Oral Biology and Oral Pathology Commons^™

An Immunohistochemical Panel For The Accurate Differentiation Between Mucoepidermoid Carcinoma And Pleomorphic Adenoma, Kuntala Mondal, Sv Sowmya, Dominic Augustine

Annual Research Symposium

Salivary Gland Tumors (SGTs) are a diverse group of neoplasms, with a wide range of histological subtypes, some of which can exhibit overlapping features. Amongst this group of tumors, Pleomorphic Adenoma (PA) and Mucoepidermoid Carcinoma (MEC) stand out as prevalent entities originating from the salivary glands. The accurate differentiation between these two entities is crucial for treatment planning, as it influences decisions regarding the extent of surgical resection. Because of the overlapping histopathological features, it is difficult to differentiate these two lesions with the help of conventional Hematoxylin & Eosin (H& E). The evaluation of Immunohistochemical (IHC) markers holds pivotal …

Cheiloscopic Characteristics Detection And Pattern Classification By Machine Learning Technique, Dr Dominic Augustine, Sowmya Sv

Annual Research Symposium

Machine Learning (ML) is a field enhancing the rapid growth of technology. Though use of digital softwares for cheiloscopic investigations have been attempted with limited success, the use of ML based techniques are scarce and seldom have been employed in forensic odontology. The present study aimed to identify cheiloscopic patterns through machine learning based methods and to correlate the segmented patterns with age and gender of individuals.

Association Between Abo Blood Grouping And Odontometry: An Unexplored Evidence In Forensics, Dr Dominic Augustine, Sowmya Sv

Annual Research Symposium

Recent research has exhibited a strong association between ABO blood groups and susceptibility to diseases. Extraoral and intraoral hard tissue landmarks provide a stable and reliable record for odontological and anthropological analysis, forensic investigations and identification. The association between anthropometric indices and ABO blood grouping have been reported in the past, however, the association between ABO blood groups and odontometric indices is yet to be comprehensively explored. This study aimed to establish the correlation of ABO blood groups with odontometric indices and extraoral hard tissue landmarks for personnel identification.

Advanced Techniques For Tooth Pulp Rna Extraction In Forensic Investigations-A Systematic Review, Kuntala Mondal, Sv Sowmya, Dominic Augustine

Annual Research Symposium

Teeth are fundamental structures in a forensic context due to their high strength and specificity. It is challenging to obtain high quality RNA from pulpal tissues. It has been described that pulp RNA degradation could be an indicator of post-mortem interval. Researchers have been in the quest to develop optimal techniques for tooth RNA extraction. The systematic review aimed to determine the most reliable method of RNA extraction from dental tooth pulp for forensic investigations.

Assessment Of Micrometastasis In Lymph Nodes Of Oral Squamous Cell Carcinoma –Attaining Excellence Through Immunohistochemistry, Dr Dominic Augustine, Sowmya Sv, Kuntala Mondal

Annual Research Symposium

Cervical lymph node metastasis is the most important prognostic factor in Squamous Cell Carcinoma of Head and Neck (SCCHN). Lymph node prognostic determinants hold immense significance in influencing both patient’s survival outcomes and the propensity for recurrence. The current study aimed to evaluate the diagnostic accuracy of Cyclin D1 and Pan-CK for the detection of lymph node micrometastasis in oral squamous cell carcinoma tissue sections and re-evaluate the tumor staging.

Clinical, Radiographic And Biochemical Evaluation Of One-Piece Vs Two-Piece Single Implants After 5 Years Of Functional Loading, Ippolito Caputo

Annual Research Symposium

The aim of this study was to compare the clinical and radiographic conditions and the expression of proinflammatory cytokines in peri-implant crevicular fluid (PICF) of two-piece/bone level (TP/BL) versus one-piece/tissue level (OP/TL) single implants with a laser-microgrooved collar after at least 5 years of functional loading.

Detection Of Cervical Lymph Node Micrometastasis - A Machine Learning Based Approach, Dr. Sowmya Sv, Dominic Augustine, Kuntala Mondal

Annual Research Symposium

No abstract provided.

Matlab Based Phenotypic Evaluation And Gene Expression Of Cd44 And Cd133 Biomarkers In The Prediction Of Oral Squamous Cell Carcinoma Metastasis, Dr. Sowmya Sv

Annual Research Symposium

Oral cancer accounts to 20–30% of all cancers in India. The major difficulty in managing carcinomas is due to failure in the control and detection of metastases (>90% deaths). Cancer stem cells (CSCs) are tumor-initiating cells that survive even after extensive radiotherapy and chemotherapy. Recently, the use of computer-assisted quantification methods employing image processing is drawing attention wherein information can be automatically extracted from the immunostained digitized images. The aim of the study was to assess the metastatic risk of Oral Squamous Cell Carcinoma (OSCC) by the phenotypic evaluation and gene expression of CD44 and CD133 biomarkers with clinical …

Determination Of The Correlation Between Age And Gender With Canine Index, Intermolar Width And Palatal Rugae Patterns, Dr. Sowmya Sv, Dominic Augustine

