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Mitochondrial Physiology Of Diapausing And Developing Embryos Of The Annual Killifsh Austrofundulus Limnaeus: Implications For Extreme Anoxia Tolerance, Jeff Duerr, Jason E. Podrabsky 2010 George Fox University

Mitochondrial Physiology Of Diapausing And Developing Embryos Of The Annual Killifsh Austrofundulus Limnaeus: Implications For Extreme Anoxia Tolerance, Jeff Duerr, Jason E. Podrabsky

Faculty Publications - Department of Biological & Molecular Science

Diapausing embryos of the annual killiWsh Austrofundulus limnaeus have the highest reported anoxia tolerance of any vertebrate and previous studies indicate modified mitochondrial physiology likely supports anoxic metabolism. Functional mitochondria isolated from diapausing and developing embryos of the annual killifish exhibited VO2, respiratory control ratios (RCR), and P:O ratios consistent with those obtained from other ectothermic vertebrate species. Reduced oxygen consumption associated with dormancy in whole animal respiration rates are correlated with maximal respiration rates of mitochondria isolated from diapausing versus developing embryos. P:O ratios for developing embryos were similar to those obtained from adult liver, but were diminished in …


Mitochondrial Physiology Of Diapausing And Developing Embryos Of The Annual Killifish Austrofundulus Limnaeus: Implications For Extreme Anoxia Tolerance, Jeffrey M. Duerr, Jason E. Podrabsky 2010 George Fox University

Mitochondrial Physiology Of Diapausing And Developing Embryos Of The Annual Killifish Austrofundulus Limnaeus: Implications For Extreme Anoxia Tolerance, Jeffrey M. Duerr, Jason E. Podrabsky

Biology Faculty Publications and Presentations

Diapausing embryos of the annual killifish Austrofundulus limnaeus have the highest reported anoxia tolerance of any vertebrate and previous studies indicate modified mitochondrial physiology likely supports anoxic metabolism. Functional mitochondria isolated from diapausing and developing embryos of the annual killifish exhibited VO2, respiratory control ratios (RCR), and P:O ratios consistent with those obtained from other ectothermic vertebrate species. Reduced oxygen consumption associated with dormancy in whole animal respiration rates are correlated with maximal respiration rates of mitochondria isolated from diapausing versus developing embryos. P:O ratios for developing embryos were similar to those obtained from adult liver, but were diminished in …


Camkii-Mediated Phosphorylation Of The Inositol 1,4,5-Trisphosphate Receptor At Serine-150 Results In Decreased Channel Activity, Joshua Thomas Maxwell 2010 Loyola University Chicago

Camkii-Mediated Phosphorylation Of The Inositol 1,4,5-Trisphosphate Receptor At Serine-150 Results In Decreased Channel Activity, Joshua Thomas Maxwell

Dissertations

One mechanism by which calcium is mobilized from intracellular stores is via the activation of inositol 1,4,5-trisphosphate receptors (InsP3Rs) by the second messenger, inositol 1,4,5-trisphosphate (InsP3). InsP3 is produced when certain factors bind to G protein-coupled receptors on the plasma membrane, causing activation of phospholipase C which cleaves InsP3 from its membrane tether, allowing InsP3 to diffuse through the cytoplasm to bind to its receptor. Activation of InsP3Rs leads to release of calcium into the cytoplasm of the cell, where it can activate a multitude of signal transduction cascades and a variety of local and global cellular events. One such …


Interspecific Variation In Palatability Suggests Cospecialization Of Antipredator Defenses In Sea Hares, Kimberly K. Takagi, Nadia N. Ono, William G. Wright 2010 Chapman University

Interspecific Variation In Palatability Suggests Cospecialization Of Antipredator Defenses In Sea Hares, Kimberly K. Takagi, Nadia N. Ono, William G. Wright

Biology, Chemistry, and Environmental Sciences Faculty Articles and Research

Prey species often deploy different kinds of antipredator defenses, which can interact with each other in ways that are not yet completely understood. Much research into these interactions has utilized gastropod mollusks, usually focusing (in part) on the protective utility of the gastropod shell. This makes the evolutionary reduction of the shell in the opisthobranch gastropods (marine slugs) particularly interesting. This loss of protective function of the shell is associated with the evolution of alternative defenses. Particularly well studied are chemical defenses, especially those using secondary metabolites derived from food resources. As a first step toward understanding interspecific variation in …


Afm Study Of Structural Changes In Supported Planar Dppc Bilayers Containing General Anesthetic Isofluorane (Plus Additional Afm Experiments), Chad McKell, Hiram Conley, David D. Busath 2010 Brigham Young University

Afm Study Of Structural Changes In Supported Planar Dppc Bilayers Containing General Anesthetic Isofluorane (Plus Additional Afm Experiments), Chad Mckell, Hiram Conley, David D. Busath

Faculty Publications

Atomic force microscopy (AFM) is a remarkable tool for assessing the structural properties of supported lipid planar bilayers under different physiological conditions. Previous work has shown that incorporation of anesthetics into artificial lipid bilayers results in domain formation [1], destruction of lipid aggregates and patches [2], anesthetic-lipid mixed micelle formation [2], and the development of interdigitated phases of reduced thickness compared to anesthetic-free bilayers [3]. In particular, these interdigitated phases are suspected to affect the structure and activity of membrane proteins, such as ion channels, and thus further research with proteinembedded bilayers exposed to anesthetics could reveal the mechanism responsible …


Pharmacology Supplement, Ahmed Mustafa, Ellioott Blumenthal 2009 Indiana University Purdue University Fort Wayne

Pharmacology Supplement, Ahmed Mustafa, Ellioott Blumenthal

Ahmed Mustafa Dr.

No abstract provided.


Research Review: Fun Or Fitness?, Mike Climstein 2009 Australian Catholic University

Research Review: Fun Or Fitness?, Mike Climstein

Mike Climstein

No abstract provided.


Research Review: Mixed-Method Cooling In The Heat?, Michael Climstein 2009 Australian Catholic University

Research Review: Mixed-Method Cooling In The Heat?, Michael Climstein

Mike Climstein

No abstract provided.


Research Review: Well Don’T Just Stand There!, Mike Climstein 2009 Australian Catholic University

Research Review: Well Don’T Just Stand There!, Mike Climstein

Mike Climstein

No abstract provided.


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