Taylor University
University of South Carolina - Columbia
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Parkland College
University of Cincinnati
Governors State University
Edith Cowan University
University of Alabama in Huntsville
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Utah State University
A Bio-Tribocorrosion Comparison Between Additively Manufactured And Forged Ti6al4v Parts,
2023
Western University
A Bio-Tribocorrosion Comparison Between Additively Manufactured And Forged Ti6al4v Parts, Sina Matin, Sahar Toorandaz, Saman Nikpour, Hamidreza Abdolvand, Eshan Toyserkani, Yolanda S. Hedberg
Chemistry Publications
Ti6Al4V has been used widely as a biomedical alloy and is increasingly manufactured by additive manufacturing due to customized shapes. As implant material, it is frequently exposed to both friction and corrosive environments. This study investigates the effect of the fabrication process (laser powder bed fusion and forging) on the tribocorrosion behavior of Ti6Al4V in various environments including diluted hydrochloric acid to simulate the acidic environment in a crevice (HCl), phosphate-buffered saline (pH 7.3) with 10 g/L bovine serum albumin (PBS+BSA), and PBS+BSA with 30 mM H2O2. While the presence of BSA hindered the repassivation (reforming of the protective passive …
Stereochemical Engineering Yields A Multifunctional Peptide Macrocycle Inhibitor Of Akt2 By Fine-Tuning Macrocycle-Cell Membrane Interactions,
2023
Clark University
Stereochemical Engineering Yields A Multifunctional Peptide Macrocycle Inhibitor Of Akt2 By Fine-Tuning Macrocycle-Cell Membrane Interactions, Arundhati Nag, Amirhossein Mafi, Samir Das, Mary Beth Yu, Belen Alvarez-Villalonga, Soo-Kyung Kim, Yapeng Su, William A. Goddard, James R. Heath
Chemistry
Macrocycle peptides are promising constructs for imaging and inhibiting extracellular, and cell membrane proteins, but their use for targeting intracellular proteins is typically limited by poor cell penetration. We report the development of a cell-penetrant high-affinity peptide ligand targeted to the phosphorylated Ser474 epitope of the (active) Akt2 kinase. This peptide can function as an allosteric inhibitor, an immunoprecipitation reagent, and a live cell immunohistochemical staining reagent. Two cell penetrant stereoisomers were prepared and shown to exhibit similar target binding affinities and hydrophobic character but 2-3-fold different rates of cell penetration. Experimental and computational studies resolved that the ligands’ difference …
Design And Synthesis Of N-Succinyl-L,L-2.6-Diaminopimelic Acid Desuccinylase Inhibitors As Potential Novel Antibiotics,
2023
Loyola University Chicago
Design And Synthesis Of N-Succinyl-L,L-2.6-Diaminopimelic Acid Desuccinylase Inhibitors As Potential Novel Antibiotics, Thomas Dipuma
Master's Theses
N-Succinyl-L,L-2,6-Diaminopimelic Acid Desuccinylase (DapE) is a bacterial enzyme located in the lysine biosynthetic pathway of all Gram-negative and most Gram-positive species of bacteria including the notorious ESKAPE pathogens, or pathogenic strains of bacteria that have developed significant levels of resistance to currently available antibiotics. As a means to combat this challenge of growing antimicrobial resistance, we have identified the bacterial enzyme DapE as a conserved, novel enzymate target within these resistant bacterial strains,as DapE is responsible for the production of m-DAP and lysine which are ultimately employed in bacterial cell wall synthesis. The overall aim of this research is to …
Atomically Dispersed Cu-N3 On Hollow Spherical Carbon Nitride For Acetaminophen Degradation: Generation Of 1o2 From H2o2,
2023
Edith Cowan University
Atomically Dispersed Cu-N3 On Hollow Spherical Carbon Nitride For Acetaminophen Degradation: Generation Of 1o2 From H2o2, Shuoyuan Tian, Yu Yin, Mengxuan Liu, Lei Shi, Shu Zhang, Abdul Hannan Asif, Xuan Li, Mengqiong Liu, Xiaoguang Duan, Shaobin Wang, Hongqi Sun
Research outputs 2022 to 2026
