Oral Biology and Oral Pathology Commons^™

Effect Of Natural And Industrial Juices On Surface Microhardness Of Microhybrid And Nanohybrid Composites, Razieh Meshki, Hanieh Hoseini

Journal of Dentistry Indonesia

Numerous studies have been conducted on the effect of various beverages on the mechanical properties of tooth-colored materials, however, little is known about the effects of these materials on composites, particularly newer types such as nanocomposites.

Objectives: This study aimed to evaluate the surface microhardness of two types of composites, micro-hybrid (point 4) and nanohybrid (premise), after exposure to natural and industrial juices.

Methods: In this experimental study, 90 disc-shaped specimens with a thickness of 2 mm and a diameter of 10 mm were taken from two composites, micro-hybrid Point4 (Kerr) and nanohybrid premise (kerr) (two groups of 45). Then, …

Comparative Analysis Of Proteomics Biomarkers Associated With Residual Ridge Resorption Induced By Denture Wear, Rohana Ahmad, Ainin Sofia Mohamad Napi, Tong Wah Lim, Su Keng Tan, Saiful Anuar Karsani, Musalmah Mazlan, Lay Kek Teh, Steven M. Morgano, Nadim Z. Baba

Makara Journal of Health Research

Background: The biochemical bone turnover markers for residual ridge resorption (RRR) are unclear. Therefore, the present study aimed to determine the biochemical bone turnover markers associated with RRR by comparing proteomics between the compressed mucosa of denture wearers and the non-compressed mucosa of non-denture wearers.

Methods: The mucosal specimens of 11 complete-denture wearers were obtained from the alveolar ridge during surgical implant exposure for implant-retained overdentures. All denture wearers had been edentulous and worn dentures for at least 5 years. The tissues of 11 non-denture wearers were taken from the ridge during minor preprosthetic surgery. The mucosal proteins …

Association Of Oral Microbiota With Lung Cancer Risk In A Low-Income Population In The Southeastern Usa, Jiajun Shi, Yaohua Yang, Hua Xie, Xiaofei Wang, Jie Wu, Jirong Long, Regina Courtney, Xiao-Ou Shu, Wei Zheng, William J. Blot, Qiuyin Cai

Biology Faculty Research

Purpose

Oral microbiome plays an important role in oral health and systemic diseases, including cancer. We aimed to prospectively investigate the association of oral microbiome with lung cancer risk.

Methods

We analyzed 156 incident lung cancer cases (73 European Americans and 83 African Americans) and 156 individually matched controls nested within the Southern Community Cohort Study. Oral microbiota were assessed using 16S rRNA gene sequencing in pre-diagnostic mouth rinse samples. Paired t test and the permutational multivariate analysis of variance test were used to evaluate lung cancer risk association with alpha diversity or beta diversity, respectively. Conditional logistic regression models …

Development Of 3d-Bioprinted Scaffolds For Oral Probiotic Application., Jhanvi Patel

Electronic Theses and Dissertations

Background: Porphyromonas gingivalis adheres to and invades gingival epithelial cells, resulting in decreased cell viability. Previous studies have indicated that probiotics are effective against dental pathogens; however, few approaches provide sustained-delivery of active agents in the oral cavity. Hypothesis: Probiotics will limit P. gingivalis effects on Telomerase Immortalized Gingival Keratinocyte (TIGK) cells and 3D-printed scaffolds will prolong probiotic release. Methods: Lactobacillus acidophilus, Lactobacillus reuteri, and Bifidobacterium bifidum were assessed with adhesion and antibiotic protection assays to limit P. gingivalis effects on TIGKs. Scaffolds were printed with a select probiotic and evaluated for release kinetics. Results: Free L.a., …

Cytokeratin Overexpression In Submandibular Salivary Glands Of Rats Treated With Botulinum Toxin And Epidermal Growth Factor, Mahmoud Bakr, Mahmoud Al Ankily, Mohamed Shamel

