Regulation Of Trophoblast Invasion By Pyruvate Kinase Isozyme M2 (Pkm2): Preemptive To Pkm2 Activation Decreases Iugr Symptoms In Mice Exposed To Second-Hand Smoke,
2019
Brigham Young University
Regulation Of Trophoblast Invasion By Pyruvate Kinase Isozyme M2 (Pkm2): Preemptive To Pkm2 Activation Decreases Iugr Symptoms In Mice Exposed To Second-Hand Smoke, Juan Mejia, Juan Arroyo, Ph.D.
Journal of Undergraduate Research
The placenta is an organ composed of highly vascular tissue. It plays an essential role in healthy fetal development as a mediator of gases and nutrients between the mother and fetus. Many complications can occur in this stage of fetal development, such as intrauterine growth restriction (IUGR) when the placenta’s invasive and vascular roles are inhibited. IUGR is an obstetric complication that affects over 10% of the population causing harmful symptoms to the fetus and mother. Physiologically, in the first trimester, high trophoblast cell invasion occurs, and the spiral arteries dilate to create a low resistance, high capacity vessel capable …
Nrf2 In Protecting Against Valproic Acid-¬‐Induced Oxidative Injury During Cellular Differentiation,
2019
Brigham Young University
Nrf2 In Protecting Against Valproic Acid-¬‐Induced Oxidative Injury During Cellular Differentiation, Alyssa Palmer, Jason Hansen
Journal of Undergraduate Research
The causes of the majority of birth defects remain largely unknown today. However, many chemicals known to cause defects are also known inducers of oxidative stress, resulting in faulty cellular function. This suggests an important link between oxidative stress and normal and abnormal embryonic development [1]. Oxidative stress is a phenomenon caused by an imbalance in the production of reactive molecules derived from oxygen called reactive oxygen species (ROS). Although basal levels of ROS are necessary in order for normal cell function to occur, an overabundance of ROS interact with molecules that they shouldn’t, disrupting vital cellular pathways. This is …
Antenatal Exposure To Secondhand Smoke Impacts Growth And Cardiopulmonary Energetics In 4-Week-Old Mice,
2019
Brigham Young University
Antenatal Exposure To Secondhand Smoke Impacts Growth And Cardiopulmonary Energetics In 4-Week-Old Mice, Kaleb Egbert, Paul Reynolds
Journal of Undergraduate Research
Secondhand smoke (SHS) is a well-established cause of respiratory illness in infants and children who live in environments where exposure is common. Recent studies have been performed to examine the potential effects of SHS exposure on fetus’s before they are born1. The data collected suggests that antenatal exposure to SHS impacts cardiovascular and respiratory function through childhood and may even have lifelong ramifications, even if the exposure is terminated shortly after birth. In our study, we sought to determine the impact of SHS exposure during development in the womb would have on 4 week-old mice, or the equivalent of an …
Microbiota Composition Trends Among High Risk Asd Individuals,
2019
Brigham Young University
Microbiota Composition Trends Among High Risk Asd Individuals, Hyrum Eddington, John M. Chaston
Journal of Undergraduate Research
Autism Spectrum Disorder is a neurodevelopmental condition which significantly affects an individual’s social behavior and ability to function in daily living. Although there is a genetic component to the disorder, current research suggests that there are other factors that influence the onset of the disease. One of these factors is the gut microbiota of the individual. Because the human microbiome is a complex system that significantly varies from person to person, finding microbial markers indicative of certain disease can be challenging and problematic. Currently, there are no established protocols that can diagnosis an individual with autism on any criteria save …
Serum Apolipoproteins And Apolipopprotein-Defined Lipoprotein Subclasses: A Hypothesis-Generation Prospective Study Of Cardiovascular Events In Type 1 Diabetes,
2019
University of Nevada, Las Vegas
Serum Apolipoproteins And Apolipopprotein-Defined Lipoprotein Subclasses: A Hypothesis-Generation Prospective Study Of Cardiovascular Events In Type 1 Diabetes, Arpita Basu Phd, Ionut Bebu Phd, Alicia J. Jenkins Md, Julie A. Stoner Phd, Ying Zhang Md; Phd, Richard L. Klein Phd, Maria F. Lopes-Virella Md; Phd, W. Timothy Garvey Md, Matthew J. Budoff Md, Peter Alaupovic Phd, Timothy J. Lyons Md
Kinesiology and Nutrition Sciences Faculty Research
