Anatomy Commons^™

Tunable Multiphase Dynamics Of Arginine And Lysine Liquid Condensates, Rachel S. Fisher, Shana Elbaum-Garfinkle

Advanced Science Research Center

Liquid phase separation into two or more coexisting phases has emerged as a new paradigm for understanding subcellular organization, prebiotic life, and the origins of disease. The design principles underlying biomolecular phase separation have the potential to drive the development of novel liquid-based organelles and therapeutics, however, an understanding of how individual molecules contribute to emergent material properties, and approaches to directly manipulate phase dynamics are lacking. Here, using microrheology, we demonstrate that droplets of poly-arginine coassembled with mono/polynucleotides have approximately 100 fold greater viscosity than comparable lysine droplets, both of which can be finer tuned by polymer length. We …

Towards Making Videos Accessible For Low Vision Screen Magnifier Users, Ali Selman Aydin, Shirin Feiz, Vikas Ashok, Iv Ramakrishnan

Computer Science Faculty Publications

People with low vision who use screen magnifiers to interact with computing devices find it very challenging to interact with dynamically changing digital content such as videos, since they do not have the luxury of time to manually move, i.e., pan the magnifier lens to different regions of interest (ROIs) or zoom into these ROIs before the content changes across frames.

In this paper, we present SViM, a first of its kind screen-magnifier interface for such users that leverages advances in computer vision, particularly video saliency models, to identify salient ROIs in videos. SViM's interface allows users to zoom in/out …

Recovery From Visual Dysfunction Following Mild Traumatic Brain Injury Is Associated With Adaptive Reorganization Of Retinal Inputs To Lateral Geniculate Nucleus In The Mouse Model Utilizing Central Fluid Percussion Injury., Vishal C. Patel

Theses and Dissertations

Traumatic brain injury (TBI) is a leading cause of morbidity and mortality nationwide. Prevalence of mild TBI (mTBI) vastly outnumbers more severe forms however the associated morbidity has only recently gained public attention. Visual dysfunction is a significant component of mTBI associated morbidity with recovery of function linked with improvement in global outcomes. Examination of sensory and motor pathways in other brain injury paradigms support that recovery is largely dependent on adaptive plasticity of remaining connections. Current examinations of visual function recovery following mTBI is limited to identifying evidence for recovery and objective evidence for adaptive plasticity is limited. Therefore, …

Investigating The Effects Of Brainstem Neuronal Adaptation On Cardiovascular Homeostasis., James H Park, Jonathan Gorky, Babatunde Ogunnaike, Rajanikanth Vadigepalli, James S Schwaber

Department of Pathology, Anatomy, and Cell Biology Faculty Papers

Central coordination of cardiovascular function is accomplished, in part, by the baroreceptor reflex, a multi-input multi-output physiological control system that regulates the activity of the parasympathetic and sympathetic nervous systems via interactions among multiple brainstem nuclei. Recent single-cell analyses within the brain revealed that individual neurons within and across brain nuclei exhibit distinct transcriptional states contributing to neuronal function. Such transcriptional heterogeneity complicates the task of understanding how neurons within and across brain nuclei organize and function to process multiple inputs and coordinate cardiovascular functions within the larger context of the baroreceptor reflex. However, prior analysis of brainstem neurons revealed …

Visual Estimates Of Blood Loss By Medical Laypeople: Effects Of Blood Loss Volume, Victim Gender, And Perspective, Rachel Phillips, Marc Friberg, Mattias Lantz Cronqvist, Carl-Oscar Jonson, Erik Prytz

Psychology Faculty Publications

A severe hemorrhage can result in death within minutes, before professional first responders have time to arrive. Thus, intervention by bystanders, who may lack medical training, may be necessary to save a victim's life in situations with bleeding injuries. Proper intervention requires that bystanders accurately assess the severity of the injury and respond appropriately. As many bystanders lack tools and training, they are limited in terms of the information they can use in their evaluative process. In hemorrhage situations, visible blood loss may serve as a dominant cue to action. Therefore, understanding how medically untrained bystanders (i.e., laypeople) perceive hemorrhage …

