Skeletal Muscle Fiber Adaptations Following Resistance Training Using Repetition Maximums Or Relative Intensity,
2019
East Tennessee State University
Skeletal Muscle Fiber Adaptations Following Resistance Training Using Repetition Maximums Or Relative Intensity, Kevin M. Carroll, Caleb D. Bazyler, Jake R. Bernards, Christopher B. Taber, Charles A. Stuart, Brad H. Deweese, Kimitake Sato, Michael H. Stone
ETSU Faculty Works
The purpose of the study was to compare the physiological responses of skeletal muscle to a resistance training (RT) program using repetition maximum (RM) or relative intensity (RISR). Fifteen well-trained males underwent RT 3 d·wk−1 for 10 weeks in either an RM group (n = 8) or RISR group (n = 7). The RM group achieved a relative maximum each day, while the RISR group trained based on percentages. The RM group exercised until muscular failure on each exercise, while the RISR group did not reach muscular failure throughout the intervention. Percutaneous needle biopsies of the vastus lateralis were obtained …
Translational Control Of Antibiotic Resistance,
2019
The Ohio State University
Translational Control Of Antibiotic Resistance, Anne Witzky, Rodney Tollerson Ii, Michael Ibba
Biology, Chemistry, and Environmental Sciences Faculty Articles and Research
Many antibiotics available in the clinic today directly inhibit bacterial translation. Despite the past success of such drugs, their efficacy is diminishing with the spread of antibiotic resistance. Through the use of ribosomal modifications, ribosomal protection proteins, translation elongation factors and mistranslation, many pathogens are able to establish resistance to common therapeutics. However, current efforts in drug discovery are focused on overcoming these obstacles through the modification or discovery of new treatment options. Here, we provide an overview for common mechanisms of resistance to translation-targeting drugs and summarize several important breakthroughs in recent drug development.
Sensitive And Reliable Measures Of Driver Performance In Simulated Motor-Racing,
2019
Griffith University, Gold Coast, Queensland, Australia
Sensitive And Reliable Measures Of Driver Performance In Simulated Motor-Racing, Christopher Irwin, Jamie Mollica, Ben Desbrow
International Journal of Exercise Science
International Journal of Exercise Science 12(6): 971-978, 2019. Motor racing is a physically and mentally demanding sport, associated with a high degree of risk for drivers. Hence, driving simulation provides a safe alternative to explore the impact acute physiological perturbations (e.g. heat stress or dehydration) on a driver’s performance. This study aimed to determine sensitive and reliable simulated driving performance parameters that could be employed in future driving performance studies. Thirty-six healthy males (age: 26.5 ± 8.1 y, body mass: 75.6 ± 12.2 kg, mean ± SD) completed a single experimental trial involving four simulated motor-racing drives (2 initial drives …
No Impact Of Heat Stress And Dehydration On Short Duration Simulated Motor-Racing Performance,
2019
School of Allied Health Sciences, Griffith University, Gold Coast, AUSTRALIA
No Impact Of Heat Stress And Dehydration On Short Duration Simulated Motor-Racing Performance, Jamie Mollica, Ben Desbrow, Christopher Irwin
International Journal of Exercise Science
International Journal of Exercise Science 12(6): 960-970, 2019. Motor-racing drivers are often exposed to hot environments and may be susceptible to fluid loss and hydration issues, which could influence driving performance. This study assessed the effect of dehydration and heat stress on performance during a short, simulated motor-racing task. Nine healthy males (age: 26.6 ± 7.5 y, body mass: 78.8 ± 12.5 kg, mean ± SD) completed two passive dehydration (sauna) procedures (targeting -1% and -3% body mass loss (BML)) on separate occasions. Driving performance was assessed pre-dehydration (Baseline), immediately post-dehydration (Hot) and following a cooling period (Cool). Measures of …
