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Creativity, Laterality And Critical State Balance In Learning, Jenny Rock, Asher Flatt 2017 University of Otago

Creativity, Laterality And Critical State Balance In Learning, Jenny Rock, Asher Flatt

The STEAM Journal

Understanding the intersecting cognitive pathways that are integral to ways of thinking, creating and functioning in both art and science is an important grounding for a STEAM educational approach. We combine three divergent concepts, including creativity, hemisphere laterality, and critical state theory, to argue for a more balanced approach to learning as part of a modern meaning-centered education in STEAM. Reviewing the concept of hemisphere laterality, or how the two hemispheres of our brain have different (though not disconnected) ways of processing sensory information, we note how these two means of interpreting the world have become unbalanced in traditional modes ...


A Role For Δ-Catenin In Synaptic Regulation, Li Yuan 2017 University of Nebraska Medical Center

A Role For Δ-Catenin In Synaptic Regulation, Li Yuan

Theses & Dissertations

The cadherin-catenin complex regulates cell-cell adhesion and signal transduction in epithelial cells. It is becoming increasingly evident that components of the complex regulate various aspects of neuronal architecture and function. δ-catenin is a cytosolic component of the cadherin-catenin complex and is predominantly expressed in the central nervous system. Loss of CTNND2, which encodes δ-catenin, is associated with intellectual disability and mutations in CTNND2 have been identified in autism, suggesting that δ-catenin is a critical component of the molecular machinery underlying neural circuit function. We have previously demonstrated that δ-catenin regulates multiple aspects of synaptic and dendritic development, including dendritic arborization ...


Type 2 Neural Progenitor Cell Activation Drives Reactive Neurogenesis After Binge-Like Alcohol Exposure In Adolescent Male Rats, Chelsea Rhea Geil Nickell, Hui Peng, Dayna M. Hayes, Kevin Y. Chen, Justin A. McClain, Kimberly Nixon 2017 University of Kentucky

Type 2 Neural Progenitor Cell Activation Drives Reactive Neurogenesis After Binge-Like Alcohol Exposure In Adolescent Male Rats, Chelsea Rhea Geil Nickell, Hui Peng, Dayna M. Hayes, Kevin Y. Chen, Justin A. Mcclain, Kimberly Nixon

Pharmaceutical Sciences Faculty Publications

Excessive alcohol consumption during adolescence remains a significant health concern as alcohol drinking during adolescence increases the likelihood of an alcohol use disorder in adulthood by fourfold. Binge drinking in adolescence is a particular problem as binge-pattern consumption is the biggest predictor of neurodegeneration from alcohol and adolescents are particularly susceptible to the damaging effects of alcohol. The adolescent hippocampus, in particular, is highly susceptible to alcohol-induced structural and functional effects, including volume and neuron loss. However, hippocampal structure and function may recover with abstinence and, like in adults, a reactive burst in hippocampal neurogenesis in abstinence may contribute to ...


Preschoolers And Pandas Making Friends: A Journey About Healing From Brain Injury, Barbara Anne Doucette 2017 State University of New York College at Buffalo - Buffalo State College

Preschoolers And Pandas Making Friends: A Journey About Healing From Brain Injury, Barbara Anne Doucette

Museum Studies Projects

Preschoolers that have obtained Non-Accidental Injury (NAI) from familial child abuse are in need of having a unique place for neurorehabilitation in correlation with traditional therapies. My thesis project suggests adding an exhibit annex to an existing giant panda exhibit that will give preschoolers an opportunity to help develop new neuropathways when exposed to mediation and creative activities. Meditation and creative activities are being examined by neuroscientists as an aid in neuroplasticity after brain injury. This thesis reviews the neurotypical preschooler’s milestones and the playful means by which they are achieved. Conjoining the contemporary museums’ and zoological gardens’ outreach ...


Jennifer Maurer Phd Thesis.Pdf, Jennifer Maurer 2017 University of Massachusetts Medical School

Jennifer Maurer Phd Thesis.Pdf, Jennifer Maurer

Jennifer Maurer


Signaling cascades, such as the extracellular signal-regulated kinase (ERK) pathway, play vital roles in early vertebrate development. Signals through these pathways are initiated by a growth factor or hormone, are transduced through a kinase cascade, and result in the expression of specific downstream genes that promote cellular proliferation, growth, or differentiation.Tight regulation of these signals is provided by positive or negative modulators at varying levels in the pathway, and is required for proper development and function. Two members of the dual-specificity phosphatase (Dusp) family, dusp6 and dusp2, are believed to be negative regulators of the ERK pathway and are ...


