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Articles 3691 - 3720 of 7150

Full-Text Articles in Physiology

Development Of Vip-Sst Interneuron Associations In Mouse Neocortex And Entorhinal Cortex, Aayushi A. Mehta May 2016

Development Of Vip-Sst Interneuron Associations In Mouse Neocortex And Entorhinal Cortex, Aayushi A. Mehta

Honors Scholar Theses

Cortical networks depend upon inhibition through the neurotransmitter GABA to control and coordinate specific spatiotemporal circuit patterns, underlying the exquisite complexity of neural signaling. Disinhibition, a form of inhibition where inhibitory neurons inhibit other inhibitory cells, further aids in amplifying local neural processing in a selective, organized manner. A subset of GABAergic interneurons, vasoactive intestinal peptide-expressing (VIP) cells, preferentially inhibit somatostatin interneurons, which provide inhibitory input onto pyramidal cells, thus creating an archetypal circuit illustrating disinhibition in the cortex. The aim of this anatomical study was to investigate variations in GABAergic VIP synapses onto somatostatin-expressing inhibitory interneurons in mice at …

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Programming Heart Disease: Does Poor Maternal Nutrition Alter Expression Of Cardiac Markers Of Proliferation, Hypertrophy, And Fibrosis In Offspring?, Cathy Chun May 2016

Programming Heart Disease: Does Poor Maternal Nutrition Alter Expression Of Cardiac Markers Of Proliferation, Hypertrophy, And Fibrosis In Offspring?, Cathy Chun

Honors Scholar Theses

Maternal malnutrition can affect fetal organogenesis, metabolic processes, and factors involved in developmental regulation. Of the many physiological effects poor maternal nutrition can induce in offspring, one of the most important organs affected is the heart. Cardiovascular disease has been associated with poor maternal diet. It also been suggested that hypertension can originate during impaired intrauterine growth and development. Hypertension can trigger hypertensive heart disease and is associated with numerous heart complications. We hypothesized that poor maternal nutrition would alter critical growth factors associated with normal heart development, specifically, insulin-like growth factor (IGF)-1, IGF-2, transforming growth factor (TGF)β, and connective …

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Description Of Cranial Elements And Ontogenetic Change Within Tropidolaemus Wagleri (Serpentes: Crotalinae)., Nicolette L. Hill May 2016

Description Of Cranial Elements And Ontogenetic Change Within Tropidolaemus Wagleri (Serpentes: Crotalinae)., Nicolette L. Hill

Electronic Theses and Dissertations

Tropidolaemus wagleri is a species of Asian pitviper with a geographic range including Thailand, Vietnam, Malaysia, Singapore, Bruniei, parts of Indonesia, and the hilippines. Tropidolaemus is a member of the Crotalinae subfamily, within Viperidae. The genus Tropidolaemus includes five species, and was once included within the genus Trimeresurus. While some osteologic characteristics have been noted a comprehensive description of cranial elements has not been produced for T. wagleri. An in-depth description of the cranial skeleton of Tropidolaemus wagleri lays the foundation for future projects to compare and contrast other taxa within Crotalinae and Viperidae. The chosen reference specimen …

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The Thioredoxin Trx-1 Regulates The Major Oxidative Stress Response Transcription Factor, Skn-1, In Caenorhabditis Elegans, Katie C. Mccallum May 2016

The Thioredoxin Trx-1 Regulates The Major Oxidative Stress Response Transcription Factor, Skn-1, In Caenorhabditis Elegans, Katie C. Mccallum

Dissertations and Theses (Open Access)

The ability to respond to hostile environmental conditions is critical for the survival of an organism. Oxidative stress is an adverse state in which reactive oxygen species (ROS) accumulate to a harmful level and, if left unresolved, can lead to cellular dysfunction and organismal disease. Sophisticated detoxification systems, characterized by a battery of enzymatic antioxidants, are utilized to neutralize ROS thereby reducing stress. However, ROS are also purposefully produced by designated cellular enzymes to facilitate the signaling and regulation of critical physiological processes. Therefore, both the production and neutralization of ROS must be tightly controlled. Indeed, the expression of detoxification …

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The Effects Of Hypohydration On Neurocognitive, Balance, Vestibular Ocular Motor Functions And Mood State, Satoshi Iida May 2016

