Physiology Commons^™

An Exploratory Analysis Of A Treatment Based Classification Algorithm To Treat Patellar Tendinopathy, Monica Matocha, Patti Syvertson, Janet Mcmurray, Emily R. Dietz, Russell T. Baker, Alan Nasypany, Don Reordan, Darcy Downey

Clinical Practice in Athletic Training

The general and athletic populations commonly experience patellar tendon pain, which is frequently treated with a gold standard 12-week eccentric exercise protocol. The present research study was designed to determine the effects of a treatment based classification (TBC) algorithm utilizing indirect treatment techniques in patellar tendinopathy participants. Ten participants (seven females, three males, mean age = 19.6 ± 1.07, mean symptom duration = 2.14 years with a range of one week to six years) with patellar tendinopathy were evaluated and included in this study. Each participant underwent a thorough evaluation process to aid in determining inclusion: participant medical history, range …

Health & Nutritional Sciences Free Communication Day: Spring 2021 Plan B Abstracts, Brianna Vig, Michael Pappan, Taylor Svehla, Alexander Iverson, Tanner Jerome, Christian Gravius, Kaitlyn Jackman, Savannah Ratermann, Gwyneth Phillips, Jenna Rheder, Erin Hallenbeck, Logan Ammons, Rachel Astleford, Francine Hoffman, Ryan Folley, Kylie Serie, Jenna Christianson, Haley Strait, Kelsey Kessler

Health and Nutritional Sciences Graduate Students Plan B Capstone Projects

This document contains Plan B abstracts presented by graduate students at the Health and Nutritional Sciences Free Communication Day, held on May 4th, 2021.

Abstract titles include:

• Local Restaurants’ Marketing and Sponsorship Within Collegiate Athletics
• Preparing the Future of Campus Recreation
• Motivational Factors Influencing College Choice: NCAA Division I Female Volleyball Athletes
• The Significance of a Successful Internship Program
• Foundations of Publicly Subsidized Sport Stadiums: The Case of U.S. Bank Stadium
• Enhancing Member Experience During a Pandemic
• The Risk of Depression in Football Players Diagnosed with a Concussion
• Effectiveness of Color-Tinted Glasses in Reducing Photophobia in Patients Diagnosed with Mild …

Myelin, Cpla2, And Azithromycin: Modulation Of Macrophage Activation In Spinal Cord Injury Inflammation, Timothy J. Kopper

Theses and Dissertations--Physiology

Spinal cord injury (SCI) produces a chronic inflammatory state primarily mediated by macrophages consisting of resident microglia and infiltrating monocytes. These chronically activated SCI macrophages adopt a pro-inflammatory, pathological state that continues to cause additional damage after the initial injury and inhibits recovery. While the roles of macrophages in SCI pathophysiology are well documented, the factors contributing to this maladaptive response are poorly understood. Here, we identify the detrimental effects of myelin debris on macrophage physiology and demonstrate a novel, activation state-dependent role for cytosolic phospholipase-A2 (cPLA₂) in myelin- mediated potentiation of pro-inflammatory macrophage activation. Macrophage- mediated inflammatory …

Estrogen Disruption Of Hypothalamic Neural Activity, Princess Dickson

Cal Poly Humboldt theses and projects

The brain is highly dependent on the endocrine system for proper neurodevelopment, as it plays a key role in many biological processes. Bisphenol A is a chemical found in plastics that has the potential to mimic the effects of Estrogen in the body, at least weakly. People interact with plastic that contains BPA regularly, and people are at risk for exposure even before being born. The abundance of BPA, along with other exogenous estrogens, makes examining the relationship between early exposure and changes in brain activity imperative. The current study aims to establish a relationship between disrupted estrogen function and …

Dry Needling And Management Of Trigger Points With Low Back Pain: An Evidence To Practice Review, Matthew J. Drescher, Matthew J. Rivera, Lindsey E. Eberman