Rotate-And-Press: A Non-Visual Alternative To Point-And-Click, Hae-Na Lee, Vikas Ashok, I. V. Ramakrishnan

Computer Science Faculty Publications

Most computer applications manifest visually rich and dense graphical user interfaces (GUIs) that are primarily tailored for an easy-and-efficient sighted interaction using a combination of two default input modalities, namely the keyboard and the mouse/touchpad. However, blind screen-reader users predominantly rely only on keyboard, and therefore struggle to interact with these applications, since it is both arduous and tedious to perform the visual 'point-and-click' tasks such as accessing the various application commands/features using just keyboard shortcuts supported by screen readers.

In this paper, we investigate the suitability of a 'rotate-and-press' input modality as an effective non-visual substitute for the visual …

Sail: Saliency-Driven Injection Of Aria Landmarks, Ali Selman Aydin, Shirin Feiz, Vikas Ashok, Iv Ramakrishnan

Computer Science Faculty Publications

Navigating webpages with screen readers is a challenge even with recent improvements in screen reader technologies and the increased adoption of web standards for accessibility, namely ARIA. ARIA landmarks, an important aspect of ARIA, lets screen reader users access different sections of the webpage quickly, by enabling them to skip over blocks of irrelevant or redundant content. However, these landmarks are sporadically and inconsistently used by web developers, and in many cases, even absent in numerous web pages. Therefore, we propose SaIL, a scalable approach that automatically detects the important sections of a web page, and then injects ARIA landmarks …

Anal Fistulotomy (Seton Placement), James M. Nottingham, Rebecca M. Rentea

Manuscripts, Articles, Book Chapters and Other Papers

An anal fistula (anorectal fistula) is one of the most common colorectal issues in the U.S. An anal or anorectal fistula is an inflammatory tract or connection between the anal canal and the perianal skin. Classic anal fistulas are the result of a perineal infection and abscess formation. These infections arise from the anal glands, which form a cryptoglandular abscess at the dentate line and then communicate outward to the perianal skin. The abscess or infections can spontaneously drain externally or be drained by a surgical incision and drainage procedure. After the drainage, a chronic tract can form that will …

Bioenergetic Functions In Subpopulations Of Heart Mitochondria Are Preserved In A Non-Obese Type 2 Diabetes Rat Model (Goto-Kakizaki), Nicola Lai, C. M. Kummitha, F. Loy, R. Isola, C. L. Hoppel

Electrical & Computer Engineering Faculty Publications

A distinct bioenergetic impairment of heart mitochondrial subpopulations in diabetic cardiomyopathy is associated with obesity; however, many type 2 diabetic (T2DM) patients with high-risk for cardiovascular disease are not obese. In the absence of obesity, it is unclear whether bioenergetic function in the subpopulations of mitochondria is affected in heart with T2DM. To address this issue, a rat model of non-obese T2DM was used to study heart mitochondrial energy metabolism, measuring bioenergetics and enzyme activities of the electron transport chain (ETC). Oxidative phosphorylation in the presence of substrates for ETC and ETC activities in both populations of heart mitochondria in …

Context Aware Deep Learning For Brain Tumor Segmentation, Subtype Classification, And Survival Prediction Using Radiology Images, Linmin Pei, Lasitha Vidyaratne, Md Monibor Rahman, Khan M. Iftekharuddin

Electrical & Computer Engineering Faculty Publications

A brain tumor is an uncontrolled growth of cancerous cells in the brain. Accurate segmentation and classification of tumors are critical for subsequent prognosis and treatment planning. This work proposes context aware deep learning for brain tumor segmentation, subtype classification, and overall survival prediction using structural multimodal magnetic resonance images (mMRI). We first propose a 3D context aware deep learning, that considers uncertainty of tumor location in the radiology mMRI image sub-regions, to obtain tumor segmentation. We then apply a regular 3D convolutional neural network (CNN) on the tumor segments to achieve tumor subtype classification. Finally, we perform survival prediction …