The Effects Of Hypohydration On Neurocognitive, Balance, Vestibular Ocular Motor Functions And Mood State, Satoshi Iida

Graduate Theses and Dissertations

Inconsistent findings have been observed on the impact of hydration state on cognitive functions. The isolated effect of hypohydration on neurocognitive performance, balance, vestibular ocular motor function and mood outcomes in widely used concussion assessment tools has not been studied. The purpose of this study was to investigate how hypohydration affected the results in concussion testing batteries. A single-blind randomized crossover design was used. Thirteen healthy males (22 ± 4y, 180.9 ± 5.7cm) without history of concussion within the past six months or any condition or disease that could influence outcome measurements participated in this study. Each subject completed concussion …

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Growth And Productivity Of Irrigated Rice (Oryza Sativa L.) For A Tropical High Altitude Environment In Rwanda, Elie Rene Gasore May 2016

Growth And Productivity Of Irrigated Rice (Oryza Sativa L.) For A Tropical High Altitude Environment In Rwanda, Elie Rene Gasore

Graduate Theses and Dissertations

Yield components, grain yield, biomass and plant N accumulation, and N fertilizer responses of irrigated rice (Oryza sativa, L.) were evaluated for a tropical inland valley environment in the high altitudes in Rwanda. Effects were measured for nitrogen (N) fertilizer rate (0, 60, 90,120,150,180 kg N ha-1), season, growth stage and cultivar of different subspecies and plant types during 2012 dry season (DS) and 2013 wet season (WS) at Cyili Rice Research Farm (1380 m above sea level). Variations in irradiance (17.2± 0.32 MJ m-2 day-1 in DS and 9.4 ± 0.66 MJ m-2 day-1in WS) were linked to seasonal …

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Mini Series Presentations, Robert L. Moody Iv, Natasha S. Natraj Apr 2016

Mini Series Presentations, Robert L. Moody Iv, Natasha S. Natraj

Senior Year Experience Student Projects

For the month of March, we implemented a mini education program at both EmblemHealth sites to engage, educate and empower members of the fitness center and weight management program. The program was designed to be fifteen minutes in length, allowing for more sessions over the course of 3 hours with one session a week alternating between topics. Upon survey evaluation of the 60 participants, they reported satisfaction with the overall program and validated the worth of EmblemHealth’s Fitness Center. The survey also showed that 10 out of 10 participants recognized sitting disease as a primary health concern after the presentation, …

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Elevational Variation In Body-Temperature Response To Immune Challenge In A Lizard, Francisco Javier Zamora-Camacho, Senda Reguera, Gregorio Moreno-Rueda Apr 2016

Elevational Variation In Body-Temperature Response To Immune Challenge In A Lizard, Francisco Javier Zamora-Camacho, Senda Reguera, Gregorio Moreno-Rueda

Dartmouth Scholarship

Immunocompetence benefits animal fitness by combating pathogens, but also entails some costs. One of its main components is fever, which in ectotherms involves two main types of costs: energy expenditure and predation risk. Whenever those costs of fever outweigh its benefits, ectotherms are expected not to develop fever, or even to show hypothermia, reducing costs of thermoregulation and diverting the energy saved to other components of the immune system. Environmental thermal quality, and therefore the thermoregulation cost/benefit balance, varies geographically. Hence, we hypothesize that, in alpine habitats, immune-challenged ectotherms should show no thermal response, given that (1) hypothermia would be …

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The Influence Of Canine Aggression And Behavioral Treatment On Heart Rate Variability, Lydia Craig Apr 2016

The Influence Of Canine Aggression And Behavioral Treatment On Heart Rate Variability, Lydia Craig

Psychology Honors Projects

Dog aggression affects many, with nearly 5 million dog bites reported yearly in the United States alone. With the physical, emotional, and monetary costs of bites, it is of considerable interest to identify dogs that are likely to bite. One physiological measure that might serve as an index of aggression is heart rate variability (HRV), which refers to vagally mediated beat-to-beat change in heart rate. Low HRV has been associated with impaired emotional and behavioral regulation and stress in both humans and animals. To assess whether this measure corresponds with aggression in dogs, resting HRV was measured for dogs with …