Clinical Practice in Athletic Training

Low back pain is a common health concern. The development of myofascial trigger points due to low back pain can cause debilitating pain and loss of functional movement in patients. Dry needling is a minimally invasive procedure that has shown to be useful in the treatment of myofascial trigger points when used with other forms of treatment. However, the literature surrounding dry needling and myofascial trigger points in patients with low back pain is lacking. The guiding systematic review and meta-analysis sought to analyze the effectiveness of dry needling for patients with low back pain. The review utilized eight databases …

Cold-Induced Metabolic Changes In Lean, Nag-1 Transgenic Mice, Rachel J. Davey

All Master's Theses

Obesity is a multifaceted metabolic disorder with severe worldwide public health consequences. While obesity can often be treated using diet and exercise, there are complex genetic interactions driving obesity that don’t always respond to such changes. One important research focus for addressing genetic factors is activating brown adipose tissue which increases thermogenesis, the process of burning stored fats to generate heat. Cold exposure is a known way to activate brown adipose tissue through b3-adrenergic signaling. This signaling pathway causes an upregulation of thermogenesis in brown adipocytes and beige adipocytes, which is white adipose tissue that “browns” and becomes metabolically active. …

Utility Of Novel Rotational Load-Velocity Profiling Methods In Collegiate Softball Players, Chad Herring

Electronic Theses and Dissertations, 2020-2023

The purposes of this study were to determine the reliability of the bat swing (BS) and rotational medicine ball throw (RMBT) load-velocity profiling (LVP) methods and the relationships between LVP variables and batting performance in NCAA Division I softball players. Current NCAA Division I softball athletes participated in this study. Bat velocity was tracked with a swing sensor during the BS method. An inertial measurement unit (IMU) tracked forearm velocity during the BS and RMBT methods. Two-way intraclass correlation coefficients (ICC) were used for relative reliability and coefficient of variation (CV) was used for absolute reliability. For the BS method …

Effectiveness Of Take-Home Naloxone Programs In Athletic Training: An Evidence-To-Practice Review, Michael J. Palm, Amanda N. Flanscha, Zachary K. Winkelmann

Clinical Practice in Athletic Training

The number of opioid overdoses (ODs) has risen in recent years and has become more complex due to the co-involvement of both prescription and illicit opioid drug use. Provisional programs for take-home naloxone (a medication designed to rapidly reverse opiate OD symptoms) kits have been distributed to combat this potentially fatal epidemic. Although there is strong evidence to support the efficacy of naloxone in the reversal of opiate OD, there is limited evidence to support the efficacy of take-home naloxone (THN) kits. The purpose of this evidence-to-practice review was to summarize a systematic review on the efficacy of THN programs. …

The Functional Movement Screen And Injury Risk In Sporting Populations: An Evidence-To-Practice Review, Taylor Niles, Federico Rossi, Zachary K. Winkelmann

Clinical Practice in Athletic Training

The Functional Movement Screen (FMS) is a functional test, which aims to identify dysfunctional, asymmetrical, and painful movements that could contribute to future injuries. Medical professionals can clinically use this information to implement appropriate, specialized prehabilitation training aimed at reducing the dysfunctional, asymmetrical, and painful movements, to help prevent injury risk. Research on this tool, however, has contradictory findings regarding FMS composite score and future risk of injury. It is unclear to what extent FMS can predict those with future injury risk, and whether there are factors, such as age, sex, or sport-type, which may be contributing to these varying …

Rater Reliability Of The Functional Movement Screen: An Evidence-To-Practice Review, Nate Orth, Adam Graham, Zachary K. Winkelmann

