Synthesis Of Bacterial Glycerophospholipids For Biomembrane Model Studies: A Means To Advanced Biofuels,
2023
East Tennessee State University
Synthesis Of Bacterial Glycerophospholipids For Biomembrane Model Studies: A Means To Advanced Biofuels, Felix Adulley
Electronic Theses and Dissertations
To reduce reliance on fossil fuels, sustainable biofuels are being pursued, especially advanced biofuels like 1-butanol that have higher energy content and greater compatibility with existing infrastructure than ethanol. A persistent challenge is the yield-limiting toxicity of biofuels and process solvents, such as tetrahydrofuran, to the microbes that ferment biomass into biofuel. The cell membrane is a focal point of toxicity, and understanding how it interacts with fuels and solvents is key to improving yield. Phospholipid bilayers are the core of biomembranes, and model biomembranes of defined composition provide the ideal platform for biophysical studies. To this end, glycerophospholipids characteristic …
Synthesis Of Biologically Active Tropolones And Stereochemically Rich Compounds Via Cross-Coupling Reactions,
2023
The Graduate Center, City University of New York
Synthesis Of Biologically Active Tropolones And Stereochemically Rich Compounds Via Cross-Coupling Reactions, Nana B. Agyemang
Dissertations, Theses, and Capstone Projects
Over the past years the Murelli lab has established research based on the synthesis and biological evaluations of alpha-hydroxytropolones (alpha-HTs). These seven-membered aromatic rings have three contiguous oxygen atoms that chelates to metals, thus, biologically having the ability to bind dinuclear metalloenzymes and promoting inhibition. Synthetic routes to alpha-HT’s are scarce and therefore has been the main driving force in developing efficient and general synthetic methods to obtain variations in alpha-HTs, enabling SAR studies. The Murelli lab have therefore developed an oxidopyrylium cycloaddition/ring-opening strategy that is able to generate polysubstituted alpha-HTs starting from kojic acid, a cheap and readily available …
Stereospecific Cross-Coupling Reactions With Enantioenriched Electrophiles,
2023
The Graduate School and University Center of the City University of New York
Stereospecific Cross-Coupling Reactions With Enantioenriched Electrophiles, Iv Kraja
Dissertations, Theses, and Capstone Projects
We have developed a novel palladium-catalyzed stereospecific C(sp3)–C(sp3) Stille cross-coupling reaction between carbastannatrane nucleophiles and α-(trifluoromethyl) benzylic tosylates. This constitutes the first example of a stereospecific C(sp3)–C(sp3) cross-coupling reaction using an enantioenriched electrophile and an alkyltin nucleophile. This system has the potential to be extended to cross-coupling reactions using configurationally stable enantioenriched nucleophiles, thus enabling stereochemical control of two newly formed contiguous stereocenters. Generating enantioenriched α-(trifluoromethyl) benzylic compounds also has importance in pharmaceutical and agrochemical industries.