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Novel Compound Heterozygous Mutations Expand The Recognized Phenotypes Of Fars2-Linked Disease, Melissa A. Walker, Kyle Mohler, Kyle W. Hopkins, Derek H. Oakley, David A. Sweetser, Michael Ibba, Matthew P. Frosch, Ronald L. Thibert Apr 2016

Novel Compound Heterozygous Mutations Expand The Recognized Phenotypes Of Fars2-Linked Disease, Melissa A. Walker, Kyle Mohler, Kyle W. Hopkins, Derek H. Oakley, David A. Sweetser, Michael Ibba, Matthew P. Frosch, Ronald L. Thibert

Biology, Chemistry, and Environmental Sciences Faculty Articles and Research

Mutations in mitochondrial aminoacyl-tRNA synthetases are an increasingly recognized cause of human diseases, often arising in individuals with compound heterozygous mutations and presenting with system-specific phenotypes, frequently neurologic. FARS2 encodes mitochondrial phenylalanyl transfer ribonucleic acid (RNA) synthetase (mtPheRS), perturbations of which have been reported in 6 cases of an infantile, lethal disease with refractory epilepsy and progressive myoclonus. Here the authors report the case of juvenile onset refractory epilepsy and progressive myoclonus with compound heterozygous FARS2 mutations. The authors describe the clinical course over 6 years of care at their institution and diagnostic studies including electroencephalogram (EEG), brain magnetic resonance …

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Designing A Mobile Space Habitat Analog, Victor Kitmanyen, Matthew Burkhard, Timothy Disher Apr 2016

Designing A Mobile Space Habitat Analog, Victor Kitmanyen, Matthew Burkhard, Timothy Disher

Human Factors and Applied Psychology Student Conference

No abstract provided.

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Factors Affecting The Immune System Of The Ornate Box Turtle (Errapene Ornata), Michelle W. Mcquinn, Abigail A. Neyer, Gwendolyn C. Bachman Apr 2016

Factors Affecting The Immune System Of The Ornate Box Turtle (Errapene Ornata), Michelle W. Mcquinn, Abigail A. Neyer, Gwendolyn C. Bachman

UCARE: Research Products

While many studies have detailed the complex intricacies of the endothermic immune system, relatively little is known about the immune system of ectotherms--specifically, reptiles. In an attempt to gain more knowledge about the factors affecting reptilian immune function, ornate box turtles (Terrapene ornata) were subjected to chronic stress in the form of high ambient temperatures in a semi-natural environment. It was hypothesized that chronic stress would lead to elevated levels of corticosterone in the blood, which would, in turn, suppress immune activity. It was found that body temperature and body mass in particular were significantly affected by chronic heat stress. …

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Cardiovascular Effects Evoked By Airway Nociceptive Reflexes In Healthy And Cardiovascular Diseased Rats, Justin Shane Hooper Apr 2016

Cardiovascular Effects Evoked By Airway Nociceptive Reflexes In Healthy And Cardiovascular Diseased Rats, Justin Shane Hooper

USF Tampa Graduate Theses and Dissertations

Acute inhalation of airborne pollutants alters cardiovascular function and has been shown to have its greatest affects on individuals with pre-existing cardiovascular disease. Evidence suggests that pollutant-induced activation of airway sensory nerves via the gating of ion channels is critical to these systemic responses. Here, we have investigated the cardiovascular responses evoked by inhalation of AITC (TRPA1 agonist) and capsaicin (TRPV1 agonist) in healthy Sprague Dawley (SD) and Wistar Kyoto (WKY) rats, and cardiovascular diseased Spontaneously Hypertensive (SH) rats. Inhalation of the agonists by healthy SD and WKY rats caused significant bradycardia, atrio-ventricular (AV) block and prolonged PR-Intervals. Inhalation of …

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Localisation And Protein-Protein Interactions Of The Helicobacter Pylori Taxis Sensor T1pd And Their Connection To Metabolic Functions, Wiebke Behrens, Tobias Schweinitzer, Jonathan L. Mcmurry, Christine Josenhans Apr 2016

Localisation And Protein-Protein Interactions Of The Helicobacter Pylori Taxis Sensor T1pd And Their Connection To Metabolic Functions, Wiebke Behrens, Tobias Schweinitzer, Jonathan L. Mcmurry, Christine Josenhans

