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Articles 9511 - 9540 of 33226

Full-Text Articles in Chemistry

Highly Improved Electrocatalytic Oxidation Of Dimethylamine Borane On Silvernanoparticles Modified Polymer Composite Electrode, Çağri Ceylan Koçak, Süleyman Koçak, Şükri̇ye Karabi̇beroğlu, Zekerya Dursun Jan 2020

Highly Improved Electrocatalytic Oxidation Of Dimethylamine Borane On Silvernanoparticles Modified Polymer Composite Electrode, Çağri Ceylan Koçak, Süleyman Koçak, Şükri̇ye Karabi̇beroğlu, Zekerya Dursun

Turkish Journal of Chemistry

Dimethylamine borane (DMAB) is a promising fuel alternative for fuel cell applications. In this work cyclic voltammetric behavior of DMAB was investigated on the polymerized aminophenol film decorated with Ag nanoparticles in alkaline media. The polymer film was formed on the glassy carbon electrode by electrochemical technique and then, the surface was modified with Ag nanoparticles. The surface of the modified electrode was identified by scanning electron microscopy, transmission electron microscopy, X-ray photoelectron spectroscopy, and electrochemical impedance spectroscopy techniques. The developed electrode has displayed high electrocatalytic activity for DMAB oxidation in alkaline media depending on the supporting electrolyte concentration. Experimental …

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Entrapment Of Organic Fluorophores In Calcium Phosphate Nanoparticles Withslow Release, Laila Sadallah, Aicha Boukhriss, Hassan Hannache, Said Gmouh Jan 2020

Entrapment Of Organic Fluorophores In Calcium Phosphate Nanoparticles Withslow Release, Laila Sadallah, Aicha Boukhriss, Hassan Hannache, Said Gmouh

Turkish Journal of Chemistry

Two organic fluorophores, fluorescein (F) and rhodamine B (Rd), were entrapped in calcium phosphate nanoparticles. The as-obtained nanoparticles can be used for biological release applications. For this aim, calcium phosphate nanoparticles were synthesized using the precipitation method. Structural analysis of these nanoparticles was performed using XRD, FTIR, and Raman spectroscopy, confirming that the synthesized nanoparticles were hydroxyapatite. TEM and SEM analyses demonstrated that these nanoparticles had a size of 20 nm and a well-defined morphology. F and Rd (about 0.5 wt.%) were entrapped in these nanoparticles and their release, as a function of time, was studied via UV-Vis spectroscopy. The …

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Blue Dye Degradation In An Aqueous Medium By A Combined Photocatalytic Andbacterial Biodegradation Process, Gabriela Perez Osorio, Flor Del Rocio Hernandez Gomez, Janette Arriola Morales, Maribel Castillo Morales, Jose Carlos Mendoza Hernandez Jan 2020

Blue Dye Degradation In An Aqueous Medium By A Combined Photocatalytic Andbacterial Biodegradation Process, Gabriela Perez Osorio, Flor Del Rocio Hernandez Gomez, Janette Arriola Morales, Maribel Castillo Morales, Jose Carlos Mendoza Hernandez

Turkish Journal of Chemistry

This paper aimed at implementing a treatment system for polluted water with textile dyes, starting with a photocatalytic decomposition process using sunlight as a source of energy and continuing with a bacterial biodegradation process, in order to reach degradation percentages higher than those obtained using only one of the processes mentioned above. When water treatment with the dye in the combined system was over, an acute ecotoxicity test was performed to make sure that toxic metabolites were not produced due to biodegradation. Solophenyl Blue azoic dye, and Erionyl Blue and Terasil Blue anthraquinone dye-colored solutions were treated with the Pd/Al$_{80}$ …

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Synthesis, Cytotoxic Assessment, And Molecular Docking Studies Of2,6-Diaryl-Substituted Pyridine And 3,4- Dihydropyrimidine-2(1h)-One Scaffolds, Zahra Hosseinzadeh, Nima Razzaghi-Asl, Ali Ramazani, Hamideh Aghahosseini, Ali Ramazani Jan 2020

Synthesis, Cytotoxic Assessment, And Molecular Docking Studies Of2,6-Diaryl-Substituted Pyridine And 3,4- Dihydropyrimidine-2(1h)-One Scaffolds, Zahra Hosseinzadeh, Nima Razzaghi-Asl, Ali Ramazani, Hamideh Aghahosseini, Ali Ramazani