Clinical Practice in Athletic Training

The purpose of this evidence-to-practice review is to summarize a systematic review on the inter- and intrarater reliability of the Functional Movement Screen (FMS). Reliability is crucial to the FMS, as clinicians may retest to view a patient’s changes and improvements in movement patterns. This review and analysis looked at 7 studies which showed that both inter- and intrarater reliability were good. Studies were only included if the primary focus was on inter- and intrarater reliability. Clinicians had varying levels of familiarity with the FMS process. Athletic training students with less than one year to no experience were found to …

Attitudes Among Collegiate Volleyball And Women’S Soccer Players Prior To The Covid-19 Altered 2020-21 Season, D M. Gallegos, B J. Warner, S A. Cage

Clinical Practice in Athletic Training

Context: In response to the global spread of SARS-CoV-2, the National Collegiate Athletic Association cancelled all 2020 winter and spring championships that had not been completed. Additionally, the majority of 2020 fall spring championships were rescheduled to take place in the spring semester of 2021. Objective: The purpose of this study was to describe the attitudes, moods, and motivations of collegiate women’s soccer and women’s volleyball players toward the alteration to the 2020-2021 season. Design: Cross-sectional design. Setting: Web-based survey. Participants: A total of 46 female collegiate soccer and volleyball players participated in this study (Age = 17.8 years ± …

Triple Oxygen Isotope Measurements (Δ'17O) Of Body Water Reflect Water Intake, Metabolism, And Δ18O Of Ingested Water In Passerines, Pablo Sabat, Seth D. Newsome, Stephanie Pinochet, Roberto Nespolo, Juan Carlos Sanchez-Hernandez, Karen Maldonado, Alexander R. Gerson, Zachary D. Sharp, John P. Whiteman

Biological Sciences Faculty Publications

Understanding physiological traits and ecological conditions that influence a species reliance on metabolic water is critical to creating accurate physiological models that can assess their ability to adapt to environmental perturbations (e.g., drought) that impact water availability. However, relatively few studies have examined variation in the sources of water animals use to maintain water balance, and even fewer have focused on the role of metabolic water. A key reason is methodological limitations. Here, we applied a new method that measures the triple oxygen isotopic composition of a single blood sample to estimate the contribution of metabolic water to the body …

Opioid Use Disorder: The Timeline For Medication Assisted Therapy, Alexander Cristofori

Capstone Showcase

Opioid Use Disorder is patterns of opioid use leading to withdrawal, giving up important life events in order to use opioids, and excessive time spent using opioids, to name a few diagnostic criteria. The clinical progression of the disorder involves periods of acute exacerbation and remission that are cyclic in nature. Treatment is most effective when it includes both pharmacological and psychosocial modalities, referred to as medication assisted therapy (MAT). Three drugs used commonly in MAT-based treatment for OUD from oldest to newest include Methadone, Buprenorphine-naloxone, and Naltrexone. Treatment program models that prioritize total abstinence from the addictive substance attached …

Analysis Of Circadian Rhythm Irregularities On The Health Of Shift Workers, Sahil Rajan

Williams Honors College, Honors Research Projects

Circadian rhythms involve the natural 24 wake-sleep cycle that governs proper maintenance of biological sleep schedules. Circadian rhythm disruption has been associated with health issues such as diabetes, obesity, and mental health disorders such as bipolar and sleep disorders. In this study, a survey method was utilized in order to analyze specific population demographics to determine whether working day or night shifts predisposed individuals to health issues due to disruptions in their circadian rhythms. This study was also carried out to observe popular coping strategies among night shift workers. Of all the variables tested comparing the difference between day and …

Sleep And Athletic Performance Of Formula 1 Race Car Drivers During The 2019 Season, Alexander Pollack

Master's Theses and Doctoral Dissertations

Sufficient, good quality sleep is associated with better performance in many sports; however, this relationship has not been examined among motorsport athletes. The purpose of this thesis is to investigate the relationship between sleep quality (SQ), sleep duration (SD), and performance metrics among professional racecar drivers. During the 2019 season, five Formula 1 drivers reported SQ, SD, and hours of time change for each race. Performance data (finishing position and points earned) were obtained from a public website. Relationships between sleep variables and driving performance were examined using correlations. Correlations between SQ and driving performance were not significant. SD and …

