Oral Biology and Oral Pathology Commons^™

Ck2 Phosphorylation Of Human Papillomavirus 16 E2 On Serine 23 Promotes Interaction With Topbp1 And Is Critical For E2 Plasmid Retention Function, Apurva Tadimari Prabhakar

Theses and Dissertations

Human papillomaviruses (HPVs) are the causative agents in most cervical cancers and have been implicated in a rising number of oropharyngeal cancers. HPV positive oropharyngeal cancers have increased significantly over the last two decades with no specific anti-viral therapeutic options for the treatment of HPV diseases. During its lifecycle, HPV16 encoded E2 protein interacts with host cellular factors to regulate viral transcription, replication and genome segregation/retention. Our understanding of the cellular partner proteins that E2 uses to mediate its functions remains incomplete.

Previously, an interaction between E2 and the host protein TopBP1 was identified. In earlier studies, it was also …

Il-36g Cytokine Induction In Oral Epithelial Cells Triggered By Treponema Denticola And Their Role In Chronic Periodontitis, Christopher Blake

Theses and Dissertations

Periodontal disease is a polymicrobial disease affecting 10-15% of the population. Periodontal disease affects the quality of life by reducing mastication and potentially causing tooth loss. Periodontal disease is also linked to more severe, systemic diseases such as cardiovascular disease and rheumatoid arthritis. Development of the diseased state occurs when the plaque biofilm shifts from healthy to dysbiotic. The shift to a dysbiotic biome brings with it a shift in bacterial presence, specifically an increase in gram-negative bacteria, such as T. denticola. T. denticola is a gram-negative, anaerobic spirochete whose relationship with oral epithelial cells is poorly understood. Preliminary data …

Trimming And Ph Effects On Nickel Ion Release From Stainless Steel Crowns Of Primary Teeth, Milad Arab-Nozari, Mohammad Shokrzadeh, Nastaran Zamehran, Jamshid Yazdani Charati, Azam Nahvi

Journal of Dentistry Indonesia

Objective: Stainless steel crowns (SSCs) are preformed metal crowns used to restore severely decayed primary teeth. The aim of this study is to evaluate the effects of pH changes and SSC margin trimming on nickel release in artificial saliva solution. Methods: A total of 90 SSCs were divided into three groups and placed in 35 ml of artificial saliva of pH 6.8, 5, and 3.5. Another group consisting 30 SSCs with trimmed margins was placed in saliva of pH 6.8. All SSCs were incubated at 37°C. The concentration of released nickel was assessed on days 1, 7, 14, 21, and …

Evaluation Of Maxillary Impacted Teeth And Their Relationship With Adjacent Teeth And Anatomic Structures With Cone Beam Computed Tomography, Emre Köse, Emin Murat Canger

Journal of Dentistry Indonesia

Objective: This study aimed to examine the cone beam computed tomography (CBCT) images of impacted maxillary canines and mesiodentes. Methods: This retrospective radiographic study was performed on 177 patients with 200 impacted maxillary canines and 12 mesiodentes. Using CBCT images, the unilateral/bilateral occurrence, presence of root dilaceration, mesio-distal and buccopalatal location, impaction condition, contact region of adjacent teeth, presence and degree of root resorption of adjacent teeth, dental follicle width, closest distance to the nasal cavity, nasopalatinal canal, and maxillary sinus were assessed. For mesiodentes, the types, follicle width, direction, and relationship with anatomical structures were evaluated. Results: No statistical …

Comparative Evaluation Of Apical Extrusion Debris And Irrigant During Calcium Hydroxide Removal And Endodontic Instrumentation Using Three Types Of Instrumentation Systems, Selen İnce Yusufoğlu, Esma Saricam

Journal of Dentistry Indonesia

Many root canal preparation techniques and instruments produce apically extruded materials to a certain extent depending on the preparation system adopted. The extrusion of debris from the apical foramen during chemomechanical preparation may cause postoperative pain and failure of endodontic treatment. Objective: This study evaluates the differences in the apical extrusion of debris and calcium hydroxide (CH) during endodontic instrumentation by using Reciproc Blue (RB), WaveOne Gold (WOG), and F6 Skytaper (F6). Methods: Six experimental study groups (n = 13) were established. The root canal procedures for all groups were prepared with different methods: Group I: One Shape (OS) instrumentation, …

