyclical Components To Improve The Forecasts Of The Stock Market And Macroeconomic Variables, Kenneth R. Szulczyk, Shibley Sadique

Journal of Modern Applied Statistical Methods

Economic variables such as stock market indices, interest rates, and national output measures contain cyclical components. Forecasting methods excluding these cyclical components yield inaccurate out-of-sample forecasts. Accordingly, a three-stage procedure is developed to estimate a vector autoregression (VAR) with cyclical components. A Monte Carlo simulation shows the procedure estimates the parameters accurately. Subsequently, a VAR with cyclical components improves the root-mean-square error of out-of-sample forecasts by 50% for a stock market model with macroeconomic variables.

Decision Making In A Changing Environment, Alan Veliz-Cuba

Annual Symposium on Biomathematics and Ecology Education and Research

No abstract provided.