Physiology Commons^™

Bi-Lateral Hand Compartment Syndrome Secondary To Autoimmune Disorder In A Former High School Multi-Sport Athlete, Alyssa Vaniman

Clinical Practice in Athletic Training

Patient is a 21-year-old female former multiple-sport athlete who has suffered from the development of multiple cases of compartment syndrome throughout their body. At the time the medical staff encountered the patient, they were diagnosed with bilateral hand compartment syndrome. An autoimmune disorder known as Scleromyositis was diagnosed as the source of the multiple diagnosed cases of compartment syndrome. Prior to surgical intervention, the patient was unable to complete everyday tasks as a student. As pressure within their hypothenar, thenar, and interosseous compartments grew, the patient was no longer able to complete everyday fine motor skill tasks. A post-surgical rehabilitation …

Telehealth Optimization – Role Of Clinical Athletic Trainers In Orthopedic/Sports Medicine Practice, Katie Harbacheck, Laura Grambo, Shaun Keefer, Eric Klein, Christine Boyd, Carolyn Ford-Hemann, Cameron D’Alpe, Steve Frick, Kevin Shea

Clinical Practice in Athletic Training

Background: Prior to COVID-19, telehealth (TH) implementation in most health systems was minimal. The transition to high rates of TH was dramatic in response to COVID-19, and many health systems struggled to develop optimal, efficient TH workflows. Hypothesis/Purpose: The primary purpose of this study was to evaluate the role of clinically integrated athletic trainers (ATs) into the TH transition of a major orthopedic academic center through growth of TH visits as well as physician satisfaction. Methods: Workflows and tip sheets were designed to include considerations of TH visit increases, adoption of appropriate technology platforms and optimal staff models. The rapid …

Novel Quantification And Localization Of Water And Solute Transporters In The Tissues Of The Spiney Dogfish (Squalus Acanthias), Tolulope B. Ojo

College of Graduate Studies: Theses & Dissertations

The dogfish, Squalus acanthias is a marine cartilaginous elasmobranch found in the North Atlantic and Pacific oceans. Dogfish synthesize and excrete urea as a product of nitrogen metabolism. They also convert ammonia into urea and retain this urea, such that their plasma is isosmotic or slightly hyperosmotic to the surrounding seawater. To facilitate the regulation of body fluid and to maintain ionic concentrations and osmotic pressure, Dogfish use ion and solute transporters (e.g., NCC, UT-1) and aquaporin water channel proteins. Studies have identified some of the aquaporin genes in the elasmobranch genome, but their functions are mostly uncharacterized. Recent transcriptomic …

Reply To “Programming May Matter Most.” Response To “Metabolic Effects Of Two High-Intensity Circuit Training Protocols: Does Sequence Matter?”, Tony P. Nuñez, Fabiano T. Amorim, Nicholas M. Beltz, Christine M. Mermier, Terence A. Moriarty, Roberto C. Nava, Trisha A. Vandusseldorp, Len Kravitz

Faculty Publications

We appreciate the interest that our study elicited and the comments from a reader. We commend the reader of our paper for critically evaluating the protocol and results of the study. Here, we would like to respond to the statement made in the letter. Indeed, the rest intervals were longer and time at VO2max was lower in our study than recommended by Bucheit and Larsen.1 However, because the reader is interested in the practical implications of our study, we ask that they consider the following:

The Role Of The Co-Chaperone Protein Bcl-2-Associated Athanogene 3 (Bag3) At The Cardiomyocyte Sarcomere, Thomas Gwynn Martin

Dissertations

The co-chaperone protein Bcl-2-associated athanogene-3 (BAG3) is a central mediator of cellular protein quality control through autophagy. In the heart, decreased BAG3 activity through mutation or decreased expression are linked to dilated cardiomyopathy (DCM). Unfortunately, though clinical data indicates BAG3 mutations are a definitive cause of DCM, few mechanistic studies had been performed to decipher the fundamental role of BAG3 in cardiomyocytes. However, several studies suggested BAG3 was involved in maintenance of the sarcomere, the molecular contractile structure in muscle cells. The goals of this dissertation were to: 1. Determine the functional significance of BAG3 for the sarcomere, 2. Identify …

