Anatomy Commons^™

Is Easier, Better? A Reevaluation Of The Use Of Non-Remodeled Bone As A Histological Predictor Of Age-At-Death From The Femoral Midshaft Using Gis Software, Mariah Elaine Moe

UNLV Theses, Dissertations, Professional Papers, and Capstones

Traditional macroscopic methods for estimating age-at-death from human skeletal remains have been highly successful in practice but are notoriously inadequate when aging individuals over the age of 50 years. Skeletal histology has the potential to overcome these challenges to narrow the gap in age estimation and more accurately address older individuals.

Primary bone is produced during normal growth and development. Once fully matured, individuals undergo the lifelong process of remodeling wherein primary bone is replaced with microstructures called secondary osteons. As individuals age, the amount of primary bone tends to decrease. This study reexamined the use of percentage of primary …

Health-Related Quality Of Life In Glomerular Disease., Pietro A. Canetta, Jonathan P. Troost, Shannon Mahoney, Amy J. Kogon, Noelle Carlozzi, Sharon M. Bartosh, Yi Cai, T Keefe Davis, Hilda Fernandez, Alessia Fornoni, Rasheed A. Gbadegesin, Emily Herreshoff, John D. Mahan, Patrick H. Nachman, David T. Selewski, Christine B. Sethna, Tarak Srivastava, Katherine R. Tuttle, Chia-Shi Wang, Ronald J. Falk, Ali G. Gharavi, Brenda W. Gillespie, Larry A. Greenbaum, Lawrence B. Holzman, Matthias Kretzler, Bruce M. Robinson, William E. Smoyer, Lisa M. Guay-Woodford, Bryce Reeve, Debbie S. Gipson, Curegn Consortium

Manuscripts, Articles, Book Chapters and Other Papers

There is scant literature describing the effect of glomerular disease on health-related quality of life (HRQOL). The Cure Glomerulonephropathy study (CureGN) is an international longitudinal cohort study of children and adults with four primary glomerular diseases (minimal change disease, focal segmental glomerulosclerosis, membranous nephropathy, and IgA nephropathy). HRQOL is systematically assessed using items from the Patient-Reported Outcomes Measurement Informative System (PROMIS). We assessed the relationship between HRQOL and demographic and clinical variables in 478 children and 1115 adults at the time of enrollment into CureGN. Domains measured by PROMIS items included global assessments of health, mobility, anxiety, fatigue, and sleep …

Defects In Fetal Mouth Movement And Pharyngeal Patterning Underlie Cleft Palate Caused By Retinoid Deficiency., Regina Friedl

Electronic Theses and Dissertations

Cleft palate is a common birth defect. Etiologic mechanisms of palate cleft include defects in palate morphogenesis, mandibular growth, or spontaneous fetal mouth movement. Cleft palate linked to deficient fetal mouth movement has been demonstrated directly only in a single experimental model of loss of neurotransmission. Here, using retinoid deficient mouse embryos, we demonstrate directly for the first time that deficient fetal mouth movement and cleft palate occurs as a result of mis-patterned development of pharyngeal peripheral nerves and cartilages. Retinoid deficient embryos were generated by inactivation of retinol dehydrogenase 10 (Rdh10), which is critical for production of …

Hemoglobin A1c Levels And Sport Participation In Children With Type 1 Diabetes., Amy Kozerski

Electronic Theses and Dissertations

This study’s purpose was to determine a possible difference in hemoglobin A1c levels and sport participation in children with type 1 diabetes. Patients with provided consent via an iPad electronic informed consent/assent (preamble) completed a physical activity and sport participation survey. The survey was linked to their medical chart including demographic and diabetes medical history (e.g. HbA1c). The analyses provided a sample of 120 participants, 40 in the no sport participation group and 78 in the sport participation group with 56 females and 64 males, with an average age12.94±2.8 years. An independent sample t-test, removing one outlier from the …

Using Peripheral Venous Pressure Waveforms To Predict Key Hemodynamic Parameters, Ali Zohair A Alalawi

Graduate Theses and Dissertations

Analysis of peripheral venous pressure (PVP) waveforms is a novel method of monitoring intravascular volume. Two cohorts were used to study the hemodynamics change of the body state and its influence on the PVP using (1) dehydration setting with infants suffering from pyloric stenosis and (2) hemorrhage setting during a craniosynostosis elective surgery. The goal of this research is to develop a minimally invasive method of analyzing the PVP waveforms and find correlations with volume loss.