Predictability Of Vo2max From Three Commercially Available Devices, Luke Daniel Mccormick

Master's Theses and Doctoral Dissertations

The Polar V800TM, A300TM, and Garmin Forerunner 235TM predict VO2max from a submaximal effort. Purpose: To examine the predictability of VO2max from two heart rate monitors (Device A and V) and a global positioning system (GPS) watch compared to measured VO2max. Methods: Forty participants, 22 males and 18 females ages 18 to 55, came to the Running Science Laboratory at Eastern Michigan University. During visit 1, participants completed a maximal graded exercise test (GXT) to determine VO2max. At visit 2, each device’s protocol was followed to estimate VO2max. Pearson correlations, repeated measures ANOVA, and a paired samples t-test were utilized …

Deciphering The Effects Of Serelaxin On The Cardiorenal Axis In Acute Heart Failure- A Canine Model, Abhinav Chinna Krishnan

Wayne State University Dissertations

Acute heart failure (HF) with underlying ischemic cardiomyopathy (ICM) is one of the leading causes of cardiovascular associated death in the United States. Acute HF pathophysiology involves a complex interplay of neurohormonal activation, increased cardiac ventricular pressures (fluid overload), vasoconstriction, impaired renal function, and progressive end-organ failure. Serelaxin (SLX), a recombinant form of the human hormone relaxin 2, is a vasodilator and an ideal pharmacological agent to treat acute HF. Though SLX was associated with positive preliminary outcome data for acute HF it however failed to provide benefit during clinical trials. Greater understanding of cardiac and renal parameters may elucidate …

The Role Of Biomaterial Substrate In Stem Cell Fate Determination, Zhenjie Liu

Wayne State University Dissertations

The physical cues, which included topography, stiffness, and mechanical forces, can influence the stem cell renewal, differentiation, and maturation in vivo and in vitro. The nano-topography of the ECM can stimulate the neural differentiation of the stem cells, while the micro-topography of the ECM can guide the neurite outgrowth. However, the role and functional size of the micro- and nano-topography in the stem cell fate determination is not clear yet. To study this aim, two biomaterial based aligned fiber platforms (ACMFP and ASMFP) were designed, fabrication and evaluated to cover the micro-, submicro-, and nano-fiber topography, which used to study …

Power Amplification Strategies Across Animals, Rayhan Asif

Williams Honors College, Honors Research Projects

Animals use muscles for movement, but some have evolved mechanisms to exceed maximum power used in a motion known as power amplification. In this literature review, I analyzed and compared the evolution of structures capable of power amplification between species. Structures capable of power amplification were broken down into the basic components of the engine, amplifier, and tool. The species analyzed were found to possess necessary structures for power amplification which were relatively similar to each other in morphology, but varied greatly in function. The ease with which these structures evolved was evaluated based on the amount of divergence which …

Effects Of Fluoxetine/Simvastatin/Ascorbic Acid Combination Treatment On Neurogenesis And Functional Recovery In A Model Of Multiple Sclerosis, Olivia Cameron Webb

Browse all Theses and Dissertations

Whereas immune modulation has proven beneficial in multiple sclerosis (MS), we hypothesized that targeting down-stream modulators of neurogenesis and subsequent remyelination may offer an additional, if not superior, point of intervention in an attempt to repair damage and recover lost function. As such, the present study assessed the effectiveness of 30-day administration of the drug combination fluoxetine (5 mg/kg), simvastatin (1 mg/kg), and ascorbic acid (50 mg/kg) (FSA) on an early marker of neurogenesis, doublecortin (DCX), and functional recovery using the Montoya Staircase following lysolecithin-induced focal demyelination of the corpus callosum in middle-aged (10-11 month) male and female rats. Lysolecithin …