Chemistry Commons^™

Purification Of Protoporphyrin Ix Using The Fplc, Ken Overway, Laura Narby

Honors Projects

Protoporphyrin IX (PPIX) is the main pigment in brown eggshells, and it is embedded in the shell gland of hens during the final stages of the egg-making process. This natural dye can be used as a substitute for organic sensitizers in dye-sensitized solar cells (DSSCs). One benefit of PPIX is that it is a natural resource and has a high absorption coefficient in the visible and near-infrared region (NIR). Purified PPIX is extremely helpful in dye-sensitized solar cells because it improves electron injection efficiency, can be chemically modified to improve its absorption efficiency, and can be mixed with nanomaterials such …

Reduced Mediators Released By Cyanobacteria During Exoelectrogenesis Detected Using Differential Pulse Voltammetry, Laura T. Wey, Monica Brachi, Yagut Allahverdiyeva, Shelley D. Minteer

Chemistry Faculty Research & Creative Works

Cyanobacteria generate electrical current through exoelectrogenesis (extracellular electron transfer) downstream of photosynthesis, yet the identity of the endogenous redox mediator(s) responsible remains unresolved. Here, we apply differential pulse voltammetry (DPV) to detect and characterise redox-active species released by Synechocystis sp. PCC 6803 under illumination. To enable sensitive detection, we developed an electrolyte intermediate between BG11 (Blue-Green-11) growth medium and MOPS (3-(N-morpholino)propanesulfonic acid) buffer that minimises background electrochemical interference while maintaining short-term cellular functionality. DPV revealed multiple light-enhanced oxidation peaks (0.1–0.65 V vs. saturated calomel electrode (SCE)) that were not resolvable using cyclic voltammetry, providing evidence that cyanobacteria release reduced compounds …

Computational Studies Of Triplet State Formation In Zinc Dipyrrin Complexes, Reuben Kwabla Adigbli

Electronic Theses and Dissertations

Zinc dipyrromethene complexes are promising earth-abundant photosensitizers due to their strong visible-light absorption and tunable excited states. To rationally design them for photocatalysis and photodynamic therapy, a molecular-level understanding of triplet-state formation is needed, but details of intersystem crossing remain unclear. To study the effect of π-extension, we synthesized an indole-substituted zinc dipyrrin complex: the dipyrromethane ligand was prepared from indole and mesitaldehyde, oxidized to the dipyrromethene, then coordinated with zinc. DFT and TD-DFT calculations determined ground and excited-state geometries and energies in different solvents, modeled absorption spectra, and visualized charge distributions. The results show how solvent polarity shifts energies …

Efficient Removal Of Methyl Orange Dye Via A Mnfe₂O₄/Go Nanocomposite With A Ctab Dual-Layer Surfactant Coating, Taher Karami, Soleiman Bahar, Reza Mostafazadeh

Research outputs 2022 to 2026

This study investigated the adsorption of methyl orange (MO) from aqueous solutions using a novel MnFe₂O₄/GO nanocomposite coated with cetyltrimethylammonium bromide (CTAB). The dual-layer surfactant modification facilitates both electrostatic and lipophilic interactions. This enhancement significantly improves dye removal efficiency. The adsorption process was monitored using spectrophotometry at 464 nm, with various characterization techniques confirming the structural and magnetic properties of the nanocomposite. The optimized parameters for maximum adsorption include a 2-minute ultrasonic dispersion, pH 6.8, and a surfactant-to-adsorbent ratio of 1, achieving a maximum adsorption capacity of 285.7 mg/g. The kinetic data followed a pseudo-second-order model, whereas the adsorption isotherm …

A Review Of Gallium And Germanium Recovery From Industrial Solid Residues, Ernest V. Oteng, Marthias Silwamba, Lana Alagha, Alex Luyima

Mining Engineering Faculty Research & Creative Works

The global demand for critical elements such as gallium (Ga) and germanium (Ge), and the shift toward circular mining has accelerated the development of new extraction and recovery processing these metals from industrial solid residues. This transition is driven by a substantial surge in demand for advanced technologies and the depletion of primary ore. Consequently, industrial solid residues, particularly zinc processing residues, smelter slags, flue dusts, and coal fly ash, are emerging as viable alternative sources. These residues incorporate Ga and Ge through isomorphic substitution in phases such as ferrites, silicates, and glassy aluminosilicates, and are enriched by industrial processes, …