Faculty Articles

The Helicobacter pylori energy sensor TlpD determines tactic behaviour under low energy conditions and is important in vivo. We explored protein-protein interactions of TlpD and their impact on TlpD localisation and function. Pull-down of tagged TlpD identified protein interaction partners of TlpD, which included the chemotaxis histidine kinase CheAY2, the central metabolic enzyme aconitase (AcnB) and the detoxifying enzyme catalase (KatA). We confirmed that KatA and AcnB physically interact with TlpD. While the TlpD-dependent behavioural response appeared not influenced in the interactor mutants katA and acnB in steady-state behavioural assays, acetone carboxylase subunit (acxC) mutant behaviour was altered. TlpD was …

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The Effect Of Training Intensity On Vo2max In Young Healthy Adults: A Meta-Regression And Meta-Analysis, Trisha Scribbans, Stephan Vecsey, Hankinson Paul, William Foster, Brendon Gurd Apr 2016

The Effect Of Training Intensity On Vo2max In Young Healthy Adults: A Meta-Regression And Meta-Analysis, Trisha Scribbans, Stephan Vecsey, Hankinson Paul, William Foster, Brendon Gurd

International Journal of Exercise Science

International Journal of Exercise Science 9(2): 230-247, 2016. Exercise training at a variety of intensities increases maximal oxygen uptake (VO2max), the strongest predictor of cardiovascular and all-cause mortality. The purpose of the present study was to perform a systematic review, meta-regression and meta-analysis of available literature to determine if a dose-response relationship exists between exercise intensity and training-induced increases in VO2max in young healthy adults. Twenty-eight studies involving human participants (Mean age: 23±1 yr; Mean VO2max: 3.4±0.8 l·min−1) were included in the meta-regression with exercise training intensity, session dose, baseline VO2max, and total training volume used as covariates. These studies …

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Metabolic And Energy Cost Of Sitting, Standing, And A Novel Sitting/Stepping Protocol In Recreationally Active College Students, Charles J. Fountaine, Josh Johann, Craig Skalko, Gary A. Liguori Apr 2016

Metabolic And Energy Cost Of Sitting, Standing, And A Novel Sitting/Stepping Protocol In Recreationally Active College Students, Charles J. Fountaine, Josh Johann, Craig Skalko, Gary A. Liguori

International Journal of Exercise Science

International Journal of Exercise Science 9(2): 223-229, 2016. The purpose of this study was to compare the differences in metabolic and energy cost (MEC) of college students while seated, standing, and during a sitting/stepping protocol. Participants were assessed via indirect calorimetry for 20 min in each of the following conditions: 1) seated in a standard office chair, 2) standing in place, and 3) a sitting/stepping protocol in which participants performed 1 min of stepping in place at 90 bpm, sat for 9 min, then repeated the stepping and sitting sequence once more. Participants completed each of the 3 trials in …

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Poor Quality Of Instruction Leads To Poor Motor Performance Regardless Of Internal Or External Focus Of Attention, M. Jay Polsgrove, Tom E. Parry, Nathan T. Brown Apr 2016

Poor Quality Of Instruction Leads To Poor Motor Performance Regardless Of Internal Or External Focus Of Attention, M. Jay Polsgrove, Tom E. Parry, Nathan T. Brown

International Journal of Exercise Science

International Journal of Exercise Science 9(2): 214-222, 2016. The view that external focus of attention provides beneficial performance outcomes when compared to an internal focus of attention has been consistently supported in the movement performance literature. While type of focus has been well investigated, the current study examined the influence of quality of instruction as a variation of the type of focus. Specifically, the purpose of the study investigated how performance-enhancing instructions would differ from performance-neutral instructions on an agility performance. An agility L-run was used to measure performance in the four counterbalanced conditions: Internal-Performance Neutral (INT-PN), Internal-Performance Enhancing (INT-PE), …

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The Effects Of A Commercial, Pre-Exercise Energy Drink Supplement On Power, Muscular Endurance, And Repeated Sprint Speed, Bill I. Campbell, Jasmine L. Richmond, J. Jay Dawes Apr 2016

The Effects Of A Commercial, Pre-Exercise Energy Drink Supplement On Power, Muscular Endurance, And Repeated Sprint Speed, Bill I. Campbell, Jasmine L. Richmond, J. Jay Dawes

