Developmental Neuroscience Commons^™

Investigation Of Mirnas Expression In A Citron-Kinase Mutant Model Of Microcephaly, Shan Parikh

Master's Theses

Mutation of Citron-Kinase (Cit-K) in rodents causes substantial reductions in the number of neurons generated in the CNS and results in a primary microcephaly-like phenotype. Evidence from drosophila genetics has further established a genetic link between Cit-K and a protein Argonaut 1 (AGO1), which is required for proper functioning of the miRNA machinery (2). Experiments characterizing the role of miRNAs in the developing cortex demonstrate the requirement of miRNAs for differentiation of neural progenitor cells starting at embryonic day 12.5 (3). Together, this evidence links the role of miRNAs to neurogenesis and thus this relationship warrants further investigation. Here miRNA …

Embraining Culture: Leaky Minds And Spongy Brains, Julian Kiverstein, Mirko Farina

Mirko Farina

We offer an argument for the extended mind based on considerations from brain development. We argue that our brains develop to function in partnership with cognitive resources located in our external environments. Through our cultural upbringing we are trained to use artefacts in problem solving that become factored into the cognitive routines our brains support. Our brains literally grow to work in close partnership with resources we regularly and reliably interact with. We take this argument to be in line with complementarity or “second-wave” defences of the extended mind that stress the functional differences between biological elements and external, environmental …

Dissociable And Dynamic Components Of Cognitive Control: A Developmental Electrophysiological Investigation, Matthew Waxer

Electronic Thesis and Dissertation Repository

One standard task used to investigate the development of cognitive control is the Dimensional Change Card Sort (DCCS). Performance and patterns of brain activity associated with the DCCS show continued age-related advances into early adolescence. According to many theoretical accounts, the DCCS places demands on a single underlying executive control process. Three experiments examined the possibility that the DCCS places demands on multiple control processes that follow distinct developmental trajectories. In Experiment 1, rule switching and conflict processing made orthogonal contributions to DCCS performance. Rule switching was associated with a cue-locked late frontal negativity (LFN) event-related potential (ERP) and conflict …

Gabaergic And Glutamatergic Identities Of Developing Midbrain Pitx2 Neurons, Mindy Waite

Mindy Waite

Sex Difference In Calbindin Cell Number In The Mouse Preoptic Area: Effects Of Neonatal Estradiol And Bax Gene Deletion, Richard F. Gilmore Iii

Masters Theses 1911 - February 2014

The sexually dimorphic nucleus of the preoptic area (SDN-POA) was first discovered in rats and is one of the most famous and best studied sex differences in the field of neuroscience. Though well documented in rats (larger in males than females), this sex difference was only recently able to be observed in mice due to the discovery of the protein calbindin-D28k as a marker. Recent studies have shown a larger, more distinct calbindin-immunoreactive (ir) cell cluster in male mice compared to females. However, the exact location of the cluster and whether the sex difference is one of total cell number …

Cognitive Systems And The Extended Mind, Mirko Farina

Mirko Farina

No abstract provided.

Relative Dependence Of Neural Plasticity On Age And Activity In The Bumblebee (Bombus Huntii), Geoffrey Nielsen

Summer Research

Neural Plasticity is one of the most fascinating and complex aspects of neuroscience. Due to the complexity of neural plasticity mechanisms, simple models are used to study neural plasticity. The bumblebee, Bombus huntii provides an ideal model organism with which to study neural plasticity, particularly the way it is affected by age and activity1. The Mushroom Body is the portion of the B. huntii brain that is responsible for higher order sensory integration and experience related learning so it will be the focus of this study.

Differentiable Cortical Networks For Inferences Concerning People’S Intentions Versus Physical Causality, Robert Mason, Marcel Just

Marcel Adam Just

No abstract provided.

Autonomy Of Lower-Level Perception From Global Processing In Autism: Evidence From Brain Activation And Functional Connectivity, Yanni Liu, Vladimir L. Cherkassky, Nancy J. Minshew, Marcel Adam Just

Marcel Adam Just

No abstract provided.

Inter-Regional Brain Communication And Its Disturbance In Autism, Sarah E. Schipul, Timothy A. Keller, Marcel Adam Just

Marcel Adam Just

No abstract provided.

Quantitative Modeling Of The Neural Representation Of Objects: How Semantic Feature Norms Can Account For Fmri Activation, Kai-Min Kevin Chang, Tom Mitchell, Marcel Adam Just

Marcel Adam Just

No abstract provided.

Individual Differences In The Neural Basis Of Causal Inferencing, Chantel S. Prat, Robert A. Mason, Marcel Adam Just

Marcel Adam Just

No abstract provided.

Commonality Of Neural Representations Of Words And Pictures, Svetlana V. Shinkareva, Vincente L. Malave, Robert A. Mason, Tom M. Mitchell, Marcel Adam Just

Marcel Adam Just

No abstract provided.

The Neural Basis Of Deictic Shifting In Linguistic Perspective-Taking In High-Functioning Autism, Akiko Mizuno, Yanni Liu, Diane L. Williams, Timothy A. Keller, Nancy J. Minshew, Marcel Adam Just

Marcel Adam Just

No abstract provided.

Rat Pup Social Motivation: A Critical Component Of Early Psychological Development, Howard C. Cromwell

Howard Casey Cromwell

Examining the role of the offspring in early social dynamics is especially difficult. Human developmental psychology has found infant behavior to be a vital part of the early environmental setting. In the rodent model, the different ways that a rodent neonate or pup can influence social dynamics are not well known. Typically, litters of neonates or pups offer complex social interactions dominated by behavior seemingly initiated and maintained by the primary caregiver (e.g., the dam). Despite this strong role for the caregiver, the young most likely influence the litter dynamics in many powerful ways including communication signals, discrimination abilities and …

Exploring The Neural Dynamics Underpinning Individual Differences In Sentence Comprehension, Chantel S. Prat, Marcel Adam Just

Marcel Adam Just

No abstract provided.

Nico-Teen: Neural Substrates That Mediate Adolescent Tobacco Abuse., Laura O'Dell

Laura Elena O'Dell

No abstract provided.

Nico-Teen: Neural Substrates That Mediate Adolescent Tobacco Abuse., Laura O'Dell

Laura Elena O'Dell

No abstract provided.

Characterizing And Treating The Neuropathology Of Tuberous Sclerosis Complex In The Mouse, Sharon W. Way

Dissertations & Theses (Open Access)

Tuberous sclerosis complex (TSC) is a multisystem, autosomal dominant disorder affecting approximately 1 in 6000 births. Developmental brain abnormalities cause substantial morbidity and mortality and often lead to neurological disease including epilepsy, cognitive disabilities, and autism. TSC is caused by inactivating mutations in either TSC1 or TSC2, whose protein products are known inhibitors of mTORC1, an important kinase regulating translation and cell growth. Nonetheless, neither the pathophysiology of the neurological manifestations of TSC nor the extent of mTORC1 involvement in the development of these lesions is known. Murine models would greatly advance the study of this debilitating disorder. This thesis …

Supersizing The Mind: Embodiment, Action And Cognitive Extension, Mirko Farina

Mirko Farina

No abstract provided.