Apolipoproteins and apolipoprotein-defined lipoprotein subclasses have been associated with dyslipidemia and cardiovascular disease (CVD). Our main objective was to define associations of serum apolipoproteins and ADLS with any CVD and major atherosclerotic cardiovascular events (MACE) in a prospective study of T1D. Serum apolipoproteins and ADLS (14 biomarkers in total) were measured in sera (obtained 1997-2000) from a subset (n=465) of the Epidemiology of Diabetes Interventions and Complications (EDIC) cohort. Prospective associations of any CVD (myocardial infarction, stroke, confirmed angina, silent MI, revascularization, or congestive heart failure) and MACE (fatal or nonfatal myocardial infarction or stroke), over 5942 and 6180 patient-years …
Downregulation Of Orco And 5-Htt Alters Nestmate Discrimination In The Subterranean Termite Ondontotermes Formosanus (Shiraki),
2019
Huazhong Agricultural University, China
Downregulation Of Orco And 5-Htt Alters Nestmate Discrimination In The Subterranean Termite Ondontotermes Formosanus (Shiraki), Pengdong Sun, Shuxin Yu, Austin Merchant, Chaoliang Lei, Xuguo Zhou, Qiuying Huang
Entomology Faculty Publications
Nestmate discrimination allows social insects to recognize nestmates from non-nestmates using colony-specific chemosensory cues, which typically evoke aggressive behavior toward non-nestmates. Functional analysis of genes associated with nestmate discrimination has been primarily focused on inter-colonial discrimination in Hymenopterans, and parallel studies in termites, however, are grossly lacking. To fill this gap, we investigated the role of two genes, Orco and 5-HTT, associated with chemosensation and neurotransmission respectively, in nestmate discrimination in a highly eusocial subterranean termite, Odontotermes formosanus (Shiraki). We hypothesized that knocking down of these genes will compromise the nestmate recognition and lead to the antagonistic behavior. To …
Comparison Of Single Leg Squat Variations On Lower Limb Muscle Activation And Center Of Pressure Alterations,
2019
University of St Thomas
Comparison Of Single Leg Squat Variations On Lower Limb Muscle Activation And Center Of Pressure Alterations, Mary Grace Knoll, Mackenzie C. Davidge, Claire E. Wraspir, John A. Korak
International Journal of Exercise Science
International Journal of Exercise Science 12(1): 950-959, 2019. Following anterior cruciate ligament reconstruction, individuals experience inadequate functioning of the quadriceps and decreased muscular strength. Decreased function delays return to physical activity and increases potential for re-injury. While several squat variations exist, a new variation has emerged in rehabilitation. The purpose of this study was to compare muscle activation of the Vastus Lateralis (VL), Vastus Medialis (VM), Rectus Femoris (RF), Gluteus Maximus (GM), and anterior posterior center of pressure (AP displacement) alterations during a single leg squat variation (SLS variation) versus a traditional split squat using electromyography (EMG) in healthy active …
Bone Mineral Density Among Men And Women Aged 35 To 50 Years,
2019
University of Mississippi
Bone Mineral Density Among Men And Women Aged 35 To 50 Years, Martha A. Bass, Ankita Sharma, Vinayak K. Nahar, Stacy Chelf, Brittany Zeller, Linda Pham, M. Allison Ford
Faculty and Student Publications
© 2019 American Osteopathic Association. Context: Osteoporosis is characterized by low bone mineral density (BMD) and has been thought to only be a major health concern for postmenopausal women. However, osteoporosis and its risk factors have been greatly understudied in the middle-aged and male populations. Objective: To assess the likelihood of low BMD and its association with related risk factors in early–middle-aged (defined in this study as 35-50 years) men and women.Methods: Eligible men and women completed a questionnaire assessing calcium intake, hours per week of exercise, and other related risk factors associated with osteoporosis and osteopenia. The primary outcome …
The Association Of Handgrip Strength And Mortality: What Does It Tell Us And What Can We Do With It?,
2019
University of South Florida, Tampa
The Association Of Handgrip Strength And Mortality: What Does It Tell Us And What Can We Do With It?, Samuel L. Buckner, Scott J. Dankel, Zachary W. Bell, Takashi Abe, Jeremy P. Loenneke
Faculty and Student Publications