International Journal of Exercise Science

International Journal of Exercise Science 9(2): 205-213, 2016. The purpose of this study was to investigate the effects of ingesting a pre-workout commercial energy drink supplement on multiple parameters of physical performance, including upper body and trunk muscular endurance, muscular power, and repeated sprint speed. 19 college-aged males (n = 8) and females (n = 11) participated in this randomized, double-blind, parallel groups study. At baseline and post-testing (about one week after baseline testing), anaerobic power (assessed via a countermovement vertical jump), muscular endurance (assessed via YMCA bench press test and a curl-up test), and repeated sprint speed were assessed. …

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Teacher Perceptions Of Fitnessgram® And Application Of Results, William M. Miller, Sean M. Bulger, Hugh D. Campbell, Eloise Elliott, Christa L. Lilly, Robert L. Wiegand Apr 2016

Teacher Perceptions Of Fitnessgram® And Application Of Results, William M. Miller, Sean M. Bulger, Hugh D. Campbell, Eloise Elliott, Christa L. Lilly, Robert L. Wiegand

International Journal of Exercise Science

International Journal of Exercise Science 9(2): 187-204, 2016. The purpose of this study was to examine perceptions of physical educators toward state-mandated use of FITNESSGRAM®. Two validated instruments were employed to collect data regarding teacher (n=174) perceptions and use. Mean (M) and standard deviations (SD) were calculated for all scale scores with t-tests and ANOVAs testing for differences by selected demographics. Overall attitudes toward FITNESSGRAM® were slightly positive (M = 4.52, SD = 1.06) on a 7-point Likert scale. The demographic variable gender (p = 0.017) was found to be …

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The Effects Of A Plyometric Training Program On Jump Performance In Collegiate Figure Skaters: A Pilot Study, Jennifer L. Hunnicutt, Craig L. Elder, J. Jay Dawes, Amanda J. Sinclair Elder Apr 2016

The Effects Of A Plyometric Training Program On Jump Performance In Collegiate Figure Skaters: A Pilot Study, Jennifer L. Hunnicutt, Craig L. Elder, J. Jay Dawes, Amanda J. Sinclair Elder

International Journal of Exercise Science

International Journal of Exercise Science 9(2): 175-186, 2016. Plyometric training has been implemented to increase jump height in a variety of sports, but its effects have not been researched in figure skating. The purpose of this study was to determine the effects of a plyometric training program on on-ice and off-ice jump performance. Six collegiate figure skaters (19.8±1.2 years; 164.7±4.9 cm; 60.3±11.6 kg) completed a six-week sport-specific plyometric training program, consisting of low to moderate intensity plyometric exercises, while eight collegiate figure skaters (21.1±3.9 years; 162.6±6.0 cm; 60.4±6.1 kg) served as the control group. Significant increases were found for vertical …

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Geometric Entropy For Lead Vs Top-Rope Rock Climbing, Phillip B. Watts, Scott N. Drum, Matthew A. Kilgas, Kevin C. Phillips Apr 2016

Geometric Entropy For Lead Vs Top-Rope Rock Climbing, Phillip B. Watts, Scott N. Drum, Matthew A. Kilgas, Kevin C. Phillips

International Journal of Exercise Science

International Journal of Exercise Science 9(2): 168-174, 2016. The complexity of movement of a rock climber’s center of mass during an ascent has been described as geometric entropy (GE). It has been proposed that lower geometric entropy could represent more fluid and economical movement during climbing. The purpose of the present study was to measure GE during rock climbing ascents under a lead condition (LD), where the climber connects a safety rope to several intermediate anchors during the ascent and under a top-rope condition (TR), where the safety rope is always anchored above the climber. Six experienced rock climbers volunteered …

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Increasing Lean Mass And Strength: A Comparison Of High Frequency Strength Training To Low Frequency Strength Training, Michael Thomas, Steve Burns Apr 2016

Increasing Lean Mass And Strength: A Comparison Of High Frequency Strength Training To Low Frequency Strength Training, Michael Thomas, Steve Burns

