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Articles 1 - 30 of 2910
Full-Text Articles in Applied Statistics
Bridging The Gap Between Career Expectations Versus Labor Market Realities, Reinette P. Madrid, Grethel T. Ledesma, Ignatius Aryono Putranto, Jyro B. Triviño
Bridging The Gap Between Career Expectations Versus Labor Market Realities, Reinette P. Madrid, Grethel T. Ledesma, Ignatius Aryono Putranto, Jyro B. Triviño
Leadership and Strategy Faculty Publications
Most students lack awareness regarding the labor market outcomes for their chosen college majors. This study aims to answer what factors affect the career expectations of graduating students at Quezon City University and how these expectations align with the prevailing labor market situation. It employed descriptive, causal, and explanatory research using a sample of 108 respondents from fourth-year information technology students for the school year 2021 to 2022. Eight of the nine null hypotheses were rejected by employing multinomial logistic and linear regression. Student fixed effects and other labor market outcomes significantly predicted salary, estimated stability, and estimated skills in …
Predicting Passenger Demand On National Flights Departing From Hartsfield-Jackson Atlanta International Airport (Atl) In 2024, Brooklyn Gossett, Ana Yu Wen
Predicting Passenger Demand On National Flights Departing From Hartsfield-Jackson Atlanta International Airport (Atl) In 2024, Brooklyn Gossett, Ana Yu Wen
Discovery Day - Daytona Beach
The aviation industry relies heavily on accurate demand forecasting to guide critical decisions regarding route planning, capacity management, and pricing strategy. Misjudging passenger demand can result in significant revenue loss and operational inefficiency, making it essential for airlines and analysts to identify the key drivers of flight patronage. This study investigates the factors that most significantly predict the number of passengers on domestic flights departing from Hartsfield-Jackson Atlanta International Airport (ATL) during the 2024 calendar year. Using passenger and route data sourced from the Bureau of Transportation Statistics (BTS) and the U.S. Department of Transportation (DOT), a multiple regression analysis …
Bounded Thunderstorm Tracking Of Lightning Events With Muon Detection, Skylar Wardlaw, Ainsley Helgerson, Maria Kaminska, Logan Velvet, Georgii Dubrov, Jackson Stewart, Aaron Jung, Nathaniel O’Hara, Amelia Koth, Nash Mcleod, Emaleth Wyckoff
Bounded Thunderstorm Tracking Of Lightning Events With Muon Detection, Skylar Wardlaw, Ainsley Helgerson, Maria Kaminska, Logan Velvet, Georgii Dubrov, Jackson Stewart, Aaron Jung, Nathaniel O’Hara, Amelia Koth, Nash Mcleod, Emaleth Wyckoff
Discovery Day - Daytona Beach
The muon is a high-energy particle that can be produced by cosmic rays and trigger upper-atmospheric particle cascades and energetic processes. It has been hypothesized that such cascades are at the onset of lightning. As such, muons serve as a valuable probe for investigating the underlying mechanisms of its initiation, whose full governing dynamics remain vastly unknown despite extensive research. Traditional approaches to lightning research involve simulations and observations of the discharge itself, but the role of high-energy particle interactions has yet to be fully constrained. The CosmicWatch Muon Detector design enables the detection of atmospheric muons through scintillation events, …
Statistical Methodologies For Count Time Series Analysis And Topological Data Analysis Of Medical Images, Yuhyeong Jang
Statistical Methodologies For Count Time Series Analysis And Topological Data Analysis Of Medical Images, Yuhyeong Jang
Statistical Science Theses and Dissertations
This dissertation addresses two distinct topics related to count time series analysis and topological medical image analysis, respectively. The first part of the dissertation comprises an application of a count time series model to analysis of US monthly sex trafficking data and development of a new model for multivariate count data that exhibits serial dependence and overdispersion. By imposing a family of multivariate mixed Poisson distributions on the count random vector, the proposed model can accommodate a broad range of overdispersion as well as positive contemporaneous correlations. For maximum likelihood estimation, a computationally feasible EM-type algorithm is derived based on …
Ground To Roof Snow Load Ratio (Gr) Data Release, Brennan Bean, Cooper Nelson, Jesse Wheeler, Scout Jarman, Salam Adil Al-Rubaye, Marc Maguire
Ground To Roof Snow Load Ratio (Gr) Data Release, Brennan Bean, Cooper Nelson, Jesse Wheeler, Scout Jarman, Salam Adil Al-Rubaye, Marc Maguire
Browse all Datasets
This data release provides historical ground-to-roof snow load ratio (GR) datasets used for snow load research and model development. The release includes original referenced datasets, cleaned country specific datasets, and a master dataset that combines Canadian and United States datasets into a standardized format for research and engineering applications.