Effect Of Pongol Methyl Ether On Cancer Stem Cell Phenotypes In Human Non-Small Cell Lung Cancer Cells, Arnon Silapech

Chulalongkorn University Theses and Dissertations (Chula ETD)

Cancer stem cells (CSCs) are an important therapeutic target. The therapeutic agents targeting CSCs should lead to improved clinical outcomes. This study demonstrated the CSC suppressing activity of pongol methyl ether (PME), a pure compound from Millettia erythrocalyx Gagnep. CSC-suppressing effects were evaluated by colony formation assay, anchorage independent growth assay, spheroid formation assay and detection of CSC markers. The related CSC cell signals were evaluated by Western blot, immunofluorescence and molecular docking analysis. Proteins affected by PME treatment were subjected to bioinformatic analysis. Protein–protein interaction (PPI) networks were constructed by the Search Tool for Interactions of Chemicals (STITCH). The …

Effects Of Low Degree Of High Ambient Temperature On Neural Pathways From Median Preoptic Nucleus To Arcuate Nucleus In Related To Food Intake., Pornsiri Suwannapaporn

Chulalongkorn University Theses and Dissertations (Chula ETD)

High ambient temperature (HTa) is one important environmental factor that decreases food intake (FI). It is well accepted that high degree HTa induced heat stress decreased FI by the activation of corticotropin-releasing factor (CRF) via hypothalamic pituitary adrenal axis. However, short-term low-degree HTa exposure has been demonstrated to decrease FI earlier than activated physiological and stress responses. This effect was related to the neuronal connection between the median preoptic nucleus (MnPO) and arcuate nucleus (Arc). Therefore, the present study aimed to investigate the effect of short-term low-degree HTa exposure on the activity of hypothalamic Arc in regarding to FI, and …

A Computational Model Relating Tissue Oxygen Consumption To Oxygen Delivery In A Krogh Cylinder Model Of Skeletal Muscle, Raghad A. Alqahtani

Theses and Dissertations

Oxygen transport from a capillary to skeletal muscle tissue is a complex process that involves convective and diffusive mechanisms to deliver adequate oxygen to meet tissue metabolic activities. Typically, oxygen uptake in tissue is set by oxygen demand, which is set by metabolic activity. The relationship between the oxygen consumption (VO₂) of an isolated perfused tissue and the rate of delivery of oxygen (QO₂) to the tissue has been a subject of interest to many investigators over the past century. Experiments have shown that there is a critical value of QO₂ below which tissue VO …

Impact Of Physical Activity And Cardiorespiratory Fitness On Vascular Homeostasis In Premenopausal Women Consuming A Westernized High-Fat Meal, Lauren N. Pedersen

Theses and Dissertations

A large percentage of adults in industrialized nations consume a Westernized dietary pattern, which contributes to fasting dyslipidemia and increased risk for atherosclerotic cardiovascular disease. Evidence suggests that a single Westernized meal containing high saturated fat may induce alterations in blood lipids as well as disturb multiple factors regulating peripheral vascular homeostasis, including innate immune cell function, oxidative stress, and vascular function. Conversely, participation in acute and chronic exercise may beneficially impact an individual’s postprandial response. Therefore, this dissertation contains three manuscripts seeking to describe how acute exercise, cardiorespiratory fitness, and physical activity level impact the lipemic and vascular homeostatic …

The Effect Of Backpack Load On Trunk Kinematics Of Imitated Pathological Gait: A Case Study, Kara Kracher

EWU Masters Thesis Collection

Background: It is well documented that loaded backpacks affect the biomechanics of gait in both children and adults. Minimal information is available with regard to the effects of backpacks on the biomechanics of gait in individuals with clinical gait abnormalities, such as those seen in cerebral palsy. Healthy, non-clinical populations can be taught how to ‘imitate’ typical gait abnormalities in order to study various experimental interventions without enlisting clinical patients. The objective of this study was to determine the acute effect of backpack load on kinematics of the trunk during typical and imitated pathological gait. Methods: COVID 19 restrictions precluded …

Role Of Training Mode On Individual And Group Responses To Sprint Interval Training, Lauren T. Digby, Seth F. Mccarthy, Claudia Jarosz, Derek P.D. Bornath, Jessica A.L. Tucker, Tom J. Hazell