Discharge of recalcitrant pharmaceuticals into aquatic systems has caused severe impacts on public health and ecosystem. Advanced oxidation processes (AOPs) are effective for eliminating these refractory pollutants, for which single-atom catalysts (SACs) become the state-of-the-art materials owing to the maximized exposure of active metal sites. In this work, hollow spherical graphitic carbon nitride (hsCN) was fabricated to incorporate copper species to develop Fenton-like catalysts for acetaminophen (ACT) removal. Through pyrolysis of supramolecular assemblies derived from melamine-Cu complex and cyanuric acid, single atom Cu-N3 sites were anchored on hsCN by N-coordination to obtain SACu-hsCN. In virtue …
The Influence Of Allostery Governing The Changes In Protein Dynamics Upon Substitution,
2023
Clemson University
The Influence Of Allostery Governing The Changes In Protein Dynamics Upon Substitution, Joseph Hess
All Dissertations
The focus of this research is to investigate the effects of allostery on the function/activity of an enzyme, human immunodeficiency virus type 1 (HIV-1) protease, using well-defined statistical analyses of the dynamic changes of the protein and variants with unique single point substitutions 1. The experimental data1 evaluated here only characterized HIV-1 protease with one of its potential target substrates. Probing the dynamic interactions of the residues of an enzyme and its variants can offer insight of the developmental importance for allosteric signaling and their connection to a protein’s function. The realignment of the secondary structure elements can …
Outgassing Behavior And Heat Treatment Optimization Of Jsc-1a Lunar Regolith Simulant,
2023
Missouri University of Science and Technology
Outgassing Behavior And Heat Treatment Optimization Of Jsc-1a Lunar Regolith Simulant, Ryan P. Wilkerson, Mihail P. Petkov, Gerald E. Voecks, Catherine S. Lynch, Holly S. Shulman, Santhoshkumar Sundaramoorthy, Amitava Choudhury, Douglas L. Rickman, Michael R. Effinger
Chemistry Faculty Research & Creative Works
As NASA Strives towards a Long Duration Presence on the Moon, It Has Become Increasingly Important to Learn How to Better Utilize Resources from the Lunar Surface for Everything from Habitats, Vehicle Infrastructure, and Chemical Extraction. to that End, a Variety of Lunar Simulants Have Been Sourced from Terrestrially Available Volcanic Minerals and Glass as Apollo Regolith is Unavailable for Experimentation Needing Large Masses. However, While Mineralogy and Chemical Composition Can Approach that of Lunar Material in These Simulants, There Are Still Distinct Non-Lunar Phases Such as Hydrates, Carbonates, Sulfates, and Clays that Can Cause Simulants to Behave Distinctly Non-Lunar …
The Investigation Of Singlet Fission From The Perspective Of Hierarchy Of Pure States (Hops),
2023
Southern Methodist University
The Investigation Of Singlet Fission From The Perspective Of Hierarchy Of Pure States (Hops), Tao (James) Chen
Chemistry Theses and Dissertations
This thesis provides a preliminary investigation of singlet fission from the perspective of Hierarchy of pure states (HOPS), which provides a numerical exact solution for the investigation of a series of open quantum systems. Since the inception of the concept of singlet fission about half a century ago, this photo-physical process has attracted the attention of a multitude of researchers and has been extensively studied theoretically and experimentally. However, these previous methods for the investigation of singlet fission focus more or less on tackling the underlying mechanisms of singlet fission from the perspective of perturbation. So far, the HOPS method …
The Effect Of Heat Treatment And Chemical Treatment On Natural Fibre To The Durability Of Wood Plastic Composites – A Review,
2023
Universiti Teknologi MARA Cawangan Pahang
The Effect Of Heat Treatment And Chemical Treatment On Natural Fibre To The Durability Of Wood Plastic Composites – A Review, Nuratiqah Asyiqin Mohd Nasharudin, Nur Fatihah Sulaiman, Nurul Aziemah Mohammad, Wan Nor Raihan Wan Jaafar, Falah Abu Dr., Siti Norasmah Surip
Journal of Materials Exploration and Findings (JMEF)
The application of WPC is not only limited to indoor applications but has been extended to exterior applications where properties of WPC could compromise during service life. WPC was derived from wood fiber of various sizes to reinforce polymers. Wood fiber has the advantage of a cheaper price, being abundantly available, and ease of processing, however, the critical factor is its hydrophilic nature, where moisture absorption is likely to occur. Thus, treatments for reducing the hydrophilicity of wood fibers are applied. By treatment of wood fiber, the surface impurities were removed, leaving the roughened surface of fibers, thus providing a …