Validity Of The Short Recovery And Stress Scale In Collegiate Weightlifters,
2019
East Tennessee State University
Validity Of The Short Recovery And Stress Scale In Collegiate Weightlifters, Spencer Kyle Travis, Alec Perkins, Satoshi Mizuguchi, Kevin Breuel, Michael H. Stone, Caleb D. Bazyler
ETSU Faculty Works
Introduction: Monitoring an athlete’s stress and recovery state across sequential training bouts can be used to gauge fitness and fatigue levels (i.e., preparedness). Previous studies have used jumping performance, biochemical markers, and questionnaires to estimate preparedness. However, self-report questionnaires are the most common due to economical and practical means. The Short Recovery and Stress Scale (SRSS) is an 8-item questionnaire ideal for monitoring; however, convergent validity of the SRSS with physiological and performance measures needs to be investigated. Purpose: Thus, the purpose of this study was to determine whether changes in collegiate weightlifter’s training volume-load, biochemical markers, and jumping performance …
Evaluation Of Kidney Injury Molecule-1 As A Disease Progression Biomarker In Diabetic Nephropathy,
2019
Jinnah Sindh Medical University, Karachi Pakistan
Evaluation Of Kidney Injury Molecule-1 As A Disease Progression Biomarker In Diabetic Nephropathy, Fatima Abid Khan, Syeda Sadia Fatima, Ghulam Mustafa Khan, Sana Shahid
Department of Biological & Biomedical Sciences
Background & Objective: Kidney Injury Molecule-1 (KIM-1) is a peptide whose release into circulation is specific to tubular injury. This study aimed to estimate levels of kidney injury molecule-1 in diabetic patients with and without kidney disease. And evaluate the role of KIM-1 as an early screening marker of progressive kidney injury.
Methods: This follow-up study included n=85 subjects from the diabetic clinic of Jinnah Post Graduate Medical Center (JPMC) in collaboration with Aga Khan University from November 2016 till September 2017. They were divided as: i) Group A1 (n=30) participants with diabetes for <5 years without microalbuminuria ii) Group A2 (n= 30) subjects with diabetes for 6-10 years with microalbuminuria; iii) Group B (n=25) subjects as healthy control group. All study participants were followed for 6 months and their blood glucose, urea, creatinine, electrolytes, albuminuria and serum KIM-1 were assayed.
Results: High KIM-1 at baseline was …
Role Of Transient Receptor Potential Channels In Epithelial Morphogenesis In Chick Embryo,
2019
Brigham Young University
Role Of Transient Receptor Potential Channels In Epithelial Morphogenesis In Chick Embryo, Trinity Q. Waddell
Theses and Dissertations
Transient Receptor Potential channels (TRP) are a superfamily of cationic specific ionchannels that are regulated by various stimuli such as temperature, pH, mechanical stress, ligandsand ion concentration. The role of TRP channels in disease states such as autosomal dominantpolycystic kidney disease, cancer metastasis, and developmental defects lend credence to thebelief that they play an important part in epithelial morphogenesis events. The development ofsomites, neural tube closure and migration of neural crest cells to form things such as the faceand heart is a good developmental model for the aforementioned cellular processes. We haveshown that TRP channels can be found in the …
Effects Of High-Carbohydrate Versus Mixed-Macronutrient Meals On Soccer Physiology And Performance,
2019
Old Dominion University
Effects Of High-Carbohydrate Versus Mixed-Macronutrient Meals On Soccer Physiology And Performance, Jaison Lee Wynne
Human Movement Studies & Special Education Theses & Dissertations
