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Musculoskeletal System Commons

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Creating A Protein Chimera To Study Regulation Of Muscle Diversity, Shannon Scarboro 2021 Kennesaw State University

Creating A Protein Chimera To Study Regulation Of Muscle Diversity, Shannon Scarboro

Symposium of Student Scholars

Creating a protein chimera to study regulation of muscle diversity.

Body muscles are made of many individual super-cells, called muscle fibers, that have distinct properties and determine every individual’s strength and endurance. Initially all muscle fibers have identical characteristics, but become differentiated into specific types in adults. The mechanism of such transition is not well understood, despite its obvious importance for shaping human physicality.

Remarkable conservation of the muscle tissue enables us to use fruit flies to study the mechanisms of muscle fiber diversity. We hypothesized that the transcription factor Mef2 acts as a molecular switch that activates structural ...


From Professor To Patient X, Anne R. Crecelius 2021 University of Dayton

From Professor To Patient X, Anne R. Crecelius

Health and Sport Science Faculty Publications

I walked into the classroom feeling nervous. It wasn't my first time teaching undergraduate students about human endocrine physiology. I knew the material well. But today's lecture was different. I pulled up slides depicting a hypothetical cancer patient and told them, “Patient X had a biopsy that detected invasive carcinoma in her breast.” I described the many months of chemotherapy, surgery, and radiation treatments she went through before going into remission. Then I taught the students about the hormonal therapy she was prescribed—drugs her doctor hoped would limit the growth of any remaining cancer cells and prevent ...


Localization Of Hand And Wrist Anatomic Structures Among Physical Medicine And Rehabilitation Residents: Implication Of Ultrasonography In Palpation Skill Verification, Se Won Lee, Phuong Uyen Le, Craig Van Dien, Stefanie Lai, Eric Aguila 2021 Sunrise Health GME Consortium

Localization Of Hand And Wrist Anatomic Structures Among Physical Medicine And Rehabilitation Residents: Implication Of Ultrasonography In Palpation Skill Verification, Se Won Lee, Phuong Uyen Le, Craig Van Dien, Stefanie Lai, Eric Aguila

HCA Healthcare Journal of Medicine

Objective

The objective of this cross-sectional study is to evaluate the accuracy of physical medicine and rehabilitation (PM&R) resident palpation skills of hand and wrist joint and soft tissue structures using ultrasonography (US) verification.

Methods

PM&R residents palpated hand and wrist anatomic structures in an outpatient musculoskeletal (MSK) clinic. Once the presumed structures were localized, residents marked a one centimeter size circle on the overlying skin with an ink marker. The accuracy of the circle over the joint line and soft tissue structures was verified using US.

Results

Overall palpation accuracy for 16 joint line and soft tissue ...


The Effect Of Chronic Alcohol Consumption On Exercise-Induced Muscle Damage In Young Men, Emma Hamilton, Grant Hilliard 2021 University of Mississippi

The Effect Of Chronic Alcohol Consumption On Exercise-Induced Muscle Damage In Young Men, Emma Hamilton, Grant Hilliard

Honors Theses

PURPOSE: To investigate the effects of chronic alcohol consumption on exercise-induced muscle damage of the knee extensors in young men. METHODS: Twenty-one males (age 21.9 ± 1.1 yr; weight 183.4 ± 27.6 lbs; height 174.0 ± 13.1 cm) performed 100 maximal eccentric contractions at 30°/sec of the knee extensors using their non-dominant leg. The isometric and isokinetic muscle strengths (60°/sec and 180°/sec) were measured pre-exercise and immediately, 24 h, 48 h, 72 h, 96 h, and 120 h post-exercise. Muscle soreness and plasma creatine kinase (CK) activity were measured pre-exercise and 24 h, 48 ...


Musculoskeletal Modeling Of The Pelvis And Lumbar Spine During Running, Ruth Higgins, Maryam Moeini, Hunter Bennett, Stacie Ringleb 2021 Old Dominion University

Musculoskeletal Modeling Of The Pelvis And Lumbar Spine During Running, Ruth Higgins, Maryam Moeini, Hunter Bennett, Stacie Ringleb

College of Engineering & Technology (Batten) Posters

Musculoskeletal modeling provides an alternative to in-vivo characteristics that are difficult to directly measure for movements such as running, especially for trunk muscles and joints. The full-body-lumbar-spine (FBLS) model by Raabe and Chaudhari, 2016 is an OpenSim model created for simulations of jogging. The lifting full-body (LFB) model by Beaucage-Gauvreau et al., 2018 is an adaptation of the FBLS created for estimating spinal loads during lifting. PURPOSE: Determine validity of the FBLS and LFB models in simulating pelvis and lumbar spine kinematics during running. METHODS: Inverse Kinematics were executed using experimental data for the FBLS and LFB models. To obtain ...


