Integumentary System Commons^™

Secukinumab Treatment Response In Moderate-To-Severe Plaque Psoriasis: A Monocentric Retrospective Study, Benny Effendi Wiryadi, Yuriawati Hendrawan, Rini Herlina, Albertus Agung Mahode

Journal of General - Procedural Dermatology and Venereology Indonesia

Background: Psoriasis affects approximately 2% of the global population and is associated with comorbidities such as depression, psoriatic arthritis, and cardiometabolic syndrome. Secukinumab, a monoclonal antibody targeting interleukin-17A, is effective for moderate-to-severe plaque psoriasis. This study assessed the real-world effectiveness of secukinumab over 52 weeks.

Methods: This retrospective cohort study included 53 patients aged ≥18 years who received secukinumab and were followed for 52 weeks. Patients received weekly loading doses followed by maintenance injections every four weeks. Effectiveness was evaluated using changes in the Psoriasis Area and Severity Index (PASI).

Results: At week 16, 86.8% of patients achieved PASI <5, 79.2% PASI <3, 69.8% PASI <2, and 64.2% PASI <1, indicating substantial improvement. PASI 75 was achieved by 77.4% of patients at week 8. PASI 90 was achieved by 71.7% of all patients and by 76.9% of patients with psoriatic arthritis at week 16. No patients discontinued treatment because of adverse events.

Conclusion: …

Syphilis And Hiv Co-Infection Risk Factors At Dr. Moewardi Hospital, 2018–2022: A Retrospective Study, Endra Yustin Ellistasari, Prasetyadi Mawardi, Pratiwi Prasetya Primisawitri, Stella Gracia Octarica

Journal of General - Procedural Dermatology and Venereology Indonesia

Background: Treponema pallidum, the agent causing syphilis, is transmitted through contact with infectious lesions, bodily fluids, blood transfusions, or perinatally. Human immunodeficiency virus (HIV) infection can mask the clinical manifestations of syphilis, while syphilis may exacerbate HIV progression. This study aimed to analyze risk factors associated with HIV co-infection among patients with syphilis.

Methods: This retrospective, analytical, observational study reviewed medical records from the Dermatology and Venereology outpatient clinic at Dr. Moewardi Hospital, Surakarta, Indonesia, between January 2018 and December 2022. Demographic, behavioral, and clinical variables were extracted. Univariable analysis was performed using simple binary logistic regression to …

Lupus Vulgaris On The Left Arm Mimicking A Skin Tumor: A Case Report, Dwi Indria Anggraini, Nuriasani Yukendri, Indri Windarti

Journal of General - Procedural Dermatology and Venereology Indonesia

Background: Lupus vulgaris (LV) is a rare, paucibacillary form of post-primary cutaneous tuberculosis, accounting for 1.5% of all extrapulmonary tuberculosis cases globally. LV may arise via hematogenous spread, lymphatic route, or contiguous dissemination. The present case highlights the importance of considering LV in patients with chronic and atypical skin lesions, particularly in tuberculosis-endemic areas.

Case Illustration: A 17-year-old female presented with a 2-month history of a solitary, tender, erythematous nodule on the left arm. Initially suspected as a skin tumor, the lesion was surgically removed and tested for biopsy. One month postoperative, a new lesion developed precisely at the same …

Prognosis Of Early-Onset Alopecia Areata: An Evidence-Based Case Report, Sarah Qanita Edwar, Lili Legiawati, Stefani Reditya Anggraini, Ratu Siti Khadijah Sarah

Journal of General - Procedural Dermatology and Venereology Indonesia

Background: Alopecia areata (AA) is an autoimmune, non-scarring hair loss disorder commonly affecting children and often characterized by a chronic or relapsing course. Early-onset AA has traditionally been associated with a poorer prognosis, although current evidence remains inconclusive. This evidence-based case report aims to evaluate the prognostic significance of early-onset AA by synthesizing available cohort data.

Methods: A structured literature search was conducted in PubMed, EMBASE, Scopus, ProQuest, and Cochrane databases using a population, intervention, comparison, and outcome framework. Keywords included “alopecia areata”, “child”, “pediatrics”, “early-onset”, “recurrence”, and “prognosis”.

Results: Five retrospective cohort studies (n = 760) were included. …

Components Of Skin Boosters: A Therapeutic Role In Dermatologic Conditions, Ita Anggraini, Yuwandita Tamara Putri Dermawan, Eka Komarasari, Prima Kartika Esti

Journal of General - Procedural Dermatology and Venereology Indonesia

Background: The term “skin booster” is commonly referred to in dermatology. These products may comprise several components, including exosomes, secretomes, chitosan, polydeoxyribonucleotide, platelet-rich plasma, and hyaluronic acid. In today’s world, the use of such products is not confined to aesthetic purposes; they are also used to treat several other skin conditions. This review paper highlights the role of “skin booster" components for different skin disorders based on their in vitro, in vivo, and clinical studies.