Turkish Journal of Chemistry

Cancer is one of the main global health problems. In order to develop novel antitumor agents, we synthesized 3,4-dihydropyrimidine-2(1H)-one (DHPM) and 2,6-diaryl-substituted pyridine derivatives as potential antitumor structures and evaluated their cytotoxic effects against several cancer cell lines. An easy and convenient method is reported for the synthesis of these derivatives, employing cobalt ferrite (CoFe$_{2}$ O$_{4}$ @SiO$_{2}$ -SO$_{3}$ H) magnetic nanoparticles under microwave irradiation and solvent-free conditions. The structural characteristics of the prepared nanocatalyst were investigated by FTIR, XRD, SEM, and TGA techniques. In vitro cytotoxic effects of the synthesized products were assessed against the human breast adenocarcinoma cell line …

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Effect Of Surfactant Types On Particle Size And Morphology Of Flame-Retardantzinc Borate Powder, Yeli̇z İpek Jan 2020

Effect Of Surfactant Types On Particle Size And Morphology Of Flame-Retardantzinc Borate Powder, Yeli̇z İpek

Turkish Journal of Chemistry

Zinc borate is a boron-containing chemical material that is used to increase the flame retardancy of polymeric materials, dyes, cables, fabrics, carpets, and the internal parts of automobiles and planes. Commercially used zinc borate, which has the formula of 2ZnO· 3B$_{2}$ O$_{3}$· 7H$_{2}$ O, has a particle size between 10 and 20 μm. However, recent studies have shown that nanosized flame retardants have more superior flame retardancy and less negative effects on mechanical properties than microsized flame retardants. Nanosized flame retardants disperse more homogeneously and even low quantities are sufficient to provide high flame resistance. In this study, nano zinc …

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Development Of Thermoplastic Polyurethane/Polyaniline-Doped Membranes Forthe Separation Of Glycine Through Electrodialysis, Khurram ., Asif Ali Qaiser, Rashid Saleem, Naveed Shahzad Ali, Shahbaz Nazir, Tousif Hussain, Abdul Ghaffar Jan 2020

Development Of Thermoplastic Polyurethane/Polyaniline-Doped Membranes Forthe Separation Of Glycine Through Electrodialysis, Khurram ., Asif Ali Qaiser, Rashid Saleem, Naveed Shahzad Ali, Shahbaz Nazir, Tousif Hussain, Abdul Ghaffar

Turkish Journal of Chemistry

Recently, membrane-based separation processes, particularly electrodialysis, have attracted attention for the separation and purification of organic and amino acids from animal feedstock waste. In this study, cation exchange membranes were synthesized by making a composite of thermoplastic polyurethane and polyaniline (PANI) via the doping of various aromatic sulfonic acids, such as ß -naphthol sulfonic acid and phenol sulfonic acid. The PANI was prepared using a standard method, which was further used in the composite blending at varying concentrations of 10%- 20%. The impact of the concentration of PANI and the nature of the dopant on the membrane characteristics were comparatively …

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Synthesis, Spectroscopic Studies, And Antioxidant Activities Of Novelthio/Carbohydrazones And Bis-Isatin Derivatives From Terephthalaldehyde, Hali̇t Muğlu, Hasan Yakan, Temel Kan Bakir Jan 2020

Synthesis, Spectroscopic Studies, And Antioxidant Activities Of Novelthio/Carbohydrazones And Bis-Isatin Derivatives From Terephthalaldehyde, Hali̇t Muğlu, Hasan Yakan, Temel Kan Bakir

Turkish Journal of Chemistry

New bis(isatins-thio/carbohydrazones) based on Schiff bases were prepared from terephthalaldehyde biscarbohydrazone and 5-substituted isatins in the presence of a drop of sulfuric acid under reflux in ethanol. Terephthalaldehyde bis(thio/carbohydrazone) was synthesized by the reaction of (thio)/carbohydrazide and terephthalaldehyde in the presence of a few drops of acetic acid under reflux in ethanol. The structures of these synthesized compounds were determined using IR, $^{1}$H NMR, and $^{13}$C NMR spectroscopy and elemental analysis. The in vitro antioxidant activity of all the compounds was determined by the 1,1-diphenyl-2-picryl hydrazyl (DPPH.) free radical scavenging method. Compound 2 showed the best antioxidant activity.

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Bet, Ftir, And Raman Characterizations Of Activated Carbon From Waste Oil Fly Ash, Rizwan Ali, Zaheer Aslam, Reyad A. Shawabkeh, Anam Asghar, Ibnelwaleed A. Hussein Jan 2020

Bet, Ftir, And Raman Characterizations Of Activated Carbon From Waste Oil Fly Ash, Rizwan Ali, Zaheer Aslam, Reyad A. Shawabkeh, Anam Asghar, Ibnelwaleed A. Hussein