Automatic Generation And Novel Validation Of Patient-Specific, Anatomically Inclusive Scoliosis Models For Biomechanics-Informed Surgical Planning, Austin Tapp, Michel Audette, James Bennett 2021 Old Dominion University

Automatic Generation And Novel Validation Of Patient-Specific, Anatomically Inclusive Scoliosis Models For Biomechanics-Informed Surgical Planning, Austin Tapp, Michel Audette, James Bennett

College of Engineering & Technology (Batten) Posters

Scoliosis is an abnormal spinal curvature of greater than 10 degrees. Severe scoliotic deformities are addressed with highly invasive procedures: anterior or posterior spinal fusion approaches. This invasiveness is due, in part, to the constraints of current surgical planning, which utilizes computed tomography (CT) scans unable to discern spinal ligaments that are dissected to make the spine sufficiently compliant for correction. If localization of ligaments and soft tissues were achieved pre-operatively, corrective procedures could become safer and more efficient by using finite element (FE) biomechanical simulations to determine decreased incidences of ligament releases. This research aims to achieve ligament localization ...


Cost Outcomes Of Physical Therapist Providers Compared To Primary Care Providers In The Treatment Of Musculoskeletal Patients In A Military Treatment Facility: A Retrospective Chart Review”, Troy E. McGill, Debra F. Stern, Morey J. Kolber, John McGee 2021 Alaska Regional Hospital

Cost Outcomes Of Physical Therapist Providers Compared To Primary Care Providers In The Treatment Of Musculoskeletal Patients In A Military Treatment Facility: A Retrospective Chart Review”, Troy E. Mcgill, Debra F. Stern, Morey J. Kolber, John Mcgee

Internet Journal of Allied Health Sciences and Practice

Purpose: The purpose of this study was to compare the cost of physical therapist (PT) management of patients with musculoskeletal (MSK) disorders to management by traditional primary care managers (PCMs); medical doctors (MDs), doctors of osteopathic medicine (DOs), advanced registered nurse practitioners (ARNPs), and physician assistants (PAs). Methods: This is a retrospective study of electronic medical records using an exploratory, non-experimental, cross-sectional, and quantitative design method. The records of patients with MSK disorders were assessed at an Air Force military medical clinic for 18 months from January 2016 through June 2017. Results: PT management of MSK patients resulted in a ...


Nox4 Mediates Skeletal Muscle Metabolic Responses To Exercise, Kalyn S. Specht, Shashi Kant, Heather Learnard, Maura Campbell, Amada D. Caliz, Yongmei Pei, Michaella M. Reif, John F. Keaney Jr., Siobhan M. Craige 2021 Virginia Polytechnic Institute and State University

Nox4 Mediates Skeletal Muscle Metabolic Responses To Exercise, Kalyn S. Specht, Shashi Kant, Heather Learnard, Maura Campbell, Amada D. Caliz, Yongmei Pei, Michaella M. Reif, John F. Keaney Jr., Siobhan M. Craige

Open Access Publications by UMMS Authors

OBJECTIVE: The immediate signals that couple exercise to metabolic adaptations are incompletely understood. Nicotinamide adenine dinucleotide phosphate oxidase 4 (Nox4) produces reactive oxygen species (ROS) and plays a significant role in metabolic and vascular adaptation during stress conditions. Our objective was to determine the role of Nox4 in exercise-induced skeletal muscle metabolism.

METHODS: Mice were subjected to acute exercise to assess their immediate responses. mRNA and protein expression responses to Nox4 and hydrogen peroxide (H2O2) were measured by qPCR and immunoblotting. Functional metabolic flux was measured via ex vivo fatty acid and glucose oxidation assays using (14)C-labeled palmitate and ...


