Applied Statistics Commons^™

An Empirical Look At The Controversy Surrounding The Nobel Prize For Magnetic Resonance Imaging, Anthony Breitzman

College of Science & Mathematics Departmental Research

Disputes between researchers over who deserves credit for technological breakthroughs are not unusual. Few such disputes, however, have attracted as much attention as the arguments surrounding the award of the 2003 Nobel Prize for Medicine. This prize was awarded to Paul Lauterbur and Peter Mansfield to honor “discoveries concerning the development of magnetic resonance imaging” – i.e. MRI. Soon after the award, another scientist, Raymond Damadian, took out full-page advertisements in national newspapers, decrying the award and stating that he should have been included alongside Lauterbur and Mansfield. This technical report examines Damadian’s claim from a strictly empirical perspective, by …

Network Exploration Of Correlated Multivariate Protein Data For Alzheimer's Disease Association, Matthew J. Lane

Theses

Alzheimer Disease (AD) is difficult to diagnose by using genetic testing or other traditional methods. Unlike diseases with simple genetic risk components, there exists no single marker determining as to whether someone will develop AD. Furthermore, AD is highly heterogeneous and different subgroups of individuals develop the disease due to differing factors. Traditional diagnostic methods using perceivable cognitive deficiencies are often too little too late due to the brain having suffered damage from decades of disease progression. In order to observe AD at early stages prior to the observation of cognitive deficiencies, biomarkers with greater accuracy are required. By using …

Poisson Windowing, David L. Farnsworth

Articles

The statistical quality-control technique of windowing takes advantage of the additive property of the Poisson probability distribution and the geometry of the data. There are abundant applications of windowing to observations that naturally occur in arrays or that are produced in them, such as computer chips, which are manufactured many at a time on wafers. Standard statistical procedures are used.

Statistically Analyzing Assembly Line Processing Times Through Incorporation Of Product Variation, Kyle Rehr, Matthew Farr

Scholars Week

Timing methods and performance metrics are important in the heavily industrialized world we live in. Industrial plants use metrics to measure quality of production, help make decisions, and drive the strategy of the organization. However, there are many factors to be considered when measuring performance based on a metric; of which we will be analyzing the importance of product variation. We will be analyzing assembly line timings, whilst controlling for product variance, to show the importance differences between products makes in one’s ability to predict performance. In addition, we will be analyzing the current “statistical” methods used by an industrial …

Application Of Inverse Problems In Imaging, Xiaoyue Luo

Post-Grant Reports

In this project, we studied how to enhance image quality by denoising and deblurring a given image mathematically. We compared some existing state-of-the-art methods for image denoising and deblurring. We implemented the algorithms numerically using Matlab.

We studied the possibility of combining statistical analysis with the traditional image restoration methods including using wavelets and framelets and we derived some encouraging preliminary results.

My research student Alleta Maier gave a sequence of talks on the project including the Pacific Northwest Mathematical Association of America conference at Oregon State University in April, 2016; Linfield College Taylor Series in March, 2016, and Linfield …

Differences In Hemodynamics And Rupture Rate Of Aneurysms At The Bifurcation Of The Basilar And Internal Carotid Arteries, Ravi Doddasomayajula, Bong Jae Chung, Farid Hamzei-Sichani, Christopher M. Putman, Juan Cebral

Department of Applied Mathematics and Statistics Faculty Scholarship and Creative Works

BACKGROUND AND PURPOSE: Cerebral aneurysms in the posterior circulation are known to have a higher rupture risk than those in the anterior circulation. We sought to test the hypothesis that differences in hemodynamics can explain the difference in rupture rates.

MATERIALS AND METHODS: A total of 117 aneurysms, 63 at the tip of the basilar artery (27 ruptured, 36 unruptured, rupture rate = 43%) and 54 at the bifurcation of the internal carotid artery (11 ruptured, 43 unruptured, rupture rate = 20%) were analyzed with image-based computational fluid dynamics. Several hemodynamic variables were compared among aneurysms at each location and …

Health Care Resource Utilization And Costs Of California Medicaid Patients With Schizophrenia Treated With Paliperidone Palmitate Once Monthly Or Atypical Oral Antipsychotic Treatment, Jacqueline A. Pesa,, Dilesh Doshi, Li Wang, Huseyin Yuce, Onur Baser

Publications and Research

Objective: To compare all-cause health care utilization and costs between patients with schizophrenia treated with once monthly paliperidone palmitate (PP1M; Invega Sustenna1) and atypical oral antipsychotic therapy (OAT).