Turkish Journal of Chemistry

Activated carbon (AC), a porous material with high pore volume, attracts increasing attention owing to its potential applications in several fields. The development of a porous structure in AC marginally relies on both the treatment methods and the type of precursor. Thus far, both renewable and nonrenewable precursor sources have been used to synthesize AC with high surface area and pore volume. This study presents the synthesis of AC via physicochemical treatment of waste oil fly ash (OFA), a waste material produced from power plants. The aim was to produce AC by adding surface pores and surface functional groups to …

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Boron Trifluoride Etherate Promoted Microwave Assisted Synthesis Of Antimalarial Acridones, Papireddy Kancharla, Rozalia A. Dodean, Yuexin Li, Jane X. Kelly Jan 2020

Boron Trifluoride Etherate Promoted Microwave Assisted Synthesis Of Antimalarial Acridones, Papireddy Kancharla, Rozalia A. Dodean, Yuexin Li, Jane X. Kelly

Chemistry Faculty Publications and Presentations

A microwave-assisted, rapid and efficient method using boron trifluoride etherate (BF3.Et2O) for the synthesis of acridones, via an intramolecular acylation of N-phenylanthranilic acid derivatives, has been developed. The reaction proceeds under solvent-free conditions, tolerates a wide range of functional groups, and provides rapid access to a range of acridones in good to excellent yields. Several of the synthesized acridones exhibited potent antimalarial activities against CQ sensitive and multi-drug resistant (MDR) parasites.

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Size-Dependent Interactions Of Lipid-Coated Gold Nanoparticles: Developing A Better Mechanistic Understanding Through Model Cell Membranes And In Vivo Toxicity, Arek M. Engstrom, Ryan A. Faase, Joe E. Baio, Marilyn R. Mackiewicz, Stacey L. Harper Jan 2020

Size-Dependent Interactions Of Lipid-Coated Gold Nanoparticles: Developing A Better Mechanistic Understanding Through Model Cell Membranes And In Vivo Toxicity, Arek M. Engstrom, Ryan A. Faase, Joe E. Baio, Marilyn R. Mackiewicz, Stacey L. Harper

Chemistry Faculty Publications and Presentations

Introduction: Humans are intentionally exposed to gold nanoparticles (AuNPs) where they are used in variety of biomedical applications as imaging and drug delivery agents as well as diagnostic and therapeutic agents currently in clinic and in a variety of upcoming clinical trials. Consequently, it is critical that we gain a better understanding of how physiochemical properties such as size, shape, and surface chemistry drive cellular uptake and AuNP toxicity in vivo. Understanding and being able to manipulate these physiochemical properties will allow for the production of safer and more efficacious use of AuNPs in biomedical applications.
Methods and Materials: Here, …

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A Simple Predictive Model For Estimating Relative E-Cigarette Toxic Carbonyl Levels, Shawna Vreeke, Xijing Zhu, Robert Strongin Jan 2020

A Simple Predictive Model For Estimating Relative E-Cigarette Toxic Carbonyl Levels, Shawna Vreeke, Xijing Zhu, Robert Strongin

Chemistry Faculty Publications and Presentations

E-cigarette devices are wide ranging, leading to significant differences in levels of toxic carbonyls in their respective aerosols. Power can be a useful method in predicting relative toxin concentrations within the same device, but does not correlate well to inter-device levels. Herein, we have developed a simple mathematical model utilizing parameters of an e-cigarette’s coil and wick in order to predict relative levels of e-liquid solvent degradation. Model 1, which is coil length/(wick surface area*wraps), performed in the moderate-to-substantial range as a predictive tool (R2 = 0.69). Twelve devices, spanning a range of coil and wick styles, were analyzed. Model …

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Synthesis Of Radioluminescent Caf2:Ln Core, Mesoporous Silica Shell Nanoparticles For Use In X-Ray Based Theranostics, Hayden Winter, Megan J. Neufeld, Lydia Makotamo, Conroy Sun, Andrea M. Goforth Jan 2020

Synthesis Of Radioluminescent Caf2:Ln Core, Mesoporous Silica Shell Nanoparticles For Use In X-Ray Based Theranostics, Hayden Winter, Megan J. Neufeld, Lydia Makotamo, Conroy Sun, Andrea M. Goforth

Chemistry Faculty Publications and Presentations

X-ray radiotherapy is a common method of treating cancerous tumors or other malignant lesions. The side effects of this treatment, however, can be deleterious to patient quality of life if critical tissues are affected. To potentially lower the effective doses of radiation and negative side-effects, new classes of nanoparticles are being developed to enhance reactive oxygen species production during irradiation. This report presents the synthesis and radiotherapeutic efficacy evaluation of a new nanoparticle formulation designed for this purpose, composed of a CaF2 core, mesoporous silica shell, and polyethylene glycol coating. The construct was additionally doped with Tb and Eu …

