Physiology Commons^™

An Acute Bout Of Self-Myofascial Release In The Form Of Foam Rolling Improves Performance Testing, Corey A. Peacock, Darren D. Krein, Tobin A. Silver, Gabriel J. Sanders, Kyle-Patrick A. Von Carlowitz

International Journal of Exercise Science

International Journal of Exercise Science 7(3) : 202-211, 2014. Recent developments in the strength and conditioning field have shown the incorporation of foam rolling self-myofascial release in adjunct with a dynamic warm-up. This is thought to improve overall training performance; however, minimal research exists supporting this theory. Therefore, determining if an acute bout of foam rolling self-myofascial release in addition to a dynamic warm-up could influence performance is of importance. In order to do so, eleven athletically trained male subjects participated in a two condition, counterbalanced, crossover within-subjects study comparing two particular warm-up routines. The two warm-up routines compared were …

The Physiologic And Behavioral Implications Of Playing Active And Sedentary Video Games In A Seated And Standing Position, Gabriel J. Sanders, Michael Rebold, Corey A. Peacock, Megan L. Williamson, Antonio Santo, Jacob E. Barkley

International Journal of Exercise Science

International Journal of Exercise Science 7(3) : 194-201, 2014. Previous studies have assessed physiologic response while playing video games per manufacturer instructions with participants standing during active video game play and seated during sedentary game play. It is not known whether an assigned seated or standing position affects positional preference and oxygen consumption (VO2) while gaming. The purpose of the study was to assess VO2 and preference of playing active and sedentary video games in a seated and standing position. VO2 was assessed in 25 participants during four, 20-minute conditions; resting, PlayStation 2 Madden NFL Football 2011, Nintendo Wii-Sports Boxing …

Effect Of Long-Term Physical Exercise On Blood Pressure In African Americans, Taunjah P. Bell, Katharine A. Mcintyre, Rosamary Hadley

International Journal of Exercise Science

International Journal of Exercise Science 7(3) : 186-193, 2014. Long-term physical exercise has been shown to noticeably reduce blood pressure (BP) and remarkably attenuate symptoms of hypertension. It is believed that physical exercise induces these beneficial effects by increasing the blood supply to the brain, enhancing the release of growth factors from skeletal muscles into the bloodstream, facilitating neurogenesis, stimulating angiogenesis, and influencing endothelial cell proliferation and subsequent endothelial cell membrane permeability. Previous findings also revealed that physical exercise significantly elevates brain-derived neurotrophic factor (BDNF) concentrations which appear to increase dramatically in BP-sensing neurons during hypertension. Elevating BDNF levels is …

Cardiovascular And Metabolic Demands Of The Kettlebell Swing Using A Tabata Interval Versus A Traditional Resistance Protocol, Howard A. Fortner, Jeanette Salgado, Angelica M. Holmstrup, Michael E. Holmstrup Phd

International Journal of Exercise Science

International Journal of Exercise Science 7(3) : 179-185, 2014. Tabata (TAB) training, consisting of eight cycles of 20 seconds of maximal exercise followed by 10 seconds of rest, is time-efficient, with aerobic and anaerobic benefit. This study investigated the cardiovascular and metabolic demands of a TAB versus traditional (TRAD) resistance protocol with the kettlebell swing. Fourteen young (18-25y), non-obese (BMI 25.7±0.8 kg/m²) participants reported on three occasions. All testing incorporated measurements of HR, oxygen consumption, and blood lactate accumulation. Each participant completed Tabata kettlebell swings (male- 8kg, female- 4.5kg; 8 intervals; 20s maximal repetitions, 10s rest). On a …

Is There An Optimal Whole-Body Vibration Exposure ‘Dosage’ For Performance Improvement?, R Hugh Morton, Darryl J. Cochrane

International Journal of Exercise Science

International Journal of Exercise Science 7(3) : 169-178, 2014. Whole-body vibration exposure has been shown to improve performance in vertical jumping and knee extensions. Some studies have addressed the question of dose optimality, but are inconclusive and inappropriately designed. Our purpose was to more thoroughly seek an optimum combination of duration, amplitude and frequency of exposure to side-alternating whole-body vibration. We used experimental designs constructed for response surface fitting and optimisation, using both blocked and unblocked second order central composite designs with 12 participants. Immediately after each exposure a discomfort index was recorded, then peak and average torque, peak and …