International Journal of Exercise Science

International Journal of Exercise Science 9(2): 159-167, 2016. The purpose of this study was to determine the effect strength training frequency has on improvements in lean mass and strength. Participants were 7 women and 12 men, age ( = 34.64 years ± 6.91 years), with strength training experience, training age ( = 51.16 months ± 39.02 months). Participants were assigned to one of two groups to equal baseline group demographics. High frequency training group (HFT) trained each muscle group as the agonist, 3 times per week, exercising with 3 sets per muscle group per session (3 total body workouts). Low …

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Three Week Hypergravity Training Intervention Decreases Ground Contact Time During Repeated Jumping And Improves Sprinting And Shuttle Running Performance, Eric M. Scudamore, Jordan B. Lowe, Veronika Přibyslavská, Samantha L. Johnson, Mary C. Stevenson, Tyler W. Langford, James M. Green, Eric K. O'Neal Apr 2016

Three Week Hypergravity Training Intervention Decreases Ground Contact Time During Repeated Jumping And Improves Sprinting And Shuttle Running Performance, Eric M. Scudamore, Jordan B. Lowe, Veronika Přibyslavská, Samantha L. Johnson, Mary C. Stevenson, Tyler W. Langford, James M. Green, Eric K. O'Neal

International Journal of Exercise Science

International Journal of Exercise Science 9(2): 149-158, 2016. This study examined the effects of a non-traditional training method, hypergravity training (HT), on anaerobic performance. Highly active men (n = 9) completed a 3 week HT protocol in which weighted vests were worn 8 h/day, 4+ days/week separate from training. Vest loads were 11.2 ± 0.6% of body mass during week one, and increased to 13.2 ± 0.7% (week 2), and 16.1 ± 0.4% (week 3). Performance testing included power clean 1-RM (PC), counter movement jumps, 4 continuous jumps, 36.6 m sprints (SP), a 137.2 m short shuttle run (SSR), and …

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The Effects Of A Lifetime Physical Activity And Fitness Course On College Students’ Health Behaviors, Ale Quartiroli, Hotaka Maeda Apr 2016

The Effects Of A Lifetime Physical Activity And Fitness Course On College Students’ Health Behaviors, Ale Quartiroli, Hotaka Maeda

International Journal of Exercise Science

International Journal of Exercise Science 9(2): 136-148, 2016. The purpose of this study was to examine motivational constructs and the effect of physical activity engagement on health behaviors in college students who were required to take a 15-week lifetime physical fitness (LPF) course for graduation. A total of fifty-eight first and second year college students aged between 17 and 23 years (M=18.72; SD=1.09). Paper and pencil questionnaires were anonymously administered at the beginning and at the end of the 15-week long spring 2012 semester. Analysis of the differences between the beginning and the end of the semester …

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Motives For Physical Activity And Physiological Variables As Predictors Of Exercise Intentions Following A High Intensity Interval Training Protocol In College-Age Females, Jody L. Langdon, Sarah Joseph, Kristina L. Kendall, Brandonn Harris, Jim Mcmillan Apr 2016

Motives For Physical Activity And Physiological Variables As Predictors Of Exercise Intentions Following A High Intensity Interval Training Protocol In College-Age Females, Jody L. Langdon, Sarah Joseph, Kristina L. Kendall, Brandonn Harris, Jim Mcmillan

International Journal of Exercise Science

International Journal of Exercise Science 9(2): 121-135, 2016. More females are classified as insufficiently active and may have little time for physical activity than males (28). Sufficient activity for adults includes a minimum of 30 minutes of moderate intensity aerobic exercise, five days per week or 20 minutes of vigorous intensity exercise three days per week, or a combination of these, in addition to the resistance training recommendation of training each muscle group two times per week (14). High intensity interval training (defined as very short intense intervals, usually above 85% maximum heart rate accompanied by alternated passive recovery periods; …

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The Effect Of Single-Leg Stance On Dancer And Control Group Static Balance, Elisabeth A. Kilroy, Olivia M. Crabtree, Brittany Crosby, Amanda Parker, William R. Barfield Apr 2016

The Effect Of Single-Leg Stance On Dancer And Control Group Static Balance, Elisabeth A. Kilroy, Olivia M. Crabtree, Brittany Crosby, Amanda Parker, William R. Barfield