Theses and Dissertations (Comprehensive)

Improvements in V̇O_2peak decrease the risk of heart disease and all-cause mortality, and is predictive of overall health. This study compared the group and individual responses of V̇O_2peak, as well as group responses of aerobic performance and anaerobic capacity following running and cycling sprint interval training (SIT) to determine the optimal modality. Twenty-three recreationally active young adults (males: n = 16, BMI = 27.5±4.9; females: n = 7, BMI = 23.6±3.0) completed 3 training sessions/week for 3 weeks (9 sessions). Pre- and post-testing measures included: aerobic capacity (V̇O_2peak), aerobic performance (time trial), and anaerobic capacity …

Mechanisms And Therapeutic Interventions For Breast Cancer-Induced Fatigue And Mitochondrial Dysfunction, David Andrew Stanton

Graduate Theses, Dissertations, and Problem Reports (ETD)

According to the latest statistics from the National Cancer Institute (NCI), about 1 in 8 U.S. women (~13%) will develop invasive breast cancer over the course of their lifetime. This translates to an estimated 268,600 new cases of breast cancer for the year 2019, and these diagnoses will collectively make up 15% of all new cancer cases across all cancer types. The majority of these women will experience the often-debilitating symptom of breast cancer-induced fatigue. these patients often have difficulty performing normal activities of daily living, have decreased tolerance to traditional tumor-directed therapies, and have higher rates of cancer recurrence. …

Conservative Clothing Effects On Body Composition Assessment By Air Displacement Plethysmography, Shaun L. Orvell, Kasuen Mauldin, John Gieng

Faculty Research, Scholarly, and Creative Activity

International Journal of Exercise Science 14(4): 687-695, 2021. Form-fitting spandex swimsuits or single-layer compression shorts are recommended during BOD POD® testing to ensure accurate results. The purpose of this study was to evaluate the effects of various outfit types on body composition measurements using the BOD POD®, and self-reported comfort level wearing each outfit. Twenty-one participants, 8 females and 13 males, (age 31.6 ± 9.8 years) wore a spandex swim cap and three different outfits during BOD POD® testing (manufacturer-recommended form-fitting spandex swimsuit, short sleeve spandex, long sleeve spandex). Measured variables include body mass, body fat percentage, body volume, and …

Short-Term Fasting And Autonomic Control, Joshua Gonzalez

Dissertations, Master's Theses and Master's Reports

Obesity is a chronic metabolic disorder associated with increased risk of cardiovascular disease. Evidence suggests that chronic intermittent fasting improves cardiometabolic health and reduces arterial blood pressure. However, the mechanisms underlying the reductions in blood pressure and improved cardiovascular health observed from chronic fasting studies remain unclear. The autonomic nervous system has a central role in the regulation of blood pressure and is essential for cardiovascular homeostasis. We conducted a study to investigate how acute fasting influences autonomic control of blood pressure at rest and during stress. Twenty-five young, healthy, normal weight, normotensive participants were tested twice, once in the …

Physiological Impacts Of Lampricides On Invasive Sea Lamprey (Petromyzon Marinus) And Non-Target Fishes, Razvan, Adrian Ionescu

Theses and Dissertations (Comprehensive)

Parasitic sea lamprey (Petromyzon marinus) ingest large quantities of blood from fishes using their oral disc and rasping tongue, most often killing the host. In the early 1900s, sea lamprey invaded the Laurentian Great Lakes, decimating sport, commercial and culturally significant fisheries. Since the early 1960s, chemical control using the lampricides 3- trifluoromethyl-4-nitrophenol (TFM) and niclosamide have helped to reduce sea lamprey populations by 90%. Lampricides are applied to larval lamprey nursery streams targeting many generations of lamprey at once. However, there is concern about the potential adverse effects of lampricides on other fishes, particularly vulnerable lake sturgeon (Acipenser fulvescens) …

Objective Physiological Measures Of Lingual And Jaw Function In Healthy Individuals And Individuals With Dysphagia Due To Neurodegenerative Diseases, Megan E. Cuellar, Elizabeth Oommen