The purpose of the study was to measure the effects of an acute pre-competition high-carbohydrate (HCHO) meal versus a mixed-macronutrient (MM) meal on physiology, perceptual responses, and performance in 15 division I female collegiate soccer players. Being there are conjectural advantages to pre-exercise meals higher in fiber, fat, and protein, this study was conducted to evaluate the physiological and perceptual effects of pre-competition MM meals. This study used a randomized, investigator-blinded, crossover design involving two dietary interventions – HCHO and MM meals – that were consumed four hours prior to two separate intra-squad soccer scrimmages. Assessments included running metrics via …
Targeting The Pin Domain Of Type Ii Toxins Is A Novel Approach To Treat Infections Caused By Nontypeable Haemophilus Influenzae,
2019
Old Dominion University
Targeting The Pin Domain Of Type Ii Toxins Is A Novel Approach To Treat Infections Caused By Nontypeable Haemophilus Influenzae, Ashley Lynne Molinaro
Biomedical Sciences Theses & Dissertations
Toxin-antitoxin (TA) gene pairs have been identified in nearly all bacterial genomes sequenced to date and are thought to facilitate persistence and antibiotic tolerance. TA loci are classified into various types based upon the characteristics of their antitoxins, with those in type II expressing proteic antitoxins. Many toxins from type II modules are ribonucleases that maintain a PilT N-terminus (PIN) domain containing conserved amino acids considered essential for activity. The vapBC (virulence associated protein) TA system is the largest subfamily in this class and has been linked to pathogenesis of nontypeable Haemophilus influenzae (NTHi). This dissertation presents three studies investigating …
Tracing Nutrient Sources To Lipid Production In Insects Using Stable Isotope (Δ13c, Δ2h) Tracers: Implications For Nutritional Physiology Of Migratory Species.,
2019
The University of Western Ontario
Tracing Nutrient Sources To Lipid Production In Insects Using Stable Isotope (Δ13c, Δ2h) Tracers: Implications For Nutritional Physiology Of Migratory Species., Libesha Anparasan, Keith A. Hobson
Western Research Forum
Using stable isotope measurements of insect tissues to determine origin and migratory patterns is well established. However, isotopically determining nutritional origins of lipids, the primary fuel of migration, has not been as thoroughly researched. We explored isotopic links between diet and stored lipids in laboratory raised True armyworm moths (Mythimna unipuncta) using δ13C and δ2H measurements. Pupae were randomly separated into four groups (n=20) and fed isotopically distinct nectar, each consisting of a combination of high δ13C (C4 sugar), or low δ13C (C3 sugar) carbohydrate, with high δ2H (deuterium spiked), …
Rage And Sage: Therapeutic Modalities For Copd,
2019
Brigham Young University
Rage And Sage: Therapeutic Modalities For Copd, Paul Reynolds
Journal of Undergraduate Research
Funding available through this MEG award has provided an opportunity for me to meet many academic objectives I’ve determined to be important at BYU. We have been successful in conducting pilot studies that reveal possible roles for SAGEs in ameliorating mechanisms of lung inflammation induced by and cigarette smoke (CS). Despite improvement in personal air quality during the past few decades, the rationale for studying mechanisms leading to adverse health effects remains important. This MEG award specifically provided opportunities for students to conduct meaningful research that led to the observation that alveolar epithelial cells and bronchiolar epithelial cells experience elevated …
Regulation Of Trophoblast Invasion By Pyruvate Kinase Isozyme M2 (Pkm2): Preemptive To Pkm2 Activation Decreases Iugr Symptoms In Mice Exposed To Second-Hand Smoke,
2019
Brigham Young University
Regulation Of Trophoblast Invasion By Pyruvate Kinase Isozyme M2 (Pkm2): Preemptive To Pkm2 Activation Decreases Iugr Symptoms In Mice Exposed To Second-Hand Smoke, Juan Mejia, Juan Arroyo, Ph.D.