Through the development of this reaction, our findings show that the addition …
Improved Stoichiometric Synthesis Of Ccc-Nhc Pincer Rh Complexes And Catalytic Activity Towards Dehydrogenative Silylation And Hydrosilylation Of Alkenes,
2023
Mississippi State University
Improved Stoichiometric Synthesis Of Ccc-Nhc Pincer Rh Complexes And Catalytic Activity Towards Dehydrogenative Silylation And Hydrosilylation Of Alkenes, Enock Amoateng
Theses and Dissertations
N-Heterocyclic carbenes (NHCs) have attracted growing interest not only as successful ancillary ligands in a wide variety of transition-metal-catalyzed reactions but have also shown to offer photophysical and electrochemical properties. The metalation/transmetalation strategy using [Zr(NMe2)4] as initial metalating reagent offers an efficient approach to the preparation of CCC-NHC pincer complexes of the late transition metals such as Rh and Ir. In the process of investigating an intermediate and the mechanism of the metalation/transmetalation to Rh sequence, a mixed valent bimetallic CCC-NHC pincer Rh complex with two chloro ligands bridged between a [(CCC-NHC)Rh(III)] and a [Rh(I)(COD)] fragment …
Expansion Of The Diazacyclobutene Motif For Antiparasitic Evaluation,
2023
Clemson University
Expansion Of The Diazacyclobutene Motif For Antiparasitic Evaluation, Brock Alexander Miller
All Dissertations
Molecules containing N-heterocycles are prevalent in pharmaceutical settings. The ability to generate highly functionalized molecules containing N-heterocycles in very few synthetic operations is valuable for drug discovery. Our group has developed a two-step synthesis to access a rarely studied diazacyclobutene scaffold via a formal [2+2] cycloaddition between 4-phenyl-1,2,4-triazolinedione and electron-rich thioalkynes. Our interest in this scaffold increased exponentially from promising preliminary biological evaluations against a protozoan parasite, Trypanosoma brucei. While we were able to double the number of historical examples of this scaffold, there were significant limitations in our methodology. The most notable limitations were the lack …
Composite And Polymer Formulation Employing Sulfur And Bio-Olefin Feedstocks,
2023
Clemson University
Composite And Polymer Formulation Employing Sulfur And Bio-Olefin Feedstocks, Claudia V. Lopez
All Dissertations
Environmental sustainability represents a challenge for society since industrial growth has a direct impact on natural resources and waste production. New technologies that effectively incorporate waste into renewable resources are critical to the development of a sustainable and circular economy. The manufacturing of structural materials like Portland cement (OPC) is responsible for >8% of the global anthropogenic emissions of carbon dioxide, with ~ 1 kg of CO2 released to the atmosphere for every kilogram of OPC produced. For instance, the development of sustainable structural materials is a key factor to reduce the greenhouse emissions and to attenuate the climate …
Development And Applications Of Novel And Practical Fluorination Reagents.,
2023
University of Louisville
Development And Applications Of Novel And Practical Fluorination Reagents., Yuhao Yang
Electronic Theses and Dissertations
The fluorine (F) atom has distinctive properties such as the highest electronegativity, small size, low polarizability, and strong C–F bond strength. Not surprisingly, fluorinated organic compounds have garnered significant attention in the pharmaceutical, agrochemical, and material fields. Since organofluorides are very rare in nature, we need fluorination reagents to help us transfer fluorine into the organic molecules. In past decades, a vast number of fluorination reagents have been developed and many of them are commercially available now. However, there is still much room for the improvement of these reagents. Our target is to develop novel and practical fluorination reagents to …
New Methodologies For Sustainable Organic Synthesis In Water.,
2023
University of Louisville
New Methodologies For Sustainable Organic Synthesis In Water., Sudripet Sharma
Electronic Theses and Dissertations
Water is stable, benign, and green solvent. Its usage as a solvent in organic synthesis is significantly enhanced by micellar catalysis. However, replacing water as a reaction medium in organic synthesis is not sufficient to meet the sustainability challenges—excessive organic solvents are still required for product isolation and purification. Notably, solvents used in syntheses contribute to more than 80% of waste generation. In addition to solvents, the use of palladium in large amounts is also a problem for the future as it is a precious, low-abundance metal, and its supply is dwindling. Therefore, this dissertation highlights the various sustainable protocols …
Synthesis And Reactivity Of Heteroatom Embedded Cycloalkynes In Spaac, Nickel Catalyzed Alkylarylation Of Alkenes, And Carbofluorination Of Alkynes,
2023
University of New Mexico
Synthesis And Reactivity Of Heteroatom Embedded Cycloalkynes In Spaac, Nickel Catalyzed Alkylarylation Of Alkenes, And Carbofluorination Of Alkynes, Namrata Khanal
Chemistry and Chemical Biology ETDs
Part I covers Chapters 1, 2, and 3
cycloaddition reactions, that is utilized in biorthogonal chemistry. This metal free version The strain promoted azide-alkyne cycloaddition (SPAAC) reaction is one of the popular 1,3-dipolar of click reaction offers advantage over copper catalyzed click reaction. Since it eliminates the use of copper that is toxic to cells, it is considered favorable for biocompatible reaction. Due to the increased reactivity with dipoles without the use of metal catalyst, cycloalkynes, in particular cyclooctynes, have been employed as the biorthogonal reagent in biorthogonal chemical reaction for the study of a biological processes in vivo. The …
The Emergence Of Zerovalent Carbon Compounds From Structural Curiosities To Organocatalysts,
2023
Chapman University
The Emergence Of Zerovalent Carbon Compounds From Structural Curiosities To Organocatalysts, Allegra L. Liberman-Martin
Biology, Chemistry, and Environmental Sciences Faculty Articles and Research
Low-valent main group compounds have reactivity patterns and properties reminiscent of transition metals. While divalent carbon compounds such as carbenes are widely studied ligands and organocatalysts, zerovalent carbon species have received considerably less attention. This perspective highlights the properties and reactivity of zerovalent carbon compounds, focusing on their first applications as organocatalysts for small molecule reduction and polymerization reactions.