Methods: This was a retrospective claims-based analysis among adult California Medicaid (Medi-Cal) patients with schizophrenia having 2 claims for PP1M or OAT from 1 July 2009 to 31 December 2013 and continuous health plan enrollment for 1 year pre- and post-index date (PP1M or OAT initiation date). Baseline characteristics were reported descriptively. Propensity score matching with a 1:1 greedy match method was used to create two matched cohorts. Treatment patterns, all-cause health …

Moneyball For Creative Writers: A Statistical Strategy For Publishing Your Work, Jon Wesick

Journal of Humanistic Mathematics

Writers face a challenge getting their poems and stories published. Rather than following the traditional strategy I model creative writing submission as a statistical process and explore the use of numerical metrics to maximize publications.

Further Advances For The Sequential Multiple Assignment Randomized Trial (Smart), Tianjiao Dai

Dissertations and Theses (Open Access)

ABSTRACT

FURTHER ADVANCES FOR THE SEQUENTIAL MULTIPLE ASSIGNMENT RANDOMIZED TRIAL (SMART)

Tianjiao Dai, M.S.

Advisory Professor: Sanjay Shete, Ph.D.

Sequential multiple assignment randomized trial (SMART) designs have been developed these years for studying adaptive interventions. In my Ph.D. study, I mainly investigate how to further improve SMART designs and optimize the interventions for each individual in the trial. My dissertation has focused on two topics of SMART designs.

1) Developing a novel SMART design that can reduce the cost and side effects associated with the interventions and proposing the corresponding analytic methods. I have developed a time-varying SMART design in …

Studying The Optimal Scheduling For Controlling Prostate Cancer Under Intermittent Androgen Suppression, Sunil K. Dhar, Hans R. Chaudhry, Bruce G. Bukiet, Zhiming Ji, Nan Gao, Thomas W. Findley

Harvard University Biostatistics Working Paper Series

This retrospective study shows that the majority of patients’ correlations between PSA and Testosterone during the on-treatment period is at least 0.90. Model-based duration calculations to control PSA levels during off-treatment are provided. There are two pairs of models. In one pair, the Generalized Linear Model and Mixed Model are both used to analyze the variability of PSA at the individual patient level by using the variable “Patient ID” as a repeated measure. In the second pair, Patient ID is not used as a repeated measure but additional baseline variables are included to analyze the variability of PSA.

A Review Of The Multiple-Sample Tests For The Continuous-Data Type, Dewi Rahardja

Journal of Modern Applied Statistical Methods

For continuous data, various statistical hypotheses testing methods have been extensively discussed in the literature. In this article a review is provided of the multiple-sample continuous-data testing methods. It includes traditional methods, such as the two-sample t-test, Welch ANOVA test, etc., as well as newly-developed ones, such as the various Multiple Comparison Procedure (MCP). A roadmap is provided in a figure or diagram format as to which methods are available in the literature. Additionally, the implementation of these methods in popular statistical software packages such as SAS is also presented. This review will be helpful to determine which continuous-data testing …

Factor Analysis By Limited Scales: Which Factors To Analyze?, Stan Lipovetsky

Journal of Modern Applied Statistical Methods

Factor Analysis (FA) and Principal Component Analysis (PCA) are well-known main tools of the multivariate statistics for data analysis, reduction, and visualization. Commonly, the analysis and interpretation of their solutions is performed for each of several main eigenvectors with variances explaining a big part of the total variability in data. The recommendation is to determine if all the main vectors are really needed in the analysis, or some of them should be skipped if they correspond to the absence of the analyzing features. A simple criterion for identifying redundant vectors of loadings is their negative correlation with the vector of …

Prediction Of Percent Change In Linear Regression By Correlated Variables, Stan Lipovetsky

Journal of Modern Applied Statistical Methods

Multiple linear regression can be applied for predicting an individual value of dependent variable y by the given values of independent variables x. But it is not immediately clear how to estimate percent change in y due to changes in predictors, especially when those are correlated. This work considers several approaches to this problem, including its formulation via predictors adjusted by their correlation structure. Ordinary least squares regression is used, together with Shapley value regression and another model based on solving some system of differential equations. Numerical estimations performed for a real marketing research data demonstrate meaningful results. The considered …

Quantum Foundations With Astronomical Photons, Calvin Leung

HMC Senior Theses

Bell's inequalities impose an upper limit on correlations between measurements of two-photon states under the assumption that the photons play by a set of local rules rather than by quantum mechanics. Quantum theory and decades of experiments both violate this limit.