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A Statistical Analysis Of Trans-Resveratrol In Grape Cane From Ten Varieties Of Cultivated Wine Grapes (Vitus Spp.), Harold Rathburn, Peter Bell, Scott Cook, Darrell D. Mayberry, Emryse Geye, Ryann Goodrich Jan 2020

A Statistical Analysis Of Trans-Resveratrol In Grape Cane From Ten Varieties Of Cultivated Wine Grapes (Vitus Spp.), Harold Rathburn, Peter Bell, Scott Cook, Darrell D. Mayberry, Emryse Geye, Ryann Goodrich

Chemistry Faculty Publications and Presentations

trans-Resveratrol (resveratrol) has been shown to have various health benefits. As a consequence, there is an effort to determine plentiful sources of this molecule. Certain plants, such as grapes, synthesize resveratrol and therefore appear to be an excellent source of this chemical. Annual pruning of grapevine yields significant amounts of cane material that is normally mulched or simply burned. Previous studies have shown this grape cane to contain economically useful resveratrol. Texas is the seventh largest producer of grapes in the USA with over 162 ha currently under cultivation. As a result it is estimated that more than $3.2 …

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Intra- And Intermolecular Self-Assembly Of A 20-Nm-Wide Supramolecular Hexagonal Grid, Zhe Zhang, Yiming Li, Bo Song, Yuan Zhang, Xin Jiang, Ming Wang, Ryan Tumbleson, Changlin Liu, Pingshan Wang, Xin-Qi Hao, Tomas Rojas, Anh T. Ngo, Jonathan L. Sessler, George R. Newkome, Saw Wai Hla, Xiaopeng Li Jan 2020

Intra- And Intermolecular Self-Assembly Of A 20-Nm-Wide Supramolecular Hexagonal Grid, Zhe Zhang, Yiming Li, Bo Song, Yuan Zhang, Xin Jiang, Ming Wang, Ryan Tumbleson, Changlin Liu, Pingshan Wang, Xin-Qi Hao, Tomas Rojas, Anh T. Ngo, Jonathan L. Sessler, George R. Newkome, Saw Wai Hla, Xiaopeng Li

Physics Faculty Publications

For the past three decades, the coordination-driven self-assembly of three-dimensional structures has undergone rapid progress; however, parallel efforts to create large discrete two-dimensional architectures—as opposed to polymers—have met with limited success. The synthesis of metallo-supramolecular systems with well-defined shapes and sizes in the range of 10–100 nm remains challenging. Here we report the construction of a series of giant supramolecular hexagonal grids, with diameters on the order of 20 nm and molecular weights greater than 65 kDa, through a combination of intra- and intermolecular metal-mediated self-assembly steps. The hexagonal intermediates and the resulting self-assembled grid architectures were imaged at submolecular …

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Synthesis And Bioactivities Of 1-(4-Hydroxyphenyl)-2-((Heteroaryl)Thio)Ethanones As Carbonic Anhydrase I, Ii And Acetylcholinesterase Inhibitors, Cem Yamali, Hali̇se İnci̇ Gül, Yeli̇z Demi̇r, Cavi̇t Kazaz, İlhami̇ Gülçi̇n Jan 2020

Synthesis And Bioactivities Of 1-(4-Hydroxyphenyl)-2-((Heteroaryl)Thio)Ethanones As Carbonic Anhydrase I, Ii And Acetylcholinesterase Inhibitors, Cem Yamali, Hali̇se İnci̇ Gül, Yeli̇z Demi̇r, Cavi̇t Kazaz, İlhami̇ Gülçi̇n

Turkish Journal of Chemistry

The discovery of enzyme targeting inhibitors is a popular area of drug research. Biological activities of the compounds bearing phenol and heteroaryl groups make them popular groups in drug design targeting important enzymes such as acetylcholinesterase (AChE, E.C.3.1.1.7) and carbonic anhydrases (CAs, EC 4.2.1.1). 1-(4-hydroxyphenyl)-2-((aryl)thio)ethanones as possible AChE and CAs inhibitors were synthesized, and their chemical structures were confirmed by IR, $^{1}$H NMR, $^{13}$C NMR, and HRMS. The compounds 2 and 4 were found potent AChE inhibitors with the Ki values of 22.13 ± 1.96 nM and 23.71 ± 2.95 nM, respectively, while the compounds 2 (Ki $=$ 8.61 ± …

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Synthesis, Biological Evaluation Of Antioxidant-Antibacterial Activities And Computational Studies Of Novel Anthracene- And Pyrene-Based Schiff Base Derivatives, Ayşegül Gümüş, Veysi̇ Okumuş, Selçuk Gümüş Jan 2020

Synthesis, Biological Evaluation Of Antioxidant-Antibacterial Activities And Computational Studies Of Novel Anthracene- And Pyrene-Based Schiff Base Derivatives, Ayşegül Gümüş, Veysi̇ Okumuş, Selçuk Gümüş