Reliability Of Panoramic Radiography For Vertical Facial Pattern Assessment, Waqar Jeelani, Maheen Ahmed, Shakeel Ahmed

Journal of Dentistry Indonesia

The orthopantomogram (OPG) is a common dental screening radiograph that has multiple implications. However, lateral cephalogram is the investigation of choice for the assessment of vertical facial pattern. Objective: The aim of the current study was to investigate the validity of an OPG parameter i.e. panoramic gonial angle (PGoA) for the assessment of the vertical facial pattern. Methods: A cross-sectional study was conducted on the pretreatment OPG and lateral cephalograms of 200 orthodontic patients aged 15-40 years. The PGoA was measured on both sides and an average was used for statistical analysis. The Pearson’s correlations of PGoA were measured with …

Effect Of Salivary Ph On Water Absorption And Solubility Of Enhanced Resin- Modified Glass Ionomer, Yosi Kusuma Eriwati, Muhammad Dhiaulfikri, Ellyza Herda

Journal of Dentistry Indonesia

The influence of immersion period and liquid pH on water absorption capacity and solubility of the resin-modified glass ionomer cement (RMGIC) raises the question of whether the critical pH of hydroxyapatite and fluoroapatite influences the water absorption capacity and solubility of enhanced resin-modified glass ionomer (ERMGI). Objective: This study was designed to investigate the effects of immersion periods and various pH levels of artificial saliva on the water absorption and solubility of RMGIC and ERMGI. Methods: Fifty-four disc-shaped specimens (15 mm x 1 mm) of enhanced RMGI (ACTIVATM BioACTIVE-RESTORATIVE, Pulpdent, Watertown, MA, USA) and 54 disc-shaped specimens (15 mm x …

The Possible Protective Role Of Vitamin E On The Induced Silver Nanoparticles Toxicity On Filiform And Circumvallate Tongue Papillae Of Albino Rats Histological And Immunohistochemical Study, Nada Tarek Zaki, Mahmoud Al Ankily, Reham Magdy Amin, Ahmed Mahmoud Halawa

Dentistry

Recently Silver nanoparticles (AgNPs) are widely used as in manufacturing of filters to purify drinking water, as a part of surgical prosthesis, splints, dental alloys and most importantly in the medical field as a bactericidal, fungicidal and as a therapeutic agent. Although these widely usage of AgNPs, can induce toxicity. to evaluate the protective role of vitamin Eon the induced silver nanoparticles toxicity on filiform and circumvallate tongue papillae of albino rats. twenty-eight male albino rats weighing 200-250 grams were divided into; the control and the experimental groups, which is subdivided into, subgroup I receiving AgNPs and subgroup II receiving …

Relation Of Oral Ulcers To Quality Of Life: A Cross-Sectional Study, Enji Ahmed, Ayat Gaml Abdelnasser, Mai Zakaria, Soheir Gafar

Dentistry

Oral ulcers affect many dental patients; impairing their lives physically, psychologically, and socially. Due to the absence of information about oral ulcers in our population, the authors undertook a pilot study to obtain a more complete picture of prevalence of oral ulcers, its probable risk factors and its burden on the quality of life. Materials and methods The authors performed a cross‑sectional study with 605 adult dental patients. All patients filled a questionnaire inquiring about the risk factors. An oral examination was performed to each participant to determine presence or absence of oral ulcers; and the type of the oral …

Assessing Nurse Practitioners' Knowledge And Clinical Practice With Regard To The Oral-Systemic Link, Angela Haynes

Electronic Theses and Dissertations

Nurse Practitioners (NPs) comprise a significant portion of the U.S. primary care workforce and play an essential role in patients' health awareness, prevention strategies, disease management, and in providing appropriate provider referrals. Nurse Practitioners receive education on the oral-systemic connection, yet there have been limited studies on the clinical practice of NPs assessing the oral cavity to evaluate the condition of the teeth and the oral tissues. The purpose of this study was to explore the nurse practitioners’ knowledge and practice habits of assessing the oral cavity for diseases or abnormalities in the mouth that can, in turn, affect overall …

J Mich Dent Assoc November 2020

The Journal of the Michigan Dental Association

Every month, The Journal of the Michigan Dental Association brings news, information, and features about Michigan dentistry to our state's oral health community and the MDA's 6,200+ members. No publication reaches more Michigan dentists!