Targeting Of Receptors For Advanced Glycation End-Products (Rage) Diminishes Acute Secondhand Smoke-Induced Inflammation In Mice, Tyler Thomas Wood

Theses and Dissertations

The receptor for advanced glycation end-products (RAGE) has increasingly been demonstrated to be an important modulator of inflammation in cases of pulmonary disease. Published reports involving tobacco smoke exposure have demonstrated increased expression of RAGE, its participation in pro-inflammatory signaling and its role in irreversible pulmonary remodeling. The current research evaluated for the first time the in vivo effects of short-term tobacco smoke exposure in RAGE null and control mice compared to identical animals exposed to room air only. Quantitative real time PCR, immunoblotting, and immunohistochemistry revealed elevated RAGE expression in controls after four weeks of exposure and an anticipated …

Clinical Investigation Of Plethysmographic Variability Index: A Derivative Index Of Pulse Oximetry In Anesthetized Dogs, Vaidehi V. Paranjape

Open Access Theses

Plethysmographic Variability Index (PVI) is a derivative index of pulse oximetry that allows evaluating an individual's intravascular volume status. Perfusion Index (PI) represents the strength of pulse signal at the anatomic site of measurement from which PVI is calculated using changes in PI over respiratory cycles. Plethysmographic Variability Index has been used to detect hypovolemia and predict fluid responsiveness in mechanically ventilated human patients however, fewer studies are available in spontaneously breathing patients. The use of PVI has not been explored extensively in dogs so far. The goals of this study were to establish a common range for PVI and …

Transcriptome Of The Female Synganglion Of The Black-Legged Tick Ixodes Scapularis (Acari: Ixodidae) With Comparison Between Illumina And 454 Systems, Noble Egekwu, Daniel E. Sonenshine, Brooke W. Bissinger, R. Michael Roe

Biological Sciences Faculty Publications

Illumina and 454 pyrosequencing were used to characterize genes from the synganglion of female Ixodes scapularis. GO term searching success for biological processes was similar for samples sequenced by both methods. However, for molecular processes, it was more successful for the Illumina samples than for 454 samples. Functional assignments of transcripts predicting neuropeptides, neuropeptide receptors, neurotransmitter receptors and other genes of interest was done, supported by strong e-values (<-6), and high consensus sequence alignments. Transcripts predicting 15 putative neuropeptide prepropeptides ((allatostatin, allatotropin, bursicon α, corticotropin releasing factor (CRF), CRF-binding protein, eclosion hormone, FMRFamide, glycoprotein A, insulin-like peptide, ion transport peptide, myoinhibitory peptide, inotocin ( = neurophysin-oxytocin), Neuropeptide F, sulfakinin and SIFamide)) and transcripts predicting receptors for 14 neuropeptides (allatostatin, calcitonin, cardioacceleratory peptide, corazonin, CRF, eclosion hormone, gonadotropin-releasing hormone/AKH-like, insulin-like peptide, neuropeptide F, proctolin, pyrokinin, SIFamide, sulfakinin and tachykinin) are reported. Similar to Dermacentor variabilis, we found transcripts matching pro-protein convertase, essential for converting neuropeptide hormones to their mature form. Additionally, transcripts predicting 6 neurotransmitter/neuromodulator receptors (acetylcholine, GABA, dopamine, glutamate, octopamine and …

The Effects Of Squat Depth On Lower Extremity Joint Kinetics, Acl Loading, Pcl Loading, Tibiofemoral Compressive Forces And Activations Of Eight Lower Extremity Muscles, Zachary A. Sievert

Human Movement Studies & Special Education Theses & Dissertations

Performing resistance training exercises are important in many facets oflife. Resistance training can be used from elite athletes preparing for the Olympics to the average person exercising for overall health. The squat is a common training exercise that can be utilized to improve lower extremity strength and performance. There has been much debate on the effects of squatting depth on lower extremity joint kinetics and kinematics. Therefore the purpose of this thesis is to examine the effects of depth and load on the muscle activation of eight lower extremity muscles and three-dimensional (30) joint moments about the right knee, hip …

Motor Cortex Electrical Stimulation Augments Sprouting Of The Corticospinal Tract And Promotes Recovery Of Motor Function, Jason B. Carmel, John H. Martin

