Fluorination Of Aromatic Ring Systems,
2013
University of Nebraska-Lincoln
Fluorination Of Aromatic Ring Systems, Stephen G. Dimagno
Department of Chemistry: Faculty Publications
This disclosure relates to reagents and methods useful in the synthesis of aryl fluorides, for example, in the preparation of 18F labeled radiotracers. The reagents and methods provided herein may be used to access a broad range of compounds, including aromatic compounds, heteroaromatic compounds, amino acids, nucleotides, and synthetic compounds.
Phosphate Esters, Thiophosphate Esters And Metal Thiophosphates As Lubricant Additives,
2013
University of Dayton
Phosphate Esters, Thiophosphate Esters And Metal Thiophosphates As Lubricant Additives, David W. Johnson, John E. Hils
Chemistry Faculty Publications
Phosphate esters, thiophosphate esters and metal thiophosphates have been used as lubricant additives for over 50 years. While their use has been extensive, a detailed knowledge of how they work has been a much more recent development. In this paper, the use of phosphate esters and thiophosphate esters as anti-wear or extreme pressure additives is reviewed with an emphasis on their mechanism of action. The review includes the use of alkyl phosphates, triaryl phosphates and metal containing thiophosphate esters. The mechanisms of these materials interacting with a range of iron and steel based bearing material are examined.
Poly (N-Isopropylacrylamide) Microgel-Based Etalons And Etalon Arrays For Determining The Molecular Weight Of Polymers In Solution,
2013
Chapman University
Poly (N-Isopropylacrylamide) Microgel-Based Etalons And Etalon Arrays For Determining The Molecular Weight Of Polymers In Solution, Molla R. Islam, Michael J. Serpe
Biology, Chemistry, and Environmental Sciences Faculty Articles and Research
Positively and/or negatively charged poly (N-isopropylacrylamide)-based microgels were deposited on a single substrate and isolated regions of Au overlayers were deposited on top of the microgels. Each spatially isolated Au overlayer region had a different thickness to make an etalon array.We found that areas with a thin Au overlayer (5 nm) responded to a range of polymer molecular weights (MW), while areas with a thick overlayer (35 nm) can only respond to low molecular weight polyelectrolytes. By comparing the optical responses of the device’s individual array elements, a good approximation of the polyelectrolyteMWin solution can be made.
Investigating Intermolecular Interactions In Crystalline Aspirin Using Cdft,
2013
Purdue University
Investigating Intermolecular Interactions In Crystalline Aspirin Using Cdft, Nicholas Turner, Tonglei Li, Mingtao Zhang
The Summer Undergraduate Research Fellowship (SURF) Symposium
Drugs today are widely administered in their crystalline form, namely via tablets and capsules. The crystal structure of a drug molecule affects important drug qualities such as solubility, bioavailability, shelf life, and compaction properties. In order to form a basis for crystal structure prediction, it is necessary to first understand how intermolecular interactions cause molecules to pack in certain ways. Being able to predict and perhaps even control a drug molecule’s crystal structure will lead to the development of higher quality drugs that perform more consistently. Scientists and engineers do not fully understand the reasons for a molecule assuming a …
Surface Modification Of Poly(Dimethylsiloxane) With 254 Nm Irradiation:A Comparison Of Functional Groups,
2013
University of Alabama in Huntsville
Surface Modification Of Poly(Dimethylsiloxane) With 254 Nm Irradiation:A Comparison Of Functional Groups, Kenya Wallace
Von Braun Symposium Student Posters
No abstract provided.
Acquisition Of An Electrochemical System Instrument For The Development Of Sensors,
2013
Dyson College of Arts and Sciences, Pace University
Acquisition Of An Electrochemical System Instrument For The Development Of Sensors, Elmer-Rico E. Mojico
Cornerstone 1 Reports : Expansion and Enhancements of the Thinkfinity Platform
No abstract provided.