Rhodium-Catalyzed Asymmetric Synthesis Of P-P And P-C Bonds,
2023
Dartmouth College
Rhodium-Catalyzed Asymmetric Synthesis Of P-P And P-C Bonds, Sarah T. Chachula
Dartmouth College Ph.D Dissertations
Chapter 1: Synthesis, Structure, Dynamics, and Enantioface-Selective η3-Benzyl Coordination in the Chiral Rhodium Complexes Rh(diphos*)(η3-CH2Ph) Abstract: The rhodium benzyl complexes Rh(diphos*)(η3-CH2Ph) (1-14, diphos* = chiral bis(phosphine)) were prepared either by treatment of Rh(COD)(η3-CH2Ph) (15, COD = 1,5-cyclooctadiene) with diphos*, or from the reaction of [Rh(diphos*)(Cl)]2 (16- 20) with PhCH2MgCl. For C2-symmetric diphos*, observation of one set of NMR signals for complexes 1-12 suggested that the two diastereomers in which different 3-benzyl enantiofaces were coordinated to rhodium interconverted rapidly on the NMR time scale via suprafacial shifts; observation of five inequivalent aryl 1H NMR signals showed that antarafacial shifts were slow …
Scalable Preparation Of The Masked Acyl Cyanide Tbs-Mac,
2023
University of Southern Mississippi
Scalable Preparation Of The Masked Acyl Cyanide Tbs-Mac, Haley Hinton, Jack Patterson, Jared Hume, Krunal Patel, Julie Pigza
Faculty Publications
This paper describes the three-step synthesis of TBS-MAC, a masked acyl cyanide (MAC) and a versatile one-carbon oxidation state three synthon. We have developed a scalable and detailed synthesis that involves: (1) acetylation of malononitrile to form the sodium enolate, (2) protonation of the enolate to form acetylmalononitrile, and (3) epoxidation of the enol, rearrangement to an unstable alcohol, and TBS-protection to form the title compound. Both the sodium enolate and acetylmalononitrile are bench-stable precursors to the intermediate hydroxymalononitrile, which can be converted to other MAC reagents beyond TBS by varying the protecting group (Ac, MOM, EE, etc.).