Characteristics Of Physiology And Physiology-Related Pre-Health Degree Programs In The Physiology Majors Interest Group, Yvonne Ogrodzinski, Erica A. Wehrwein, Kevin Kelly, James M. Poteracki, Valerie VanRyn, Anne R. Crecelius 2021 Michigan State University

Characteristics Of Physiology And Physiology-Related Pre-Health Degree Programs In The Physiology Majors Interest Group, Yvonne Ogrodzinski, Erica A. Wehrwein, Kevin Kelly, James M. Poteracki, Valerie Vanryn, Anne R. Crecelius

Health and Sport Science Faculty Publications

The Physiology Majors Interest Group (P-MIG), a grassroots organization of educators, has collected data on the history and characteristics of Physiology and highly related undergraduate programs (ex: Human Biology, Pre-Medicine, Biomedical Sciences, etc.) that serve a common population of prehealth students. Data was obtained as part of an online survey sent out to P-MIG conference attendees at the 2017-2019 annual meetings (n=30). Participating institutions indicate that 25.9% have degrees called Physiology aligned with 28% being housed in a department of physiology, 75.9% are a Bachelor of Science program, 34.9% are affiliated with a College of Arts ...


The Role Of Gsk3 Alpha And Beta In Embryonic Craniofacial Development, Harman Jassar 2021 The University of Western Ontario

The Role Of Gsk3 Alpha And Beta In Embryonic Craniofacial Development, Harman Jassar

Electronic Thesis and Dissertation Repository

Background: The GSK-3 genes (Gsk3a and Gsk3b) have been known to affect many cellular processes and signaling pathways some of which are implicated in the growth and development of the craniofacial skeleton.

Aim: The purpose of this study was to assess the effect of chondrocyte-specific deletion of Gsk3a and Gsk3b on the size of the mandible and craniofacial skeleton in embryonic mice.

Materials & Methods: Mice were bred to generate cartilage-specific Gsk3a and Gsk3b KO mice. On embryonic day 18.5 (E18.5) the offspring were gathered by caesarian section. Whole mount skeletal staining was completed on the specimens using Alcian ...


Trabecular Bone Organoid Model For Studying The Regulation Of Localized Bone Remodeling, Yongkuk Park, Eugene Cheong, Jun-Goo Kwak, Ryan Carpenter, Jae-Hyuck Shim, Jungwoo Lee 2021 University of Massachusetts Amherst

Trabecular Bone Organoid Model For Studying The Regulation Of Localized Bone Remodeling, Yongkuk Park, Eugene Cheong, Jun-Goo Kwak, Ryan Carpenter, Jae-Hyuck Shim, Jungwoo Lee

Open Access Publications by UMMS Authors

Trabecular bone maintains physiological homeostasis and consistent structure and mass through repeated cycles of bone remodeling by means of tightly localized regulation. The molecular and cellular processes that regulate localized bone remodeling are poorly understood because of a lack of relevant experimental models. A tissue-engineered model is described here that reproduces bone tissue complexity and bone remodeling processes with high fidelity and control. An osteoid-inspired biomaterial-demineralized bone paper-directs osteoblasts to deposit structural mineralized bone tissue and subsequently acquire the resting-state bone lining cell phenotype. These cells activate and shift their secretory profile to induce osteoclastogenesis in response to chemical stimulation ...


Effectiveness Of Physical Therapy Interventions For Women With Dysmenorrhea: A Systematic Review, Emily Hammond, Abigail Applegate, Emma Caldwell, Hayley Witmer, Amy Tremback-Ball 2021 Misericordia University

Effectiveness Of Physical Therapy Interventions For Women With Dysmenorrhea: A Systematic Review, Emily Hammond, Abigail Applegate, Emma Caldwell, Hayley Witmer, Amy Tremback-Ball

Student Research Poster Presentations 2021

Background and aims: Primary dysmenorrhea, or painful menstruation, is common in menstruating females. However, in some, it can cause intense pain, disrupt activities of daily living, and impact quality of life. The treatment of dysmenorrhea does not traditionally include physical therapy. A systematic review was conducted to explore the role of physical therapy in treating dysmenorrhea. Methods: A search was performed in August 2020 and January 2021 using EBSCOhost, Academic Search Ultimate, CINAHL Complete, and MEDLINE. Search terms included exercise or physical activity or fitness AND dysmenorrhea or menstrual pain or painful menstruation. Inclusion criteria were articles that were peer-reviewed ...


