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Unique Aspects Of Graft-Versus-Host-Disease Management In The Eastern Mediterranean Region: Report From The Eastern Mediterranean Blood And Marrow Transplantation Group: Special Report, Shahrukh Hashmi, Marwan Shaheen, Salman Adil, Parvez Ahmed, Syed Ahmed, Nour Ben Abdeljelil, Amal Alabdulwahab, Amal Albeihany, Saad Aldaama, Murtadha Al-Khabori, Salam Alkindi, Fahad Almohareb, Ahmed Alsaeed, Amal Alseraihy, Salem Alshemari, Mouhab Ayas, Naeem Chaudhri, Waleed Da’na, David Dennison, Asma ElQuessar, Alaa Elhaddad, Ahmad Ibrahim, Hasan Hashem, Wasil Jastaniah, Hani Mawardi, Amr Nassar, Tariq Satti, Lamia Torjemane, Khalid Tabbara, Hassan El Solh, Bassim Albeirouti, Mahmoud Aljurf 2023 Department of Adult Hematology and Stem Cell Transplantation, KFSHRC, Riyadh, Saudi Arabia

Unique Aspects Of Graft-Versus-Host-Disease Management In The Eastern Mediterranean Region: Report From The Eastern Mediterranean Blood And Marrow Transplantation Group: Special Report, Shahrukh Hashmi, Marwan Shaheen, Salman Adil, Parvez Ahmed, Syed Ahmed, Nour Ben Abdeljelil, Amal Alabdulwahab, Amal Albeihany, Saad Aldaama, Murtadha Al-Khabori, Salam Alkindi, Fahad Almohareb, Ahmed Alsaeed, Amal Alseraihy, Salem Alshemari, Mouhab Ayas, Naeem Chaudhri, Waleed Da’Na, David Dennison, Asma Elquessar, Alaa Elhaddad, Ahmad Ibrahim, Hasan Hashem, Wasil Jastaniah, Hani Mawardi, Amr Nassar, Tariq Satti, Lamia Torjemane, Khalid Tabbara, Hassan El Solh, Bassim Albeirouti, Mahmoud Aljurf

Hematology/Oncology and Stem Cell Therapy

Ther is no abstract for this article type.


Escalated Dose Donor Lymphocyte Infusion Treatment In Patients With Primary Immune Deficiencies After Hsct With Reducedintensity Conditioning Regimen, Tahani Ali, Maryam Behfar, Rashin Mohseni, Pourya Salajegheh, Maged Kheder, Faihaa Abou-Fakher, Zeynab Nikfetrat, Fahimeh Jafari, Parisa Naji, Amir Ali Hamidieh 2023 Pediatric Cell and Gene Therapy Research Center, Tehran University of Medical Sciences, Tehran, Iran

Escalated Dose Donor Lymphocyte Infusion Treatment In Patients With Primary Immune Deficiencies After Hsct With Reducedintensity Conditioning Regimen, Tahani Ali, Maryam Behfar, Rashin Mohseni, Pourya Salajegheh, Maged Kheder, Faihaa Abou-Fakher, Zeynab Nikfetrat, Fahimeh Jafari, Parisa Naji, Amir Ali Hamidieh

Hematology/Oncology and Stem Cell Therapy

Objective/Background: Mixed chimerism is a major concern after allogenic hematopoietic stem cell transplantation (HSCT) using a reduced-intensity conditioning (RIC) regimen in primary immunodeficiencies (PIDs). A donor lymphocyte infusion (DLI) escalating dose regimen has been developed with the aim of reducing toxicity while preserving efficacy. However, the graft-versus-host disease (GvHD) development remains the most common and adverse effect of DLI and continues to be a limiting factor in its application, especially nonmalignant diseases such as PIDs. We prospectively evaluated PID patients after HSCT using RIC in Children s Medical Center, who were candidates for an escalating dose of DLI for MC …


Oxidative Stress And Hepcidin Expression In Pediatric Sickle Cell Anemia With Iron Overload, Eman A. Elbostany, Eman A. Elghoroury, Eman H. Thabet, Alaa A. Rashad, Enas A. Rasheed, Gamila S.M. El-Saeed, Dalia A. Abdelhalim, Safa N. Abdelfattah, Iman I. Salama, Niveen Salama 2023 Department of Pediatrics, National Research Centre, Cairo, Egypt