International Journal of Exercise Science

International Journal of Exercise Science 9(2): 110-120, 2016. The purpose of this study was to compare kinetic differences of static balance between female dancers (D) with at least seven years of dance experience and female non-dancers (ND) who were typical college students. Participants were tested in single-leg stance. Both the dominant leg (DL) and non-dominant leg (NDL) were tested with the participants shod (S) and barefoot (BF). Kinetic variables (vertical, medio-lateral [ML], antero-posterior [AP] maximum ground reaction forces (GRF), and center of pressure (COP) ML and AP) were measured by a Bertec force platform at 1000 Hz with participants S …

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Investigating The Role Of The Basic Helix-Loop-Helix Transcription Factor Mist1 In Pancreatic Diseases, Anju Karki Apr 2016

Investigating The Role Of The Basic Helix-Loop-Helix Transcription Factor Mist1 In Pancreatic Diseases, Anju Karki

Open Access Dissertations

Acinar cells of the exocrine pancreas are dedicated to synthesize, package and secrete immense quantities of pro-digestive enzymes to maintain proper metabolic homeostasis for the organism. Dysregulation of enzyme secretion in acinar cells can give rise to exocrine diseases including acute pancreatitis (AP), a disease that targets acinar cells, leading to acinar-ductal metaplasia (ADM), inflammation and fibrosis—events that can transition into the earliest stages of pancreatic ductal adenocarcinoma (PDAC). The focus of this thesis is to interrogate transcriptional regulatory networks that are susceptible to AP and the role that these networks play in acinar cell and exocrine pancreas responses. The …

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Novel Mitochondrial Complex I Inhibitors Restore Glucose-Handling Abilities Of High-Fat Fed Mice, Darren Martin, Siobhan Leonard, Robert Devine, Clara Redondo, Gemma Kinsella, Conor Breen, Victoria Mceneaney, Mary Rooney, Tim Munsey, Richard Porter, Asipu Sivaprasadarao, John Stephens, John Findlay Apr 2016

Novel Mitochondrial Complex I Inhibitors Restore Glucose-Handling Abilities Of High-Fat Fed Mice, Darren Martin, Siobhan Leonard, Robert Devine, Clara Redondo, Gemma Kinsella, Conor Breen, Victoria Mceneaney, Mary Rooney, Tim Munsey, Richard Porter, Asipu Sivaprasadarao, John Stephens, John Findlay

Articles

Metformin is the main drug of choice for treating type 2 diabetes, yet the therapeutic regimens and side effects of the compound are all undesirable and can lead to reduced compliance. The aim of this study was to elucidate the mechanism of action of two novel compounds which improved glucose handling and weight gain in mice on a high-fat diet. Wildtype C57Bl/6 male mice were fed on a high-fat diet and treated with novel, anti-diabetic compounds. Both compounds restored the glucose handling ability of these mice. At a cellular level, these compounds achieve this by inhibiting complex I activity in …

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An Evaluation Of The Influences Of Extra-Hippocampal Processes On Pattern Separation, Malia L. Anderson Apr 2016

An Evaluation Of The Influences Of Extra-Hippocampal Processes On Pattern Separation, Malia L. Anderson

Theses and Dissertations

Long-term declarative memory depends on pattern separation, which reduces the degree of overlap between similar representations, to maintain memory specificity, and on pattern completion, which occurs when a degraded cue is used to retrieve a previously stored memory. Previous studies aimed at evaluating the underlying neuronal substrates of these computational processes have used a mnemonic discrimination paradigm and fMRI to focus on the hippocampus, to the exclusion of cortical processing. We aim to investigate the influences extra-hippocampal processes have on pattern separation in the following two studies. Study 1. Computational models of pattern completion suggest it occurs cortically and results …

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Anti-Predator Responses Of Squid Throughout Ontogeny, Carly Anne York Apr 2016

Anti-Predator Responses Of Squid Throughout Ontogeny, Carly Anne York

Biological Sciences Theses & Dissertations

Multiple sensory modalities and a complex array of escape behaviors have evolved as components of anti-predator responses in squids. The goals of this study include: (1) examine the role of the lateral line analogue and vision in successful predator evasion; (2) measure kinematics of escape jetting; (3) document how chromatic patterning, posturing and inking in squid change in response to predators; and (4) investigate escape jet hydrodynamics of squid. Given that squids undergo considerable morphological, ecological, and behavioral changes throughout ontogeny, the goals above were all investigated across different life history stages. To test the respective roles of vision and …

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