Acetabular Labral Pathologies And Interventions In Relation To Hip Joint Abnormalities, Natalie Perez 2021 Iowa State University

Acetabular Labral Pathologies And Interventions In Relation To Hip Joint Abnormalities, Natalie Perez

Creative Components

The hip joint is pivotal for the basis of movement of the lower extremities. However, with increased movement often comes increased risk for injury. One of the most common injuries seen within the hip joint is damage to the acetabular labrum. There are various hip abnormalities that can attribute to these pathologies, but as knowledge of the labrum advances, these pathologies are becoming more commonly seen in athletes who have and isolated traumatic event or repetitive microtraumas to the hip joint seen in movements such as excessive pivoting and hyperextension of the hip. While the pain alone from a labral ...


Wearing Knee Sleeves During Back Squats Does Not Improve Mass Lifted Or Affect Knee Biomechanics, Hunter J. Bennett, Alexandria Trypuc, Kevin A. Valenzuela, Zachary A. Sievert 2021 Old Dominion University

Wearing Knee Sleeves During Back Squats Does Not Improve Mass Lifted Or Affect Knee Biomechanics, Hunter J. Bennett, Alexandria Trypuc, Kevin A. Valenzuela, Zachary A. Sievert

Human Movement Sciences Faculty Publications

Purpose:
Knee sleeves have become widely popular in the exercise realm, especially for knee support during back squats. Knee sleeves are successful in providing frontal plane knee support during functional tasks, but have not been investigated in back squats. Knee wraps, a somewhat similar elastic material, provide elastic energy that increases weight lifted during back squats. Thus, it is possible the thick neoprene knee sleeves could prove advantageous for back squats. The purpose of this study was to examine the effects of knee sleeves on weight lifted, knee biomechanics, and muscle activations during back squats.

Methods:
Fifteen resistance trained men ...


Genome-Wide Meta-Analysis Of Muscle Weakness Identifies 15 Susceptibility Loci In Older Men And Women, Garan Jones, Katerina Trajanoska, Adam J. Santanasto, Najada Stringa, Chia-Ling Kuo, Janice L. Atkins, Joshua R. Lewis, ThuyVy Duong, Shengjun Hong, Mary L. Biggs, Jian’an Luan, Chloe Sarnowski, Kathryn L. Lunetta, Toshiko Tanaka, Mary K. Wojczynski, Ryan Cvejkus, Maria Nethander, Sahar Ghasemi, Jingyun Yang, M. Carola Zillikens, Stefan Walter, Kamil Sicinski, Erika Kague, Cheryl L. Ackert-Bicknell, Dan E. Arking, B. Gwen Windham, Eric Boerwinkle 2021 Edith Cowan University

Genome-Wide Meta-Analysis Of Muscle Weakness Identifies 15 Susceptibility Loci In Older Men And Women, Garan Jones, Katerina Trajanoska, Adam J. Santanasto, Najada Stringa, Chia-Ling Kuo, Janice L. Atkins, Joshua R. Lewis, Thuyvy Duong, Shengjun Hong, Mary L. Biggs, Jian’An Luan, Chloe Sarnowski, Kathryn L. Lunetta, Toshiko Tanaka, Mary K. Wojczynski, Ryan Cvejkus, Maria Nethander, Sahar Ghasemi, Jingyun Yang, M. Carola Zillikens, Stefan Walter, Kamil Sicinski, Erika Kague, Cheryl L. Ackert-Bicknell, Dan E. Arking, B. Gwen Windham, Eric Boerwinkle

ECU Publications Post 2013

© 2021, The Author(s). Low muscle strength is an important heritable indicator of poor health linked to morbidity and mortality in older people. In a genome-wide association study meta-analysis of 256, 523 Europeans aged 60 years and over from 22 cohorts we identify 15 loci associated with muscle weakness (European Working Group on Sarcopenia in Older People definition: n = 48,596 cases, 18.9% of total), including 12 loci not implicated in previous analyses of continuous measures of grip strength. Loci include genes reportedly involved in autoimmune disease (HLA-DQA1p = 4 × 10−17), arthritis (GDF5p = 4 × 10−13), cell cycle control ...