N–((2–Acetylphenyl)Carbamothioyl)Benzamide: Synthesis, Crystal Structure Analysis, And Theoretical Studies,
2023
Department of Chemistry, Faculty of Science, Mersin University, TR33343, Mersin, Türkiye
N–((2–Acetylphenyl)Carbamothioyl)Benzamide: Synthesis, Crystal Structure Analysis, And Theoretical Studies, Akin Oztaslar, Hakan Arslan
Karbala International Journal of Modern Science
N–((2–Acetylphenyl)carbamothioyl)benzamide has been synthesized and characterized. The molecular conformation of the investigated compound is stabilized by C16–H16B⋅⋅⋅O2i (i: 1+x, y, z) intermolecular and C14–H14⋅⋅⋅S1, N2–H2⋅⋅⋅O2, and N2–H2⋅⋅⋅O1 intramolecular H–bonds. All DFT calculations have been implemented at the B3LYP level with the 6–311G(d,p) basis set. The optimized molecular structure parameters have been compared with the experimental one in the solid phase. The energy gap, global chemical reactivity descriptor parameters, MEP, Fukui functions, DoS, NLO, and NBO analysis were also computed and investigated. The intermolecular interactions and their energies are evaluated using Hirshfeld surface and energy framework analyses. To determine …
Study Of Antioxidant Activity Of The Derivatives Of Quinoline-4-Carboxylic Acids By The Modification Of Isatin Via Pfitzinger Reaction,
2023
Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Indonesia, Depok 16424, Indonesia
Study Of Antioxidant Activity Of The Derivatives Of Quinoline-4-Carboxylic Acids By The Modification Of Isatin Via Pfitzinger Reaction, Sakti Hidayati Fikriya, Antonius Herry Cahyana
Makara Journal of Science
In this study, a quinoline-4-carboxylic acid derivative was synthesized through Pfitzinger reaction. In this reaction, isatin is modified via its reaction with ketone and refluxed for 24 h to obtain quinoline-4-carboxylic acid. The presence of a carboxylic group was identified by Fourier Transform Infrared (FTIR) spectroscopy and ultraviolet–visible (UV-Vis) spectrophotometry. The results showed that the absorption peaks of C=O and O–H stretching’s were detected in the range of 1724–1708 and 3436–3242 cm−1, respectively. In the UV-vis spectrum, a shift in the absorption peak was observed toward a larger wavelength, which is referred as a bathochromic shift. The formation …
Investigation Of Challenging Transformations In Gold Catalysis,
2023
University of South Florida
Investigation Of Challenging Transformations In Gold Catalysis, Qi Tang
USF Tampa Graduate Theses and Dissertations
This dissertation mainly contains three parts: 1) Divergent gold catalysis for alkyne trifunctionalization, encompassing three distinct modes to achieve the simultaneous formation of C-N, C-O, and C-C bonds in a single step 2) the study and development of a new method to synthesize azaborine derivatives; and 3) the construction of benzotriazole boranes (BTAB) as stable four-coordinate N-B heterocycles through gold-catalyzed alkyne hydroboration.
In the first part, alkyne trifunctionalization via divergent gold catalysis will be introduced. This novel approach involves a sequence of reactions that combine gold π-activation, vinyl gold nucleophilic addition, and gold (III) reductive elimination. By utilizing this methodology, …
Design, Synthesis, And Kinetic Study Of The First Generation Phenyloxadiazole Compounds And The Second Generation Phenyloxadiazole Compounds And Highly Selective Hydroboration Of Alkenes, Ketones And Aldehydes Catalyzed By A Well-Defined Manganese Complex,
2023
The Graduate Center, City University of New York
Design, Synthesis, And Kinetic Study Of The First Generation Phenyloxadiazole Compounds And The Second Generation Phenyloxadiazole Compounds And Highly Selective Hydroboration Of Alkenes, Ketones And Aldehydes Catalyzed By A Well-Defined Manganese Complex, Haisu Zeng
Dissertations, Theses, and Capstone Projects
This thesis focuses on two projects. In the first project, my goal was to discover a new variant of phenyloxadiazole compounds that could exhibit increased thiol-reactivity during bioconjugation processes. To achieve this, I synthesized several phenyloxadiazole derivatives and subjected them to NMR kinetic studies to assess their reactivity with a model thiol. Based on the results, I was able to identify a phenyloxadiazole analog that demonstrated enhanced reactivity, which included a chlorine atom located in the meta-position of the phenyl ring.