Oxidative Stress And Hepcidin Expression In Pediatric Sickle Cell Anemia With Iron Overload, Eman A. Elbostany, Eman A. Elghoroury, Eman H. Thabet, Alaa A. Rashad, Enas A. Rasheed, Gamila S.M. El-Saeed, Dalia A. Abdelhalim, Safa N. Abdelfattah, Iman I. Salama, Niveen Salama

Hematology/Oncology and Stem Cell Therapy

Background: Blood transfusion (BT) is essential in treating sickle cell disease (SCD); however, it leads to iron overload (IO) and oxidative stress. We studied the relationship between oxidative stress, iron status parameters, hepcidin mRNA gene expression, and IO in SCD patients. Methods: We classified all SCD patients (n = 90) into two groups: Group I, 45 children (s.ferr itin 938 ng/mL) and Group II, 45 children (s.ferritin < 938 ng/mL). A total of 55 children, age and sex matched, participated as a control group. Malondialdehyde (MDA), nitrite, s.iron, s.total iron-binding capacity (sTIBC), transferrin saturation %, s.ferritin, s.hepcidin, and hepcidin mRNA gene expression were assessed. Results: Among SCD BT-dependent patients (>3 times/year), 63% were from Group I and 37% from Group II, p < .01. The two patient groups had significantly lower s.hepcidin and hepcidin gene expression than controls (p < .001). TIBC, s.iron, s.ferritin, transferrin saturation %, ferritin/ hepcidin ratio, and MDA levels were higher among SCD patients than controls (p < .001).

Group I had higher mean level of ferritin/hepcidin ratio and MDA than Group II (p < .01). The higher level of MDA and increased frequency of BT were the significant predicting risk factors for IO (p < .05). A receiver-operating characteristic curve indicates that MDA is the outstanding significant biomarker for high level of s.ferritin with subsequent IO progression. Conclusion: MDA may serve as a biomarker of oxidative stress and IO in SCD patients. This result paid attention for urgent initiation of antioxidant and chelation therapy on detecting increased MDA level.


The Impact Of Beta-Blocker Use At The Time Of Hematopoietic Cell Transplantation On The Development Of Acute And Chronic Graftversus- Host Disease, Arjun Patel, Guru Subramanian Guru Murthy, Mehdi Hamadani, Aniko Szabo, Jennifer M. Knight 2023 Medical College of Wisconsin, Milwaukee, WI, United States

The Impact Of Beta-Blocker Use At The Time Of Hematopoietic Cell Transplantation On The Development Of Acute And Chronic Graftversus- Host Disease, Arjun Patel, Guru Subramanian Guru Murthy, Mehdi Hamadani, Aniko Szabo, Jennifer M. Knight

Hematology/Oncology and Stem Cell Therapy

Sympathetic nervous system activation plays a role in the development of acute and chronic graft-versus-host disease (GVHD) following allogeneic hematopoietic cell transplantation (HCT). Primary objective was to compare the cause-specific hazard of grade II-IV and III-IV acute GVHD (aGVHD) and chronic GVHD (cGVHD) in the context of ß-blocker use and type (selective vs. non-selective). Secondary objectives included overall survival (OS), relapse-free survival (RFS), and cumulative incidence of relapse, non-relapse mortality (NRM), and grade II-IV and III-IV aGVHD and cGVHD. The current study included 151 patients ages 18 and older diagnosed with hematological malignancies who underwent reduced intensity conditioning allogeneic HCT …


Effects Of Different Types Of Allogeneic Hematopoietic Stem Cell Transplantation Donors On Philadelphia Chromosome-Positive Acute Lymphoblastic Leukemia During The Tyrosine Kinase Inhibitor Era: A Systematic Review And Meta-Analysis, Ben Ponvilawan, Weerapat Owattanapanich, Nipith Charoenngam, Smith Kungwankiattichai 2023 Department of Pharmacology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand

Effects Of Different Types Of Allogeneic Hematopoietic Stem Cell Transplantation Donors On Philadelphia Chromosome-Positive Acute Lymphoblastic Leukemia During The Tyrosine Kinase Inhibitor Era: A Systematic Review And Meta-Analysis, Ben Ponvilawan, Weerapat Owattanapanich, Nipith Charoenngam, Smith Kungwankiattichai