Structure, Theoretical Studies And Coupling Reactions Of Some New Cyclic Boronic Esters,
2013
University of Dayton
Structure, Theoretical Studies And Coupling Reactions Of Some New Cyclic Boronic Esters, Andrew Kuttler, Sravanthi Durganala, Albert Fratini, Alexander Morgan, Vladimir Benin
Chemistry Faculty Publications
The present report describes the X-ray structural and theoretical studies of some new pinacolboronate esters, and it also outlines the use of the target structures in Suzuki coupling reactions to produce new aromatic or heteroaromatic esters and amides. X-ray structural analysis of the studied compounds revealed that the pinacolborane ring's position with respect to the benzene ring varies, depending on the particular environment. An ortho-positioned carboxylic ester (methyl ester) causes a nearly perpendicular orientation of the pinacolborane unit with respect to the benzene ring, whereas an ortho-positioned amide (N,N-dimethylamide) causes the pinacolborane unit to orient itself nearly coplanar. A plausible …
Investigation Of Ozone In Urban And Rural Areas Of California,
2013
San Francisco State University
Investigation Of Ozone In Urban And Rural Areas Of California, Mia J. Hiles, David Parrish
STAR Program Research Presentations
Ozone is the air pollutant about which we have probably heard the most. Two types of ozone exist: stratospheric and tropospheric. Stratospheric ozone absorbs most of the damaging ultra-violet sunlight and tropospheric ozone comes into direct contact with life-forms and is toxic at high levels. Ozone concentration in California has been studied for over five decades, and there is a long history of control efforts. During 2010, California Air Resources Board (CARB) and National Oceanic and Atmospheric Administration (NOAA) conducted a major climate and air quality study in California called CalNex 2010 (California Research at the Nexus of Air Quality …
Characterization By Nmr Of Reactants And Products Of Hydrofluoroether Isomers, Cf3(Cf2)3och3 And (Cf3)2c(F)Cf2och3, Reacting With Isopropyl Alcohol,
2013
University of Dayton
Characterization By Nmr Of Reactants And Products Of Hydrofluoroether Isomers, Cf3(Cf2)3och3 And (Cf3)2c(F)Cf2och3, Reacting With Isopropyl Alcohol, Howard Knachel, Vladimir Benin, William E. Moddeman, Janine C. Birkbeck, Thomas A. Kestner, Tayna L. Young
Chemistry Faculty Publications
The 3M Company product Novec™ 71IPA DL, a mixture of methoxyperfluorobutane, methoxyperfluoroisobutane and 4.5 wt.% isopropyl alcohol, has been found to be very stable at ambient temperature, producing fluoride at the rate of ~1 ppm/year. Our earlier kinetic and theoretical studies have identified the reaction mechanism. This paper identifies the 1H and 19F NMR chemical shifts, multiplicities, and coupling constants of reactants and the major products that result from aging the mixture in sealed Pyrex NMR tubes for periods up to 1.8 years at temperatures from 26 °C to 102 °C. Chemical shifts and coupling constants of fluorine …
Label-Free Detection Of Low Protein Concentration In Solution Using A Novel Colorimetric Assay,
2013
Chapman University
Label-Free Detection Of Low Protein Concentration In Solution Using A Novel Colorimetric Assay, Molla R. Islam, Michael J. Serpe
Biology, Chemistry, and Environmental Sciences Faculty Articles and Research