© Copyright 2019, Mary Ann Liebert, Inc., publishers 2019. The relationship between grip strength and mortality is often used to underscore the importance of resistance exercise in physical activity guidelines. However, grip strength does not appear to appreciably change following traditional resistance training. Thus, grip strength could be considered reflective of strength independent of resistance exercise. If true, grip strength is not necessarily informing us of the importance of resistance exercise as an adult, but potentially highlighting inherent differences between individuals who are stronger at "baseline" compared to their weaker counterpart. The purpose of this article is to discuss: (1) …
Anti-Human Cd9 Antibody Fab Fragment Impairs The Internalization Of Extracellular Vesicles And The Nuclear Transfer Of Their Cargo Proteins.,
2019
Touro University Nevada
Anti-Human Cd9 Antibody Fab Fragment Impairs The Internalization Of Extracellular Vesicles And The Nuclear Transfer Of Their Cargo Proteins., Mark F. Santos, Germana Rappa, Jana Karbanová, Cheryl Vanier, Chikao Morimoto, Denis Corbeil, Aurelio Lorico
College of Osteopathic Medicine (TUN) Publications and Research
The intercellular communication mediated by extracellular vesicles (EVs) has gained international interest during the last decade. Interfering with the mechanisms regulating this cellular process might find application particularly in oncology where cancer cell-derived EVs play a role in tumour microenvironment transformation. Although several mechanisms were ascribed to explain the internalization of EVs, little is our knowledge about the fate of their cargos, which are crucial to mediate their function. We recently demonstrated a new intracellular pathway in which a fraction of endocytosed EV-associated proteins is transported into the nucleoplasm of the host cell via a subpopulation of late endosomes penetrating …
The Proteomic Response Of Northern Elephant Seal (Mirounga Angustirostris) Pups To Physiological Stress During Development,
2019
California Polytechnic State University, San Luis Obispo
The Proteomic Response Of Northern Elephant Seal (Mirounga Angustirostris) Pups To Physiological Stress During Development, Melissa P. Voisinet
Master's Theses
Background: Northern elephant seals transition from terrestrial nursing pups to pelagic foraging juveniles in a short period of just 8-12 weeks. During the post-weaning period, pups rely solely on the energy reserves gained during nursing for their caloric demands and water supply. The prolonged absence of food after weaning is the first of many fasts for which the seals have evolved adaptations such as decreased urine production and increased blubber reserves. The stressors experienced from learning to dive for the first time are also stressors that they will experience frequently as an adult and for which they have evolved adaptations. …
Effects Of Life-Long Wheel Running Behavior On Plantar Flexor Contractile Properties,
2019
California State University - San Bernardino
Effects Of Life-Long Wheel Running Behavior On Plantar Flexor Contractile Properties, Alexander Nicholas Beechko
Electronic Theses, Projects, and Dissertations
Aging in skeletal muscle is characterized by a loss in muscular performance. This is in part related to the direct loss of muscle mass due to senescence, known as sarcopenia. With age, skeletal muscles lose force production, contractile speed, and power production. The force velocity relationship of muscle is a product of force production and contraction speed, both of which decline with age; however, the mechanisms and trajectory of this decline are not well understood. Exercise has positive effects on muscle, and thus may assist in maintaining performance in old age. However, few long-term studies have been performed to examine …
The Consequences Of Cold Water Immersion: Impacts And Treatment,
2019
Water Safety 4 All
The Consequences Of Cold Water Immersion: Impacts And Treatment, Patrick J. Buck Ph.D., Commander William Roberts, Commander Ken Minehane
International Journal of Aquatic Research and Education
This paper documents a demonstration project conducted by the authors under the auspices of the Irish Naval service. It explores and describes in detail the consequences that cold water immersion can have on the human body. Further, this study investigates post immersion treatment and survival challenges and proposes appropriate casualty care regimes with specific focus on ‘post rescue collapse’ and ‘afterdrop.’ Observations of individual differences in response are reported.