Optimizing Multi-Layer/Multi-Physics Passive Adaptive Thermal Enclosures For Climate-Responsive Energy Regulation: A Numerical Study, Rajae Bousselham, Mingjiang Tao, Sergio Granados-Focil, Adriana Hera, Steven Van Dessel

Chemistry

Adaptive facades regulate heat transfer by adjusting their thermal behavior in response to environmental conditions. Passive adaptive systems, including stimuli-responsive thermal storage materials, tunable radiative coatings, and variable-conductivity layers, offer significant potential for material-based thermal regulation. However, their combined potential remains unexplored, as most studies examine individual mechanisms in isolation. As a result, trade-offs among energy savings, material usage, design complexity, and climate responsiveness are often underrepresented, overlooking coupled interactions in multilayer assemblies limiting their effectiveness. This study develops a transient three-dimensional numerical framework coupling heat transfer with multi-objective optimization to evaluate trade-offs between minimizing annual energy consumption and enclosure …

Microwave Spectrum And Iodine Nuclear Quadrupole Coupling Constants Of Difluorodiiodomethane, Cf2i2, Michael J. Carrillo, Michael J. Tubergen, Garry S. Grubbs, S. A. Cooke, Stewart E. Novick

Chemistry Faculty Research & Creative Works

The high-resolution rotational spectrum of difluoro diiodomethane is reported for the first time. A molecular-beam broadband Fourier transform microwave spectrometer recorded the spectrum over the frequency range of 5.9–18.1 GHz. The rotational constants, centrifugal distortion constants, nuclear quadrupole coupling constants, and nuclear spin-rotation constants for the two equivalent iodine nuclei were determined from fitting 1378 hyperfine transitions of 163 rotational transitions: A = 2743.79691(18)MHz, B = 587.83103(5) MHz, C = 528.72470(5) MHz, χaa = −1213.287(6) MHz, χbb – χcc = −885.210(5) MHz, and χab = 1437.721(5) MHz. 31 dipole-forbidden/quadrupole-allowed transitions, arising from the large nuclear quadrupole coupling effect of iodine, …

Ph-Compensated Hydrogen Peroxide Quantification Using A Dual-Modal Fiber-Optic Probe, Homayoon Soleimani Dinani, Bohong Zhang, Maryam Karimi, Rex E. Gerald, Shelley D. Minteer, Jie Huang

Electrical and Computer Engineering Faculty Research & Creative Works

We report a dual-modal fiber-optic probe that integrates electrochemical quantification of hydrogen peroxide (H₂O₂) with co-localized fluorescent pH sensing for pH-indexed interpretation of the H₂O₂ response. H₂O₂ is a reactive oxygen species involved in oxidative stress, inflammation, and cellular signaling, and local pH modulates both its production and electrochemical response. Many electrochemical H₂O₂ sensors exhibit pH-dependent sensitivity, creating ambiguity unless pH is measured and used for compensation, which is difficult in small, heterogeneous, or rapidly changing microenvironments. A three-electrode configuration—working (WE), counter (CE), and Ag/AgCl pseudo-reference (pRE) electrodes—is fabricated directly on the cylindrical surface of a 710-µm-diameter optical fiber using …

A Fundamental Study Of Fatty Acid Ionic Liquids And Their Effects On Biomolecules, Achismita Dutta

Theses and Dissertations

Fatty acid ionic liquids (FAILs) are a class of ionic liquids (ILs) with relatively low toxicity and potential applications in biological systems. This study examined the interactions of tetramethylguanidinium decanoate, tetramethylguanidinium octanoate, choline decanoate, and choline octanoate with lipid membranes, proteins, and nucleic acids. Membrane leakage experiments using model lipid vesicles showed that decanoate-based FAILs produced greater membrane permeabilization than octanoate-based analogues, consistent with their higher membrane permeability. These effects were stronger for the ILs than for decanoate alone and occurred below the critical micelle concentration (CMC), suggesting that micelle formation may not be essential for membrane disruption. The ability …

Gc-Ms Profiling And Antibacterial Activity Of Cold-Macerated Garlic Extracts Against Multidrug-Resistant Uropathogens, Fatima A. Khalaf, Saeed A. Fayadh

