Physiology Commons^™

Premature Osteoarthritis In The Temporomandibular Joint Of Heterozygous Disporportionate Micromelia Mice, Jason Farrell, Dr. Robert Seegmiller

Journal of Undergraduate Research

The purpose of this study, as also summarized in the proposal for this research grant, was to analyze the temporomandibular joints (TMJs) of mice with a specific collagen defect, Disproportionate Micromelia. Examining these joints was done to provide an animal model to be used in Osteoarthritis research, and to propose a potential mechanism for osteoarthritis in this joint in humans. Better understanding of Osteoarthritis in this joint using an animal model can help lead to potential future treatments for a wide variety of TMJ disorders.

Modeling The Influence Of Vitamin D Deficiency On Cigarette Smoke-Induced Emphysema, Mardi A. Crane-Godreau, Candice C. Black, Andrew J. Giustini, Tenzin Dechen, Jihan Ryu, James A. Jukosky, Hong-Kee Lee, Katherine Bessette, Nora R. Ratcliffe, P. Jack Hoopes, Steven Fiering, John A. Kelly, J. C. Leiter

Dartmouth Scholarship

Chronic obstructive pulmonary disease (COPD) is a major cause of morbidity and mortality worldwide. While the primary risk factor for COPD is cigarette smoke exposure, vitamin D deficiency has been epidemiologically implicated as a factor in the progressive development of COPD-associated emphysema. Because of difficulties inherent to studies involving multiple risk factors in the progression of COPD in humans, we developed a murine model in which to study the separate and combined effects of vitamin D deficiency and cigarette smoke exposure. During a 16-week period, mice were exposed to one of four conditions, control diet breathing room air (CD-NS), control …

Molecular Remodeling Of Tip Links Underlies Mechanosensory Regeneration In Auditory Hair Cells, Artur A. Indzhykulian, Ruben Stepanyan, Anastasiia Nelina, Kateri J. Spinelli, Zubair M. Ahmed, Inna A. Belyantseva, Thomas B. Friedman, Peter G. Barr-Gillespie, Gregory I. Frolenkov

Physiology Faculty Publications

Sound detection by inner ear hair cells requires tip links that interconnect mechanosensory stereocilia and convey force to yet unidentified transduction channels. Current models postulate a static composition of the tip link, with protocadherin 15 (PCDH15) at the lower and cadherin 23 (CDH23) at the upper end of the link. In terminally differentiated mammalian auditory hair cells, tip links are subjected to sound-induced forces throughout an organism's life. Although hair cells can regenerate disrupted tip links and restore hearing, the molecular details of this process are unknown. We developed a novel implementation of backscatter electron scanning microscopy to visualize simultaneously …

Scfkmd Controls Cytokinin Signaling By Regulating The Degradation Of Type-B Response Regulators, Hyo Jung Kim, Yi-Hsuan Chiang, Joseph J. Kieber, G. Eric Schaller

Dartmouth Scholarship

Cytokinins are plant hormones that play critical roles in growth and development. In Arabidopsis, the transcriptional response to cytokinin is regulated by action of type-B Arabidopsis response regulators (ARRs). Although central elements in the cytokinin signal transduction pathway have been identified, mechanisms controlling output remain to be elucidated. Here we demonstrate that a family of F-box proteins, called the kiss me deadly (KMD) family, targets type-B ARR proteins for degradation. KMD proteins form an S-phase kinase-associated PROTEIN1 (SKP1)/Cullin/F-box protein (SCF) E3 ubiquitin ligase complex and directly interact with type-B ARR proteins. Loss-of-function KMD mutants stabilize type-B ARRs and exhibit an …

Associations Between Alcohol Consumption And Fasting Blood Glucose In Young Adults, Julie Ann Lucca

Master's Theses

Current research shows moderate alcohol consumption is associated with decreased risk of diabetes and excessive consumption or binge drinking can cause insulin resistance and diabetes. In 2010, diabetes was the seventh leading cause of death in the United Statesand was responsible for significant health complications: blindness, kidney failure, and limb amputations, and is a large national economic burden. Fasting blood glucose (FBG) is a tool used to help diagnose diabetes. Abnormally high FBG, ≥100 mg/dl, is indicative of diabetes and pre-diabetes. Few studies have observed diabetic prevalence among young adults or college students. Studying young adults can help provide added …

Does Naloxone Reinstate Secondary Hyperalgesia In Humans After Resolution Of A Burn Injury? A Placebo-Controlled, Double-Blind, Randomized, Cross-Over Study, Manuel P. Pereira, Mads U. Werner, Thomas K. Ringsted, Michael C. Rowbotham, Bradley K. Taylor, Joergen B. Dahl

Physiology Faculty Publications

INTRODUCTION: Development of secondary hyperalgesia following a cutaneous injury is a centrally mediated, robust phenomenon. The pathophysiological role of endogenous opioid signalling to the development of hyperalgesia is unclear. Recent animal studies, carried out after the resolution of inflammatory pain, have demonstrated reinstatement of tactile hypersensitivity following administration of μ-opioid-receptor-antagonists. In the present study in humans, we analyzed the effect of naloxone when given after the resolution of secondary hyperalgesia following a first-degree burn injury.