Publications and Research

The corticospinal system—with its direct spinal pathway, the corticospinal tract (CST) – is the primary system for controlling voluntary movement. Our approach to CST repair after injury in mature animals was informed by our finding that activity drives establishment of connections with spinal cord circuits during postnatal development. After incomplete injury in maturity, spared CST circuits sprout, and partially restore lost function. Our approach harnesses activity to augment this injury-dependent CST sprouting and to promote function. Lesion of the medullary pyramid unilaterally eliminates all CST axons from one hemisphere and allows examination of CST sprouting from the unaffected hemisphere. We …

Targeting The Wnt/Β-Catenin Signaling Pathway In Liver Cancer Stem Cells And Hepatocellular Carcinoma Cell Lines With Fh535, Roberto Gedaly, Roberto Galuppo, Michael F. Daily, Malay B. Shah, Erin Colleen Maynard, Changguo Chen, Xiping Zhang, Karyn A. Esser, Donald A. Cohen, B. Mark Evers, Jieyun Jiang, Brett T. Spear

Surgery Faculty Publications

Activation of the Wnt/β-catenin pathway has been observed in at least 1/3 of hepatocellular carcinomas (HCC), and a significant number of these have mutations in the β-catenin gene. Therefore, effective inhibition of this pathway could provide a novel method to treat HCC. The purposed of this study was to determine whether FH535, which was previously shown to block the β-catenin pathway, could inhibit β-catenin activation of target genes and inhibit proliferation of Liver Cancer Stem Cells (LCSC) and HCC cell lines. Using β-catenin responsive reporter genes, our data indicates that FH535 can inhibit target gene activation by endogenous and exogenously …

Trnas As Regulators Of Biological Processes, Medha Raina, Michael Ibba

Biology, Chemistry, and Environmental Sciences Faculty Articles and Research

Transfer RNAs (tRNA) are best known for their role as adaptors during translation of the genetic code. Beyond their canonical role during protein biosynthesis, tRNAs also perform additional functions in both prokaryotes and eukaryotes for example in regulating gene expression. Aminoacylated tRNAs have also been implicated as substrates for non-ribosomal peptide bond formation, post-translational protein labeling, modification of phospholipids in the cell membrane, and antibiotic biosyntheses. Most recently tRNA fragments, or tRFs, have also been recognized to play regulatory roles. Here, we examine in more detail some of the new functions emerging for tRNA in a variety of cellular processes …

Vitamin A Deficiency Causes Ovulation Abnormalities In Mice, Rebecca Ursin

DePaul Discoveries

Retinoic acid (RA) is an active metabolite of vitamin A (VA) and is involved in tissue organization, patterning, and growth. RA has been shown to regulate male reproduction, however information on its role in ovary development is limited. To investigate the functions of RA in the ovary, we examined its role in ovary development and ovulation using an in vivo dietary VA-deprivation animal model. Our preliminary results have shown that VA deficiency causes a variety of ovarian pathologies, including reduced numbers of total follicles and corpus lutea, formation of hemorrhagic and atretic follicles, and formation of bursa and follicular cysts. …

Effects Of Plyometric And Endurance Training On Aerobic And Anaerobic Power., T. Snyder, E. Shaw, A. Mueller, E. Stoeckel, A. Strom, T. Vanderveeken, T. Swensen

International Journal of Exercise Science: Conference Proceedings

Snyder, T., Shaw, E., Mueller, A., Stoeckel, E., Strom, A., VanDerVeeken, T., Swensen, T., Exercise and Sport Sciences, Ithaca College, Ithaca NY

Purpose and Methods: Extending the work of Burgomaster and Gibala, we compared the effects of four weeks of plyometric and endurance training on various indices of aerobic and anaerobic performance in 29 active college age males and females (19.4 ± 1.8 years and 69.9 ± 13.8 kg), who were assigned to a plyometric (6 males and 9 females) or endurance training group (6 males and 8 females). Endurance training consisted of 30 min of cycling at a heart …

The Effects Of Various Recovery Techniques On Collegiate Pitching Performance, B. Snyder, S. Davis, G. Moir, M. Miltenberger

International Journal of Exercise Science: Conference Proceedings

Snyder, B., Davis, S., Moir, G., Miltenberger, M., East Stroudsburg University, East Stroudsburg, PA

Purpose: This study was designed to compare pitching performance (velocity, accuracy), symptomology and functional movement across three recovery techniques (active recovery (pedaling on a stationary bike at 40% Max Age Predicted Heart Rate), passive recovery (sitting down with a jacket around the pitchers arm), and Electro muscular stimulation (sitting down with stim placed on the pitchers arm at the anterior and posterior deltoid) in NCAA Division II collegiate pitchers. Methods: Eight male Division II collegiate baseball athletes (Age: 20.1 ± 1.7 years, Mass: 84.8 ± 10.9 …