Efficacy Of Radiomics And Genomics In Predicting Tp53 Mutations In Diffuse Lower Grade Glioma, Zeina A. Shboul, Khan Iftekharuddin

Electrical & Computer Engineering Faculty Publications

An updated classification of diffuse lower-grade gliomas is established in the 2016 World Health Organization Classification of Tumors of the Central Nervous System based on their molecular mutations such as TP53 mutation. This study investigates machine learning methods for TP53 mutation status prediction and classification using radiomics and genomics features, respectively. Radiomics features represent patients' age and imaging features that are extracted from conventional MRI. Genomics feature is represented by patients’ gene expression using RNA sequencing. This study uses a total of 105 LGG patients, where the patient dataset is divided into a training set (80 patients) and testing set …

Deep Learning With Context Encoding For Semantic Brain Tumor Segmentation And Patient Survival Prediction, Linmin Pei, Lasitha Vidyaratne, Md Monibor Rahman, Khan M. Iftekharuddin

Electrical & Computer Engineering Faculty Publications

One of the most challenging problems encountered in deep learning-based brain tumor segmentation models is the misclassification of tumor tissue classes due to the inherent imbalance in the class representation. Consequently, strong regularization methods are typically considered when training large-scale deep learning models for brain tumor segmentation to overcome undue bias towards representative tissue types. However, these regularization methods tend to be computationally exhaustive, and may not guarantee the learning of features representing all tumor tissue types that exist in the input MRI examples. Recent work in context encoding with deep CNN models have shown promise for semantic segmentation of …

Hear Me Roar, Abigail R. Seethoff

Graduate Student Theses, Dissertations, & Professional Papers

Hear Me Roar, a compilation of personal essays interspersed with short forms, grapples with the nuances of compliance versus autonomy in the context of the male gaze, beauty standards, and pop culture. The collection also explores what it means to treasure something—another person, an object—and how to express and deepen that affection.

A Short Remark On Bong Han Duct System (Pvs) As A Neutrosophic Bridge Between Eastern And Western Medicine Paradigms, Victor Christianto, Florentin Smarandache

Branch Mathematics and Statistics Faculty and Staff Publications

In a previous paper in this journal (IJNS), it is mentioned about a possible approach of “curemony” as a middle way in order to reconcile Eastern and Western’s paradigms of medicine [1]. Although it is known in literature that there are some attempts to reconcile between Eastern and Western medicine paradigms, known as “integrative medicine,” here a new viewpoint is submitted, i.e. Bong Han duct system (PVS), which is a proof of Meridian system, can be a bridge between those two medicine paradigms in neutrosophic sense. This can be considered as a Neutrosophic Logic way to bridge or reconcile the …

The Issue Of Skeletal Muscle Growth And Regeneration, Ayman Ghallab, Ayman Mohammed Ghallab

Dentistry

The aim of our criticism of the paper authored by Makovický and Makovický (2020) was to prevent the readers from being misinformed by a paper based on a major flaw such as confusing splitting muscle fibers with a stretch receptor.