Phase- Specific Changes In Rate Of Force Development And Muscle Morphology Throughout A Block Periodized Training Cycle In Weightlifters,
2019
East Tennessee State University
Phase- Specific Changes In Rate Of Force Development And Muscle Morphology Throughout A Block Periodized Training Cycle In Weightlifters, Dylan G. Suarez, Satoshi Mizuguchi, William Guy Hornsby, Aaron J. Cunanan, Donald J. Marsh, Michael H. Stone
ETSU Faculty Works
The purpose of this study was to investigate the kinetic and morphological adaptations that occur during distinct phases of a block periodized training cycle in weightlifters. Athlete monitoring data from nine experienced collegiate weightlifters was used. Isometric mid-thigh pull (IMTP) and ultrasonography (US) results were compared to examine the effects of three specific phases of a training cycle leading up to a competition. During the high volume strength-endurance phase (SE) small depressions in rate of force development (RFD) but statistically significant (p ≤ 0.05) increases in vastus lateralis cross-sectional area (CSA), and body mass (BM) were observed. The lower volume …
Stimulatory Effect Of 5-Hydroxytryptamine (5-Ht) On Rat Capsaicin-Sensitive Lung Vagal Sensory Neurons Via Activation Of 5-Ht3 Receptors,
2019
Taipei Medical University, Taiwan
Stimulatory Effect Of 5-Hydroxytryptamine (5-Ht) On Rat Capsaicin-Sensitive Lung Vagal Sensory Neurons Via Activation Of 5-Ht3 Receptors, Chun-Chun Hsu, Ting Ruan, Lu-Yuan Lee, You Shuei Lin
Physiology Faculty Publications
5-hydroxytryptamine (5-HT) is an inflammatory mediator known to be released in lung. Capsaicin-sensitive lung vagal (CSLV) afferents function as a primary sensor for detecting chemical stimuli and produce consequent reflexes during lung inflammation. To characterize the effect of 5-HT on CSLV afferents, responses of cardiorespiratory reflexes and single-unit C-fiber afferents to right-atrial injections of 5-HT were investigated in anesthetized Sprague-Dawley rats. Bolus injection of 5-HT (8 μg/kg) caused an immediate augmented breath and apnea, accompanied by hypotension and bradycardia. These initial responses were then followed by a brief pressor response and a more sustained depressor response. After a perineural treatment …
Time-Course Of Changes In Physiological, Psychological And Performance Markers Following A Functional-Fitness Competition,
2019
Programa de Pós-Graduação em Educação Física, Universidade Católica de Brasília, Brasília, Distrito Federal, Brasil.