Dentistry

Botulinum toxin (BTX) is used in different cosmetic and therapeutic procedures. In dentistry, BTX has been used successfully for management of drooling. BTX injection into salivary glands has damaging adverse effects on all components of the gland. Epidermal Growth Factor (EGF) is well known for its regenerative properties. The aim of this study was to investigate the effect of BTX injections on the submandibular salivary glands of adult female Albino rats, when administered solely or in conjunction with EGF through measuring the expression of cytokeratin in the parenchyma of the gland. Sixty rats were used in this study and were …

Objective Physiological Measures Of Lingual And Jaw Function In Healthy Individuals And Individuals With Dysphagia Due To Neurodegenerative Diseases, Megan E. Cuellar, Elizabeth Oommen

Faculty Research, Scholarly, and Creative Activity

Swallowing is a neuromuscular process that involves a complex sequence of sensorimotor events, which are executed to efficiently and safely transport food and liquid from the mouth to the stomach. Safe oropharyngeal swallowing involves the activation, modulation, and coordination of oral, pharyngeal, laryngeal, and esophageal structures and musculature. Impaired or atypical patterns of swallowing are considered characteristic of a swallowing disorder, otherwise referred to as dysphagia, and affect the performance of all stages, i.e., oral preparatory, oral transit, pharyngeal, and esophageal. Lingual and jaw musculature play critical roles in mediating swallowing function, particularly during the oral preparatory and oral transit …

Molecular Screening And Analysis Reveal Novel Oral Site-Specific Locations For The Cariogenic Pathogen Scardovia Wiggsiae, Steven Mcdaniel, Jaydene Mcdaniel, Katherine M. Howard, Karl Kingsley

Dental Medicine Faculty Research

Introduction: Scardovia wiggsiae (SW) is a newly identified cariogenic pathogen associated with severe early childhood caries and oral disease. New studies have confirmed the presence of this organism among clinical samples from both pediatric and adult patients. However, the recent discovery of this organism has left researchers with only limited information available regarding the prevalence of this organism—and virtually no information regarding oral site-specific locations. Based upon this lack of information, the overall objective of this study was to perform an oral site-specific analysis of SW prevalence from clinical samples. Methods: Using an approved human subjects protocol, samples (n = …

Assessment Of Microrna (Mir)-365 Effects On Oral Squamous Carcinoma Cell Line Phenotypes, Jeffery Coon, Karl Kingsley

Dental Medicine Faculty Research

miR-365 is a microRNA that regulates transcription and has been demonstrated to promote oncogenesis and metastasis in some cancers while suppressing these effects in others. Virtually no information is known about the presence or function of miR-365 in oral cancers. Based upon this information, the primary goal of this project was to evaluate the expression of miR-365 in existing oral cancer cell lines. Five commercially available oral cancer cell lines (SCC4, SCC9, SCC15, SCC25, and CAL27) were obtained and cultured. RNA was then screened by PCR using primers specific for miR-365, as well as matrix metalloproteinase (MMP-2) and a downstream …

Microbial Screening Reveals Oral Site-Specific Locations Of The Periodontal Pathogen Selenomonas Noxia, Jaydene Mcdaniel, Steven Mcdaniel, Beanca Jhanine Samiano, Matthew Marrujo, Karl Kingsley, Katherine M. Howard

Dental Medicine Faculty Research

Introduction: Selenomonas noxia (SN) is an important periodontal pathogen, associated with gingivitis and periodontitis. Many studies have found associations between SN and indicators of poor health outcomes, such as smoking, low socioeconomic status and obesity. However, less is known about the prevalence of this organism and more specifically about other oral site-specific locations that may harbor this organism. Methods: Using an existing patient repository (n = 47) of DNA isolated from saliva and other oral sites (n = 235), including the dorsum of the tongue, lower lingual incisor, upper buccal molar and gingival crevicular fluid (GCF), molecular screening for SN …