Spinal Motor Neuron Excitability And Balance Control Changes Following Downslope Walking, Nikki Aitcheson-Huehn

Theses and Dissertations (Comprehensive)

Downslope walking (DSW) has been proposed as a rehabilitation tool for people with Multiple Sclerosis (PwMS) although there are mixed findings in young adults (YA) regarding the balance control changes, despite both populations experiencing depressed spinal motor neuron (MN) pool excitability. Our aim was to determine whether YAs could demonstrate improved balance control in conjunction with SOL H reflex depression (estimate of spinal MN excitability) following DSW. We also aimed to determine whether reciprocal inhibition was a potential mechanism for H reflex depression via conditioned SOL H reflexes. Thirty young adults (23±1.4y, 6 males) were assigned to 30-minutes of DSW …

Theoretical Investigation Of The Low Frequency Fundamental Mechanism Of The Objective Occlusion Effect Induced By Bone-Conducted Stimulation, Kevin Carillo, Olivier Doutres, Franck Sgard

Études primaires

The objective occlusion effect induced by bone-conducted stimulation refers to the low frequency acoustic pressure increase that results from occluding the ear canal opening. This phenomenon is commonly interpreted as follows: the bone-conducted sound “leaks” through the earcanal opening and is “trapped” by the occlusion device. This instinctive interpretation misrepresents the fundamental mechanism of the occlusion effect related to the earcanal impedance increase and already highlighted by existing electro-acoustic models. However, these models simplify the earcanal wall vibration (i.e., the origin of the phenomenon) to a volume velocity source which, in the authors' opinion, (i) hinders an exhaustive comprehension of …

Analysis Of Adult Neural Retina Extracellular Vesicle Release, Rna Transport And Proteomic Cargo, Jason Mighty, Jing Zhou, Alberto Benito-Martin, Sami Sauma, Samer Hanna, Onyekwere Onwumere, Cui Shi, Martin Muntzel, Moira Sauane, Michael Young, Henrik Molina, Dianne Cox, Stephen Redenti

Publications and Research

PURPOSE. Extracellular vesicles (EVs) contain RNA and protein cargo reflective of the genotype and phenotype of the releasing cell of origin. Adult neural retina EV release, RNA transfer, and proteomic cargo are the focus of this study.

METHODS. Adult wild-type mouse retinae were cultured and released EV diameters and concentrations quantified using Nanosight. Immunogold transmission electron microscopy (TEM) was used to image EV ultrastructure and marker protein localization. Quantitative real-time polymerase chain reaction (qRT-PCR) was used to analyze retinal cell transcripts present in EVs. Super-resolution microscopy was used to image fluorescent (green) RNA and (red) lipid membrane labeled EVs, released …

Pathways To Success In Anatomy And Physiology At The Community College: The Role Of Prerequisite Courses, Staci B. Forgey, Mitchell R. Williams, Shana Pribesh

Educational Leadership & Workforce Development Faculty Publications

Gatekeeper courses such as Anatomy and Physiology are often referenced in discussions regarding the national shortage of persons in allied health professions. In an attempt to bolster access to STEM professions, some community colleges are mandating prerequisite courses such as Natural Sciences and/or General Biology for STEM gatekeeping courses. In this study, we examined which of these prerequisite courses helped students to pass Anatomy and Physiology and whether the courses are an additional barrier to STEM field completion. This was the first study to evaluate whether a prerequisite course was predictive of success in Anatomy and Physiology, and it contributes …

A Case Of Ana-Negative Systemic Sclerosis Treated With Methylprednisolone, Carminda P. Rogacion, Veronica S, Uy, Reynaldo L. Ugalde, Emmerson Gale S. Vista

Journal of General - Procedural Dermatology and Venereology Indonesia

Background: Systemic sclerosis is a multi-systemic disease characterized by excessive fibrosis, inflammation, and vasculopathy. Common clinical features include skin thickening, telangiectasias, salt and pepper skin, beak-shaped nose, and microstomy. We report a case of ANA-negative systemic sclerosis in a male patient.

Case illustration: Our patient presented with a 10-month history of diffuse hyperpigmentation, skin tightening and decreased mouth aperture, accompanied by digital ulcers, hypopigmented macules and violaceous discoloration of the digits upon exposure to cold temperature. Punch biopsy done revealed mild acanthosis of the epidermis with basal cell layer hyperpigmentation, vacuolar alteration and thickening of the basement membrane …