METHODS: Twenty-two healthy volunteers were included in this placebo-controlled, randomized, double-blind, cross-over study. Following baseline assessment of thermal and mechanical thresholds, a first-degree burn injury …

Intra-Mitochondrial Injury During Ischemia-Reperfusion, Hema Aluri

Theses and Dissertations

Cardiac injury is increased following ischemia-reperfusion. Mitochondria are the “effector organelles” that are damaged during ischemia (ISC) when there is no blood flow. Resumption of metabolism by damaged mitochondria during reperfusion (REP) results in increased cell injury. Current therapeutic interventions to pre-condition and post-condition the heart during ISC are ineffective during certain conditions like aging and diabetes due to defects in the signaling cascades. In contrast, mitochondrial-based strategies are effective in protecting the heart during ISC-REP. Hence direct therapeutic targeting of dysfunctional mitochondria will provide the potential to bypass the upstream signaling defects and intervene directly upon the effector organelle. …

Validation Of Antibodies Used To Study Hypoxia Inducible Factors In Two Species Of Fundulus, Jenna D. Hill

LSU New Orleans Theses and Dissertations

Hypoxia inducible factors (HIFs) are transcription factors and the master regulators of oxygen-dependent gene expression in animals. The focus of this thesis is the distribution of HIF protein in tissues of the fish Fundulus heteroclitus and F. grandis, two widespread species that occur in naturally hypoxic waters. Polyclonal antibodies against HIF-1α, HIF-2α, and HIF-3α were tested on proteins made in vitro and on extracts made from several tissues of normoxic and hypoxic fish. Antibodies against HIF-1α and 3α bound specifically to full length protein made in vitro, and produced bands on western blots of nuclear extracts of near …

Unhealthy Behaviors And The Relationship To Body Mass Index (Bmi) In College Students, J. Popivchak, B. Larouere, Carena S. Winters

International Journal of Exercise Science: Conference Proceedings

Please view abstract in the attached PDF file.

Comparing Physiological Responses While Walking On A Standard Motorized Treadmill And Curve Treadmill, J. Phipps, S. Miller, S. Voran, M. Lister, Harold S. Kieffer

International Journal of Exercise Science: Conference Proceedings

Please view abstract in the attached PDF file.

Relationships Between Peak Oxygen Uptake And Arterial Function: A Preliminary Study, M. Pearman, E. Devallance, S. Fournier, D. Bonner, B. E. Warden, W. Gharib, D. Donley, P. Chantler

International Journal of Exercise Science: Conference Proceedings

Please view abstract in the attached PDF file.

Cardiovascular Responses To High Intensity Aerobic And Anaerobic Exercises, A. Parker, P. Messersmith, K. Beil, K. Mahoney, K. Jones, J. A. Mckenzie, S. D. Mccole

International Journal of Exercise Science: Conference Proceedings

Please view abstract in the attached PDF file.

The Effects Of Caffeine On Maximal Anaerobic Exercise, K. Ogden, J. Haak, Harold S. Kieffer, N. Marlowe

International Journal of Exercise Science: Conference Proceedings

Please view abstract in the attached PDF file.

Effects Of Creatine Monohydrate Vs. Creatine Hydrochloride On Muscle Endurance Performance, K. Naylor, C. Albright, C. Liggitt, A. Kolenc, R. Robinson, W. Braun, J. Sanders

International Journal of Exercise Science: Conference Proceedings

Please view abstract in the attached PDF file.

Gender-Specific Equations For Predicting Maximal Heart Rate In Exercise Stress Testing, T. Nagle, E. Godlasky, S. Weber-Peters, R. Bradford, N. Miller, M. Lott

International Journal of Exercise Science: Conference Proceedings

Please view abstract in the attached PDF file.

The Relationship Between Body Composition And Baseball Performance In Division Ii Baseball Players, B. Muth, C. A. Witmer, S. E. Davis, J. Guers

International Journal of Exercise Science: Conference Proceedings

Please view abstract in the attached PDF file.

Body Image And Associated Behaviors Among College-Aged Students, E. Miller, B. Larouere, Carena S. Winters

International Journal of Exercise Science: Conference Proceedings

Please view abstract in the attached PDF file.

Validity Of Using Functional Threshold Power And Intermittent Power To Predict Mountain Bike Race Outcome, M. Miller, G. Moir

International Journal of Exercise Science: Conference Proceedings

Please view abstract in the attached PDF file.

Can Standing Long Jump Distance Be Predicted From Standing Vertical Jump Distance?, L. Merk, C. Michael, Ben Meyer

International Journal of Exercise Science: Conference Proceedings

Please view abstract in the attached PDF file.

Effects Of A Two Week College Weight Training Course On Body Weight, Power, And Strength, J. Mcnamara

International Journal of Exercise Science: Conference Proceedings

Please view abstract in the attached PDF file.