The Role Of Sleep On Inhibitory Control In Young Children With Attention-Deficit/Hyperactivity Disorder (Adhd), Amanda Cremone 2017 University of Massachusetts Amherst

The Role Of Sleep On Inhibitory Control In Young Children With Attention-Deficit/Hyperactivity Disorder (Adhd), Amanda Cremone

Doctoral Dissertations

Alongside the hallmark symptoms of hyperactivity and inattention, children with attention-deficit/hyperactivity disorder (ADHD) often report having sleep problems. Although sleep deficits are consistently found when evaluated subjectively, impairments in sleep physiology are inconsistent. Compared to typically developing (TD) children, children with ADHD have greater spectral power in the delta (0.5 to 4 Hz) and theta frequency bands (4 to 7 Hz). Moreover, activity in these bands is differentially related to cognitive outcomes in ADHD and TD populations. As such, this dissertation sought to examine relations between sleep physiology and inhibitory control, a primary deficit of ADHD, in young ...


The Secreted Neurotrophin Spatzle 3 Promotes Glial Morphogenesis And Supports Neuronal Survival And Function, Jaeda C. Coutinho-Budd, Amy E. Sheehan, Marc R. Freeman 2017 University of Massachusetts Medical School

The Secreted Neurotrophin Spatzle 3 Promotes Glial Morphogenesis And Supports Neuronal Survival And Function, Jaeda C. Coutinho-Budd, Amy E. Sheehan, Marc R. Freeman

Neurobiology Publications

Most glial functions depend on establishing intimate morphological relationships with neurons. Significant progress has been made in understanding neuron-glia signaling at synaptic and axonal contacts, but how glia support neuronal cell bodies is unclear. Here we explored the growth and functions of Drosophila cortex glia (which associate almost exclusively with neuronal cell bodies) to understand glia-soma interactions. We show that cortex glia tile with one another and with astrocytes to establish unique central nervous system (CNS) spatial domains that actively restrict glial growth, and selective ablation of cortex glia causes animal lethality. In an RNAi-based screen, we identified alphaSNAP (soluble ...


Regulation Of The Fgf/Erk Signaling Pathway: Roles In Zebrafish Gametogenesis And Embryogenesis, Jennifer M. Maurer 2017 University of Massachusetts Medical School

Regulation Of The Fgf/Erk Signaling Pathway: Roles In Zebrafish Gametogenesis And Embryogenesis, Jennifer M. Maurer

GSBS Dissertations and Theses

Signaling cascades, such as the extracellular signal-regulated kinase (ERK) pathway, play vital roles in early vertebrate development. Signals through these pathways are initiated by a growth factor or hormone, are transduced through a kinase cascade, and result in the expression of specific downstream genes that promote cellular proliferation, growth, or differentiation. Tight regulation of these signals is provided by positive or negative modulators at varying levels in the pathway, and is required for proper development and function. Two members of the dual-specificity phosphatase (Dusp) family, dusp6 and dusp2, are believed to be negative regulators of the ERK pathway and are ...


Role Of The Swi/Snf Chromatin Remodelling Complex In The Axon Development Of The Drosophila Mushroom Body, Melissa C. Chubak 2017 The University of Western Ontario

Role Of The Swi/Snf Chromatin Remodelling Complex In The Axon Development Of The Drosophila Mushroom Body, Melissa C. Chubak

Electronic Thesis and Dissertation Repository

The SWI/SNF complex is an evolutionarily conserved ATP-dependent chromatin remodelling complex that has been implicated in the aetiology of intellectual disability (ID). Among the dominant ID genes, the SWI/SNF complex is the most highly enriched protein complex. However, its role in the nervous system is not yet understood. I systematically investigated the role of this complex in the development of the Drosophila mushroom body (MB), a complex brain structure required for learning and memory. Gross MB morphology was assessed using confocal microscopy to identify morphological defects following RNAi-mediated knockdown of the 15 individual SWI/SNF genes in the ...


Amelioration Of Prenatal Alcohol Effects By Environmental Enrichment In A Mouse Model Of Fasd, Aniruddho Chokroborty-Hoque 2017 The University of Western Ontario

Amelioration Of Prenatal Alcohol Effects By Environmental Enrichment In A Mouse Model Of Fasd, Aniruddho Chokroborty-Hoque

Electronic Thesis and Dissertation Repository

Maternal alcohol consumption during pregnancy results in a spectrum of behavioural and cognitive deficits collectively known as Fetal Alcohol Spectrum Disorders (FASD). Currently, little is know about if and how the external environment may modulate these deficits. I have used C57BL/6 mice to study this interaction between prenatal alcohol exposure and the postnatal environment. Alcohol exposure during synaptogenesis produces high levels of anxiety-like traits and decreased memory performance. Alcohol-exposed mice (and matched unexposed controls) were put in 'environmentally-enriched' conditions of voluntary exercise, physical activities and cognitive stimulation to ascertain the effects of a positive postnatal environment. The results show ...