Hematology/Oncology and Stem Cell Therapy

Background: Matched donor (MD) allogeneic hematopoietic stem cell transplantation (allo- HSCT) is currently the preferred choice of treatment for Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph+ ALL) patients who have achieved complete remission. This systematic review and meta-analysis was conducted to investigate the effects of allo-HSCTs from different donor types for Ph+ ALL patients who received tyrosine kinase inhibitors (TKIs). Methods: Studies in EMBASE and MEDLINE between inception and December 2020 were identified using search terms related to ‘‘Ph+ ALL” and ‘‘HSCT.” Eligible studies were studies with Ph+ ALL patients who received a TKI and allo-HSCT. The primary outcomes of interest—the …


Carfilzomib-Induced Thrombotic Microangiopathy: A Case Based Review, Nishant Jindal, Aditya Jandial, Arihant Jain, Deepesh Lad, Gaurav Prakash, Alka Khadwal, Ritambhra Nada, Jasmine Sethi, Jasmina Ahluwalia, Pankaj Malhotra 2023 Department of Internal Medicine, 4th floor, Nehru Hospital, Post Graduate Institute of Medical Education and Research, Sector 12 Chandigarh (160012), India.

Carfilzomib-Induced Thrombotic Microangiopathy: A Case Based Review, Nishant Jindal, Aditya Jandial, Arihant Jain, Deepesh Lad, Gaurav Prakash, Alka Khadwal, Ritambhra Nada, Jasmine Sethi, Jasmina Ahluwalia, Pankaj Malhotra

Hematology/Oncology and Stem Cell Therapy

Carfilzomib is an irreversible proteasome inhibitor currently approved for the treatment of relapsed multiple myeloma. It has been implicated as a cause of thrombotic microangiopathy (TMA) in several case reports. The incidence, risk factors, and treatment of carfilzomib-related TMA remain unclear. Here we describe the clinical presentation and outcome of a 58-year-old man with biopsy-proven TMA that occurred following treatment with carfilzomib-based therapy. We also reviewed the published literature with regard to the incidence, risk factors, treatment options, and outcome of carfilzomib-related TMA.


Fam-Trastuzumab Deruxtecan (Enhertu) Induced Pyloric Perforation In Hormonal Receptor Positive/ Her2 Low Express Metastatic Breast Cancer., Taher AL-Tweigeri 2023 Medical Oncology Section, Oncology Centre, King Faisal Specialist Hospital and Research Centre, PO Box 3354, Riyadh 11211, Saudi Arabia

Fam-Trastuzumab Deruxtecan (Enhertu) Induced Pyloric Perforation In Hormonal Receptor Positive/ Her2 Low Express Metastatic Breast Cancer., Taher Al-Tweigeri

Hematology/Oncology and Stem Cell Therapy

There is no abstract for this article.


Serum Electrolyte And Metabolic Changes During Conditioning Of Autologous Hematopoietic Stem Cell Transplantation In Patients With Autoimmune Diseases: A Prospective Study In A Single Institution., Brenda J. MÉNDEZ-LAUREANO, Moisés M. GALLARDO-PÉREZ, Claudia MINUTTI-ZANELLA, Guillermo J. RUIZ-ARGÜELLES 2023 Laboratorios Ruiz. SYNLAB. Puebla, México

Serum Electrolyte And Metabolic Changes During Conditioning Of Autologous Hematopoietic Stem Cell Transplantation In Patients With Autoimmune Diseases: A Prospective Study In A Single Institution., Brenda J. Méndez-Laureano, Moisés M. Gallardo-Pérez, Claudia Minutti-Zanella, Guillermo J. Ruiz-Argüelles

Hematology/Oncology and Stem Cell Therapy

Background: A hematopoietic stem cell transplant (HSCT) includes a conditioning regimen which may cause unwanted metabolic changes. Objective: Analyze the changes in electrolytes, glucose, urea and glomerular filtration rate in patients with MS who underwent an autologous HSCT employing the “Mexican method”. Methods: Serum and urinary electrolytes, blood glucose, creatinine, uric acid and estimated glomerular filtration rate (eGFR) were prospectively assessed on days -11, - 9, and 0 in a group of 75 patients with multiple sclerosis (MS) receiving an autologous HSCT employing the “Mexican Method”, which includes high doses of both cyclophosphamide (Cy, 200 mg/Kg) and rituximab (1000 mg). …


Improved Quality Of Life Of Sickle Cell Disease Patients Post Allogeneic Stem Cell Transplant: Another Indication For Transplant, Bader Ali Aljaafri, Mohammad Fahad Albawardi, Abdulaziz Yahya Alghamdi, Khaled Mohammad Altowairgi, Yazeed Saleh Alhoshan, Bader Alahmari, Husam Alsadi, Mazin Ahmed, Mohammed Alnahdi, Zied Aljubour, Mohsen Alzahrani 2023 King Abdullah International Medical Research Center, Riyadh, Saudi Arabia