Karbala International Journal of Modern Science

The growing number of cases of multidrug-resistant (MDR) urinary tract infections has made the clinical management of urinary tract diseases a significant challenge; therefore, the need for effective adjunctive therapies cannot be overemphasized. This study evaluated the bioactive components and antibacterial efficacy of cold-macerated garlic extracts obtained using distilled water, 70% ethanol and hexane solvents against antimicrobial-resistant urinary isolates. Out of 250 urine samples that were analyzed, 124 (49.6%) showed significant microbial growth, with Escherichia coli being the most frequently isolated organism. The results of the phytochemical screening and Gas Chromatography-Mass Spectrometry (GC-MS) analysis showed that the ethanolic extract had …

Chemistry In The City Module, Ji Kim

Open Educational Resources

This project integrates a historical environmental health report from the CUNY Digital History Archive into an online Introductory Chemistry course to connect core chemical concepts with real urban pollution issues. Students analyze perchloroethylene contamination in apartments above dry cleaners, apply concepts such as volatility, vapor pressure, and concentration units, and reflect on chemical principles underlying indoor air pollution.

Chemistry In The City Module, Ji Kim

Open Educational Resources

This project integrates a historical environmental health report from the CUNY Digital History Archive into an online Introductory Chemistry course to connect core chemical concepts with real urban pollution issues. Students analyze perchloroethylene contamination in apartments above dry cleaners, apply concepts such as volatility, vapor pressure, and concentration units, and reflect on chemical principles underlying indoor air pollution.

Waste Streams From Next Generation Molten Salt Reactors: The Challenge Of Creating An Insoluble Ceramic For Chloride Salt Waste, Alevtina A. Maksimova, Jake W. Amoroso, Matthew Page, Gregory Morrison, Hans Conrad Zur Loye

Faculty Publications

Molten salt reactors (MSRs) design development is of interest to many research groups and companies. Waste management for MSRs is one of the most important issues that needs to be resolved due to its impact on environmental safety, primarily via the dissolution of radionuclides in water. Furthermore, the waste treatment strategy will have a significant influence on the operating cost of MSRs, which is why a reliable process for the immobilization, transportation, storage and disposal of MSR waste must be addressed. This work presents a new approach for the immobilization of chloride salts from molten salt reactors in stable oxyhalide …

Catalytic Synthesis Of Protoberberine Alkaloids And Their Evaluation As Selective Dopamine Receptor Ligands, Ashok Reddy Gudipally

Dissertations, Theses, and Capstone Projects

Dopamine regulates motor control, cognition, reward, motivation, and neuroendocrine signaling. Disruption of dopaminergic neurotransmission is closely linked to central nervous system disorders, including Parkinson’s disease, schizophrenia, addiction, and related neuropsychiatric conditions. Because these functions are mediated by multiple dopamine receptor subtypes with distinct roles in physiology and disease, the discovery of subtype-selective ligands remains an important goal in neuropharmacology. Within this context, protoberberine alkaloids, particularly tetrahydroprotoberberines (THPBs), are attractive molecular frameworks because they combine structural complexity with broad biological relevance, including measurable activity in CNS-related diseases. Prior work from our laboratory and others established (–)-stepholidine (1.60) as an important lead …

Development Of Ultrafast Protein Digestion And Standards Free Quantitation Methods For Mass Spectrometric Analysis, Praneeth Ivan Joel Fnu

Dissertations

A wide variety of biologically important molecules, such as enzymes, antibodies, hormones, transporters and receptors are proteins by composition and they play key roles in biological functions such as cellular regulation, communication, metabolism and physiological function. Protein dysfunctions and abnormalities are associated with numerous diseases, making proteins critical targets for understanding disease mechanisms and developing therapeutic interventions. Protein-based therapeutics such as monoclonal antibodies, hormones and vaccines gained popularity due to their high specificity, efficacy, and ability to treat complex diseases that are often difficult to address with small-molecule drugs.