Mesenchymal Chondrosarcoma Simulating A Periodontal Disease: A Case Report, Adham Fahmy, Abanoub Selim, Yara Youssef, Iman Mostafa, Hala El-Kammar

Future Dental Journal

Mesenchymal chondrosarcoma (MCS) is a rare high-grade variant of chondrosarcoma. MSC`s represent about 1% to 9% of chondrosarcomas. Less than 500 cases of MCS have been reported in literature, so far. As opposed to other variants, MSC develops outside of the bone in almost third of the cases. Pain and swelling are the most common symptoms at presentation. The overall prognosis of MSC is poor, with frequent distant metastases. Histopathologically, MCS typically exhibits a biphasic pattern consisting of both small cells, and islands of atypical cartilage. The immunohistochemical profile of this lesion overlaps with several other entities. Resection with wide …

Oral Manifestations Of Covid-19, Ibeth Erazo

Publications and Research

Some oral manifestations have been observed in patients with coronavirus disease 2019 (COVID-19). However, there is still a question about whether these lesions are due to coronavirus infection or secondary manifestations resulting from patient's stress, medications, and/or other related immunosuppressive factors and systemic conditions or by the actions of opportunistic infections brought by other viruses, bacteria, and fungi in the oral cavity. There is growing evidence that angiotensin-converting enzyme 2 (ACE2), the main host cell receptor of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is highly expressed on the cells of the oral mucosal epithelia and of the salivary glands, …

Raman Spectroscopic Characterisation Of Non Stimulated And Stimulated Human Whole Saliva, Genecy Calado, Isha Behl, Hugh Byrne, Fiona Lyng

Articles

Human saliva is a unique biofluid which can reflect the physiopathological state of an individual. The wide spectrum of molecules present in saliva, compounded by the close association of salivary composition to serum metabolites, can provide valuable information for clinical diagnostic applications through highly sensitive vibrational spectroscopic techniques such as Raman spectroscopy. However, the nature of saliva, in terms of collection and patient-related characteristics, can be considered factors which may strongly affect the Raman spectral profile of salivary samples and disrupt the search for specific salivary biomarkers in the detection of diseases. The main objective of this study was to …

Associations Of Electromyographic Activity Of Anterior Temporalis Muscles, Sex, And Occlusal Classes In Asymptomatic Young Adults, Aneta Wieczorek, Marcin Czarnek, Jolanta E. Loster

Journal of Dentistry Indonesia

Symmetry evaluation of the craniofacial complex generally involves models of mandibular movement and masticatory muscle activity, especially during the growth of the craniofacial complex. Objectives: The aim of the study was to determine what, if any, associations exist between the activity of the masticatory muscles, sex, and occlusal classes in asymptomatic young adults. Methods:18-year-old volunteers, showing no symptoms of TMD based on an RDC/TMD examination, were included in the study.Surface electromyography (sEMG) recording was used to quantify the activity of masticatory muscles. The occlusal contact points were analyzed using a T-scan III Evolution 7.01 device. Occlusal classes were …

Periodontal Parameters And Anti-Cardiolipin Antibodies Following Periodontal Therapy In Chronic Periodontitis, Wan Majdiah Wan Mohamad, Noor Rashidah Saad, Siti Lailatul Akmar Zainuddin, Haslina Taib

Journal of Dentistry Indonesia

Anti-cardiolipin (anti-CL) antibodies are autoantibodies which are directed against cell membrane phospholipids. A significant number of periodontitis patients showed positive for anti-CL antibody. Objective: This study aimed to determine the periodontal parameters and anti-CL antibodies levels before and after non-surgical periodontal therapy in chronic periodontitis. Methods: This cross-sectional study had been carried out at Periodontal Clinic, Hospital Universiti Sains Malaysia, Kubang Kerian, Kelantan, Malaysia. Thirty five chronic periodontitis (CP) and 39 non-periodontitis (NP) patients underwent clinical periodontal examination at baseline. Plaque index (PI), gingival index (GI), periodontal pocket depth (PPD), and clinical attachment loss (CAL) were measured. Scaling …