Improved Quality Of Life Of Sickle Cell Disease Patients Post Allogeneic Stem Cell Transplant: Another Indication For Transplant, Bader Ali Aljaafri, Mohammad Fahad Albawardi, Abdulaziz Yahya Alghamdi, Khaled Mohammad Altowairgi, Yazeed Saleh Alhoshan, Bader Alahmari, Husam Alsadi, Mazin Ahmed, Mohammed Alnahdi, Zied Aljubour, Mohsen Alzahrani

Hematology/Oncology and Stem Cell Therapy

Introduction: Sickle Cell Disease (SCD) is among the most frequently inherited diseases worldwide. The severity of SCD ranges from mild to severe, and the disease involves multiple complications, including pulmonary hypertension, stroke, recurrent vaso-occlusive crises, end-organ damage, and an increased mortality risk. Allogeneic hematopoietic cell transplantation (HCT) is potentially a curative option for patients with SCD.

Objectives of the Study: The study objective was to assess the quality of life of adolescent and adult SCD patients receiving HCT pre-and post-transplant.

Methods: An analytical cross-sectional study was conducted. SCD patients with at least one year of follow-up after HCT were interviewed …


Therapy-Related Acute Myeloid Leukemia In Non-Hodgkin Lymphoma Survivors: Risk, Survival Outcomes And Prognostic Factor Analysis, Utsav Joshi, Adheesh Bhattarai, Suman Gaire, Pravash Budhathoki, Vishakha Agrawal, Roshan Subedi, Bishesh Sharma Poudyal, Prajwal Dhakal, Ronald Sham, Vijaya Raj Bhatt 2023 Department of Internal Medicine, Rochester General Hospital, Rochester, NY, USA

Therapy-Related Acute Myeloid Leukemia In Non-Hodgkin Lymphoma Survivors: Risk, Survival Outcomes And Prognostic Factor Analysis, Utsav Joshi, Adheesh Bhattarai, Suman Gaire, Pravash Budhathoki, Vishakha Agrawal, Roshan Subedi, Bishesh Sharma Poudyal, Prajwal Dhakal, Ronald Sham, Vijaya Raj Bhatt

Hematology/Oncology and Stem Cell Therapy

Background: Therapy-related acute myeloid leukemia (tAML) is a serious complication in patients with Non-Hodgkin lymphoma (NHL) exposed to chemotherapy or radiation. This large database study aims to quantify the risk of tAML in NHL, and determine the impact of tAML on overall survival (OS) of patients with NHL. Materials and Methods: Patients diagnosed with NHL and de novo AML from 2009 to 2018 were identified from the Surveillance, Epidemiology, and End Results database. Multiple primary standardized incidence ratio (SIR) sessions of the SEER*Stat software were used to calculate SIR and absolute excess risk of tAML. Overall survival (OS) was evaluated …


Protacs – A Novel And Rapidly Developing Field Of Targeted Protein Degradation, Hannah R. Gatley 2023 Virginia Commonwealth University

Protacs – A Novel And Rapidly Developing Field Of Targeted Protein Degradation, Hannah R. Gatley

Theses and Dissertations

There is a continued need for new technology and strategies for tackling cancer and other diseases, and within the current century a novel therapeutic strategy has emerged in the realm of targeted protein degradation called Proteolysis-Targeting Chimeras (PROTACs). This technology specifically targets and degrades disease-causing proteins via the ubiquitin-proteasome system, and has seen an explosion of research and intrigue in both academia and industry over the past two decades. The diversity of PROTAC classes based on the E3 ligase recruiting ligand and the target protein allows for a universal molecular structure that can be customized for a specific target and …


The Role Of Myocardin In The Progression Of Non-Small Cell Lung Cancer, Soromidayo Akinsiku 2023 University of Texas at Tyler

The Role Of Myocardin In The Progression Of Non-Small Cell Lung Cancer, Soromidayo Akinsiku