Turkish Journal of Chemistry

Schiff base derivatives with anthracene- and pyrene-based units, A1-A6 and P1-P6 were synthesized (89%-99% yields). Schiff base derivatives were designed to possess an heterocyclic moiety on one side to enhance the coordination ability towards metals. To investigate the biological assay of the newly synthesized compounds, their DPPH (2,2-diphenyl-1-picrylhydrazyl) radical scavenging, metal chelating, reducing power, antibacterial and DNA binding activities were tested. A6 (63.1%) showed the maximum free radical scavenging activity among all. However, compound P3 at concentration of 200 \textmu g/mL possessed the highest metal chelating (45.8%) activity and power of reduction. In addition, P3 and A6 showed antibacterial activity …

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Magnetite Nanoparticles-Based Hydroxyl Radical Scavenging Activity Assay Ofantioxidants Using N, N-Dimethyl-P-Phenylenediamine Probe, Zi̇ya Can, Büşra Keski̇n, Ayşem Arda, Erol Erçağ, Mustafa Reşat Apak Jan 2020

Magnetite Nanoparticles-Based Hydroxyl Radical Scavenging Activity Assay Ofantioxidants Using N, N-Dimethyl-P-Phenylenediamine Probe, Zi̇ya Can, Büşra Keski̇n, Ayşem Arda, Erol Erçağ, Mustafa Reşat Apak

Turkish Journal of Chemistry

Excessive amounts of reactive oxygen species (ROS), unless counterbalanced by antioxidants, can cause cellular damage under oxidative stress conditions; therefore, antioxidative defenses against ROS must be measured. With the development of nanotechnology, nanoparticles have found numerous applications in science, health, and industries. Magnetite nanoparticles (Fe$_{3}$O$_{4}$:MNPs) have attracted attention because of their peroxidase-like activity. In this study, hydroxyl radicals (?OH) generated by MNPs-catalyzed degradation of H$_{2}$O$_{2}$ converted the N,N-dimethyl-p-phenylenediamine (DMPD) probe into its colored DMPD$^{•+}$ radical cation, which gave an absorbance maximum at λ = 553 nm. In the presence of antioxidants, $^{•}$OH was partly scavenged by antioxidants and produced less …

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Synthesis, Characterization And Evaluation Of Antidengue Activity Of Enantiomeric Schiffbases Derived From S-Substituted Dithiocarbazate, Maqsood Maryam, Sang Loon Tan, Karen Ann Crouse, Mohamed Ibrahim Mohamed Tahir, Hui Yee Chee Jan 2020

Synthesis, Characterization And Evaluation Of Antidengue Activity Of Enantiomeric Schiffbases Derived From S-Substituted Dithiocarbazate, Maqsood Maryam, Sang Loon Tan, Karen Ann Crouse, Mohamed Ibrahim Mohamed Tahir, Hui Yee Chee

Turkish Journal of Chemistry

A series of Schiff bases have been successfully synthesized through the acid-catalyzed condensation of S-substituted dithiocarbazates and three enantiomerically pure monoterpenes, (1R)-(+)-camphor, (1S)-(-)-camphor, (1R)-(-)-camphorquinone, (1S)- (+)-camphorquinone, (R)-(-)-carvone and (S)-(+)-carvone. Spectroscopic results revealed that the Schiff bases containing camphor or carvone likely adopted an E-configuration along the characteristic imine bond while those containing camphorquinone assumed a Z-configuration. The antidengue potential of these compounds was evaluated based on DENV 2 caused cytopathic effect (CPE) reduction-based in vitro evaluation. The compounds were validated through secondary foci forming unit reduction assay (FFURA). Compounds were also tested for their cytotoxicity against Vero cells. The compounds …

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Preparation Of Different Thin Film Catalysts By Direct Current Magnetron Sputtering Forhydrogen Generation, Gamze Bozkurt, Abdulkadi̇r Özer, Ayşe Bayrakçeken Yurtcan Jan 2020

Preparation Of Different Thin Film Catalysts By Direct Current Magnetron Sputtering Forhydrogen Generation, Gamze Bozkurt, Abdulkadi̇r Özer, Ayşe Bayrakçeken Yurtcan

Turkish Journal of Chemistry

In this study, thin films of Co, Ni, Pd, and Pt were prepared on Co$_{3}$O$_{4}$ support material in pellet form using the direct current (DC) magnetron sputtering method for use as catalysts for hydrogen generation from NaBH4.Characterization of the catalysts was carried out using X-ray diffraction (XRD), scanning electronic microscopy (SEM), and X-ray photoelectron spectroscopy (XPS). According to cross-sectional SEM images, catalyst thicknesses were observed in the range of approximately 115.3-495.8 nm. The particle sizes were approximately 25.0, 21.4, 33.9, and 9.5 nm for Ni-Co$_{3}$O$_{4}$, Co-Co$_{3}$O$_{4}$, Pd-Co$_{3}$O$_{4}$, and Pt-Co$_{3}$O$_{4}$ catalysts, respectively. The increase in NaOH initial concentration provides an increase …