Journal of Undergraduate Research
The placenta is an organ composed of highly vascular tissue. It plays an essential role in healthy fetal development as a mediator of gases and nutrients between the mother and fetus. Many complications can occur in this stage of fetal development, such as intrauterine growth restriction (IUGR) when the placenta’s invasive and vascular roles are inhibited. IUGR is an obstetric complication that affects over 10% of the population causing harmful symptoms to the fetus and mother. Physiologically, in the first trimester, high trophoblast cell invasion occurs, and the spiral arteries dilate to create a low resistance, high capacity vessel capable …
Nrf2 In Protecting Against Valproic Acid-¬‐Induced Oxidative Injury During Cellular Differentiation,
2019
Brigham Young University
Nrf2 In Protecting Against Valproic Acid-¬‐Induced Oxidative Injury During Cellular Differentiation, Alyssa Palmer, Jason Hansen
Journal of Undergraduate Research
The causes of the majority of birth defects remain largely unknown today. However, many chemicals known to cause defects are also known inducers of oxidative stress, resulting in faulty cellular function. This suggests an important link between oxidative stress and normal and abnormal embryonic development [1]. Oxidative stress is a phenomenon caused by an imbalance in the production of reactive molecules derived from oxygen called reactive oxygen species (ROS). Although basal levels of ROS are necessary in order for normal cell function to occur, an overabundance of ROS interact with molecules that they shouldn’t, disrupting vital cellular pathways. This is …
Antenatal Exposure To Secondhand Smoke Impacts Growth And Cardiopulmonary Energetics In 4-Week-Old Mice,
2019
Brigham Young University
Antenatal Exposure To Secondhand Smoke Impacts Growth And Cardiopulmonary Energetics In 4-Week-Old Mice, Kaleb Egbert, Paul Reynolds
Journal of Undergraduate Research
Secondhand smoke (SHS) is a well-established cause of respiratory illness in infants and children who live in environments where exposure is common. Recent studies have been performed to examine the potential effects of SHS exposure on fetus’s before they are born1. The data collected suggests that antenatal exposure to SHS impacts cardiovascular and respiratory function through childhood and may even have lifelong ramifications, even if the exposure is terminated shortly after birth. In our study, we sought to determine the impact of SHS exposure during development in the womb would have on 4 week-old mice, or the equivalent of an …
Microbiota Composition Trends Among High Risk Asd Individuals,
2019
Brigham Young University
Microbiota Composition Trends Among High Risk Asd Individuals, Hyrum Eddington, John M. Chaston
Journal of Undergraduate Research
Autism Spectrum Disorder is a neurodevelopmental condition which significantly affects an individual’s social behavior and ability to function in daily living. Although there is a genetic component to the disorder, current research suggests that there are other factors that influence the onset of the disease. One of these factors is the gut microbiota of the individual. Because the human microbiome is a complex system that significantly varies from person to person, finding microbial markers indicative of certain disease can be challenging and problematic. Currently, there are no established protocols that can diagnosis an individual with autism on any criteria save …
Serum Apolipoproteins And Apolipopprotein-Defined Lipoprotein Subclasses: A Hypothesis-Generation Prospective Study Of Cardiovascular Events In Type 1 Diabetes,
2019
University of Nevada, Las Vegas
Serum Apolipoproteins And Apolipopprotein-Defined Lipoprotein Subclasses: A Hypothesis-Generation Prospective Study Of Cardiovascular Events In Type 1 Diabetes, Arpita Basu Phd, Ionut Bebu Phd, Alicia J. Jenkins Md, Julie A. Stoner Phd, Ying Zhang Md; Phd, Richard L. Klein Phd, Maria F. Lopes-Virella Md; Phd, W. Timothy Garvey Md, Matthew J. Budoff Md, Peter Alaupovic Phd, Timothy J. Lyons Md
Kinesiology and Nutrition Sciences Faculty Research
Apolipoproteins and apolipoprotein-defined lipoprotein subclasses have been associated with dyslipidemia and cardiovascular disease (CVD). Our main objective was to define associations of serum apolipoproteins and ADLS with any CVD and major atherosclerotic cardiovascular events (MACE) in a prospective study of T1D. Serum apolipoproteins and ADLS (14 biomarkers in total) were measured in sera (obtained 1997-2000) from a subset (n=465) of the Epidemiology of Diabetes Interventions and Complications (EDIC) cohort. Prospective associations of any CVD (myocardial infarction, stroke, confirmed angina, silent MI, revascularization, or congestive heart failure) and MACE (fatal or nonfatal myocardial infarction or stroke), over 5942 and 6180 patient-years …