I provided a detailed description of the synthesis and characterization of the newly discovered phenyloxadiazole analog and demonstrate its …
Synthesis And Study Of High-Spin Stable Organic Radicals For Electrical Conductors And Mannosamine Nitroxide For Mri Contrast Agents,
2023
University of Nebraska - Lincoln
Synthesis And Study Of High-Spin Stable Organic Radicals For Electrical Conductors And Mannosamine Nitroxide For Mri Contrast Agents, Shuyang Zhang
Chemistry Department: Theses, Dissertations, and Student Research
In the first project, we describe the synthesis of an ambient stable high spin organic diradical 4 based on the Blatter moiety. The high-spin (S = 1) organic diradical 4, which consists of two Blatter radical moieties in a conjugated structure, exhibits a nearly exclusive population (88%) on triplet ground state at room temperature as a consequence of a large single-triplet energy gap (ΔEST = 0.5 kcal/mol). The target diradical molecule is synthesized over five steps with structural confirmation by single-crystal X-ray diffraction. The thermogravimetric analysis (TGA) shows the onset of decomposition at ~264 oC, indicating the diradical molecule has …
Photoacid-Catalyzed C–C And C–O Bond Formation And The Synthesis Of Triazole - Containing Bis(Indolyl)Methanes,
2023
Seton Hall University
Photoacid-Catalyzed C–C And C–O Bond Formation And The Synthesis Of Triazole - Containing Bis(Indolyl)Methanes, Jason Saway
Seton Hall University Dissertations and Theses (ETDs)
From photosynthesis to transition metal-type photocatalysts, the conversion of light energy into chemical energy is a fundamental process in chemistry. While photochemistry is not new to the world of science, there has been a renewed interest in the field, specifically with the use of photocatalysts. There is a wide variety of compounds that function as photocatalysts, ranging from transitions metal complexes, organic dyes, and photoacids. Photoacids, which have typically been used for polymer synthesis and the pH modulation of biological systems and have recently gained popularity due to their catalytic potential. These compounds offer an efficient, cost-effective way to conduct …
Visible Light Photoacid Generator Catalyzed Michael Additions & In-Situ Photoredox Generated Carbocation Catalysis,
2023
Seton Hall University
Visible Light Photoacid Generator Catalyzed Michael Additions & In-Situ Photoredox Generated Carbocation Catalysis, Zena M. Salem
Seton Hall University Dissertations and Theses (ETDs)
Proton transfer is essential in many natural and chemical processes, and photoacids that undergo proton dissociation or generation upon photoirradiation can be beneficial for use in acid-sensitive reactions. This work describes the use of photoacid generators (PAGs) as tools for organic synthesis, generating strong acids upon light absorption catalyzing Michael addition reactions. Specifically, visible-light-induced PAGs were used to facilitate the 1,4-conjugate addition between indoles and vinyl ketones. Furthermore, carbocations have gained attention as Lewis acid catalysts in a variety of reactions providing good selectivity and yields. We also demonstrate the viability of in-situ photoredox-generated carbocation catalysis in the context of …
Isolating The Electronic Effects Of Systematic Twist In Highly Substituted Aromatic Hydrocarbons Using Density Functional Theory,
2023
Loyola Marymount University
Isolating The Electronic Effects Of Systematic Twist In Highly Substituted Aromatic Hydrocarbons Using Density Functional Theory, Grace Tully, Emily A. Jarvis
Honors Thesis
Density functional theory (DFT) was employed to investigate dodecaphenyltetracene as well as similar molecules containing differing backbone lengths and electron withdrawing groups with interest in manipulating the twist to lower the LUMO level for increased electron mobility. Optimization and frequency time-independent calculations followed by time-dependent (TD-DFT) energy calculations were performed at the B3LYP/G-311G level of theory to analyze electronic trends as a result of increased backbone length and consequently distorted end-to-end molecular twist. These calculations demonstrate a linear relationship with negative slope between the estimated HOMO-LUMO, fundamental, and optical gaps as a function of the number of fused rings along …