Modeling Mean And Variability Of Anxiety In Ecological Momentary Assessment Data Using Mixed-Effects Location–Scale Models, Trenzy Odero
Modeling Mean And Variability Of Anxiety In Ecological Momentary Assessment Data Using Mixed-Effects Location–Scale Models, Trenzy Odero
Electronic Theses and Dissertations
Ecological Momentary Assessment is a method of collecting repeated measures of people in real time within natural environments. This results in hierarchical data that has a significant amount of variation at the person level. The traditional linear mixedeffects models assume that the residual variance is constant, which might not be true when the residual variance varies among individuals as well as in time. This thesis uses mixed-effects location-scale (MELS) models to model the mean and variance of an EMA outcome together. By introducing the possibility of variability in residual variance within and across individuals and with covariates, the MELS framework …
Volatility Spillovers Between Stock Prices And Exchange Rates: Insights For Risk Management And Investment Strategies: Evidence From China, India, And Pakistan Using Bekk-Garch Models, Samreen Fatima, Humera Sultana, Muhammad Najamuddin Dr., Saba Naz
Volatility Spillovers Between Stock Prices And Exchange Rates: Insights For Risk Management And Investment Strategies: Evidence From China, India, And Pakistan Using Bekk-Garch Models, Samreen Fatima, Humera Sultana, Muhammad Najamuddin Dr., Saba Naz
The Indonesian Capital Market Review
This study investigates the dynamics of volatility and its spillover effects between the stock markets of China, India, and Pakistan, and their respective exchange rates (USD/CNY, USD/INR, and USD/ PKR). Volatility is modeled using the Symmetric and Asymmetric BEKK-GARCH (1,1) and DCCGARCH (1,1) models, based on daily return series covering the period from January 1, 2019, to January 31, 2025. The empirical results indicate that both the employed models are adequate for capturing the volatility dynamics. The findings reveal that the highest value of portfolio weights and hedging efficiency of KSE-100 Index–USD/PKR provide optimal portfolio allocation and highest hedging performance …
It's All In The (Exponential) Family: An Equivalence Between Maximum Likelihood Estimation And Control Variates For Sketching Algorithms, Keegan Kang, Kerong Wang, Ding Zhang, Rameshwar Pratap, Bhisham Dev Verma, Benedict Wong
It's All In The (Exponential) Family: An Equivalence Between Maximum Likelihood Estimation And Control Variates For Sketching Algorithms, Keegan Kang, Kerong Wang, Ding Zhang, Rameshwar Pratap, Bhisham Dev Verma, Benedict Wong
Faculty Conference Papers and Presentations
Maximum likelihood estimators (MLE) and control variate estimators (CVE) have been used in conjunction with known information across sketching algorithms and applications in machine learning. We prove that under certain conditions in an exponential family, an optimal CVE will achieve the same asymptotic variance as the MLE, giving a fixed point algorithm for the MLE. Experiments show the fixed point algorithm is faster and numerically stable compared to other root finding algorithms for the MLE for the bivariate Normal distribution, and we expect this to hold across distributions satisfying these conditions. We show how this algorithm leads to reproducibility for …
What We Know About Accounting Ratios: Methodological Considerations, Wojciech Kuryłek, Oskar Kowalewski
What We Know About Accounting Ratios: Methodological Considerations, Wojciech Kuryłek, Oskar Kowalewski
Studia i Materiały Wydział Zarządzania Uniwersytet Warszawski
Purpose: This paper provides a comprehensive literature review of the methodological aspects of financial ratio analysis, consolidating dispersed knowledge on the computation, statistical properties, and appropriate usage of accounting ratios.
Design/Methodology/Approach: The study adopts a narrative literature review methodology, systematically surveying published research on financial ratio distributions, normality testing, data transformations, outlier handling, the proportionality assumption, dimensionality reduction techniques, compositional data analysis, and recommended ratio sets for corporate financial research.