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The Production Of Enantiomerically Pure 1-Phenylethanol By Enzymatic Kineticresolution Method Using Response Surface Methodology, Ayşe Bozan, Rahi̇me Songür, Ülkü Mehmetoğlu Jan 2020

The Production Of Enantiomerically Pure 1-Phenylethanol By Enzymatic Kineticresolution Method Using Response Surface Methodology, Ayşe Bozan, Rahi̇me Songür, Ülkü Mehmetoğlu

Turkish Journal of Chemistry

As the enantiomers of 1-phenylethanol are valuable intermediates in several industries, the lipase catalyzed kinetic resolution of (R,S) -1-phenylethanol is a relevant research topic. In this study, the goal was to determine the optimum reaction parameters to produce enantiomerically pure 1-phenylethanol by lipase (Novozyme 435) catalyzed kinetic resolution using response surface methodology (RSM). Reactions were performed with 40-400 mM (R,S)-1-phenylethanol, 120-1200 mM vinyl acetate and 2-22 mg/ mL biocatalyst concentrations (BC$_{L}$), at 20-60 °C and with a stirring rate of 50-400 rpm for 5-120 min. The samples were analyzed using high performance liquid chromatography (HPLC) with a Chiralcel OB column. …

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Innovational Combination Of Hetero-Bifunctional N-Peg Quinoline Scaffolds Derivatives With Improved Anticancer Activity Against Breast And Colon Cancer Cell Lines And P-Glycoprotein, Cytochrome P450 Enzyme Activity Prediction, Mahesh Gaidhane, Ajay Ghatole, Kushal Lanjewar, Kishor Hatzade Jan 2020

Innovational Combination Of Hetero-Bifunctional N-Peg Quinoline Scaffolds Derivatives With Improved Anticancer Activity Against Breast And Colon Cancer Cell Lines And P-Glycoprotein, Cytochrome P450 Enzyme Activity Prediction, Mahesh Gaidhane, Ajay Ghatole, Kushal Lanjewar, Kishor Hatzade

Turkish Journal of Chemistry

Polyethylene glycol (PEG) is a polymer that is widely used as a carrier for drug delivery systems (DDS). A library of N-PEGylated quinoline derivatives of PEG molecular weight 200 was prepared rapidly after the activation of PEGs using maleic anhydride. Quinoline with a polymer backbone is essential as new material. PEG is a water-soluble nonionic polymer approved by food and drug organizations for medicine applications. Because of its nontoxic grapheme, it is widely utilized in numerous biochemical, cosmetic, pharmaceutical, and industrialized applications. The modern SwissADME is a web tool that stretches free admittance to a pool of hasty, yet solid, …

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Newly Synthesized Peripherally Octa-Substituted Zinc Phthalocyanines Carrying Halogenterminated Phenoxy-Phenoxy Moiety: Comparative Photochemical And Photophysicalfeatures, Erkan Kirbaç, Ali̇ Erdoğmuş Jan 2020

Newly Synthesized Peripherally Octa-Substituted Zinc Phthalocyanines Carrying Halogenterminated Phenoxy-Phenoxy Moiety: Comparative Photochemical And Photophysicalfeatures, Erkan Kirbaç, Ali̇ Erdoğmuş

Turkish Journal of Chemistry

This study reports the 3 new phthalonitrile derivatives, namely 4, 5 Bis-[4-(4-bromophenoxy) phenoxy] phthalonitrile (1), 4,5 Bis-[4-(4-chlorophenoxy) phenoxy]phthalonitrile (2), and 4, 5 Bis[4-(4-fluorophenoxy) phenoxy] phthalonitrile (3). Their octasubstituted zinc phthalocyanines (4, 5, 6) are reported for the first time in this study. The resulting compounds were characterized by utilizing some spectroscopic methods, such as UV-Vis, 1HNMR, FT-IR spectroscopy, as well as mass spectraand elemental analysis. To show photosynthesizer's potential, emission (FF), singlet oxygen (1O2), and photodegradation quantum yields (ΦΔ, Φd) of octaperipherally phthalocyanines (Pcs) were performed in the solutions, such as biocompatible solvent DMSO (dimethyl sulfoxide) as well as DMF …