Assessment Of Gingival Status And Gingival Overgrowth Among Immunosuppressed Patients In Universiti Sains Malaysia Hospital, Wan Majdiah Wan Mohamad, Syamimi Izzati Mat Zaid, Haslina Taib

Journal of Dentistry Indonesia

Drug-induced gingival overgrowth (DIGO) is defined as an abnormal growth of the gingiva due to adverse effect of some drugs such as immunosuppressant, calcium channel blocker, and anticonvulsant. Immunosuppressive drugs play an important role in controlling organ transplant rejection and were widely used to treat different diseases. Objective: Immunosuppressive drugs are used for prevention of transplant rejection and management of autoimmune disease. Drug-induced gingival overgrowth (GO) is abnormal growth of gingiva due to adverse effect of these drugs. This study aimed to assess the gingival status, the prevalence of gingival overgrowth and its associated factors among immunosuppressed patients. Methods …

Multiple Oral Ulcerations In A Seizure Patient With Undiagnosed Brain Arteriovenous Malformation, Ambar Kusuma Astuti, Febrina Rahmayanti

Journal of Dentistry Indonesia

Multiple ulcerations are rarely caused by a traumatic event, but seizures can induce repeated injury to the oral mucosa. A patient with a seizure history possesses a challenge in their dental management. Objective: In order to describe a case of multiple oral ulceration in a post-seizure patient with undiagnosed arteriovenous malformation (AVM) in the left parietal lobe and provide short guidelines for dentists in managing patient with a seizure history. Case report: A 23-years old female had multiple oral ulceration in the right and left buccal mucosa and her tongue. She reported having a seizure attack six days before. …

A Case Of Ameloblastic Fibrodentinoma In The Posterior Maxilla, Akane Mochizuki, Rei Fukui, Toshihiko Amemiya, Yoshinori Arai, Masatake Asano

Journal of Dentistry Indonesia

Ameloblastic fibrodentinoma (AFD) is a rare tumor with an incidence rate of less than 1%. When lesion with the histomorphology of ameloblastic fibroma(AF), which is true neoplasms, form dysplastic dentin, and had been referred to as AFD. It histologically consists of odontogenic ectomesenchyme resembling the dental papilla, epithelial strands, and nests resembling dental lamina and enamel organ with dentin formation. Although newly categorized as an odontoma by the WHO in 2017, this lesion was previously referred to as a rare odontogenic tumor by the WHO in 2005. Objective: We aim to summarize our case with other previous case reports …

B13: The Cd5 Coreceptor’S Effect On T Cell Proliferation In Periodontal Disease, Yuko Sperry

Annual Research Symposium

No abstract provided.

B6: In- Vitro Anticancer Effects Of Cinnamomum Verum J. Presl, Cinnamaldeyde, 4 Hydroxyvcinnamic Acid And Eugenol On An Oral Squamous Cell Carcinoma Cell Line, Saranya Varadarajan, Thodur Madapusi Balaji, Malathi Narasimhan, Durai Pandian Chamundeeswari, Dhanapal Sakthisekaran

Annual Research Symposium

No abstract provided.

B4: Study Of Cytokine Profile In Oral Submucous Fibrosis Tissues: Unveiling A Novel Pathogenesis, Dr. D. Y. Patil Dental College And Hospital, Dr. D. Y. Patil Vidyapeeth, Pune, Maharashtra, India, Department Of Maxillofacial Surgery And Diagnostic Sciences, Division Of Oral Pathology, College Of Dentistry, Jazan University, Kingdom Of Saudi Arabia., Roseman University Of Health Sciences, College Of Dental Medicine, South Jordan, Utah

Annual Research Symposium

No abstract provided.