Twenty-three pyloric stenosis patients PVP were acquired at five stages and were divided into euvolemic, normal fluid volume, and hypovolemic, significant fluid loss. Seven …

Effects Of An 8-Week Pelvic Core Stability And Nutrition Community Programme On Maternal Health Outcomes, Gretchen Elizabeth Krivak, Lori Maria Walton, Veena Raigangar, Mini Sara Abraham, Cherisse Buddy, Magaly Hernandez, Rose Caceras

Faculty Publications

Introduction

Women, during the antenatal and post‐partum period, report pelvic, low back pain, stress and urge urinary incontinence, colorectal dysfunction, and other co‐morbidities that negatively affect health‐related quality of life. Exercise and nutrition are important considerations for improving maternal health in this period.

Purpose

The purpose of this study was to examine the effects of a community‐driven nutrition and exercise programme focused on pelvic floor and core stability, healthy nutrition, and breastfeeding counselling over an 8‐week period on pelvic floor and urinary distress (UDI), prolapse and colorectal distress for antenatal and post‐partum women with limited access to health care, and …

Suffering In Silence: Is Gastroparesis Underdiagnosed?, Dennis J. Baumgardner

Journal of Patient-Centered Research and Reviews

In this introduction to Volume 6, Issue 2, the editor-in-chief of the Journal of Patient-Centered Research and Reviews offers additional comment to the clinical review of diabetic gastroparesis authored by Farmer and colleagues (p. 148), regarding the problem of undiagnosed disease. Increased awareness of this entity and appropriate questioning regarding symptoms of diabetic gastroparesis in the primary care setting may prevent the “suffering in silence” experienced by many patients with this complication.

A Perfusion Decellularization Heart Model - An Interesting Tool For Cell-Matrix Interaction Studies, Mihai Meșină, Ion Mîndrilă, Cristian Mesina, Cosmin Vasile Obleagă, Octavian Istrătoaie

Journal of Mind and Medical Sciences

Objective. In this paper, we present a technique for whole human, pig, or rat heart decellularization in order to obtain a tool for cell-matrix interaction studies and to obtain the extracellular matrix scaffold with applications to the study of cardiac connective tissue architecture for tissue bioengineering.

Material and methods. In order to achieve tissue decellularization we present two separate protocols, the first for large animal hearts (e.g., pig hearts) and human hearts, the second for smaller hearts (e.g., rat hearts). We have performed the cardiac decellularization technique on 20 pig hearts, 5 human hearts, and 20 rat hearts.

Results. The …

Behavioral And Neural Correlates Of Normal Aging Effects On Motor Preparatory Mechanisms Of Speech Production And Limb Movement, Karim Johari, Dirk B. Den Ouden, Roozbeh Behroozmand

Communication Sciences and Disorders Faculty Articles and Research

Normal aging is associated with decline of the sensorimotor mechanisms that support movement function in the human brain. In this study, we used behavioral and event-related potential (ERP) recordings to investigate the effects of normal aging on the motor preparatory mechanisms of speech production and limb movement. The experiment involved two groups of older and younger adults who performed randomized speech vowel vocalization and button press motor reaction time tasks in response to temporally predictable and unpredictable visual stimuli. Behavioral results revealed age-related slowness of motor reaction time only during speech production in response to temporally unpredictable stimuli, and this …

Camel Anatomy; More Than Just A Hump, Michael Chase

The Review: A Journal of Undergraduate Student Research

The one-humped camel (Camelus dromedarius) is capable of living in extreme, arid environments due to its numerous anatomical adaptations. Its modified features of the muscular system, integument, skeletal system, and several internal organs allow this animal to survive in such harsh environmental conditions. Many of these adaptations allow for conservation of energy and water as well as improvement of locomotion to acquire scarce resources. In this paper we will look more closely at some of these adaptations and determine their function in promoting the survival and reproduction of the one-humped camel in desert environments.