University Faculty Publications and Creative Works

Swallowing is a neuromuscular process that involves a complex sequence of sensorimotor events, which are executed to efficiently and safely transport food and liquid from the mouth to the stomach. Safe oropharyngeal swallowing involves the activation, modulation, and coordination of oral, pharyngeal, laryngeal, and esophageal structures and musculature. Impaired or atypical patterns of swallowing are considered characteristic of a swallowing disorder, otherwise referred to as dysphagia, and affect the performance of all stages, i.e., oral preparatory, oral transit, pharyngeal, and esophageal. Lingual and jaw musculature play critical roles in mediating swallowing function, particularly during the oral preparatory and oral transit …

Nucleus Type-Specific Dna Methylomics Reveals Epigenetic “Memory” Of Prior Adaptation In Skeletal Muscle, Yuan Wen, Cory M. Dungan, C. Brooks Mobley, Taylor Valentino, Ferdinand Von Walden, Kevin A. Murach

Health, Human Performance and Recreation Faculty Publications and Presentations

Using a mouse model of conditional and inducible in vivo fluorescent myonuclear labeling (HSA-GFP), sorting purification of nuclei, low-input reduced representation bisulfite sequencing (RRBS), and a translatable and reversible model of exercise (progressive weighted wheel running, PoWeR), we provide the first nucleus type-specific epigenetic information on skeletal muscle adaptation and detraining. Adult (>4 mo) HSA-GFP mice performed PoWeR for 8 wk then detrained for 12 wk; age-matched untrained mice were used to control for the long duration of the study. Myonuclei and interstitial nuclei from plantaris muscles were isolated for RRBS. Relative to untrained, PoWeR caused similar myonuclear CpG …

When Working Out Makes You Sick To Your Stomach: What To Know About Exercise-Induced Nausea, Anne R. Crecelius

Health and Sport Science Faculty Publications

You’re doing it! You’re working out, reaping all those benefits of exercise that have been drilled into your head.

So you’re pedaling your heart out or running like you’re escaping a zombie horde. You’re feeling accomplished, on cloud nine, until … your stomach starts to churn. You may even feel dizzy. Your feelings of accomplishment have turned to agony as you deal with a bout of nausea.

Exercise-induced nausea is quite common, as are exercise-induced gastrointestinal (GI) problems in general, affecting perhaps up to 90% of endurance athletes.

So why does this happen and, more important, how can you prevent …

Diverse And Complex Muscle Spindle Afferent Firing Properties Emerge From Multiscale Muscle Mechanics, Kyle P. Blum, Kenneth S. Campbell, Brian C. Horslen, Paul Nardelli, Stephen N. Housley, Timothy C. Cope, Lena H. Ting

Physiology Faculty Publications

Despite decades of research, we lack a mechanistic framework capable of predicting how movement-related signals are transformed into the diversity of muscle spindle afferent firing patterns observed experimentally, particularly in naturalistic behaviors. Here, a biophysical model demonstrates that well-known firing characteristics of mammalian muscle spindle Ia afferents – including movement history dependence, and nonlinear scaling with muscle stretch velocity – emerge from first principles of muscle contractile mechanics. Further, mechanical interactions of the muscle spindle with muscle-tendon dynamics reveal how motor commands to the muscle (alpha drive) versus muscle spindle (gamma drive) can cause highly variable and complex activity during …

Inhibition Of Oxidative Metabolism By Nitric Oxide Restricts Emcv Replication Selectively In Pancreatic Beta-Cells, Joshua D. Stafford, Chay Teng Yeo, John A. Corbett

Biological Sciences Faculty Research & Creative Works

Environmental factors, such as viral infection, are proposed to play a role in the initiation of autoimmune diabetes. In response to encephalomyocarditis virus (EMCV) infection, resident islet macrophages release the pro-inflammatory cytokine IL-1b, to levels that are sufficient to stimulate inducible nitric oxide synthase (iNOS) expression and production of micromolar levels of the free radical nitric oxide in neighboring b-cells. We have recently shown that nitric oxide inhibits EMCV replication and EMCV-mediated b-cell lysis and that this protection is associated with an inhibition of mitochondrial oxidative metabolism. Here we show that the protective actions of nitric oxide against EMCV infection …