Annual Research Symposium

Dental records are of paramount importance in human identification considering the distinct traits of every individual. Although DNA and finger print analysis are techniques employed for faster and secure identification, in mass disasters, odontometric analysis can play a vital role in identification. Studies in the past have used parameters like arch perimeters, lip prints and palatal rugae pattern to determine age and gender of an individual. However, these studies correlated one parameter at a time and concluded that there was no significant correlation of the parameters to age and gender. The present study aimed to assess the canine index, intermolar …

Convolutional Neural Network Based Analysis - An Aid To Diagnose Bacterial And Fungal Osteomyelitis, Saiprasad Alva, Dominic Augustine, Sowmya Sv, Mukul Saini, Sanjana Shetty

Annual Research Symposium

Osteomyelitis may be classified as Bacterial (Actinomycotic), Fungal (Mucormycotic), or combined based on the etiological agent. During histopathological examination, there is a high chance that bacterial colonies or fungal hyphae may be missed by the human eye, especially when there is a paucity of organisms. This may lead to a faulty diagnosis of the type of osteomyelitis which along with an improper treatment plan would cause further progression of the disease and various other complications. Therefore, the diagnosis of the exact etiological variant of osteomyelitis is of prime importance to design an appropriate treatment plan. In the present study, bone …

Convolutional Neural Network Based Machine Learning For Ameloglyphics: A Forensic Analysis, Sanjana Shetty, Sowmya Sv, Dominic Augustine, Saiprasad Alva, Mukul Saini

Annual Research Symposium

Convolutional Neural Network based Machine Learning for Ameloglyphics: A Forensic Analysis

Sanjana Shetty, Sowmya SV , Dominic Augustine, Saiprasad Alva, Mukul Saini Author Affiliations: Department of Oral & Maxillofacial Pathology and Oral Microbiology, Faculty of Dental Sciences, MS Ramaiah University of Applied Sciences, MSR Nagar, Bengaluru-560054, Karnataka, India.

Purpose:

Tooth prints, considered to be the hard tissue analogues of finger prints have been studied extensively over the years by manual and in some cases, digital methods. While Artificial intelligence and Machine Learning have witnessed a steady rise in their applications in various fields with promising results, its utility in ameloglyphics …

Estimation And Comparison Of Superoxide Dismutase Level In Patients With Oral Submucous Fibrosis, Dr Sinitha Sreedhar, Dr Joseph Johny, Dr Vani M H

Annual Research Symposium

The study was conducted to evaluate and compare the levels of antioxidant enzyme superoxide dismutase(SOD) in blood samples of patients diagnosed with Oral SubmucousFibrosis(OSMF) and their age and sex matched controls and also to compare the SOD levels within the study group between patients with stage I, stage II, stage III and stage IV OSMF

Double-Blinded Randomized Control Trial Investigating The Efficacy Of Probiotic Mouth Rinse In Enhancing Oral Health, Sudeep C B Prof. Dr., Sunil P M Prof. Dr.

Annual Research Symposium

The efficacy of probiotic mouth rinse in enhancing oral health was investigated through a double-blinded randomized controlled trial involving 45 children aged 12 to 15 over a two-week period. Comparing probiotic mouth rinse, chlorhexidine mouth rinse, and a control group, plaque and gingival accumulation were assessed using established indices. Results indicated both probiotic and chlorhexidine groups exhibited reduced plaque compared to the control, with the probiotic group showing superior reduction in gingival inflammation. These findings suggest the potential of probiotic mouth rinse in improving oral hygiene and overall oral health.

Overlooked Dental Disease In Cbct Imaging And The Impact Of Oral Radiologist Interpretation, Jared Fausnaught

Annual Research Symposium

This study aims to underscore the necessity for a comprehensive interpretation of Cone Beam Computed Tomography (CBCT) volume images obtained by dentists. The research demonstrates and quantifies potentially overlooked dental pathology, categorizing incidental findings into three groups: 1) requiring some form of treatment or follow-up, 2) necessitating follow-up (monitoring) only, and 3) demanding no further treatment or follow-up.

Impact Of Smoking And Drinking Habits On Lipid Profiles In Diabetic And Non-Diabetic Individuals & Their Oral Implications, Dinraj Kulkarni

Annual Research Symposium

The rising prevalence of lifestyle-related diseases, notably diabetes mellitus and cardiovascular diseases (CVD), underscores the importance of investigating modifiable risk factors such as smoking and alcohol consumption. These habits are known to influence lipid profiles, crucial indicators of cardiovascular health. Main aim of this study To investigate & evaluate the effect of smoking and drinking habits on lipid profiles of diabetic and non-diabetic individuals and their oral implications.