Local In Vivo Measures Of Muscle Lipid And Oxygen Consumption Change In Response To Combined Vitamin D Repletion And Aerobic Training In Older Adults, D. Travis Thomas, David M. Schnell, Maja Redzic, Mingjun Zhao, Hideat Abraha, Danielle Jones, Howard Brim, Guoqiang Yu

Health and Clinical Sciences Faculty Publications

Intramyocellular (IMCL), extramyocellular lipid (EMCL), and vitamin D deficiency are associated with muscle metabolic dysfunction. This study compared the change in [IMCL]:[EMCL] following the combined treatment of vitamin D and aerobic training (DAT) compared with vitamin D (D), aerobic training (AT), and control (CTL). Male and female subjects aged 60–80 years with a BMI ranging from 18.5–34.9 and vitamin D status of ≤ 32 ng/mL (25(OH)D) were recruited to randomized, prospective clinical trial double-blinded for supplement with a 2 × 2 factorial design. Cholecalciferol (Vitamin D₃) (10,000 IU × 5 days/week) or placebo was provided for 13 weeks …

Different Effects Of Static And Vibrating Foam Rollers On Ankle Plantar Flexion Flexibility And Neuromuscular Activation, Brianna G. Mazzei

Honors College Theses

The relatively new implementation of vibration into foam rollers was developed in response to the positive feedback of whole-body vibration treatment and foam rolling therapy. The purpose of the study is to research the changes in range of motion and myoelectric activity of the ankle dorsiflexors in female NCAA Division I swimmers when using a vibrating foam roller in comparison to a static foam roller. Combining the self-myofascial release with the increased blood flow and muscle temperature exerted from vibration could possibly enhance the effects of foam-rolling treatment. The different effects of ankle flexibility and motor unit activation after static …

The Relationship Between Biological And Psychosocial Risk Factors And Resting‐State Functional Connectivity In 2‐Monthold Bangladeshi Infants: A Feasibility And Pilot Study, Ted K. Turesky, Sarah K.G. Jensen, Xi Yu, Swapna Kumar, Yingying Wang, Danielle D. Sliva, Borjan Gagoski, Joseph Sanfilippo, Lilla Zöllei, Emma Boyd, Rashidul Haque, Shahria Hafiz Kakon, Nazrul Islam, William A. Petri Jr., Charles A. Nelson, Nadine Gaab

Center for Brain, Biology, and Behavior: Faculty Publications

Childhood poverty has been associated with structural and functional alterations in the developing brain. However, poverty does not alter brain development directly, but acts through associated biological or psychosocial risk factors (e.g. malnutrition, family conflict). Yet few studies have investigated risk factors in the context of infant neurodevelopment, and none have done so in low‐resource settings such as Bangladesh, where children are exposed to multiple, severe biological and psychosocial hazards. In this feasibility and pilot study, usable resting‐state fMRI data were acquired in infants from extremely poor (n = 16) and (relatively) more affluent (n = 16) families in Dhaka, …

Rediscovering The Axolotl As A Model For Thyroid Hormone Dependent Development, Anne Crowner, Shivam Khatri, Dana Blichmann, S. Randal Voss

Neuroscience Faculty Publications

The Mexican axolotl (Ambystoma mexicanum) is an important model organism in biomedical research. Much current attention is focused on the axolotl's amazing ability to regenerate tissues and whole organs after injury. However, not forgotten is the axolotl's equally amazing ability to thwart aspects of tissue maturation and retain juvenile morphology into the adult phase of life. Unlike close tiger salamander relatives that undergo a thyroid hormone regulated metamorphosis, the axolotl does not typically undergo a metamorphosis. Instead, the axolotl exhibits a paedomorphic mode of development that enables a completely aquatic life cycle. The evolution of paedomorphosis allowed axolotls …

