Distinct Roles Of C-Jun N-Terminal Kinase Isoforms In Neurite Initiation And Elongation During Axonal Regeneration, 2010 Université Pierre et Marie Curie
Distinct Roles Of C-Jun N-Terminal Kinase Isoforms In Neurite Initiation And Elongation During Axonal Regeneration, Monia Barnat, Herve Enslen, Friedrich Propst, Roger J. Davis, Sylvia Soares, Fatiha Nothias
Davis Lab Publications
c-Jun N-terminal kinases (JNKs) (comprising JNK1-3 isoforms) are members of the MAPK (mitogen-activated protein kinase) family, activated in response to various stimuli including growth factors and inflammatory cytokines. Their activation is facilitated by scaffold proteins, notably JNK-interacting protein-1 (JIP1). Originally considered to be mediators of neuronal degeneration in response to stress and injury, recent studies support a role of JNKs in early stages of neurite outgrowth, including adult axonal regeneration. However, the function of individual JNK isoforms, and their potential effector molecules, remained unknown. Here, we analyzed the role of JNK signaling during axonal regeneration from adult mouse dorsal root ...
Developmental Changes In The Structure And Composition Of The Postsynaptic Density, 2010 University of Texas Graduate School of Biomedical Sciences at Houston
Developmental Changes In The Structure And Composition Of The Postsynaptic Density, Matthew T. Swulius
The University of Texas MD Anderson Cancer Center UTHealth Graduate School of Biomedical Sciences Dissertations and Theses (Open Access)
The development of the brain and its underlying circuitry is dependent on the formation of trillions of chemical synapses, which are highly specialized contacts that regulate the flow of information from one neuron to the next. It is through these synaptic connections that neurons wire together into networks capable of performing specific tasks, and activity-dependent changes in their structural and physiological state is one way that the brain is thought to adapt and store information. At the ultrastructural level, developmental and activity-dependent changes in the size and shape of dendritic spines have been well documented, and it is widely believed ...
Locus Of Control And The Age Difference In Free Recall From Episodic Memory, 2010 Montclair State University
Locus Of Control And The Age Difference In Free Recall From Episodic Memory, Paul Amrhein, Judith K. Bond, Derek Hamilton
Department of Psychology Faculty Scholarship and Creative Works
The authors investigated the relation of locus of control (LOC) to age differences in free-recall memory performance. Older and younger participants completed P. C. Duttweiler's (1984) Internal Control Index (ICI) and subsequently performed free-recall memory tasks. Compared with the younger participants, the older participants exhibited poorer recall with more intrusions and uncorrected repetition errors as well as reduced categorical clustering. For the older participants with less internal LOC, recall proportion and item-pair associative recall clustering were lower than for the older participants with more internal LOC. By contrast, the younger participants did not exhibit any LOC effects in their ...
Effects Of Socioeconomic Status On Brain Development, And How Cognitive Neuroscience May Contribute To Levelling The Playing Field, Rajeev Raizada, Mark M. Kishiyama
The study of socioeconomic status (SES) and the brain finds itself in a circumstance unusual for Cognitive Neuroscience: large numbers of questions with both practical and scientific importance exist, but they are currently under-researched and ripe for investigation. This review aims to highlight these questions, to outline their potential significance, and to suggest routes by which they might be approached. Although remarkably few neural studies have been carried out so far, there exists a large literature of previous behavioural work. This behavioural research provides an invaluable guide for future neuroimaging work, but also poses an important challenge for it: how ...
Effects Of Chlordiazepoxide On Predator Odor-Induced Reductions Of Playfulness In Juvenile Rats, 2010 Gettysburg College
Effects Of Chlordiazepoxide On Predator Odor-Induced Reductions Of Playfulness In Juvenile Rats, Stephen M. Siviy, Courtney L. Steets, Lauren M. Debrouse
Psychology Faculty Publications
The extent to which a non-sedative dose of chlordiazepoxide (CDP) is able to modify the behavioral responses toward a predator odor was assessed in juvenile rats. Play behavior was suppressed and defensive behaviors were enhanced in the presence of a collar previously worn by a cat, when tested 24 hours later in the same context as that where the exposure occurred, and when tested in a context different than that in which the exposure occurred for up to 3 hours after exposure. CDP had no effect on the ability of cat odor to suppress play when rats were tested in ...
Influence Of Perinatal Exposure To A Polychlorinated Biphenyl Mixture On Learning And Memory, Hippocampal Size, And Estrogen Receptor-Beta Expression, Howard Cromwell
Howard Casey Cromwell
Abstract. Perinatal exposure to PCB has been reported to cause a variety of health effects including endocrine disruption, and immunologic, reproductive, neurologic, and behavioral deficits. In the present study, a mixture of two PCB congeners, one non-coplanar (PCB 47) and one coplanar (PCB 77), were administered to young female Sprague-Dawley rats by route of maternal dietary consumption (either 12.5 ppm or 25.0 ppm, w/w). Impact on learning and memory were examined by radial arm maze on postnatal day 24-27. After behavioral tests were completed, the rats were transcardially perfused, and brains were excised. Immunohistochemistry for ER- β ...
Cortical Underconnectivity Coupled With Preserved Visuospatial Cognition In Autism: Evidence From An Fmri Study Of An Embedded Figures Task, Saudamini Damarla, Timothy A. Keller, Rajesh K. Kana, Vladimir L. Cherkassky, Diane L. Williams, Nancy J. Minshew, Marcel Adam Just
Marcel Adam Just
No abstract provided.
Reason And Desire: The Case Of Affective Desires, 2009 University of Liverpool
Reason And Desire: The Case Of Affective Desires, Attila Tanyi
The paper begins with an objection to the Desire-Based Reasons Model. The argument from reason-based desires holds that since desires are based on reasons (first premise), which they transmit but to which they cannot add (second premise), they cannot themselves provide reasons for action. In the paper I investigate an attack that has recently been launched against the first premise of this argument by Ruth Chang. Chang invokes a counterexample: affective desires. The aim of the paper is to see if there is a way to accommodate the counterexample to the first premise. I investigate three strategies. I first deal ...
A Neurosemantic Theory Of Concrete Noun Representation Based On The Underlying Brain Codes, 2009 Carnegie Mellon University
A Neurosemantic Theory Of Concrete Noun Representation Based On The Underlying Brain Codes, Marcel Adam Just, Vladimir L. Cherkassky, Sandesh Aryal, Tom M. Mitchell
Marcel Adam Just
No abstract provided.