Findings: Financial ratios predominantly deviate from normal distributions, exhibiting skewness, excess kurtosis, and sensitivity to outliers. Transformation techniques such as logarithmic, square root, and Box‑Cox methods yield mixed results in …
Mengukur Capaian Dan Identifikasi Konvergensi Pembangunan Infrastruktur Antarprovinsi Di Indonesia, Ressa Isnaini Arumnisaa', Aisyah Fitri Yuniasih
Mengukur Capaian Dan Identifikasi Konvergensi Pembangunan Infrastruktur Antarprovinsi Di Indonesia, Ressa Isnaini Arumnisaa', Aisyah Fitri Yuniasih
Jurnal Ekonomi dan Pembangunan Indonesia
Indonesia’s economic challenges are characterized by stagnant economic growth and regional development disparities. This study analyzes the achievement and convergence of infrastructure development across provinces in Indonesia during 2011–2021 through the construction of an Infrastructure Development Index (IPI). The study employs panel data from 33 provinces, using factor analysis to construct the IPI and the First Difference Generalized Method of Moments (FD-GMM) to examine convergence and its determinants. The results show that many provinces still have IDI scores below the national average. Furthermore, the FD-GMM model shows that σ-convergence and β-convergence occur in Indonesia. In addition, GRDP per capita, inflation, …
Estimasi Underground Economy Triwulanan Di Indonesia Pada Tahun 2010–2023, Ghina Anandhia, Hardius Usman
Estimasi Underground Economy Triwulanan Di Indonesia Pada Tahun 2010–2023, Ghina Anandhia, Hardius Usman
Jurnal Ekonomi dan Pembangunan Indonesia
Underground economics have a significant impact on economy. Underground economy leads to low potential state revenues from the tax sector. This study estimates the quarterly value of the underground economy in Indonesia from 2010 to 2023 using the Error Correction Model (ECM) method. The results show that the average value of the underground economy in Indonesia is IDR138,392.32 billion, equivalent to 5.36 percent of Gross Domestic Product (GDP) and 35.72 percent of tax revenue from 2010 to 2023. GDP and tax burden variables have a positive influence on currency demand.
(R2174) A Stationary First-Order Autoregressive Process With New Discrete Lindley Marginal Distribution, Tégawendé Martin Kabore, Jean-Etienne Ouindllassida Ouédraogo
(R2174) A Stationary First-Order Autoregressive Process With New Discrete Lindley Marginal Distribution, Tégawendé Martin Kabore, Jean-Etienne Ouindllassida Ouédraogo
Applications and Applied Mathematics: An International Journal (AAM)
This paper introduces a new stationary first-order autoregressive integer-valued process with a marginal distribution following the New Discrete Lindley distribution, referred to as NDLINAR( 1). The process is developed to model over-dispersed count time series exhibiting a mixed behavior arising from the combination of multiple distributions. Its statistical properties are thoroughly investigated, and the parameters are estimated using conditional maximum likelihood. The asymptotic properties of the estimators are also analyzed. The performance of the proposed model is evaluated by comparing it with other existing INAR(1) processes through applications to real datasets. Results demonstrate that the NDL-INAR(1) process effectively captures the …
Mycelial Modeling: Teaching Biology Students Statistical Modeling With Mushrooms, Colette Wolf
Mycelial Modeling: Teaching Biology Students Statistical Modeling With Mushrooms, Colette Wolf
University Honors Theses
This paper summarizes and describes the development of a set of learning materials that were created to educate students and professionals from other fields in statistical modeling techniques. These materials are primarily aimed at biology students, but are still intended to be useful for anyone who is interested in incorporating decision trees and random forest models into their personal research in the future. By directing the reader towards the JMP software, these materials navigate around the statistical knowledge base and coding implementation practices that otherwise would serve as a barrier to learning statistical modeling techniques, and instead focus on the …
Muon Lifetime: Theory, Experiment, And Simulation, Soren Agustin Munoz
Muon Lifetime: Theory, Experiment, And Simulation, Soren Agustin Munoz
Physics
This senior project investigates the muon lifetime through three complementary approaches: theoretical calculation, laboratory measurement, and computational simulation. The theoretical component develops the necessary background from relativistic field theory to the effective weak interaction, culminating in the leading-order Fermi-theory prediction of τ ≈ 2.2 μs, which explains why the muon lifetime lies on the microsecond scale.