Investigating The Effects Of The Sugar Alcohol Osmolytes Glycerol And Erythritol In Aot Reverse Micelles,
2023
DePauw University
Investigating The Effects Of The Sugar Alcohol Osmolytes Glycerol And Erythritol In Aot Reverse Micelles, Animesh Dali '24, Bridget Gourley
Student Research
Water is a polar molecule that participates in hydrogen bonding and proton transfer. Geometric confinement and water’s interactions with osmolytes (small water soluble compounds) affect the ability of water molecules to hydrogen bond and transfer charges. Study of this behaviour of water with different osmolytes in controlled environments will help us develop predictive models. In our study, we have prepared Sodium bis(2-ethylhexyl)sulfosuccinate (AOT) reverse micelles (RM) in 2,2,4-Trimethylpentane (Isooctane). Our principle osmolytes were the straight chain sugar alcohols glycerol and erythritol. Study of water-osmolyte behaviour in the small and confined pool of a reverse micelle allows us examine the difference …
Application Of Two-Parameter Item Response Theory For Determining Form-Dependent Items On Exams Using Different Item Orders,
2023
Grand Valley State University
Application Of Two-Parameter Item Response Theory For Determining Form-Dependent Items On Exams Using Different Item Orders, Thomas C. Pentecost, Jeffery R. Raker, Kristen L. Murphy
Practical Assessment, Research, and Evaluation
Using multiple versions of an assessment has the potential to introduce item environment effects. These types of effects result in version dependent item characteristics (i.e., difficulty and discrimination). Methods to detect such effects and resulting implications are important for all levels of assessment where multiple forms of an assessment are created. This report describes a novel method for identifying items that do and do not display form dependence. The first two steps identify form dependent items using a differential item functioning (DIF) analysis of item parameters estimated by Item Response Theory. The method is illustrated using items that appeared in …
Adsorption Performance Of Mg0.33ni0.33co0.33fe2o4 Nanoparticles Doped With Gadolinium And Lanthanum For Lead (Ii) Removal,
2023
Departement of Chemistry, Faculty of Science, Beirut Arab University, Debbieh, Lebanon
Adsorption Performance Of Mg0.33ni0.33co0.33fe2o4 Nanoparticles Doped With Gadolinium And Lanthanum For Lead (Ii) Removal, Mariam Rabaa, Amani Aridi, Ghassan Younes, Ramadan Awad
BAU Journal - Science and Technology
The issue of water pollution has become a major concern in recent times, and the need for effective strategies for treating contaminated water sources has become more urgent. One promising approach that has been gaining attention in the field of wastewater treatment is the use of nano-ferrites. In this regard, novel Mg0.33Ni0.33Co0.33LaxFe2-xO4 and Mg0.33Ni0.33Co0.33GdxFe2-xO4 nanoparticles (NPs), where x = 0.00, 0.01 and 0.08, were synthesized to test their adsorption performance for the removal of Pb (II). The structural …
Modeling Exciton Migration In Two-Dimensional Space,
2023
DePaul University
Modeling Exciton Migration In Two-Dimensional Space, Christian D. Etnyre
DePaul Discoveries
Computational analysis through density matrix quantum mechanics was performed to model exciton migration in two-dimensional space for a zinc-substituted tetraazaphthalocyanine. The model produced resembles a two-dimensional sheet of molecules. Energy transport mechanisms, controlled by point dipole couplings, were evaluated while altering the size of the crystal lattice. It was determined that energy transport was much more significant with a decreasing size of the crystal lattice. Likewise, the result of increasing the size of the crystal lattice had the effect of dampening the rate of energy transport. It was of interest to determine, with varying crystal lattice dimensions, the time that …
N–((2–Acetylphenyl)Carbamothioyl)Benzamide: Synthesis, Crystal Structure Analysis, And Theoretical Studies,