Downregulation Of Orco And 5-Htt Alters Nestmate Discrimination In The Subterranean Termite Ondontotermes Formosanus (Shiraki),
2019
Huazhong Agricultural University, China
Downregulation Of Orco And 5-Htt Alters Nestmate Discrimination In The Subterranean Termite Ondontotermes Formosanus (Shiraki), Pengdong Sun, Shuxin Yu, Austin Merchant, Chaoliang Lei, Xuguo Zhou, Qiuying Huang
Entomology Faculty Publications
Nestmate discrimination allows social insects to recognize nestmates from non-nestmates using colony-specific chemosensory cues, which typically evoke aggressive behavior toward non-nestmates. Functional analysis of genes associated with nestmate discrimination has been primarily focused on inter-colonial discrimination in Hymenopterans, and parallel studies in termites, however, are grossly lacking. To fill this gap, we investigated the role of two genes, Orco and 5-HTT, associated with chemosensation and neurotransmission respectively, in nestmate discrimination in a highly eusocial subterranean termite, Odontotermes formosanus (Shiraki). We hypothesized that knocking down of these genes will compromise the nestmate recognition and lead to the antagonistic behavior. To …
Comparison Of Single Leg Squat Variations On Lower Limb Muscle Activation And Center Of Pressure Alterations,
2019
University of St Thomas
Comparison Of Single Leg Squat Variations On Lower Limb Muscle Activation And Center Of Pressure Alterations, Mary Grace Knoll, Mackenzie C. Davidge, Claire E. Wraspir, John A. Korak
International Journal of Exercise Science
International Journal of Exercise Science 12(1): 950-959, 2019. Following anterior cruciate ligament reconstruction, individuals experience inadequate functioning of the quadriceps and decreased muscular strength. Decreased function delays return to physical activity and increases potential for re-injury. While several squat variations exist, a new variation has emerged in rehabilitation. The purpose of this study was to compare muscle activation of the Vastus Lateralis (VL), Vastus Medialis (VM), Rectus Femoris (RF), Gluteus Maximus (GM), and anterior posterior center of pressure (AP displacement) alterations during a single leg squat variation (SLS variation) versus a traditional split squat using electromyography (EMG) in healthy active …
Bone Mineral Density Among Men And Women Aged 35 To 50 Years,
2019
University of Mississippi
Bone Mineral Density Among Men And Women Aged 35 To 50 Years, Martha A. Bass, Ankita Sharma, Vinayak K. Nahar, Stacy Chelf, Brittany Zeller, Linda Pham, M. Allison Ford
Faculty and Student Publications
© 2019 American Osteopathic Association. Context: Osteoporosis is characterized by low bone mineral density (BMD) and has been thought to only be a major health concern for postmenopausal women. However, osteoporosis and its risk factors have been greatly understudied in the middle-aged and male populations. Objective: To assess the likelihood of low BMD and its association with related risk factors in early–middle-aged (defined in this study as 35-50 years) men and women.Methods: Eligible men and women completed a questionnaire assessing calcium intake, hours per week of exercise, and other related risk factors associated with osteoporosis and osteopenia. The primary outcome …
The Association Of Handgrip Strength And Mortality: What Does It Tell Us And What Can We Do With It?,
2019
University of South Florida, Tampa
The Association Of Handgrip Strength And Mortality: What Does It Tell Us And What Can We Do With It?, Samuel L. Buckner, Scott J. Dankel, Zachary W. Bell, Takashi Abe, Jeremy P. Loenneke
Faculty and Student Publications
© Copyright 2019, Mary Ann Liebert, Inc., publishers 2019. The relationship between grip strength and mortality is often used to underscore the importance of resistance exercise in physical activity guidelines. However, grip strength does not appear to appreciably change following traditional resistance training. Thus, grip strength could be considered reflective of strength independent of resistance exercise. If true, grip strength is not necessarily informing us of the importance of resistance exercise as an adult, but potentially highlighting inherent differences between individuals who are stronger at "baseline" compared to their weaker counterpart. The purpose of this article is to discuss: (1) …