Diagnostic Accuracy Of Mcmurry’S Test In The Diagnosis Of Meniscal Tears, Jessica Smyth, Hartwell Rainey 2020 James Madison University

Diagnostic Accuracy Of Mcmurry’S Test In The Diagnosis Of Meniscal Tears, Jessica Smyth, Hartwell Rainey

Physician Assistant Capstones, 2020-current

No abstract provided.


The Physiological Interaction Of Sleep Deprivation And Zoledronate On Distal Femur Trabecular Thickness Of Ovariectomized Rats, Erin Nolte, Frank Frisch, Oliver Lopez 2020 Chapman University

The Physiological Interaction Of Sleep Deprivation And Zoledronate On Distal Femur Trabecular Thickness Of Ovariectomized Rats, Erin Nolte, Frank Frisch, Oliver Lopez

Health Sciences and Kinesiology Faculty Articles

Osteoporosis, a disease resulting in an increased risk of fracture due to compromised bone, affects 1 in 3 postmenopausal women. Discontinuities in the microarchitecture of bone, such as trabeculae, are seen in postmenopausal osteoporosis. This study aimed to evaluate how sleep deprivation affects the distal femur trabecular thickness of estrogen-deficient rats treated with Zoledronate. 29 ovariectomized Wistar female rats were separated into 4 groups. The control group (C) was housed in standard housing with a 12-hour light/dark cycle and was given an intravenous injection of 0.45 mL of 0.9% saline. The Zoledronate group (Z) were also housed ...


Novel Computational Infant Musculoskeletal Model For Biomechanical Analysis Of Infant Movement, Yeram Lim 2020 Embry-Riddle Aeronautical University

Novel Computational Infant Musculoskeletal Model For Biomechanical Analysis Of Infant Movement, Yeram Lim

PhD Dissertations and Master's Theses

Computational musculoskeletal models are increasing in commonality and popularity in the study of biomechanics. These models, however, are mainly used to represent fully developed adults, while infant musculoskeletal models are nonexistent. This study aims to develop a novel computational infant musculoskeletal model for biomechanical analysis of infant movement. For this study, 31 reflective markers were placed on an infant, and marker-based motion capture data was collected. The computational study used a generic GAIT2392 OpenSim musculoskeletal model that was scaled to create a customized subject-specific infant model. By using the motion capture data recorded of the infant during a kicking motion ...


An Investigation On The Influences Of Radial Head Hemiarthroplasty Stem Fixation Techniques On Articular Mechanics, Jakub Szmit 2020 The University of Western Ontario

An Investigation On The Influences Of Radial Head Hemiarthroplasty Stem Fixation Techniques On Articular Mechanics, Jakub Szmit

Electronic Thesis and Dissertation Repository

Radial head hemiarthroplasty design has been extensively studied with a focus on utilizing the geometrical characteristics of the native radial dish as a guide of implant placement and design. Although implant design has been studied, optimal radial head implant fixation technique remains unknown. This thesis focused on the effect of stem fit on radiocapitellar contact mechanics, using both finite element and experimental bench-top approaches. Additionally, investigation into the impact of varus/valgus malalignment of the radial head in both the native state and following hemiarthroplasty was conducted. It was found that loose fitting a smooth stem axisymmetric radial head implant ...


Extra Axial Chordoma Of The Distal Femoral Metaphysis: A Case Report, Long Nguyen, Irene Vasko DO, Gord G. Zhu DO, Veniamin Barshay MD, MS, PhD 2020 Cooper Medical School of Rowan University

Extra Axial Chordoma Of The Distal Femoral Metaphysis: A Case Report, Long Nguyen, Irene Vasko Do, Gord G. Zhu Do, Veniamin Barshay Md, Ms, Phd

Cooper Rowan Medical Journal

Background

Chordomas are malignant bone tumors that are derived from remnant embryonic tissue of the notochord and are typically found in the axial midline. When they are found outside of the axial skeleton, the diagnosis can be challenging and elusive. Often, they are overlooked on initial presentation in lieu of other more common lesions, including cartilage tumors (eg, enchondroma, chondrosarcoma, osteochondromatosis) due to their overlapping features.

Case Report

A 30-year-old female with a four-year history of intermittent left knee pain presented for initial evaluation. Physical exam of the knee was unremarkable except for moderate tenderness on palpation. Radiographs showed a ...


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