Ventilatory Threshold Responses At Different Percentages Of Body Weight On The Alter-G Anti-Gravity Treadmill: A Pilot Study, N. Santillo, M. Figueroa, T. Lasala, J. Manning

International Journal of Exercise Science: Conference Proceedings

Santillo, N., Figueroa, M., Lasala, T., Manning, J., William Paterson University, Wayne NJ

Purpose: The purpose of this study was to determine if changes occurred in the ventilatory threshold (VT) upon manipulation of body weight (BW) when comparing 80% to 100% of BW in healthy college aged individuals on the Alter-G® anti-gravity treadmill. Methods: A modified Bruce Protocol was used to measure oxygen consumption (VO_2peak) on 10 subjects (5 males, 5 females) at 100%, and 80% of BW. Testing protocols were randomized with two weeks in between each test. VT was determined by the software algorithm in the …

Examination Of Exercise Behaviors, Exercise Barriers And Exercise Self-Efficacy Of British Adults, M. Sadler, M. Brown, K. Dugan, J. Litchauer, K. Port, K. Smith

International Journal of Exercise Science: Conference Proceedings

Sadler, M., Brown, M., Dugan, K., Litchauer, J., Port, K., Smith, K., Slippery Rock University, Slippery Rock, PA

Purpose: To examine the exercise behaviors, barriers and self-efficacy of British adults. Methods: A survey was constructed based upon previously validated questionnaires and was randomly administered to subjects in various British cities. Seventy nine subjects, with a mean age of 31.92+12.03 participated in this study. Results: Subjects reported engaging in vigorous physical activity 3.5+2.94 days/week. The table below illustrates the modes of exercise regularly performed by the subjects. Subjects could report participating in more than one mode of exercise. Table1. The Table …

Effect Of Beta-Adrenergic Blockade On Coronary Blood Flow During Isometric Exercise In Older Adults, A. Ross, Z. Gao, M. Heffernan, U. Leuenberger, L. Sinoway, M. Muller

International Journal of Exercise Science: Conference Proceedings

Ross A., Gao Z., Heffernan M., Leuenberger U., Sinoway L., Muller M. Penn State Hershey Heart and Vascular Institute, Pennsylvania State University College of Medicine, Hershey, PA

The rise in heart rate (HR) and cardiac contractility during exercise is due to activation of myocardial b-adrenergic receptors. b-receptors are also located on coronary blood vessels and are thought to participate in exercise hyperemia, thereby helping to preserve the balance between myocardial oxygen supply and demand. However, experimental data in human subjects are lacking. Purpose: We hypothesized that intravenous b-adrenergic blockade would attenuate the reflex tachycardia and coronary hyperemia in response to …

Comparison Of Young And Functional Fit Older Adults On Temporal Spatial Gait Parameters, S. Paulson, M. Gray

International Journal of Exercise Science: Conference Proceedings

¹Paulson, S., ²Gray, M. ¹Shippensburg University, Shippensburg, PA; ²University of Arkansas, Fayetteville, AR

Gait speed (GS) has been recognized as an integral component of functional independence. Further, step length (SL), cadence (CAD) and the percentage of the gait cycle in spent in stance (%ST) have been associated with risk of falls and mobility disability among older adults. Purpose: This study examined temporal spatial gait variables in young and low and high functionally fit older adults. Methods: Twenty older and 12 younger adults (CON; M±SD = age: 22.3±1.8, height 1.7±0.1 m, mass 66.1±11.8 kg) completed two 20 …

Increased Frequency Of Moderate Intensity Walking Increases Consumption Of Low Energy Density Foods, L. Panek-Scarborough, J. Temple

International Journal of Exercise Science: Conference Proceedings

Panek-Scarborough, L., Temple, J., University at Buffalo, Buffalo, NY

Figure 1: Mean + SEM change in laboratory energy consumed from pre to post exercise intervention from HED foods (top) and LED foods (bottom). The 5 day/week group consumed significantly more energy from LED food from pre- to post-exercise treatment (p = 0.002) compared to the other groups.