The experimental component measures the lifetime of stopped cosmic-ray muons using a plastic scintillator, photomultiplier tube, and analog timing electronics. A binned Poisson likelihood fit to the primary 15-day acquisition run τ = 2.17+0.03-0.09 μs, consistent with the accepted value within the …
A Predictive Coding Account Of Spatial Working Memory Following Prophylactic Levetiracetam Administration Prior To Traumatic Brain Injury, Omeima Mutwali
A Predictive Coding Account Of Spatial Working Memory Following Prophylactic Levetiracetam Administration Prior To Traumatic Brain Injury, Omeima Mutwali
Dissertations, Theses, and Capstone Projects
Traumatic brain injury (TBI) symptom prevention and remediation is an important area of research that would benefit vulnerable groups, including active-duty and veteran soldiers. These patients can sustain penetrative forces in fields of combat or in training, which result in focal lesions that trigger inflammatory and degenerative processes in the brain. Both primary and secondary injuries are associated with changes to cognition, behavior and affective state. This disease poses increased risk of epileptogenesis, as well. Given these outcomes, prior research has evaluated levetiracetam (LEV) as a prophylactic treatment for seizures, cognitive deficits and negative emotionality. LEV acts as a presynaptic …
Developing A Humpback Whale Vocalization Detector Using Machine Learning Models, Lucas Kantorowski
Developing A Humpback Whale Vocalization Detector Using Machine Learning Models, Lucas Kantorowski
Master's Theses
Humpback whale songs are notoriously complex. Identification of humpback whale song units requires bioacousticians to tediously listen, analyze, and annotate collected sound data. Even sparse data requires listening to the entirety of the collected acoustic data. In this study, three hours of audio containing over one-thousand humpback whale song units was collected in Monterey Bay, California.
Prior studies have seen success using convolutional neural networks by performing image classification on hundreds of hours worth of spectrograms. Our study uses traditional machine learning models, as they are less computationally demanding, and require less data.
We use time splitting and Mel-frequency cepstrum …
Crab: A Novel Clustering Score Using Clustering With Rivals And Buddies For Unsupervised Learning, Allen Choi
Crab: A Novel Clustering Score Using Clustering With Rivals And Buddies For Unsupervised Learning, Allen Choi
Master's Theses
Unsupervised clustering algorithms today are used across a wide variety of fields such as biology, engineering, and industry in order to classify observations into groups where labels are not provided. This can provide important latent information regarding the observations within groups, as well as insight regarding the groups themselves. In order to judge the optimal number of clusters for an unsupervised clustering algorithm, many methods exist such as the Elbow Method and Silhouette Score; however, these methods come with drawbacks and are not necessarily flexible across many unsupervised methods. We present a novel clustering score framework relying on a resampling-based …
Hot Hands Or Chance Happenings? A Simulation-Based Approach For Wnba Teams, Ruben Jimenez
Hot Hands Or Chance Happenings? A Simulation-Based Approach For Wnba Teams, Ruben Jimenez
Master's Theses
The hot hand is a polarizing topic in basketball analytics: fans, stakeholders, and even players themselves assert confidently their belief or disbelief in the idea that players who perform well will continue to do so over an extended period of time. Statistical research has been conducted since as early as 1985 to attempt to disprove or prove the existence of this phenomenon. More recent works have refuted the earliest objections to the hot hand’s existence, with conclusions aided by robust simulation techniques. In this work, we compare hypothesis tests using multiple simulation techniques to explore the hot hand at the …
Structured Dynamic Factor Analysis Of Environmental Time Series With Application To Morro Bay Estuary, Jose Garcia
Structured Dynamic Factor Analysis Of Environmental Time Series With Application To Morro Bay Estuary, Jose Garcia
Master's Theses
This thesis develops a structured dynamic factor analysis (sDFA) framework for decomposing multivariate environmental time series into latent biological and physical components. The methodology is applied to five years of high-resolution passive monitoring data collected from two sites in Morro Bay, California from 2020 through 2024. Relative contribution indices are developed based on the structured DFA that measure how much each latent process contributes to each observed variable at any given time. Structured DFA models fit to the application data suggest site-specific patterns in how biological and physical processes affect water quality variables. At the bay mouth location, physical processes …
Multimodal Machine Learning For Soil Burn Severity Mapping Across California Wildfires, Sanjana Checker
Multimodal Machine Learning For Soil Burn Severity Mapping Across California Wildfires, Sanjana Checker
Master's Theses
Accurate mapping of soil burn severity (SBS) is critical for post-fire watershed management, erosion risk assessment, and ecological recovery planning, yet traditional field-based approaches remain costly, time-intensive, and spatially limited. This thesis presents a machine learning pipeline for wall-to-wall SBS classification across California wildfires using multi-sensor satellite imagery, terrain derivatives, and bioclimatic covariates. Field-collected SBS observations (n = 2,180) from 52 wildfires occur- ring between 2013 and 2025, sourced from the U.S. Forest Service and CAL FIRE, were used to train and evaluate multiple classification architectures within a Google Earth Engine and Google Cloud-based prediction framework. After upsampling the unburned …
Conditional Product Sampling For Gaussian Process Implicit Surfaces, Song Shi
Conditional Product Sampling For Gaussian Process Implicit Surfaces, Song Shi
Dartmouth College Master’s Theses
Gaussian Process Implicit Surfaces (GPISes) provide a powerful and unified stochastic geometry representation for rendering surfaces, volumes, and the rich continuum between them. Recent work has shown that GPISes can model a broad space of visual appearances under a unified light transport framework. However, practical rendering with GPISes remains challenging: existing estimators can become inefficient for particular correlation structures, and highly anisotropic or heightfield-like GPISes require specialized treatment to obtain robust variance reduction.
