Ornithine Decarboxylase (Odc) Regulation By Mtor: New Insights From Tsc1 Knockout Cells,
2010
University of Northern Iowa
Ornithine Decarboxylase (Odc) Regulation By Mtor: New Insights From Tsc1 Knockout Cells, Alyssa Mae Cates
Honors Program Theses
The polyamine pathway, when improperly regulated, is one central cause of skin carcinogenesis. The purpose of this project was to investigate the relationship between two biochemical signaling pathways, the mTOR (mammalian target of rapamycin) pathway and the polyamine pathway. It is known that the protein mTOR serves to regulate a key protein in the polyamine pathway, ornithine decarboxylase (ODC), but the precise mechanism remains unclear. It has been postulated that mTOR acts to regulate ODC through two RNA binding proteins, HuR (a member of the Hu family of proteins) and TIP (tristetraprolin). The project entailed characterizing that relationship using TSCl …