Discussion: “Skin boosters” are bioactive agents typically administered into the dermal layer. Understanding the mechanisms of each component is important because their applications extend beyond …

Topical Normal Saline, Alcohol, And Petrolatum For Marsi: A Randomized Controlled Trial, Michael Hartanto Angriawan, Shannaz Nadia Yusharyahya, Rahadi Rihatmadja

Journal of General - Procedural Dermatology and Venereology Indonesia

Background: Medical adhesive-related skin injury (MARSI) is a common complication associated with acrylic-based adhesive removal. Topical agents such as 0.9% NaCl (normal saline), white petrolatum, and 70% alcohol are commonly used to assist adhesive removal; however, their effectiveness in reducing MARSI remains unclear.

Methods: This single-blind randomized controlled trial with a within-subject design included 56 healthy adults. Acrylic-based adhesives were applied to four sites on the upper arms. Adhesive removal was performed on days 3 and 6 using three interventions (normal saline, petrolatum, alcohol) and one control (no topical agent). Outcomes included MARSI incidence, clinical erythema score, erythema index, transepidermal …

Oral Tofacitinib For Recalcitrant Lichen Planus Pigmentosus: A Hospital-Based Retrospective Study, Rashmi Singh, Prachi Sharma, Rajnish Kumar, Mugdha Kulkarni, Tripti Upadhyay

Journal of General - Procedural Dermatology and Venereology Indonesia

Background: Cutaneous lichen planus (CLP) is a chronic inflammatory disease typically involving the flexor surfaces of the extremities. It is a CD8-positive T-cell-mediated disease of the skin in which an immune mechanism targets basal keratinocytes. Lichen planus pigmentosus (LPP), a variant of CLP, predominantly involves the extensor aspect and has recently been under the umbrella term of acquired dermal macular hyperpigmentation. The primary objective of our study was to determine the effectiveness of oral tofacitinib in treating LPP, and the secondary objective was to assess its safety.

Methods: Medical records of patients attending the Dermatology Outpatient Department between …

Exploring Pediatric Leprosy In An Endemic Area: Case Series Of Eight Patients In Indonesia, Gitalisa Andayani Adriono, Tri Rahayu, Sri Linuwih Sw Menaldi, Nelfidayani Nelfidayani, Retno Sulistyo Wardani, Kahlil Gibran, Malika Sabrina Yunifananda, Kartika Qonita Putri, Yunia Irawati

Journal of General - Procedural Dermatology and Venereology Indonesia

Background: Leprosy remains a significant public health concern in endemic regions such as Indonesia. Children are particularly vulnerable due to their naive immunity and close familial contacts. This study aims to report cases of pediatric leprosy in Lembata, Indonesia, focusing on clinical characteristics and associated risk factors.

Case Illustration: A case series of eight pediatric patients (<15 >years) diagnosed with leprosy was conducted during a community-based screening program in Lembata, Indonesia, in 2022. Of 140 individuals examined, 8 were children. Most patients were male (6/8) with a mean age of 11.75 years. Multibacillary (MB) leprosy predominated (7/8), and a history …

Combination Therapy For Post-Acne Mandibular Keloid: Suprakeloidal Flap, Intralesional Triamcinolone, And Intense Pulsed Light, Miya Khalidah, Arief Budiyanto, Yohanes Widodo Wirohadidjojo, He Yeon Asva Nafaisa, Sonia Diovani, Dwinanda Almira Rizkiani, Dyah Ayu Mira Oktarina

Journal of General - Procedural Dermatology and Venereology Indonesia

Background: Keloid is a benign fibroproliferative skin disorder characterized by excessive collagen deposition resulting from abnormal wound healing that extends beyond the original wound margins. It is particularly challenging to treat, especially in areas with high mechanical tension and skin stiffness, such as the mandibular region, which is associated with increased risk of persistence and recurrence. Combination therapy has shown superior outcomes in reducing recurrence and improving keloids.