2023
Department of Chemistry, Faculty of Science, Mersin University, TR33343, Mersin, Türkiye
N–((2–Acetylphenyl)Carbamothioyl)Benzamide: Synthesis, Crystal Structure Analysis, And Theoretical Studies, Akin Oztaslar, Hakan Arslan
Karbala International Journal of Modern Science
N–((2–Acetylphenyl)carbamothioyl)benzamide has been synthesized and characterized. The molecular conformation of the investigated compound is stabilized by C16–H16B⋅⋅⋅O2i (i: 1+x, y, z) intermolecular and C14–H14⋅⋅⋅S1, N2–H2⋅⋅⋅O2, and N2–H2⋅⋅⋅O1 intramolecular H–bonds. All DFT calculations have been implemented at the B3LYP level with the 6–311G(d,p) basis set. The optimized molecular structure parameters have been compared with the experimental one in the solid phase. The energy gap, global chemical reactivity descriptor parameters, MEP, Fukui functions, DoS, NLO, and NBO analysis were also computed and investigated. The intermolecular interactions and their energies are evaluated using Hirshfeld surface and energy framework analyses. To determine …
Eutectic Formation And Cutaneous Wound Healing By Binary Allantoin- Octadecenedioic Acid System,
2023
Department of Chemistry, Hazara University, Mansehra, Pakistan;
Eutectic Formation And Cutaneous Wound Healing By Binary Allantoin- Octadecenedioic Acid System, Syed Waqar Hussain Shah, Farah Ali, Iram Bibi, Kashif Ali, Neelam Pervaiz, Mariyum Yousaf
Karbala International Journal of Modern Science
Eutectic formation in allantoin-octadecenedioic acid system (AOM) has been studied. The binary phase diagram revealed the existence of eutectic at Xallantoin = 0.7. Dioic acid caused disruption of network in allantoin and induced defects, ultimately causing the reduction in crystallinity as shown by XRD and SEM analysis. The thermal stability in TGA graphs of allantoin was negligibly altered after mixture formation. Classical hydrogen bonding and alkyl interactions were predicted using software Avogadro and BIOVIA Discovery Studio. The functionalities involved in interactions taking place in the system were studied through in-depth FT-IR spectroscopy. The eutectic showed efficacy for cutaneous wound …
Skin Permeation Studies Of Chromium Species - Evaluation Of A Reconstructed Human Epidermis Model.,
2023
Western University
Skin Permeation Studies Of Chromium Species - Evaluation Of A Reconstructed Human Epidermis Model., L Hagvall, M Munem, M Hoang Philipsen, M Dowlatshahi Pour, Yolanda S. Hedberg, P Malmberg
Chemistry Publications
A reconstructed human epidermis (RHE) model, the EpiDerm, was investigated and compared to human skin ex vivo regarding tissue penetration and distribution of two chromium species, relevant in both occupational and general exposure in the population. Imaging mass spectrometry was used in analysis of the sectioned tissue. The RHE model gave similar results compared to human skin ex vivo for skin penetration of Cr
Physicochemical Changes And Role Of Analytical Chemistry In Black Garlic (Allium Sativum L.) Processing,
2023
Department of Chemistry, Universitas Negeri Malang, Malang 65145, Indonesia
Physicochemical Changes And Role Of Analytical Chemistry In Black Garlic (Allium Sativum L.) Processing, Surjani Wonorahardjo, Dian Puspita Sari, Arini Salsabila, Estiyawati Estiyawati, Dewi Yuliani, Anugrah Ricky Wijaya, Suharti Suharti, Irma Kartika Kusumaningrum, Chariztya Anggita Maharani, Thjiong Angelina Noviyanti
Makara Journal of Science
Black garlic is a traditional spice having potential of herbal medicine; however, continuous heating darkens its color and changes its taste due to chemical processes and new equilibrium in the system. In this study, fresh garlic was processed into black garlic at 60 °C for 24 days. Changes in physical and chemical parameters, such as browning and protein content, reducing sugar content, and antioxidative components were recorded. Protein content was measured by Kjeldahl method, brown color development was analyzed using a color reader, reducing sugar was examined using a dinitro salicylic DNS reagent, and antioxidative activities were studied with a …
Study Of Antioxidant Activity Of The Derivatives Of Quinoline-4-Carboxylic Acids By The Modification Of Isatin Via Pfitzinger Reaction,
2023
Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Indonesia, Depok 16424, Indonesia