Recent theoretical work in quantum foundations has demonstrated that a local realist model can explain the non-local correlations observed in experimental tests of Bell's inequality if the underlying probability distribution of the local hidden variable depends on the choice of measurement basis, or ``setting choice''. By using setting choices determined by astrophysical events in the distant past, it is …

Meta-Analyses Of The Relationship Between Depression And Nine Dimensions Of Perfectionism, Gabriel Lynn Hottinger

Electronic Theses and Dissertations

Perfectionism has been shown to be related to depression, but perfectionism is multidimensional. Some dimensions are related to positive psychological characteristics and outcomes and other dimensions are related to negative psychological characteristics and outcomes. This study reports results of nine meta-analyses performed to investigate the association between each of nine subscales of perfectionism and depression to determine which dimensions of perfectionism are most strongly associated with depression. The two subscales that were used from the Hewitt and Flett (1991b) Multidimensional Perfectionism scale were Self-Oriented Perfectionism (SOP) and Socially-Prescribed Perfectionism (SPP). The five subscales that were used from the Frost et …

Case Study For Guided Project In Stochastic Hydrology, Meghna Babbar-Sebens

All ECSTATIC Materials

Attached are two guided project activities for hydrology and climate data of Eagle Creek Watershed, Indiana, USA. The zip files have flow and precipitation datasets at daily, monthly, and annual time scales.

The Document Similarity Network: A Novel Technique For Visualizing Relationships In Text Corpora, Dylan Baker

HMC Senior Theses

With the abundance of written information available online, it is useful to be able to automatically synthesize and extract meaningful information from text corpora. We present a unique method for visualizing relationships between documents in a text corpus. By using Latent Dirichlet Allocation to extract topics from the corpus, we create a graph whose nodes represent individual documents and whose edge weights indicate the distance between topic distributions in documents. These edge lengths are then scaled using multidimensional scaling techniques, such that more similar documents are clustered together. Applying this method to several datasets, we demonstrate that these graphs are …

Machine Learning On Statistical Manifold, Bo Zhang

HMC Senior Theses

This senior thesis project explores and generalizes some fundamental machine learning algorithms from the Euclidean space to the statistical manifold, an abstract space in which each point is a probability distribution. In this thesis, we adapt the optimal separating hyperplane, the k-means clustering method, and the hierarchical clustering method for classifying and clustering probability distributions. In these modifications, we use the statistical distances as a measure of the dissimilarity between objects. We describe a situation where the clustering of probability distributions is needed and useful. We present many interesting and promising empirical clustering results, which demonstrate the statistical-distance-based clustering algorithms …

A Study Of Mathematics Achievement, Placement, And Graduation Of Engineering Students, Sara Hahler Blazek

Doctoral Dissertations

The purpose of this study was to determine how background knowledge impacts freshmen engineering students' success at Louisiana Tech University in terms of grades in two different freshman classes and graduation. To determine what factors impact students, three different studies were implemented. The first study used linear regression to analyze which demographic and academic variables significantly impacted freshman math and engineering courses. Using regression discontinuity, the second study determined if the university's placement requirement for Pre-Calculus was appropriate. The final study analyzed factors that impact graduation for engineering students as well as other disciplines to determine which significant variables were …

What’S Brewing? A Statistics Education Discovery Project, Marla A. Sole, Sharon L. Weinberg

Publications and Research

We believe that students learn best, are actively engaged, and are genuinely interested when working on real-world problems. This can be done by giving students the opportunity to work collaboratively on projects that investigate authentic, familiar problems. This article shares one such project that was used in an introductory statistics course. We describe the steps taken to investigate why customers are charged more for iced coffee than hot coffee, which included collecting data and using descriptive and inferential statistical analysis. Interspersed throughout the article, we describe strategies that can help teachers implement the project and scaffold material to assist students …