Background: There is evidence that exercise has an effect on the type and amount of food consumed. One factor that regulates eating is the reinforcing value of food. While previous studies have demonstrated interactions between exercise and eating, to date, no one has …

The Influence Of Prophylactic Ankle Strategies On Vertical Jump Performance, C. Nelson, S. Paulson

International Journal of Exercise Science: Conference Proceedings

Nelson, C., Paulson, S. Shippensburg University, Shippensburg, PA

Purpose: This study examined the effects of prophylactic ankle taping (PAT) and bracing (PAB) on lower extremity kinematics during vertical jump (VJ) performance. Methods: Eighteen volunteers (M±SD = age: 21.4±0.9, height 170.9±10.0 cm, mass 73.2±14.5 kg, body fat 17.3±6.7%) completed the VJ under three conditions: standard PAT, lace-up PAB, and no treatment (CON). Each testing session was separated by a min of 24 hrs in a randomized and counter-balanced order. Prior to testing, the prophylactic ankle condition was applied and six reflective markers were placed along the right side of the body. …

Predictability Of Muscle Fiber Characteristics Using The Biodex System 3, N. Nannapaneni, G. Schmidt, M. Cox, R. Boutote

International Journal of Exercise Science: Conference Proceedings

Nannapaneni, N., Schmidt, G. (FACSM), Cox, M., Boutote, R., William Paterson University, Wayne, NJ.

Purpose: The purpose of this study was to examine whether the isokinetic dynamometer is capable of distinguishing muscle fiber characteristics between men and women. Methods: 14 participants (7 men and 7 women) of various fitness levels volunteered for this study. Isokinetic testing was conducted using the BIODEX System 3 dynamometer. Each participant was secured in the chair; seat height was adjusted; knee alignment was set at the lateral joint line adjacent to the dynamometer. Power Test: Participants performed 5 sets of 1 maximal voluntary contraction (MVC) …

Vigorous And High Intensity Training With An Anti-Gravity Treadmill, E. Muñoz, M. Figueroa, J. Manning

International Journal of Exercise Science: Conference Proceedings

Muñoz, E., Figueroa, M., Manning, J.,William Paterson University, Wayne, NJ

Purpose: The purpose of this study was to compare two different training intensities on and anti-gravity treadmill and to determine whether or not one elicited changes that were more favorable. Methods: Pre and post measures of oxygen consumption (VO₂peak), body fat (BF)% and body mass index (BMI) were collected on twelve subjects, which were divided into 2 groups. Group 1 trained at 80% body weight (BW) 3 x / week, for 8 weeks, at 70% heart rate reserve (HRR) for 30 minutes. Group 2 trained at 90% BW, …

Predictive Validity Of Critical Power And Functional Threshold Power For Mountain Bike Race Performance., M. Miller, C. Witmer, G. Moir, S. Davis

International Journal of Exercise Science: Conference Proceedings

Miller, M., Witmer, C., Moir, G., Davis, S., East Stroudsburg University, East Stroudsburg, PA

Purpose: This study tested the predictive validity of critical power (CP) and functional threshold power (FTP) for mountain bike cross-country (MTB) race performance. Methods: Five well-trained MTB athletes (mean ± s: age: 31.4 ± 9.3 years; mass: 70.8 ± 9.5kg; VO_2max: 63.8 ± 7.0 ml/kg/min) volunteered for this study. Participants’ FTP was measured during a ramped cycle ergometer test to exhaustion and was indicated as the point at which blood lactate reached 4.0 mmol/L. This test also served to measure the gas exchange …

The Effects Of Ankle Taping And Bracing On Agility, Vertical Jump, And Power, T.M. Leonard, J.S. Rotay, S. Paulson, J. Sanders

International Journal of Exercise Science: Conference Proceedings

Leonard, T. M., Rotay, J. S., Paulson, S., Sanders, J., Shippensburg University, Shippensburg, PA

Ankle sprains are the most common injury in athletics. Ankle bracing and taping are widely used in order to prevent ankle injuries. Purpose: The primary purpose was to examine the effects of ankle taping and bracing on agility, maximum vertical jump (MVJ) height, and vertical power. The secondary purpose was to determine if there were performance differences in training status (athletic vs. non-athletic) between the conditions. Methods: Nineteen participants (Age 20.6±1.5 yr, Height 173.7±11.9 cm, Mass 77.3±18.0 kg) volunteered. Of the 19 participants, 10 (8 male, …