This thesis extends recent work on GPIS rendering by introducing a new next-event estimation (NEE) technique for anisotropic GPISes.We show that standard NEE provides diminishing benefits as …
Bayesian Designs For Two-Arm Clinical Trials With Time-To-Event Endpoints: Incorporating Historical Data Through Power Priors, Sara Hajraf H. Almutiri
Bayesian Designs For Two-Arm Clinical Trials With Time-To-Event Endpoints: Incorporating Historical Data Through Power Priors, Sara Hajraf H. Almutiri
Mathematics & Statistics ETDs
Bayesian methods provide a flexible framework for time-to-event analysis by incorporating prior information. The power prior offers a systematic way to borrow information from historical data. This approach is especially valuable in clinical research, where historical data can enhance inference in early-phase trials with limited sample sizes. This dissertation develops Bayesian approaches for two-arm survival studies using both closed-form and simulation-based methods. The closed-form inference is derived under exponential and Weibull survival models. Under the proportional hazards framework, the posterior is derived through a normal approximation to the log hazard ratio, allowing inference on the treatment effect when the variance …
An Analytical Framework For Quantifying Urban And Community Resilience To Natural Hazards From Cell-Phone Gps-Location And Traffic-Flow Data, Georgios Chatzikyriakidis
An Analytical Framework For Quantifying Urban And Community Resilience To Natural Hazards From Cell-Phone Gps-Location And Traffic-Flow Data, Georgios Chatzikyriakidis
Civil and Environmental Engineering Theses and Dissertations
Urban areas are increasingly exposed to natural hazards while accommodating a growing share of the global population, yet a consistent science-based framework for quantifying urban and community resilience remains lacking. This dissertation develops a physics-based analytical framework grounded in statistical mechanics and the quantitative theory of Brownian motion. A city is conceptualized as a complex medium in which citizens move analogously to Brownian particles within a viscoelastic environment, influenced by socioeconomic interactions and infrastructure functionality.
A central premise is that urban resilience, interpreted as engineering resilience (an outcome), can be quantified through a single metric: the mean-square displacement MSD=⟨r²(t)⟩, of …
Bayesian Spatiotemporal Model For Counterfactual Estimation In Socioeconomic Studies, Duwani W. Gonzalez
Bayesian Spatiotemporal Model For Counterfactual Estimation In Socioeconomic Studies, Duwani W. Gonzalez
Statistical Science Theses and Dissertations
Impact evaluations of regional development programs often require estimating counterfactual outcomes for a small number of treated regions using survey-based areal data. In practice, evaluators typically rely on two-group quasi-experimental methods such as propensity score matching (PSM) and Difference-in-Differences (DiD). These approaches perform poorly when only a few regions receive treatment, and when the set of observed covariates is limited or only partially relevant. Moreover, they typically do not explicitly exploit the spatial and temporal dependence present in survey-based areal data such as in ACS (American Community Survey). This dissertation develops a family of Bayesian spatial predictive models for directly …
Digital Literacy And Language Proficiency As Factors Of Accessible Digital Training In The Hospitality Industry: Employee Perspectives Of Training And Working In A Diverse Industry, Gillian Bowden
UNLV Theses, Dissertations, Professional Papers, and Capstones
This explanatory sequential mixed methods study explored how digital literacy and language proficiency impact employees’ access to and engagement with digital training, as well as how these experiences influence their perceptions of training and the organization. In the quantitative phase, survey data were collected from hourly employees at a large foodservice corporation (n=67). Four constructs were assessed: digital literacy, language proficiency, accessibility, and engagement. Results indicated strong, statistically significant relationships with higher levels of digital literacy and language proficiency associated with greater accessibility and increased engagement with digital training materials. The large effect sizes suggest these competencies play a meaningful …
Using Multilevel Modeling To Understand Nested Data, Holmes Finch
Using Multilevel Modeling To Understand Nested Data, Holmes Finch