The Use Of Tissue Grafts Associated With Immediate Implant Placement To Achieve Better Peri-Implant Stability And Efficacy: A Systematic Review And Meta-Analysis, Enrico Maria Rondone, Bruno Leitão-Almeida, Miguel Silva Pereira, Gustavo Fernandes, Tiago Borges

MOSDOH Faculty Publications

Background: The goal of this systematic study and meta-analysis was to evaluate the efficacy of hard and/or soft tissue grafts associated with type-1 implants on healing and treatment outcomes. The primary outcomes studied were implant survival rate, pocket depth, marginal periimplant recession, bone loss, bone thickness (volumetric change), interproximal bone level, mesial and distal papilla migration, and radiographic evaluation; and the secondary parameters were Pink Esthetic Score (PES), vertical distance from implant shoulder and bone, Visual Analogue Score (VAS), Implant Stability Quotient (ISQ), and biological complications (fistulas, pain, mucositis, and peri-implantitis). Methods: The PICO strategy was used to formulate the …

Impaired Neutrophil Extracellular Trap-Forming Capacity Contributes To Susceptibility To Chronic Vaginitis In A Mouse Model Of Vulvovaginal Candidiasis, Junko Yano, Paul L. Fidel

School of Dentistry Faculty Publications

Vulvovaginal candidiasis (VVC), caused by is characterized by aberrant inflammation by polymorphonuclear neutrophils (PMNs) in the vaginal lumen. Data from the established murine model shows that despite potent antifungal properties, PMNs fail to clear due to local heparan sulfate that inhibits the interaction between PMNs and , resulting in chronic vaginal immunopathology. To understand the role of neutrophil extracellular traps (NETs) in defense against at the vaginal mucosa, we investigated the NET-forming capacity of PMNs in chronic VVC-susceptible (CVVC-S/C3H) and -resistant (CVVC-R/CD-1) mouse strains. Immunofluorescence revealed the formation of NETs (release of DNA with PMN-derived antimicrobial proteins) in PMN cocultures …

Fibroblasts And Osteoblasts Behavior After Contact With Different Titanium Surfaces Used As Implant Abutment: An In Vitro Experimental Study, Jose Henrique Cavalcanti De Lima, Patricia Cristina Matos Robbs, Elena Mavropoulos Oliveira Tude, Piedad N. De Aza, Eleani Maria Da Costa, Antonio Scarano, Juan Carlos Prados-Frutos, Gustavo Fernandes, Sergio Alexandre Gehrke

MOSDOH Faculty Publications

Background: The goal of this in vitro study was to compare three different surfaces: two types of implant surfaces commercially available ([a] smooth/machined and [b] acid-treated surface) versus (c) anodized surface. Discs were manufactured with commercially pure titanium (CP) grade IV, which were subsequently analyzed by scanning microscopy and fibroblastic and osteoblastic cell cultures. Methods: Ninety-nine discs (5 × 2 mm) were manufactured in titanium grade IV and received different surface treatments: (i) Mach group: machined; (ii) AA group: double acid etch; and (iii) AN group: anodizing treatment. Three discs from each group were analyzed by Scanning Electron Microscopy (SEM) …

Minimally Invasive Periodontal Regeneration With The Buccal Approach: A Systematic Review And Meta-Analysis Of Clinical Studies, Elisa Pasqualini, Filipe Castro, Denise Curado, Ana Martelete, Artak Heboyan, Muhammad H. Saleh, Juliana Campos Hasse Fernandes, Gustavo Fernandes

MOSDOH Faculty Publications

OBJECTIVE: The aim of this study was to investigate clinical periodontal parameters after treatment using the Minimally Invasive Surgical Technique (MIST), Modified Minimally Invasive Surgical Technique (M-MIST), and/or any technique for papilla preservation, such as Entire Papilla Preservation (EPP), modified-papilla preservation technique (M-PPT), or simplified-papilla preservation technique (SPPT). METHODS: The focus question was “For patients with periodontal intrabony defects (P), what is the best minimally invasive regenerative approach (I), comparing MIST, M-MIST, and papilla preservation techniques’ outcomes (C) to improve PD, CAL, GR, and periodontal stability (O)?” An online search was conducted on PubMed, Cochrane Library, and Embase. Only randomized …

Is The Facial Bone Wall Critical To Achieving Esthetic Outcomes In Immediate Implant Placement With Immediate Restoration? A Systematic Review, Sergio Charifker Ribeiro Martins, Marcio Da Costa Marques, Michael Gomes Vidal, Pedro Henrique Moreira Paulo Tolentino, Roberto Galvão Dinelli, Gustavo Fernandes, Jamil Awad Shibli

MOSDOH Faculty Publications

Background. Rehabilitation in the anterior region requires specific conditions for success, such as the presence of papilla, emergence profile, and balance between pink and white esthetic. Objectives. This systematic review aimed to evaluate the esthetic risk associated with immediate implant placement with immediate restoration in the anterior superior area, where the facial bone plate may be absent or deficient. Materials and methods. The search was done in PubMed, Embase, Cochrane, Lilacs, Scopus, Scielo, and Google Scholar databases. The investigation involved clinical studies and observational studies published between January 2012 and July 2023. Studies were excluded if there was less than …