Resistance Exercise, Carotid Artery Stiffness, And Cerebral Blood Flow Pulsatility, W. Lefferts, J. Augustine, K. Heffernan

International Journal of Exercise Science: Conference Proceedings

Lefferts, W., Augustine, J., Heffernan, K., Department of Exercise Science, Syracuse University, Syracuse, NY

Cross-sectional studies have identified arterial stiffness as an important correlate of cerebral blood flow (CBF) pulsatility, an important predictor of cerebrovascular damage. Central artery stiffness increases acutely following a bout of resistance exercise (RE). It has yet to be elucidated whether RE-induced increases in arterial stiffness affect CBF pulsatility. Purpose: To investigate the effects of acute RE on carotid artery stiffness and CBF pulsatility. Methods: 18 healthy men (age 22 ± 1 yr; BMI 23.7 ± 0.5 kg∙m^-2) underwent a) acute RE …

Effects Of Simple Carbohydrate Vs. Carbohydrate-Protein Intake On Glucose Homeostasis Following Intense Exercise, J. Kluka, J. Baskerville, K. Clifton, K. Fisher, D. Marks, C. Weidner, P. Veerabhadrappa, W.A. Braun

International Journal of Exercise Science: Conference Proceedings

Kluka, J., Baskerville, J., Clifton, K., Fisher, K., Marks, D., Weidner, C., Veerabhadrappa, P. and Braun, W.A. (FACSM), Shippensburg University, Shippensburg, PA.

Purpose: To test the effects of simple carbohydrate (CHO) and the combination of CHO and protein on blood glucose (BG) clearance following intense anaerobic exercise. Methods: Eight members (age = 18.8 ± 1.4 years) of the Shippensburg University Football team participated in the study. On separate test days, subjects were given either a placebo (PL) drink, a CHO drink (74 g CHO in 473 ml), or a carbohydrate-protein (C-PRO) drink (58 g CHO and 16 g PRO in …

Oxidation Of Cellular Amino Acid Pools Leads To Cytotoxic Mistranslation Of The Genetic Code, Tammy J. Bullwinkle, Noah M. Reynolds, Medha Raina, Adil Moghal, Eleftheria Matsa, Andrei Rajkovic, Huseyin Kayadibi, Farbod Fazlollahi, Christopher Ryan, Nathaniel Howitz, Kym F. Faull, Beth A. Lazazzera, Michael Ibba

Biology, Chemistry, and Environmental Sciences Faculty Articles and Research

Aminoacyl-tRNA synthetases use a variety of mechanisms to ensure fidelity of the genetic code and ultimately select the correct amino acids to be used in protein synthesis. The physiological necessity of these quality control mechanisms in different environments remains unclear, as the cost vs benefit of accurate protein synthesis is difficult to predict. We show that in Escherichia coli, a non-coded amino acid produced through oxidative damage is a significant threat to the accuracy of protein synthesis and must be cleared by phenylalanine-tRNA synthetase in order to prevent cellular toxicity caused by mis-synthesized proteins. These findings demonstrate how stress …

Effectiveness Of A Football Over Helmet Padding System In Reducing Peak Acceleration Of The Head And Severity Index 2014, Nicole Cuccurullo

Master's Theses

The purpose of this study was to determine if: (a) a football helmet equipped with the Guardian Cap meets the National Operating Committee on Standards for Athletic Equipment (NOCSAE) football helmet standards and (b) if the Severity Indexes and peak accelerations produced during the NOCSAE impact tests were smaller for a football helmet equipped with the Guardian Cap over-helmet padding system than for the same helmet without the Guardian Cap. A total of 54 drop impact tests were completed, 27 on the football helmet alone and 27 on the football helmet equipped with the Guardian Cap. Tests were completed on …

Smooth Muscle Cell Organization In The Stem Region Of The Gracilis Collateral Circulation, Amanda Krall

Biomedical Engineering

Many patients who suffer from the ischemic Peripheral Arterial Occlusive Disease (PAOD) experience intermittent claudication, which can be attributed to impaired vasodilation. Collateral vessels are the primary site of resistance to blood flow downstream; therefore maximizing vasodilation in collaterals is crucial for efficient circulation. Collaterals function as natural bypasses around the occluded arteries and the increase in flow into these vessels causes them to outwardly remodel into conduit vessels. However, functional vasodilation in the stem region of collateral vessels is impaired at day 7 following femoral ligation, which can be attributed to smooth muscle cell malfunction. However, the increase in …