Perspectives on Early Childhood Psychology and Education
Researchers in the social sciences often work with nested data, in which individuals are collected in higher level clusters. For example, educational research often involves working with samples in which students are nested within schools. Standard data analyses, such as regression and analysis of variance (ANOVA), yield statistically biased results when this nested structure is ignored. One widely used and effective approach for handling such nested data is multilevel modeling. The purpose of this manuscript is to review the basics of multilevel modeling and to provide the reader with a fully worked example in which the analytic approach and results …
Using Effect Sizes, Confidence Intervals, And The Bayes Factor To Better Understand The T-Test, Analysis Of Variance, And Regression Results, Holmes Finch
Perspectives on Early Childhood Psychology and Education
Null hypothesis testing is a widely used paradigm for assessing research hypotheses across the social sciences. Despite their ubiquity, researchers have discussed a number of problems and limitations to hypothesis testing and have suggested alternatives that might provide greater depth and explanation of research results. The purpose of this paper is to describe the use of several such alternatives and to show how they can be integrated with one another and with null hypothesis testing in order to provide a more holistic view of research hypotheses.
A Statistical Analysis Of Current And Future Hurricane Activity In The North Indian Ocean, Basil Lund
A Statistical Analysis Of Current And Future Hurricane Activity In The North Indian Ocean, Basil Lund
2026 Symposium
A hurricane is defined as a tropical storm with winds sustained at 74 mph or greater. I examined major (category 3 and above) hurricane activity over the North Indian Ocean from the years 1972-2019 as reported by Colorado State University Hurricane Forecast Archive. Using RStudio, I conducted a binomial analysis of the CSU dataset to calculate probabilities of zero to ten years with one or more major North Indian Ocean hurricanes in the next decade. I conducted a geometric analysis to determine probabilities associated with waiting periods for the next year with a major hurricane, as well as a Poisson …
Developing A Comprehensive Resource Guide For Caregivers Within The Area Agency On Aging, Aiden R. Murphy
Developing A Comprehensive Resource Guide For Caregivers Within The Area Agency On Aging, Aiden R. Murphy
Public Health Capstone Projects
This project developed a new universal caregiver resource guide for caregivers within the Area Agency on Aging, in order to improve resource navigation and workflow efficiency. Resources were collected, verified, and organized into a new, streamlined guide via the ARIA chatbot, covering multiple needs. Caregiver resources were collected and verified by the capstone student and mentor, Michael Kroeker, and organized into a centralized knowledge base within the ARIA chatbot. A mixed methods evaluation was conducted utilizing a 5-point Likert scale with three quantitative questions and one open-ended qualitative question. The data was given to the SeniorLine staff, who wanted to …
Genetic Analysis Of Triplicated Genes Affecting Sex-Specific Skeletal Deficits In Down Syndrome Model Mice, Kourtney Sloan, Kristina M. Piner, Pathum Randunu Nawarathna Kandedura Arachchige, Charles R. Goodlett, Yann Herault, Gayla R. Olbricht, Joseph M. Wallace, Randall J. Roper
Genetic Analysis Of Triplicated Genes Affecting Sex-Specific Skeletal Deficits In Down Syndrome Model Mice, Kourtney Sloan, Kristina M. Piner, Pathum Randunu Nawarathna Kandedura Arachchige, Charles R. Goodlett, Yann Herault, Gayla R. Olbricht, Joseph M. Wallace, Randall J. Roper
Mathematics and Statistics Faculty Research & Creative Works
Down syndrome (DS) is caused by the triplication of human chromosome 21 (Hsa21), resulting in skeletal insufficiency (low bone mineral density) and altered bone development. DS mouse models recapitulate these deficits, including sexual dimorphism in long bone alterations. Historically, Ts65Dn mice provided much of the insight behind DS-related skeletal deficits with ∼100 trisomic orthologous genes, but there are concerns about the genetic fidelity in this model due to the included triplication of genes not homologous to Hsa21. A new DS model, Ts66Yah, subtracted the non-Hsa21 homologous trisomic genes from Ts65Dn but has not been evaluated for long bone deficits. Comparing …