Given the important role of proteins in a variety of biological …

Synthesizing Viscoelasticity: Living Polymers, Micro-Macro Relations, And Paths For Resolution, Adam M. Hasler

Graduate Masters Theses

This thesis investigates the relationship between macroscopic rheological signals and underlying microscopic dynamics in complex fluids, specifically focusing on ”living polymers” within the cetyltrimethylammonium bromide (CTAB) and sodium salicylate (NaSal) surfactant system. The research addresses the inverse parameterization problem, demonstrating how bulk measurements like zero-shear viscosity can mask fundamentally different physical topologies, such as purely cylindrical, reptating micelles versus highly branched networks. Through the successful synthesis of viscoelastically ”degenerate” samples, the study utilizes an array of characterization techniques including frequency sweeps, Large Amplitude Oscillatory Shear (LAOS) to resolve these unique underlying states. Furthermore, the work explores further avenues of study …

Electrolyte Development And Interfacial Reactions At Multivalent Metal Anode For Next Generation Energy Storage Systems, Leslie Gates

Graduate Masters Theses

The increasing demand for safe, sustainable, and high-performance energy storage systems has driven significant interest in multivalent-ion batteries, including aluminum, magnesium, and zinc-based systems. These technologies have attracted attention due to their high theoretical energy densities, natural abundance, low cost, and environmentally benign nature. However, their development remains hindered by a limited fundamental understanding of electrolyte development and interfacial processes at the electrode–electrolyte interface, where complex electrochemical interactions govern battery performance and stability.

This thesis investigates electrode–electrolyte interactions in both a novel aluminum electrolyte and divalent magnesium and zinc systems. Beginning with the development and characterization of a novel aluminum …

Multicomponent Reaction-Initiated Synthesis Of Polyheterocyclic Compounds, Ashutosh Nath

Graduate Doctoral Dissertations

Efficient synthesis of novel heterocycles with biological interest remains a challenge in modern organic chemistry. This dissertation presents the development of efficient synthetic strategies that combine multicomponent reactions (MCRs) with sequential reactions for rapid access a diverse array of polyheterocyclic compounds. The projects are: 1) Groebke-Blackburn-Bienaymé (GBB) reaction followed by N-acylation and Friedel-Crafts (FC) cyclization for the construction of imidazopyridine- and indole-fused azepinones involving an unusual ring-expansion process. 2) Modified GBB condensation products for intramolecular Diels-Alder (IMDA) cycloaddition and dehydrative re-aromatization to access imidazopyridine-fused isoquinolinones. 3) Integration of the Ugi-three component reaction (Ugi-3CR) and Pictet-Spengler (PS) reaction followed by …

Enhanced Osseointegration Of Functionally Graded Co˗Cr˗Mo˗Ti/Ha Implants: In Vitro And In Vivo Study In A Rabbit Model, Afrah M. Al Hussainey, Randa Kamel Hussain, Aseel Mustafa Abdul Majeed

Karbala International Journal of Modern Science

    The present investigation aims to evaluate the effects of acid and laser surface treatments on the surface characteristics, biocompatibility, and osseointegration of functionally graded implants fabricated from a Co–Cr–Mo–Ti/HA alloy. The implant surfaces were modified using either an Nd: YAG laser or hydrochloric acid (HCl), while untreated implants served as controls. Atomic force microscopy (AFM) showed that the acid-treated surface exhibited the highest mean surface roughness (Sa) of 58.10 ± 0.24 nm compared to the laser-treated surface (42.64 ± 0.83 nm) and the untreated surface (37.73 ± 0.89 nm). The MTT assay also demonstrated a favourable cellular response on the …

In Situ Electrochemical Characterization Techniques For Active Hydrogen In Electrocatalytic Nitrate Reduction To Ammonia, Hong-Mei Li, Mei Yi, Zhao-Yu Jin, Ming-Hao Xie, Khalid M. Omer, Yong Guo, Pan-Pan Li

Journal of Electrochemistry

Electrocatalytic nitrate reduction to ammonia (NitRR) represents a sustainable pathway that integrates environmental remediation with the production of high-value ammonia. However, the activity and selectivity of this process are limited by the generation, consumption, and dynamic equilibrium of the key transient intermediate—active hydrogen (*H). Precise modulation of *H necessitates a comprehensive understanding of its behavior, which relies fundamentally on advanced in situ electrochemical characterization techniques. However, a systematic review dedicated to the rational selection and application of in situ electrochemical techniques for the specific characterization of *H in NitRR, with clear definitions of each technique's "detectable targets, quantitative accuracy, and …