In this issue, the reader will find the following original content:

• Feature articles on how “Routine Blood Lead Testing During Pregnancy Empowers Future Dental Caries and Neurotoxicity Research”, how to “Recoup Your Dues and More with MDA-Endorsed Programs”, and your “2021 MDA Membership Benefits Guide”.
• News you need, Editorial and regular department articles on MDA Foundation activities, Dentistry and the Law, Staff Matters, 10-Minute EBD, Headquarters …

Biofilm Forming Ability Of Bacteria Isolated From Dental Caries: With Reference To Streptococcus Species, Sonali Kaustubh Ambulkar, Vidya Tale, Abhijit Jadhav, Komal Kulkarni

Future Dental Journal

Dental caries is formed by the group of microorganisms attached to a tooth surface embedded in a matrix of polymers. Biofilm plays an important role in the development of dental caries, plaque and other periodontal diseases. The present study is aimed to isolate, identify and characterize bacteria from dental caries. The ability of biofilm formation of these isolates was confirmed by Congo red agar method, Tube method and Microtitre plate method. High biofilm-forming bacteria were identified by 16S rRNA sequencing. Streptococcus mutans, Streptococcus anginosus, Enterococcus faecalis and Rothia dentocariosa are the predominant biofilm forming bacteria associated with dental caries.

Expression Of Mir-720 Is Correlated With Dnmt3 In Oral Squamous Cell Carcinomas, Andrew Graves, Sukhdeep Sandhu, Karl Kingsley

Dental Medicine Faculty Research

Background: Many factors are involved with cellular differentiation and pluripotency, such as long non-coding and microRNAs (miRNA). miR-720 has been demonstrated to affect development, differentiation and pluripotency in dental pulp stem cells but has also been linked to many cancers (renal, prostate, skin, colorectal, breast, cervical and esophageal) through shared pathways including DNA methyltransferase family members (DNMT)3a and DNMT3b, which are highly upregulated in many oral cancers. However, little is known about the expression (or function, if expressed) of miR-720 in oral cancers. Based upon this lack of information, the primary objective of this project was to evaluate the expression …

Nanomaterials And Nanorobotics In Dentistry: A Review, Yelda Kasimoglu, Derya Tabakcilar, Zeynep A. Guclu, Seiko Yamamoto-Nemoto, Elif B. Tuna, Bugra Ozen, Tamer Tuzuner, Gökhan Ince

Journal of Dentistry Indonesia

Nanotechnology is a branch of science focusing on the manipulation of materials measured on the nanoscale (size = 1–100 nm). Recent advances in the field of nanodentistry have resulted in the development of alternative treatment plans for common dental problems, bringing about a paradigm shift in dentistry. Nanorobots, also known as “nanites” or “nanomachines,” are theoretical microscopic devices that may be used for the diagnosis and treatment of oral health problems. This paper aims to discuss the latest innovations in the field of nanodentistry.

Effect Of Short- And Long-Term Use Of Home And In-Office Bleaching With Carbamide Peroxide And Hydrogen Peroxide On Enamel Microhardness, Nazila Ameli, Niloofar Kianvash Rad, Farzane Nikpour, Raheb Ghorbani, Shadi Mohebi

Journal of Dentistry Indonesia

Bleaching is a well-known esthetic dental treatment performed to lighten the tooth shade. Among different cosmetic dental procedures, including direct and indirect tooth-colored restorations, bleaching is likely the most conservative approach. Bleaching has been accepted well by patients and proven as a safe and effective approach. Objective: Tooth bleaching can be conducted at home or in offices. This study was performed to compare the enamel microhardness before bleaching and one and eight weeks after the application of different bleaching agents. Methods: Forty human premolars were randomly divided into four groups, and their buccal surface underwent a Vickers microhardness test …