Early Life Immune And Physical Stress Directly Influences Anxiety-Like Behaviour In Adolescent Rats: Examining Sex Differences, Jordan M. Ward 2017 The University of Western Ontario

Early Life Immune And Physical Stress Directly Influences Anxiety-Like Behaviour In Adolescent Rats: Examining Sex Differences, Jordan M. Ward

Electronic Thesis and Dissertation Repository

This thesis examined the effects of neonatal acute immune activation with the endotoxin, lipopolysaccharide (LPS) on postnatal days 3 and 5 on adolescent anxiety-like behaviour in rats before and after a stress period. Previous research has shown that adults rats exposed to LPS during the neonatal stage show anxiety-like behaviour following a period of stress. This thesis investigated this effect in adolescence. The present results showed significantly higher anxiety-like behaviour in saline controls, and a potential neuroprotective effect of low dose LPS (15 µg/kg) contrary to what was reported in adult rats. As well, a phase of stressful, aversive ...


Intergenerational Effects Of Nicotine In An Animal Model Of Paternal Nicotine Exposure, Markus Parzival Vallaster 2017 University of Massachusetts Medical School

Intergenerational Effects Of Nicotine In An Animal Model Of Paternal Nicotine Exposure, Markus Parzival Vallaster

GSBS Dissertations and Theses

Environmental conditions imposed onto organisms during certain phases of their life cycles such as embryogenesis or puberty can not only impact the organisms’ own health, but also affect subsequent generations. The underlying mechanisms causing intergenerational phenotypes are not encoded in the genome, but the result of reversible epigenetic modifications. This work investigates in a mouse model the impact of paternal nicotine exposure on the next generation regarding addictive behavior modulation, metabolic changes, and molecular mechanisms. It provides evidence that male offspring from nicotine-exposed fathers (NIC offspring) is more resistant to lethal doses of nicotine. This phenotype is gender-specific and depends ...


Molecular And Pathological Analyses Of Three New Mouse Mutations That Affect Ear Development And Function, Cong Tian 2017 University of Maine

Molecular And Pathological Analyses Of Three New Mouse Mutations That Affect Ear Development And Function, Cong Tian

Electronic Theses and Dissertations

This dissertation presents three new mouse models that help to study the functions of Enpp1, Atp6v1b1, and Tbx1 for ear development and function. asj (aging with stiffened joints) carries a missense mutation in the mouse Enpp1 gene. Enpp1 encodes the enzyme ENPP1 that regulate soft-tissue calcification and bone mineralization, and is associated with generalized arterial calcification of infancy and hypophosphatemic rickets in human patients. asj mutant mice show severe middle ear infection and tissue calcification, which provide a new mouse model to study otitis media and tympanoscleorosis. Atp6v1b1 encode a protein that is a subunit of the V-ATPase pump, which ...


Mindfulness And Law Enforcement: An Effective Approach To Implementing Mindfulness For First Responders, Gina White 2017 Lesley University

Mindfulness And Law Enforcement: An Effective Approach To Implementing Mindfulness For First Responders, Gina White

Mindfulness Studies Theses

An increasing number of studies show that people employed as first responders in high trauma service jobs tend to experience a high level of stress, at work and after hours. Studies suggest that constant exposure to job related stress leads to both physical and mental dysregulation. This study looks at the effects of implementing mindfulness tools and techniques to those working in law enforcement. Other works on this topic report mindfulness as a successful tool to increase wellbeing to a broad spectrum of populations. The methodology used in this study was designed specifically for first responders. The data findings were ...


Understanding The Structure Of Amyloid Fibrils Using Atomic Force Microscopy (Afm) To Design New Therapeutic Strategies For Neurodegenerative Diseases, Sumeyra Gokalp, Michelle Foster 2017 University of Massachusetts Boston

Understanding The Structure Of Amyloid Fibrils Using Atomic Force Microscopy (Afm) To Design New Therapeutic Strategies For Neurodegenerative Diseases, Sumeyra Gokalp, Michelle Foster

UMass Center for Clinical and Translational Science Research Retreat

Amyloid fibrils are misfolded proteins that are irreversible once they are formed. In human beings, there are different kinds of proteins that form into amyloid fibrils and are associated with several degenerative diseases. For example, insulin, Huntington, Amyloid β-42 and α- synuclein proteins are linked with Type-2 Diabetes, Huntington’s, Alzheimer’s and Parkinson’s diseases, respectively. The mechanism for the misfolding and creation of the fibrils is thought to be the same for all of these proteins. Hen Egg White Lysozyme (HEWL) is a low-cost and widely recognized model protein to work with to help us understand the mechanisms ...