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Chemical Composition, And Antibacterial And Antioxidant Activities Of Essential Oils From Laggera Tomentosa Sch. Bip. Ex Oliv. Et Hiern (Asteraceae), Tokuma Getahun, Vinit Sharma, Deepak Kumar, Neeraj Gupta Jan 2020

Chemical Composition, And Antibacterial And Antioxidant Activities Of Essential Oils From Laggera Tomentosa Sch. Bip. Ex Oliv. Et Hiern (Asteraceae), Tokuma Getahun, Vinit Sharma, Deepak Kumar, Neeraj Gupta

Turkish Journal of Chemistry

Laggera tomentosa Sch. Bip. ex Oliv. et Hiern (Asteraceae), an endemic Ethiopian medicinal plant, is traditionally used to treat various ailments. Previously, the chemical constituents of the essential oil (EO) of its leaves and inflorescence were documented. However, no data about the chemical compositions of other parts of the EOs of the plant have been reported to date. Moreover, there are no previous biological activity reports on any parts of the EOs of this plant. Thus, in this study, the EOs were isolated from the stem bark and roots of this plant by hydrodistillation and analyzed using gas chromatography-mass spectrometry …

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Synthesis And Molecular Docking Studies Of Quinoline Derivatives As Hiv Non-Nucleoside Reverse Transcriptase Inhibitors, Nivedita Bhardwaj, Diksha Choudhary, Akashdeep Pathania, Somesh Baranwal, Pradeep Kumar Jan 2020

Synthesis And Molecular Docking Studies Of Quinoline Derivatives As Hiv Non-Nucleoside Reverse Transcriptase Inhibitors, Nivedita Bhardwaj, Diksha Choudhary, Akashdeep Pathania, Somesh Baranwal, Pradeep Kumar

Turkish Journal of Chemistry

Quinoline moiety is an important scaffold in the field of drug discovery and drug development, with a wide range of pharmacological activities. Quinoline derivatives are potent inhibitors for reverse transcriptase, which is responsible for the conversion of single-stranded viral RNA into double-stranded viral DNA.In the present study, we have designed and synthesized 2 series, namely pyrazoline and pyrimidine containing quinoline derivatives as non nucleoside reverse transcriptase inhibitors (NNRTIs). Eleven compounds were synthesized and characterized by 1H and 13C NMR and mass spectrophotometry. The synthesized compounds were also docked on an HIV reverse transcriptase binding site (PDB: 4I2P); most of these …

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Microplastic Fragment And Fiber Contamination Of Beach Sediments From Selected Sites In Virginia And North Carolina, Usa, Gabrielle Z. Dodson, A. Katrina Shotorban, Patrick G. Hatcher, Derek Waggoner, Sutapa Ghosal, Nora Noffke Jan 2020

Microplastic Fragment And Fiber Contamination Of Beach Sediments From Selected Sites In Virginia And North Carolina, Usa, Gabrielle Z. Dodson, A. Katrina Shotorban, Patrick G. Hatcher, Derek Waggoner, Sutapa Ghosal, Nora Noffke

OES Faculty Publications

Microplastic particles (<5 >mm) constitute a growing pollution problem within coastal environments. This study investigated the microplastic presence of estuarine and barrier island beaches in the states of Virginia and North Carolina, USA. Seventeen sediment cores were collected at four study sites and initially tested for microplastic presence by pyrolysis-gas chromatography–mass spectrometry. For the extraction, microplastic particles were first separated from the sediment using a high-density cesium chloride solution (1.88 g/mL). In a second step, an oil extraction collected the remaining microplastic particles of higher densities. Under the light microscope, the extracted microplastic particles were classified based on their morphologies …

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Pyrene-Bodipy-Substituted Novel Water-Soluble Cyclotriphosphazenes: Synthesis,Characterization, And Photophysical Properties, Seda Çeti̇ndere, Serkan Yeşi̇lot, Adem Kiliç Jan 2020

Pyrene-Bodipy-Substituted Novel Water-Soluble Cyclotriphosphazenes: Synthesis,Characterization, And Photophysical Properties, Seda Çeti̇ndere, Serkan Yeşi̇lot, Adem Kiliç

Turkish Journal of Chemistry

In the present work, pyrene-boron-dipyrromethene (BODIPY)-substituted novel water-soluble cyclotriphosphazene derivatives (6 and 7) were synthesized by click reactions between a cyclotriphosphazene derivative with a hydrophilic glycol side group (2) and BODIPYs (4 and 5). All of the new compounds (2, 6, and 7) were characterized by Fourier-transform infrared and nuclear magnetic resonance spectroscopy, as well as mass spectrometry and elemental analysis. The photophysical properties of the BODIPY-substituted cyclotriphosphazenes (6 and 7) were investigated by UV-Vis and fluorescence emission spectroscopy in water and water/solvent mixtures. It was found that the target compounds were soluble in water and could be potential candidates …