Oral Rehabilitation Of A Patient With Congenital Erythropoietic Porphyria: A Rare Case Report, Raif Alan, Hakkı Çelebi, Fahriye Kilinc, Recep Dursun

Journal of Dentistry Indonesia

Congenital erythropoietic porphyria (CEP) is an extremely rare disorder involved in chronic porphyrias. One of the recommended evaluations to determine disease severity and needs of a person with CEP is dental assessment. Objective: To present a case of CEP and its oral rehabilitation. Case Report: A 32-year-old female patient was admitted to the clinic with hyperkeratinization, skin fragility, fissures, and wounds in her perioral region and hands. Intraoral gingival bleeding, mucogingival stress, and missing teeth were recorded. After medical consultation, phase I and II periodontal therapies were performed. The patient expressed satisfaction of the results of the procedures in terms …

Treatment Of A Class I Malocclusion With Severe Crowding Using Passive Self-Ligating Brackets, Agita Pramustika, Retno Widayati

Journal of Dentistry Indonesia

Presently, dental crowding is the most common problem among orthodontic patients. The prevalence of crowding in the dental arch is significantly increased in modern dentitions, and it is the most common reason why patients pursue orthodontic treatment. Objective: To report an advanced bracket systems, namely self-ligating brackets, to increase the efficacy of orthodontic treatment especially in patients with severe crowding. Case Report: A 22-year-old female patient presented with severe crowding of the maxillary and mandibular arches. In the upper arch, both second premolars were palatally positioned; in the lower arch, the lower right canine was lingually positioned and the lower …

Direct Composite Resin Restoration Of Anterior Maxillary Teeth And Esthetic Smile Design: A Case Report, Christina Widya Nugrohowati, Wignyo Hadriyanto, Tunjung Nugraheni

Journal of Dentistry Indonesia

Dental esthetic complex involves more than one caries with malformed shape and malposition. Dental trauma most commonly affects maxillary anterior teeth, and subsequently affects the esthetics, functions, and psychological well-being of the individual. Composite resins have become an integral part of contemporary restorative and minimally invasive dentistry. Objective: To summarize the successful use of direct composite resin restoration in the management of a 29-year old male patient. Case Report: A 29-year old male patient presenting with multiple secondary caries and crown fractures in the anterior maxillary teeth, resulting in an unaesthetic smile. Comprehensive esthetic dental treatment was carried out. The …

Effectiveness Of Lentinus Edodes Mushroom Extract On Eradication Of Enterococcus Faecalis Biofilm, Putri Lestari Anggiarini, Meiny F Amin, Juanita A Gunawan, Armelia Sari Widyarman

Journal of Dentistry Indonesia

Sodium hypochlorite is a commonly used irrigation solution in endodontic procedures, but it irritates tissues and has toxic effects. Lentinus edodes is a mushroom that has antibacterial properties. Enterococcus faecalis is an anaerobic bacterium that can cause root canal treatment failure. Objective: This study aimed to determine the effect of L. edodes extract on the eradication of E. faecalis biofilms. Methods: Phytochemical tests of L. edodes were performed to analyze alkaloids, steroids, triterpenoids, phenolics, tannins, flavonoids, and glycosides from this extract qualitatively. E. faecalis ATCC 29212 was cultured in brain heart infusion broth for 24 h at 37°C …

Epithelial Responses To Porphyromonas Gingivalis In The Community Context., Zackary Ray Fitzsimonds

Electronic Theses and Dissertations

Porphyromonas gingivalis, a keystone pathogen for periodontal disease, initiates a complex molecular dialogue with gingival epithelial cells, leading ultimately to disruption of host signaling pathways. Dysbiotic host responses are also thought to contribute to the initiation and progression of oral squamous cell carcinomas. Recently, the homeostatic commensal Streptococcus gordonii has been shown to antagonize P. gingivalis-induced epithelial cell signaling events in host cells, such as proliferation and migration. The aim of this study was to characterize pathways that P. gingivalis targets to disturb host signaling, with a specific focus on pathways that S. gordonii can restore to homeostatic …