An Anatomical And Functional Analysis Of Digital Arteries, Katie Highsmith

Student Scholar Showcase

Blood flow to the tissue of the hands and digits is efficiently regulated by vasoconstriction and vasodilation. Through a series of cadaveric dissection, we examined arteries in the hands and digits, including ulnar artery, radial artery, palmar arteries, and digital arteries, for their distribution (branching) patterns and morphological parameters (e.g., thickness, length between branches, external and internal diameters). Using data directly collected from three female cadavers as input variables to our mathematical model, we simulated vasoconstriction (-20% and -10% diameter) and vasodilation (+10% and +20 diameter) to evaluate the extent of changes in blood volume and flow within the arteries. …

Mobilization Of Calcium Across Mineralized Tissues In Yellow Perch, Perca Flavescens, Taylor Bopp

Student Scholar Showcase

Bones in many higher teleost fish, such as percids and centrarchids, lack osteocytes that function as both chemo- and mechano-sensors, and thus, are not actively involved in homeostasis of blood calcium level. Nonetheless, the vertebrae of yellow perch, Perca flavescens (P. flavescens), living in darker and low calcium (Ca) water, have demonstrated adaptive modeling and remodeling of vertebrae to be more mineralized and thus enhance transmission of the axial muscle torque into the thrust force for the C-start predator escape behavior. The prey-predator interaction is expected to occur at closer range between prey fish and predator fish in …

Fluorometholone Modulates Gene Expression Of Ocular Surface Mucins, Jonathan Taniguchi, Ajay Sharma

Pharmacy Faculty Articles and Research

Purpose

Mucins are vital to keep the ocular surface hydrated. Genes encoding for mucins contain a glucocorticoid response element. The purpose of this study was to evaluate the effect of fluorometholone, a glucocorticoid receptor agonist used in the management of dry eye, on the gene expression of conjunctival and corneal epithelial cell mucins.

Methods

Stratified cultures of human conjunctival and corneal epithelial cells were exposed to 25, 50 and 100 nM of fluorometholone alone or in presence of mifepristone, a glucocorticoid receptor antagonist. The mRNA was isolated from the cells and reverse transcribed to cDNA. The cDNA was used for …

A Horseshoe Kidney With A Unique Constellation Of Renal Vasculature - A Case Report, Guiyan Zhang, Richard Schmidt

Department of Pathology, Anatomy, and Cell Biology Posters

Horseshoe kidney with variable vascular supply is of interest to clinicians and anatomists due to its immense surgical significance. A horseshoe kidney encountered during cadaveric dissection is reported here. The left kidney is vertical and the right kidney is slightly horizontal. The isthmus is narrow and 1.5cm inferior to the inferior mesenteric artery. The hilum of the right kidney opens anteriorly and the left opens anteromedially. The ureters lie on the anterior surfaces of both kidneys. In addition to renal arteries arising from the aorta described in previous reports, a unique renal artery (Renal Artery 3) was found supplying the …

A Visual Exploration Of Walking In Mild Traumatic Brain Injury (Mtbi), Bryana Popa

OHSU-PSU School of Public Health Annual Conference

Visual exploration of the environment is vital for safe and effective walking, and is influenced by cognitive load. Eye movement deficits can occur following mTBI and may impact visual exploration when walking, leading to issues with mobility. This study aims to examine visual exploration when walking under single and dual-task in mTBI and controls.

Sixteen people with mTBI (Age: 30.1±12.8 yrs, days since injury: 39.5±21.7) and 10 healthy controls (Age: 26.3±5.2 yrs) walked for 1 minute while wearing a mobile eye tracker under single and dual-task conditions. The primary outcome was visual exploration measured by saccade frequency (sacc/sec). Secondary outcomes …

Bmp Regulation Of Cyst Stem Cell Division In The Drosophila Testis Stem Cell Niche, Mohamoud Ahmed

Ursidae: The Undergraduate Research Journal at the University of Northern Colorado

Adult stem cells are found throughout the body and divide to replace dead cells or regenerate damaged tissues. We study the Drosophila melanogaster (fruit fly) testis as a model to investigate how adult stem cells are maintained by the intricate microenvironments in which they live, called stem cell niches. Many basic characteristics of adult stem cells in higher organisms were first discovered in the simple stem cell niches found in Drosophila. The testis niche is comprised of two distinct stem cells called germline stem cells (GSCs) and cyst stem cells (CySCs). This niche also contains a structure called the hub …