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Novel Bodipy-Bridged Cyclotriphosphazenes, Hande Eserci̇, Ezel Öztürk, Eli̇f Okutan Jan 2020

Novel Bodipy-Bridged Cyclotriphosphazenes, Hande Eserci̇, Ezel Öztürk, Eli̇f Okutan

Turkish Journal of Chemistry

Three new 2-component unsubstituted (4P), diiodo- (5P), and dibromo- (6P) distyryl-BODIPY-bridged cyclotriphosphazene dimers were designed and synthesized. The newly synthesized BODIPY-cyclotriphosphazene systems were characterized by $^{1}$H, $^{13}$C, and $^{31}$P NMR spectroscopy. The photophysical properties of the distryl-BODIPYs (4-6) and BODIPY-cyclotriphosphazene dyads (4P-6P) were studied by UV-Vis absorption and fluorescence emission spectroscopy. In these derivatives, the bino-type cyclotriphosphazene derivative bearing unsubstituted BODIPY unit 4 P exhibited high fluorescence and no singlet oxygen generation due to the lack of spin converter. The attachment of heavy atoms (iodine and bromine) enabled the production of singlet oxygen. The bino-type BODIPY-cyclotriphosphazenes (5P and 6P) were …

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Choline Derivatives Immobilized On Silica To Catalyze Transesterification Reaction For Production Of Glycerophosphocholine, Longhui Wei, Binglin Li, Xiaoli Zhang, Kai Tang, Wenwen Zheng, Dan Chen, Binxia Zhao Jan 2020

Choline Derivatives Immobilized On Silica To Catalyze Transesterification Reaction For Production Of Glycerophosphocholine, Longhui Wei, Binglin Li, Xiaoli Zhang, Kai Tang, Wenwen Zheng, Dan Chen, Binxia Zhao

Turkish Journal of Chemistry

Choline derivatives were covalently immobilized on the surface of γ -aminated silica. The obtained immobilized choline derivative was then successfully used for a transesterification reaction to produce glycerophosphocholine (GPC). Fourier transform infrared analysis and thermogravimetric analysis/differential thermal gravimetry indicated that the surface of the γ -aminated silica was covered by choline derivatives and the highest immobilization amount reached 1.1 mmol/g under optimal conditions. More importantly, the highest yield of GPC reached 97.9% during transesterification. With regard to GPC in food or medicine for human use, the immobilization technology can avoid catalyst contamination of the product and increase the safety of …

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So$_{2}$ Sorption Properties Of Fly Ash Zeolites, Natalia Czuma, Wojciech Franus, Pawel Baran, Agnieszka Cwik, Katarzyna Zarebska Jan 2020

So$_{2}$ Sorption Properties Of Fly Ash Zeolites, Natalia Czuma, Wojciech Franus, Pawel Baran, Agnieszka Cwik, Katarzyna Zarebska

Turkish Journal of Chemistry

In the presented study, the sulfur dioxide sorption properties of fly ash zeolite X were investigated. Sorption tests were performed on fly ash zeolite samples that were not prepared specially for sorption, in addition to dried samples and samples in the presence of water vapor. The samples saturated with water vapor showed the highest sorption capacity. The sorption capacity of the samples additionally dried prior to the sorption experiment was higher than that of the samples that were not specially prepared for the sorption test. Regeneration tests indicated relatively good regeneration properties. The obtained results were described with the use …

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Synthesis Of Metallo-Supramolecular Materials Based On Terpyridine Functionalized Double-Decker Silsesquioxane With Improved Complexation Efficienc, Asuman Çeli̇k Küçük, Jun Matsui, Tokuji Miyashita Jan 2020

Synthesis Of Metallo-Supramolecular Materials Based On Terpyridine Functionalized Double-Decker Silsesquioxane With Improved Complexation Efficienc, Asuman Çeli̇k Küçük, Jun Matsui, Tokuji Miyashita

Turkish Journal of Chemistry

Silsesquioxane-based transition-metal complexes have come to the forefront due to the ability of silsesquioxane to control nanostructures and properties. However, some difficulties in complete complexation and purification limit the widespread use of transition-metal-based supramolecular coordination complexes comprising silsesquioxane. Herein, 2 different approaches have been proposed for the synthesis of metallo-supramolecular materials on the basis of ruthenium(II)-terpyridine functional double-layer silsesquioxane (DDSQ) (Tpy/Ru-DDSQ) (Routes 1 and 2). In Route 1, complexation was followed by functionalization of DDSQ with the ligand, whereas in Route 2, complexation was performed before the ligand was inserted into the DDSQ. Tpy/Ru-DDSQ obtained from both approaches was characterized …

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