Biotechnology Theses

Lung cancer is the leading cause of cancer-related mortality in the world and NSCLC accounts for 85% of all lung cancer cases. The mainstay of treatment for patients with stage I, II and IIIA NSCLC is surgery, followed by post-operative cisplatin-based chemotherapy. Additional adjuvant therapy involving targeted tyrosine kinase inhibitors has been in use, however even for the targeted therapy, resistance eventually develops. Therefore, there is a need for identifying novel targets for this life-threatening disease. Given that preliminary studies in Ikebe lab revealed that myocardin knockdown significantly promoted caspase-3 degradation, in this study, using myocardin siRNA, we investigated the …


Bioinformatic Analysis Of Proteomic And Genomic Data From Nsclc Tumors On Prognostic And Predictive Factors Of Immunotherapy Treatment, Mark Wuenschel 2023 University of Kentucky

Bioinformatic Analysis Of Proteomic And Genomic Data From Nsclc Tumors On Prognostic And Predictive Factors Of Immunotherapy Treatment, Mark Wuenschel

Theses and Dissertations--Pharmacy

Recent lung cancer research has led to advancements in molecular immunology, resulting in development of small molecule inhibitors, or immune checkpoint inhibitors, that propagate an anti-tumor T cell response. Despite increased overall and progression-free survival with reduced adverse effects compared to traditional chemotherapy, treating advanced stage lung adenocarcinoma patients remains non-curative, and evidence of non-responders or tumor recurrence to immune checkpoint inhibitor therapy is growing. Also, compared to traditional chemotherapy, there is a lower percentage of patients who respond to small molecule inhibitors. In this analysis of proteomic and genomic data from The Cancer Proteome Atlas and Global Data Commons …


Targeting Ezh2 To Improve Outcomes Of Lung Squamous Cell Carcinoma, Tanner DuCote 2023 University of Kentucky

Targeting Ezh2 To Improve Outcomes Of Lung Squamous Cell Carcinoma, Tanner Ducote

Theses and Dissertations--Toxicology and Cancer Biology

Only 20% of patients diagnosed with lung squamous cell carcinoma (LSCC) respond to immunotherapy. Anti-PD1 immunotherapy is most commonly prescribed to these patients; however, most will become refractory. It is important to understand the mechanisms underlying this problem to increase durability and survival. Building upon the work of other groups, our lab has demonstrated that the inhibition of the histone methyltransferase, EZH2, is crucial to maintaining an immunologically responsive microenvironment. Based on our data, we hypothesize that combining EZH2 inhibitors with anti-PD1 therapy will increase response and durability. To study non-small cell lung cancers (NSLC) our lab uses a variety …


Identification Of Novel Biosynthetic Gene Clusters Encoding For Polyketide/Nrps-Producing Chemotherapeutic Compounds From Marine-Derived Streptomyces Hygroscopicus From A Marine Sanctuary, Hannah Ruth Flaherty 2023 University of New Hampshire, Durham

Identification Of Novel Biosynthetic Gene Clusters Encoding For Polyketide/Nrps-Producing Chemotherapeutic Compounds From Marine-Derived Streptomyces Hygroscopicus From A Marine Sanctuary, Hannah Ruth Flaherty

Honors Theses and Capstones

Nearly one out of six deaths in 2020, around ten million people, were caused by cancer, making it a leading cause of death worldwide (WHO, 2022). This major public health issue, in addition to the rise of multidrug-resistant (MDR) pathogens, provides a high demand for the discovery of new pharmaceutical drugs to be used clinically to treat these conditions. The Streptomyces genus accounts to produce 39% of all microbial metabolites currently approved for human health, indicating its potential as an important species to study for antimicrobial and anticancer agents. The long linear genome of Streptomyces contains specialized sequences known as …


Targeting Stat3 In Triple Negative Breast Cancer Using Gsk3Ꞵ And Integrin Inhibitors, Emily A. Pratt 2023 University of New Hampshire, Durham

Targeting Stat3 In Triple Negative Breast Cancer Using Gsk3Ꞵ And Integrin Inhibitors, Emily A. Pratt

Honors Theses and Capstones

Triple negative breast cancer (TNBC) is the most aggressive subtype of breast cancer and is known for its chemoresistance and high rate of recurrence. TNBC lacks the hormone receptors that are found in other types of breast cancer, and therefore cannot be treated with hormonal therapies. Although the initial response to chemotherapy is favorable, many TNBC patients experience a recurrence of this cancer at a secondary location and this recurrence is often more lethal than the original tumor. The Signal Transducer and Activator of Transcription (STAT) pathway is a major contributor to cancer growth and metastasis, and STAT3 is constitutively …