Case Illustration: A 41-year-old male with a post-acne keloid on his right mandible underwent surgical management using the suprakeloidal flap method followed by intralesional triamcinolone acetonide (TAC, 10 mg/mL, 20 mg) and …

Rocatinlimab As A Novel Treatment Strategy For Atopic Dermatitis, Haylee Whyde, Evan Blazek, Macy Davis, Parker George, Alex Lowery, Connor Dains, Brenna Hissong, David Koh

Pharmacy and Wellness Review

Atopic dermatitis is a common chronic inflammatory skin disease that affects millions of children and adults in the United States. Atopic dermatitis is characterized by recurrent pruritus, erythema, and relapsing symptoms that can significantly impair quality of life. The pathophysiology of atopic dermatitis involves epidermal barrier dysfunction, immune dysregulation, and genetic susceptibility. Atopic dermatitis guidelines follow a stepwise approach that begins with a severity assessment, trigger avoidance, and nonpharmacologic and pharmacologic treatments. First-line therapies include topical corticosteroids (TCSs), topical calcineurin inhibitors (TCIs), and emollients. Crisaborole and topical ruxolitinib are used for mild-to-moderate disease when prior therapy has been inadequate. Monoclonal …

Selective Retention Of Birdshot Pellets In The Rearfoot: A Case Demonstrating Tissue Preservation And Functional Recovery, Yasim Zafar, Steven Bolton, Alexandria Armstrong, Hooman Mir

School of Podiatric Medicine - Student Research

Level of Evidence: III (Case Study)

Statement of Purpose: Gunshot wounds to the foot pose a unique surgical dilemma—whether to pursue aggressive foreign body removal or to preserve soft tissue integrity. This case highlights the management of a birdshot injury to the rearfoot where selective non-removal of pellets near the neurovascular bundle led to complete healing and full functional recovery. The purpose is to emphasize tissue preservation over aggressive exploration in complex ballistic foot injuries.

Case Study: A 26-year-old female sustained a birdshot gunshot wound to the right rearfoot. Multiple small entry wounds were noted on the posterior and plantar …

Association Between Vitamin D And Cholesterol In Post-Acne Hypertrophic Scars And Keloids: A Cross-Sectional Study, Yuli Kurniawati, Yulia Farida Yahya, Sarah Diba, Rina Novriani, Hasbiallah Yusuf, Ekta Martgaredta

Journal of General - Procedural Dermatology and Venereology Indonesia

Background: Post-acne hypertrophic scars and keloids result from abnormal wound healing within the pilosebaceous unit. Ruptured microcomedones create wounds that can lead to prolonged inflammation, increased collagen synthesis, and fibrinolysis inhibition, resulting in elevated scar tissue in acne lesions. Vitamin D deficiency can lead to prolonged inflammation and damage to dermal collagen. High total cholesterol levels can lead to excessive sebum production, exacerbating inflammation and fibrosis. This study aimed to determine the association between serum vitamin D and total cholesterol levels with scar severity in patients with post-acne hypertrophic scars and keloids.

Methods: This analytical cross-sectional study was conducted at …

Extensive Superficial Dermatomycosis Caused By Cladophialophora Sp., A Deep Mycosis Pathogen: A Case Report, Nikko Vanda Limantara, Agnes Sri Siswati, Flandiana Yogianti

Journal of General - Procedural Dermatology and Venereology Indonesia

Background: Superficial dermatomycosis, predominantly caused by dermatophytes, affects approximately 20–25% of the global population. However, non-dermatophytic fungi, such as Cladophialophora species (sp.), can also cause similar cutaneous infections. Although less common, these organisms are particularly concerning in immunocompromised individuals.

Case Illustration: A 66-year-old immunocompromised male presented with widespread pruritic and erythematous patches, initially misdiagnosed as tinea corporis. Despite receiving standard antifungal therapy, his condition persisted. Further investigation through fungal culture identified Cladophialophora sp., which was resistant to common antifungal agents such as fluconazole, itraconazole, and ketoconazole. However, the fungus was sensitive to terbinafine, which has …

The Efficacy Of Tranexamic Acid In Melasma: A Review, Ninda Sari, Rachmah Diana Putri, Syahriani Syahrir, Agustina Agustina, Mikyal Bulqiah

Journal of General - Procedural Dermatology and Venereology Indonesia

Background: Melasma is a common acquired pigmentary condition presenting as dark macules or patches on sun-exposed areas of the face. Conventional treatments rely on topical bleaching agents and sun protection, while additional adjuvant options such as chemical peels, dermabrasion, and laser procedures are often applied. However, recurrence is frequent, and overall therapeutic success remains modest, significantly affecting patient quality of life. Recently, tranexamic acid (TXA) has gained attention as a novel therapeutic approach. This review provides an overview of the available evidence on the efficacy of TXA, used as monotherapy or in combination regimens, for the management of melasma. …

Successful Management Of Generalized Pustular Psoriasis With Cyclosporine In Hiv-Infected Patient, Rasinta Ayudya Deltania, Anggun Putri Yuniaswan

Journal of General - Procedural Dermatology and Venereology Indonesia

Background: Generalized pustular psoriasis (GPP) can be associated with human immunodeficiency virus (HIV) infection, making its management more challenging and complex. This case report aims to evaluate the effectiveness and safety of cyclosporine in HIV-associated GPP.