Dual pH and temperature sensitive microgel-based etalons were fabricated by sandwiching a “monolithic” microgel layer between two semitransparent, Au layers. The devices exhibit visual color and multipeak reflectance spectra, both of which primarily depend on the distance between the Au surfaces mediated by the microgel diameter. We found that a polycationic polyelectrolyte can penetrate through the Au overlayer to interact with negatively charged microgel confined between Au overlayers. In this submission we report that biotinylated polycationic polymer can penetrate through the Au overlayer of a poly (N-isopropylacrylamide)-co-acrylic acid (pNIPAm-co-AAc) microgel-based etalon and cause the microgel layer to collapse. The collapse …
Synthesis Of Rhenium And Manganese Pyridazoal Complexes,
2013
Western Kentucky University
Synthesis Of Rhenium And Manganese Pyridazoal Complexes, Jesse Evans
Masters Theses & Specialist Projects
Pyridazines are a heterocyclic aromatic compound containing a characteristic N-N bond that are utilized in many fields, including medicine and electronics. It is this latter field that Dr. Snyder's research group is focused upon. Organometallic compounds are a better conducting material than the current inorganic compounds used in electronics due to better conductance of electricity, lower production cost, and the ability to be formed into thin films. With this in mind, Dr. Snyder's research group has set out to synthesize organometallic compounds for this purpose. Following procedures set forth by Snyder etc, and altered to form an off-metal route, we …
Interaction Between Lubricants Containing Phosphate Ester Additives And Stainless Steels,
2013
University of Dayton
Interaction Between Lubricants Containing Phosphate Ester Additives And Stainless Steels, David W. Johnson, Matthew Bachus, John E. Hils
Chemistry Faculty Publications
One way to improve fuel efficiency in today’s jet aircraft engines is to create an environment for higher operating temperatures and speeds. New and improved lubricants and bearing materials must be developed to remain stable in these elevated operating temperatures. Three lubricants, with varying amounts of tricresyl phosphate added as an anti-wear/extreme pressure additive were tested on two different stainless steels at varying temperatures ranging from 300 °C to 350 °C in vacuum. Significant decomposition of the lubricant base-stocks and the phosphate ester additive did occur in most of the trials resulting in the formation of carboxylic acids and phenols. …
Incorporating Catalysis In Inorganic Chemistry 1 Lecture And Laboratory At Onu,
2013
Ohio Northern University
Incorporating Catalysis In Inorganic Chemistry 1 Lecture And Laboratory At Onu, Bradley M. Wile
Chemistry and Biochemistry Faculty Scholarship
No abstract provided.
Patent: Dual Function Proteins For Treating Metabolic Disorders,
2013
Novartis Institutes for BioMedical Research
Patent: Dual Function Proteins For Treating Metabolic Disorders, Brian R. Boettcher, Shari L. Caplan, Susan E. Cellitti, Douglas S. Daniels, Norio Hamamatsu, Bernhard Hubert Geierstanger, Stuart Licht, Andreas Loew, Stephen Craig Weldon
Chemistry Faculty Publications
The present invention relates to new proteins comprising fibroblast growth factor 2 1 (FGF21 ) and other metabolic regulators known to improve metabolic profiles in subjects to whom they are administered.
Patent: Fusion Proteins For Treating Metabolic Disorders,
2013
Novartis Institutes for BioMedical Research
Patent: Fusion Proteins For Treating Metabolic Disorders, Brian R. Boettcher, Shari L. Caplan, Douglas S. Daniels, Norio Hamamatsu, Stuart Licht, Stephen Craig Weldon
Chemistry Faculty Publications
The invention relates to the identification of fusion proteins comprising polypeptide and protein variants of fibroblast growth factor 21 (FGF21) with improved pharmaceutical properties. Also disclosed are methods for treating FGF21 associated disorders, including metabolic conditions.