Therapy Dogs And The Impact On Employees In The Pediatric Medical Setting, Laine Foith 2017 Abilene Christian University

Therapy Dogs And The Impact On Employees In The Pediatric Medical Setting, Laine Foith

Electronic Theses and Dissertations

More than 40% of nurses reported experiencing significant burnout. Burnout is characterized by disengagement, cynicism, negative views of personal accomplishment and ability, and emotional exhaustion. The healthcare providers that experience burnout can possibly expect a decrease in ability to recognize/report errors, increase of negative feelings toward the patient, and decrease levels of patient satisfaction (Ernest, 2014). One of the ways Schub (2015) suggested to regulate burnout for employees was to provide psychosocial support to colleagues to reduce stress. This study is one of the first attempts to bridge the gap between the unknown correlation between qualitative and quantitative benefits ...


Complementary Multimodal Compartments In The Developing Inferior Colliculus, Roxana Behrooz 2017 James Madison University

Complementary Multimodal Compartments In The Developing Inferior Colliculus, Roxana Behrooz

Senior Honors Projects, 2010-2019

The auditory system is responsible for detecting, encoding, and deciphering hearing. The inferior colliculus (IC) is a major relay hub situated in the midbrain, that is subdivided into a central nucleus, and surrounding dorsal and lateral cortices. The central nucleus of the inferior colliculus (CNIC) is organized tonotopically based on a frequency gradient and strictly processes auditory information. In contrast, recent studies show that the lateral cortex of the inferior colliculus (LCIC) is actually multimodal, receiving inputs from not just auditory sources, but also somatosensory and visual structures. The precise organization of patterned inputs to the LCIC and their development ...


Neurostructural Organization And Neocortical Projecting Neuron Distribution In A Mouse Model Of Timothy Syndrome-Mediated Autism Spectrum Disorder, Aiden L. Ford 2017 University of Connecticut - Storrs

Neurostructural Organization And Neocortical Projecting Neuron Distribution In A Mouse Model Of Timothy Syndrome-Mediated Autism Spectrum Disorder, Aiden L. Ford

Honors Scholar Theses

Aims: This study investigates the nuanced effect of the CACNA1C mutation on neurocognition and neurodevelopment via an extended study of the Timothy Syndrome (TS) mediated Autism Spectrum Disorder (ASD) mouse model – TS2-neo. It includes: (1) an expanded assessment of the TS2-neo behavioral phenotype, and (2) a comprehensive histological analysis of cortical structural and laminar features.

Methods: 24 age-matched male mice – 12 TS2-neo (B6.Cg-Cacna1ctm2Itl, knock-in G406R mutation), 12 WT (C57BL/6J) – were tested on paradigms examining motor, socio-communicative and cognitive abilities. Neural tissue was processed for either volumetric analysis through Nissl stain (8 TS2-neo, 8 WT) or immunohistochemical ...


Acute Intoxication Affects Pavlovian Conditioning In Zebrafish (Danio Rerio), Fabiana T. Arrazola 2017 College of William and Mary

Acute Intoxication Affects Pavlovian Conditioning In Zebrafish (Danio Rerio), Fabiana T. Arrazola

Undergraduate Honors Theses

The study explored the effects of alcohol on short-term memory in zebrafish. Memory impairments are pervasive in several conditions resulting from long-term alcohol exposure, for example Fetal Alcohol Syndrome (FAS) and Wernicke-Korsakoff Syndrome. Most of the memory effects observed link to abnormal functioning of the hippocampus and frontal lobes. The effects of alcohol on memory are that it acts as a general central nervous system depressant, but it also affects some areas of the brain more than others. In our laboratory we use two variations of Pavlovian conditioning: Delay and Trace, to examine learning and memory with acute alcohol intoxication ...


Modeling 3d Retinogenesis In Mouse Embryonic Stem Cells Following Crispr-Mediated Crx Knockdown, Pooja Prasad 2017 Dominican University of California

Modeling 3d Retinogenesis In Mouse Embryonic Stem Cells Following Crispr-Mediated Crx Knockdown, Pooja Prasad

Graduate Master's Theses, Capstones, and Culminating Projects

An emerging technology known as three-dimensional (3D) tissue engineering has allowed scientists to mimic tissues found in vivo. Previous studies indicate that it is possible to differentiate dissociated mouse embryonic stem cells (mESCs) into 3D retinal tissues in vitro (Bertacchi, 2015; Eiraku, 2012). The newly differentiated retinal tissues are said to encompass all of the major components found in retinal tissues. The generation of in vitro 3D tissues holds great potential in terms of patient-specific disease modeling. Although various diseases have been well-studied in animal models, there are limitations with regards to patient-specificity. The generation of animal models to study ...


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