Study Of Antioxidant Activity Of The Derivatives Of Quinoline-4-Carboxylic Acids By The Modification Of Isatin Via Pfitzinger Reaction, Sakti Hidayati Fikriya, Antonius Herry Cahyana
Makara Journal of Science
In this study, a quinoline-4-carboxylic acid derivative was synthesized through Pfitzinger reaction. In this reaction, isatin is modified via its reaction with ketone and refluxed for 24 h to obtain quinoline-4-carboxylic acid. The presence of a carboxylic group was identified by Fourier Transform Infrared (FTIR) spectroscopy and ultraviolet–visible (UV-Vis) spectrophotometry. The results showed that the absorption peaks of C=O and O–H stretching’s were detected in the range of 1724–1708 and 3436–3242 cm−1, respectively. In the UV-vis spectrum, a shift in the absorption peak was observed toward a larger wavelength, which is referred as a bathochromic shift. The formation …
Tio2 Crystallization At Room Temperature And Preparation Of Transparent Carbon Counter Electrode For Low-Cost Dye-Sensitized Solar Cells,
2023
Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Indonesia, Depok 16424, Indonesia
Tio2 Crystallization At Room Temperature And Preparation Of Transparent Carbon Counter Electrode For Low-Cost Dye-Sensitized Solar Cells, Muhammad Iqbal Syauqi, Afiten Rahmin Sanjaya, Mohammad Jihad Madiabu, Munawar Khalil, Jarnuzi Gunlazuardi
Makara Journal of Science
We developed a low-cost dye-sensitized solar cell (DSSC) using TiO2 fabricated via rapid breakdown anodization (RBA) and ultrafast room-temperature crystallization (URTC). The prepared TiO2 was deposited on a self-made fluorine-doped tin oxide (FTO) conductive glass, and the FTO/TiO2 system was sensitized using curcumin dye. The DSSC was constructed by sandwiching the FTO/TiO2/curcumin electrode with an I−/I2 electrolyte and a transparent carbon counter electrode prepared using a liquid–liquid interface system. The characterization results showed that the TiO2 freshly prepared via URTC was transformed into an anatase crystalline phase, which exhibited a 3.10 …
Symbiotic Ucyn-A Strains Co-Occurred With El Niño, Relaxed Upwelling, And Varied Eukaryotes Over 10 Years Off Southern California,
2023
University of Southern California
Symbiotic Ucyn-A Strains Co-Occurred With El Niño, Relaxed Upwelling, And Varied Eukaryotes Over 10 Years Off Southern California, Colette Fletcher-Hoppe, Yi-Chun Yeh, Yubin Raut, J. L. Weissman, Jed A. Fuhrman
Biology, Chemistry, and Environmental Sciences Faculty Articles and Research
Biological nitrogen fixation, the conversion of N2 gas into a bioavailable form, is vital to sustaining marine primary production. Studies have shifted beyond traditionally studied tropical diazotrophs. Candidatus Atelocyanobacterium thalassa (or UCYN-A) has emerged as a focal point due to its streamlined metabolism, intimate partnership with a haptophyte host, and broad distribution. Here, we explore the environmental parameters that govern UCYN-A’s presence at the San Pedro Ocean Time-series (SPOT), its host specificity, and statistically significant interactions with non-host eukaryotes from 2008-2018. 16S and 18S rRNA gene sequences were amplified by “universal primers” from monthly samples and resolved into Amplicon …
The Effect Of Solution Parameters On The Interfacial Chemical Dynamics Of Early-Stage Corrosion,
2023
The University of Western Ontario
The Effect Of Solution Parameters On The Interfacial Chemical Dynamics Of Early-Stage Corrosion, Brianna K. Rector
Electronic Thesis and Dissertation Repository
Corrosion is a key long-term degradation process for metallic components in nuclear industry infrastructure. Accurately predicting the corrosion rate of a component in its service environment is considered a grand challenge in the corrosion community. Corrosion is a multi-step electrochemical process, with elementary steps involving mass transfer across more than one stage. Due to the multi-step, multi-phase nature of corrosion systems, predicting corrosion behaviour over time is complex. Existing corrosion models can describe electron transfer and mass transport steps independently, under narrow sets of conditions or over a specified duration but cannot account for the changes that occur over time …