Overexpression Of Human Fatty Acid Transport Protein 2/Very Long Chain Acyl-Coa Synthetase 1 (Fatp2/Acsvl1) Reveals Distinct Patterns Of Trafficking Of Exogenous Fatty Acids,
2013
University of Nebraska-Lincoln
Overexpression Of Human Fatty Acid Transport Protein 2/Very Long Chain Acyl-Coa Synthetase 1 (Fatp2/Acsvl1) Reveals Distinct Patterns Of Trafficking Of Exogenous Fatty Acids, Elaina M. Melton, Ronald Cerny, Concetta C. Dirusso, Paul N. Black
Ronald Cerny Publications
In mammals, the fatty acid transport proteins (FATP1 through FATP6) are members of a highly conserved family of proteins, which function in fatty acid transport proceeding through vectorial acylation and in the activation of very long chain fatty acids, branched chain fatty acids and secondary bile acids. FATP1, 2 and 4, for example directly function in fatty acid transport and very long chain fatty acids activation while FATP5 does not function in fatty acid transport but activates secondary bile acids. In the present work, we have used stable isotopically labeled fatty acids differing in carbon length and saturation in cells …
Organic Thin-Film Transistors And Tips-Pentacene,
2013
University of Kentucky
Organic Thin-Film Transistors And Tips-Pentacene, Zachary Stewart
Lewis Honors College Capstone Collection
TIPS-Pentacene, an organic semiconductor characterized by its good electronic properties, solubility, and stability, is used primarily in organic thin-film transistors (OTFT). This research seeks to create an OTFT by crafting a stencil, depositing the source and drain onto a substrate’s surface, and processing TIPS-Pentacene onto the channel between them. In addition, if time permits, the electronic properties of several OTFTs will be compared to determine how to optimize their production.
A Facile, Low-Cost Route For The Preparation Of Calcined
Porous Calcite And Dolomite And Their Application As
Heterogeneous Catalysts In Biodiesel Production,
2013
Guiyang College
A Facile, Low-Cost Route For The Preparation Of Calcined Porous Calcite And Dolomite And Their Application As Heterogeneous Catalysts In Biodiesel Production, Rui Wang, Hu Li, Fei Chang, Jiafeng Luo, Milford A. Hanna, Daoyang Tan, Deyu Hu, Yuping Zhang, Baoan Song, Song Yang
Department of Chemistry: Faculty Publications
Despite their potential for biodiesel synthesis, directly calcined minerals rich in magnesium/calcium carbonates are used at the expense of large amounts of the catalyst, high alcohol loading, long processing times, and severe conditions. We report a facile and low-cost route for preparing calcined porous calcite (CPC) and dolomite (CPD) via simple thermal decomposition of the reaction mixtures of natural calcite and dolomite with stearic acid. CPC and CPD, both of which have porous structures, were compared with previously reported catalysts and examined as promising heterogeneous base catalysts under mild conditions. A 40% increase in conversion through CPC and CDC was …
Re2o7-Catalyzed Reaction Of Hemiacetals And
Aldehydes With O-, S-, And C-Nucleophiles,
2013
University of Nebraska - Lincoln
Re2o7-Catalyzed Reaction Of Hemiacetals And Aldehydes With O-, S-, And C-Nucleophiles, Wantanee Sittiwong, Michael W. Richardson, Charles E. Schiaffo, Thomas J. Fisher, Patrick H. Dussault
Department of Chemistry: Faculty Publications
Re(VII) oxides catalyze the acetalization, monoperoxyacetalization, monothioacetalization and allylation of hemiacetals. The reactions, which take place under mild conditions and at low catalyst loadings, can be conducted using hemiacetals, the corresponding O-silyl ethers, and, in some cases, the acetal dimers. Aldehydes react under similar conditions to furnish good yields of dithioacetals. Reactions of hemiacetals with nitrogen nucleophiles are unsuccessful. 1,2-Dioxolan-3-ols (peroxyhemiacetals) undergo Re(VII)-promoted etherification but not allylation. Hydroperoxyacetals (1-alkoxyhydroperoxides) undergo selective exchange of the alkoxide group in the presence of either Re2O7 or a Brønsted acid.
Stress Reduction For Pillar Filled
Structures,
2013
Oakland, CA
Stress Reduction For Pillar Filled Structures, Rebecca J. Nikolic, Adam Conway, Qinghui Shao, Lars Voss, Chin Li Cheung, Mushtaq A. Dar
Department of Chemistry: Faculty Publications
According to one embodiment, an apparatus for detecting neutrons includes an array of pillars, wherein each of the pillars comprises a rounded cross sectional shape where the cross section is taken perpendicular to a longitudinal axis of the respective pillar, a cavity region between each of the pillars, and a neutron sensitive material located in each cavity region.