Case illustration: A 31-year-old male with a six-year history of HIV on antiretroviral therapy presented with rapidly spreading erythematous plaques with scaling and patches, along with “lakes of pus”, involving 50% of the body surface area (BSA). He reported oral burning, dysgeusia, and odynophagia; tongue Gram stain showed budding yeast and pseudohyphae. The patient was diagnosed with GPP and oral candidiasis in the setting …

Laser And Light-Based Therapy For Hair Growth And Hair Removal, Michelle Wiryadana, Nelva Karmila Jusuf

Journal of General - Procedural Dermatology and Venereology Indonesia

Background: Recent advances in laser and light-based technologies have introduced new options for both the stimulation of hair growth for alopecia and the reduction of unwanted hair growth. However, the clinical evidence remains varied, and treatment outcomes are influenced by factors such as device type, wavelength, and individual response. Ongoing evaluation of safety, efficacy, and standardization of treatment parameters is therefore essential.

Discussion: This review provides an in-depth discussion of the principles, mechanisms, safety, and efficacy of lasers in promoting hair growth, as well as on lasers and light-based therapies used for hair removal. The mechanisms of laser-induced hair growth …

Difficulties In Diagnosing Primary Cutaneous Mucormycosis: Excluding Mycobacterium Other Than Tuberculosis, Chinda Liaska Indah, Sri Linuwih Susetyo Wardhani Menaldi, Sondang Pandjaitan Sirait, Sandra Widaty

Journal of General - Procedural Dermatology and Venereology Indonesia

Background: Mucormycosis is a rare fungal infection caused by a group of opportunistic fungi from the class Zygomycetes. Primary cutaneous mucormycosis is the most common type of mucormycosis in immunocompetent patients. This study reported a case of primary cutaneous mucormycosis with nonspecific clinical characteristics and various supporting examinations. The patient was successfully treated with in toto excision and oral ketoconazole.

Case Illustration: A 40-year-old female presented with purplish-red spots and painless lumps on the second finger of her right hand, which had been present for a year. She had a history of frequent fish tank cleaning and gardening but …

The Profile Of Skin Cancer Patients At Dr Pirngadi Hospital Medan: A Retrospective Study, Febrina Dewi Pratiwi Lingga, Aisya Indira, Remenda Siregar

Journal of General - Procedural Dermatology and Venereology Indonesia

Background: Skin cancer is among the most common malignancies, including basal cell carcinoma (BCC), squamous cell carcinoma (SCC), and malignant melanoma. In Indonesia, it ranks third after cervical and breast cancer. This study aimed to analyze the demographic, clinical, and treatment patterns of skin cancer cases at Dr. Pirngadi General Hospital, Medan, Indonesia from 2019 to 2023.

Methods: A retrospective descriptive study was conducted using medical record data of all skin cancer patients treated from 2019 to 2023. Variables analyzed included age, sex, occupation, lesion site, skin cancer type, and treatment modality. Data were analyzed using univariate statistics and presented …

Effectiveness And Safety Of Moisturizing Wash And Cream In The Treatment Of Elderly Xerosis Cutis, Lili Legiawati, Shannaz Nadia Yusharyahya, Rinadewi Astriningrum, Fathirah Rahmatiah Puteri, Nabila Chalisya Ilyas

Journal of General - Procedural Dermatology and Venereology Indonesia

Background: The skin undergoes degenerative and metabolic changes with aging, increasing susceptibility to dermatological conditions. Xerosis cutis, characterized by rough, scaly skin on the lower legs, is the most common cause of pruritus in elderly patients, with a prevalence of 38–85%. Treating xerosis cutis is challenging due to its multifactorial causes, especially in the elderly. Moisturizers remain the primary and most effective treatment, providing convenience and efficacy. This study aimed to evaluate the effects of QV Intensive Moisturizing Cleanser™️ and QV Intensive Cream™️ (Ego Pharmaceuticals, Australia), which contain humectants, emollients, and occlusives.

Case Illustration: This observational case series involved six …

The Recurrence Of Bowen’S Disease After Topical 5% 5-Fluorouracil Cream Application: A Systematic Review, Mohammad Agassi Antoniman, Ika Anggraini

Journal of General - Procedural Dermatology and Venereology Indonesia

Background: Bowen’s disease (BD) may develop into cutaneous squamous cell carcinoma (CSCC), which can spread to other parts of the body. 5% 5-fluorouracil (5-FU) cream is commonly used for topical therapy on BD; however, the frequency and duration of treatment per cycle have not been standardized. This systematic review aimed to identify the most effective frequency and duration of 5% 5-FU treatment for achieving complete clearance or minimal recurrence.

Methods: A literature search was conducted using three electronic databases (PROSPERO ID: CRD42024607488): MEDLINE, Cochrane, and Scopus. The articles were selected based on their relevance to the clinical question. Appraisals were …