Time-Course Of Changes In Physiological, Psychological And Performance Markers Following A Functional-Fitness Competition, Ramires Alsamir Tibana, Jonato Prestes, Nuno Frade Sousa, Vinicius C. De Souza, Otávio De Tolêdo Nóbrega, Matheus Baffi, Carlos Ernesto S. Ferreira, Gabriel Veloso Cunha, James W. Navalta, Joice Cristina Dos Santos Trombeta, Cláudia R. Cavaglieri, Fabrício Azevedo Voltarelli
International Journal of Exercise Science
International Journal of Exercise Science 12(3): 904-918, 2019. Functional Fitness Training (FFT) programs are characterized by utilizing a high volume of training and using a variety of high intensity exercises. While FFT are growing in the number of practitioners and popularity, the relationship between physiological biomarkers and subjective scales in the specific context of FFT has not yet been evaluated in the literature. The purpose of the present study was to monitor the time-course response of cytokines (IL-10 and 1L-1b), immune variables (C-reactive protein -CRP and immunoglobulin A-IgA), hormonal milieu (cortisol-C, total testosterone-TT, free testosterone-FT and testosterone/cortisol-T/C ratio), creatine kinase-CK, …
Breathing Limited Air Situational Training Masks (Blastmask) Versus Self-Contained Breathing Apparatus (Scba) For Firefighters: A Pilot Study,
2019
University of Mississippi (Ole Miss)
Breathing Limited Air Situational Training Masks (Blastmask) Versus Self-Contained Breathing Apparatus (Scba) For Firefighters: A Pilot Study, Thomas Andre, Silvio Valladao, Shana Walsh, Derek Reisbeck
International Journal of Exercise Science
International Journal of Exercise Science 12(6): 941-949, 2019. Despite maintaining high levels of fitness, firefighters’ performance may be negatively impacted by the use of a Self-Contained Breathing Apparatus (SCBA), an essential piece of safety equipment worn during structural firefighting. Routine training with SCBAs can be cost-prohibitive and inefficient. The Breathing Limited Air Situational Training Mask (BlastMask) was developed as a training aid used to simulate the SCBA. The purpose of this study was to examine physiological and perceptual responses elicited by firefighters during steady state exercise when using the BlastMask compared to the SCBA. Current staff male firefighters (n …
The Impact Of Physical Activity And Sleep On Physiology Following A Mtbi,
2019
University of Oregon, Eugene, OR
The Impact Of Physical Activity And Sleep On Physiology Following A Mtbi, Garrett L. Lindsey, Alia Yasen, Anita Christie
International Journal of Exercise Science
International Journal of Exercise Science 12(3): 919-931, 2019. A mild traumatic brain injury (mTBI) is a common injury that happens to people across a range of lifestyles. Rest has been regarded as the most effective remedy to restore impaired physiological functions in those who have experienced this kind of injury. However, recent data suggests that a gradual increase in physical activity post-injury can lead to quicker recovery from negative symptoms. The impact of physical activity on physiologic recovery is not completely understood and the purpose of this study was to better understand how physical activity and sleep influence physiological outcomes …
Comparison Of College Student Hypertension Prevalence Between The Jnc7 And Acc/Aha Diagnostic Criteria,
2019
Pennsylvania State University
Comparison Of College Student Hypertension Prevalence Between The Jnc7 And Acc/Aha Diagnostic Criteria, Kadiatu Kamara, Oliver W A Wilson, Zack Papalia, Melissa Bopp, C M. Bopp
International Journal of Exercise Science
International Journal of Exercise Science 12(3): 898-903, 2019. Hypertension is highly prevalent and associated with non-communicable diseases and increased premature mortality risk. However, the impact of the new hypertension diagnostic criteria on the prevalence of hypertension diagnoses has yet to be examined among college students. The purpose of this study was to compare the prevalence of hypertension between the JNC7 and the ACC/AHA hypertension diagnostic criteria among college students. The blood pressure of 5,945 college students was assessed, and chi-square tests for independence examined differences between JNC7 and ACC/AHA criteria. The mean age of participants was 21.30 ± 1.05 years, …
The Validity Of Resting Metabolic Rate (Rmr)-Prediction Equations And Reliability Of Measured Rmr In Female Athletes,
2019
University of Waikato
The Validity Of Resting Metabolic Rate (Rmr)-Prediction Equations And Reliability Of Measured Rmr In Female Athletes, Kelsi Mackay, Katie Schofield, Stacy Sims, Joseph Mcquillan, Matthew Driller
International Journal of Exercise Science
International Journal of Exercise Science 12(2): 886-897, 2019. The aim of the current study was to; 1) assess the test-retest reliability of an indirect calorimetry analyzer (Parvo Medics TrueOne), and 2) compare measured RMR with three RMR-predictive (pRMR) equations in female athletes. In part one, 12 recreationally-exercising women (mean ± SD; age 27.5 ± 12.3 y) performed two RMR assessments, on separate days, utilising the Parvo Medics TrueOne analyser. In part two, 25 recreationally-exercising women to sub-elite athletes (mean ± SD; age 30.1 ± 10.2 y) underwent an RMR assessment using the Parvo Medics TrueOne analyser, which was compared to …