Kpt-330 Synergizes With Everolimus To Reduce Mtorc1-Overactive Basal-Like Triple-Negative Breast Cancer Brain Metastasis Burden, Aaron D. Valentine 2023 Virginia Commonwealth University

Kpt-330 Synergizes With Everolimus To Reduce Mtorc1-Overactive Basal-Like Triple-Negative Breast Cancer Brain Metastasis Burden, Aaron D. Valentine

Theses and Dissertations

Triple-negative breast cancer (TNBC), a highly metastatic breast cancer subtype, accounts for approximately 20% of all breast cancer diagnoses. Basal-like TNBC is notably difficult to treat due to the lack of actionable drug targets such as estrogen and progesterone receptors, as well as HER2. Due to the deficiency in TNBC-targeting drugs that are able to cross the blood-brain barrier (BBB) for breast-to-brain metastasis, there is a need to develop novel BBB-permeable treatments. After preliminary testing, KPT-330 (XPO1 inhibitor) and everolimus (FKBP1A/mTOR inhibitor) were selected as drug candidates for this study. Patient-derived xenograft (PDX) models for in vitro and in vivo …


The Effects Of Cucurbitacin B And Silmitasertib On Metastasis And Itga6 Using The Zebrafish Tumor-Xenograft, Alexandra Griffis 2023 Georgia Southern University

The Effects Of Cucurbitacin B And Silmitasertib On Metastasis And Itga6 Using The Zebrafish Tumor-Xenograft, Alexandra Griffis

Electronic Theses and Dissertations

Ninety percent of cancer deaths are resultant from the metastasis of cancer cells. When cancer cells translocate through blood vessels or the lymphatic system, they may form tumors outside of their primary site. The processes of metastasis can begin quickly; after onset, metastasis is unforgiving, as it does not participate with the body’s physiological systems in an orderly way. In the past, our lab produced results indicating that a cell adhesion molecule, Integrin Alpha-6, may contribute to cancer cells' ability to metastasize. Integrins mediate interactions between the cell and the Extracellular Matrix (ECM), regulating cell attachment and cell migration. With …


Enhancing The Conformational Stability Of The Cl-Par-4 Tumor Suppressor Via Site-Directed Mutagenesis, Samjhana Pandey, Krishna K. Raut, Andrea M. Clark, Antoine Baudin, Lamya Djemri, David S. Libich, Komala Ponniah, Steven M. Pascal 2023 Old Dominion University

Enhancing The Conformational Stability Of The Cl-Par-4 Tumor Suppressor Via Site-Directed Mutagenesis, Samjhana Pandey, Krishna K. Raut, Andrea M. Clark, Antoine Baudin, Lamya Djemri, David S. Libich, Komala Ponniah, Steven M. Pascal

Chemistry & Biochemistry Faculty Publications

Intrinsically disordered proteins play important roles in cell signaling, and dysregulation of these proteins is associated with several diseases. Prostate apoptosis response-4 (Par-4), an approximately 40 kilodalton proapoptotic tumor suppressor, is a predominantly intrinsically disordered protein whose downregulation has been observed in various cancers. The caspase-cleaved fragment of Par-4 (cl-Par-4) is active and plays a role in tumor suppression by inhibiting cell survival pathways. Here, we employed site-directed mutagenesis to create a cl-Par-4 point mutant (D313K). The expressed and purified D313K protein was characterized using biophysical techniques, and the results were compared to that of the wild-type (WT). We have …


Investigation Of Inflammation And Apoptosis Mediated Toxicity In Response To Metal Oxide Nanoparticles In Ml-1 And Ca77 Cancer Cell Lines, Alyse N. Peters 2023 Missouri State University

Investigation Of Inflammation And Apoptosis Mediated Toxicity In Response To Metal Oxide Nanoparticles In Ml-1 And Ca77 Cancer Cell Lines, Alyse N. Peters

MSU Graduate Theses

Metal oxide nanoparticles (MONPs) are becoming more popular in today’s environment. They contribute significantly to the technologies in agriculture and food development but there is little understanding to how MONPs, including ZnO, CuO, TiO2, and SnO2, impact human health and the environment. Our growth assay revealed that none of these negatively affects viability in the budding yeast, Saccharomyces cerevisiae. In contrast, both human thyroid cancer cells (ML-1) and rat medullary thyroid cancer cells (CA77) displayed a significant reduction in viability with the treatment of CuO and ZnO. The production of ROS in these cell lines when treated with CuO and …


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