Physiology Commons^™

Hypothyroidism, Kelly Cruz '23, Riman Doodin '23, Venus Obazuaye '23

Human Diseases Graphic Novels

No abstract provided.

Med13 Degradation Defines A New Receptor-Mediated Autophagy Pathway Activated By Nutrient Deprivation, Sara E. Hanley

Graduate School of Biomedical Sciences Theses and Dissertations

Cells are exposed to an enormous amount of diverse extracellular cues but have a limited arsenal of weapons for protecting and maintaining homeostasis. To overcome these restrictions, nature has engineered proteins that have multiple functions. The pleiotropy of using one protein to carry out a variety of functions allows cells to rapidly execute tailored responses to a diverse set of signals. The Cdk8 kinase module (CKM) is a conserved detachable unit of the Mediator complex predominantly known for its role in transcriptional regulation. The CKM is composed of four proteins, the scaffolding proteins Med13 and Med12, as well as the …

Neurofibromatosis, Sanjana Nekkanti '23, Divya Choudhary '23

Human Diseases Graphic Novels

No abstract provided.

Endometriosis, Illinois Mathematics And Science Academy

Human Diseases Graphic Novels

No abstract provided.

Does Stress Physiology Mediate Disease Resistance In The Arizona Tiger Salamander (Ambystoma Mavortium Nebulosum)?, Megan Zerger

2023 Midwest Ecology & Evolution Conference

Amphibian biodiversity has greatly diminished in recent years due to disease. Panzootic pathogenic fungi Batrachochytrium dendrobatidis (Bd) causes the deadly disease chytridiomycosis (chytrid), a primary driver of catastrophic global amphibian declines and extinctions. The pathogenesis of chytrid is still unclear, as certain species and individuals within a species are differentially affected. Susceptibility and mortality of Bd are influenced by prolonged chronic stress. Prolonged glucocorticoid activity deleteriously affects many of the same physiological processes as Bd infections, and corticosterone is the primary glucocorticoid released by amphibians in response to stress. Thus, the objective of our study is to assess …

Effect Of Functional Trait Variation On Bee Body Temperature, Gabriella A. Muller

2023 Midwest Ecology & Evolution Conference

Bees are both ecologically and economically important pollinators for maintaining agricultural production and the health of many diverse ecosystems. As our world continues to change, bee diversity and population numbers are declining due to increasing temperatures. Functional traits such as body size and coloration can mediate the effects of such harsh thermal conditions on insect performance. Specifically, bee body size can significantly impact thermal parameters, with larger bees gaining and losing heat more slowly than smaller bees due to higher surface area to volume ratios. To obtain a better understanding of these relationships, we studied the variation in body temperature …

Effect Of Temperature Variation On Endurance Swimming Capacity Of Juvenile White Sturgeon (Acipenser Transmontanus), Alex M. Stolberg

2023 Midwest Ecology & Evolution Conference

White sturgeon (Acipenser transmontanus), a species within one of the most globally threatened taxa, are highly susceptible to changes in their environments due to unique life history traits. Specifically, juvenile white sturgeon are impacted by altered watershed dynamics caused by water diversion structures such as dams, weirs, irrigation ditches, or levees. One location of great concern is the Sacramento-San Joaquin (S-SJ) watershed where decades of water diversion has brought on changes to the temperature, flow, and management of the area. This study looks to primarily identify the impact of water temperature on the endurance swimming capacity of juvenile white sturgeon, …

The Miracle Doctor Vs. Pcos, Ellen Nguyen '24, Sindhu Chalasani '24, Iris Amit '24, Karina Byers '24

Human Diseases Graphic Novels

No abstract provided.

The Importance Of Translationally Evaluating Steroid Hormone Contributions To Substance Use, Erin E. Maher, Ashley Strzelecki, Jessica J. Weafer, Cassandra D. Gipson

Markey Cancer Center Faculty Publications

Clinically, women appear to be more susceptible to certain aspects of substance use disorders (SUDs). The steroid hormones 17β-estradiol (E2) and progesterone (Pg) have been linked to women-specific drug behaviors. Here, we review clinical and preclinical studies investigating how cycling ovarian hormones affect nicotine-, cocaine-, and opioid-related behaviors. We also highlight gaps in the literature regarding how synthetic steroid hormone use may influence drug-related behaviors. In addition, we explore how E2 and Pg are known to interact in brain reward pathways and provide evidence of how these interactions may influence drug-related behaviors. The synthesis of this review demonstrates the critical …

Effect Of Resistance Training On White Blood Cell Count And Chemotherapy Efficacy In Triple-Negative Breast Cancer Patients During Adriamycin-Cyclophosphamide Chemotherapy Treatment, Mimi Wassef

The Larrie and Bobbi Weil Undergraduate Research Award

Triple-negative breast cancer (TNBC) is one of the most difficult subtypes of breast cancer to treat due to a lack of molecular targets. While chemotherapy (CT) has become the standard form of treatment, the administration of CT depends on adequate white blood cell (WBC) count. When WBC becomes too low, patients risk becoming ineligible for treatment. In the general population, WBC count has been shown to increase as a result of exercise, but little research has been done on the effects of exercise and WBC count in the TNBC population. The purpose of this study is to determine if 12 …

Life Line Spring 2023, Otterbein Biology And Earth Science Department

Life Line - The Biology Department Newsletter

In this Issue:

Feathered Friends Living on Campus; The Hidden Mussels of the Olentangy River; Early Assurance Program Students Graduate from HCOM; Students Present at American Society for Microbiology Microbe 2022 Meeting; Environmental Science Upgrades Its Remote Monitoring Capabilities; Speed!; UK Students Visit Local Attractions; That's a Lottl Axolotls.

Introduction To Human Biology, Sharon S. Ellerton, Christopher Roblodowski

Open Educational Resources

This OER is intended as a textbook for a one semester introductory course in Human Anatomy and Physiology for non-science majors. It covers the major topics typically covered in A&P, but in a simplified, easier to understand manner. This textbook aims to educate students interested in lower-level health careers and non-science majors without the intimidating detail found in current textbooks. Text and images were created to be more accessible for these student populations.

The Possible Role For Basigin Receptor Function In The Induction Of Matrix Metalloproteinase Expression In Human Endometrial Stromal Cells, Amy Abel

All NMU Master's Theses

10-15% of couples worldwide are affected by infertility. The leading cause of infertility is implantation failure. Molecular communication in precise time and space between an implanting embryo and a receptive uterus is essential for successful implantation. Basigin has been shown to have vital functions within the implantation process. Basigin is best known for inducing the expression of matrix metalloproteinases. Basigin has been shown to induce MMP expression in vitro in human endometrial stromal cell lines (HESC). Understanding how basigin induces matrix metalloproteinases within normal cellular conditions will help researchers understand how these signaling cascades flow in the framework of implantation. …

Flexible Materials And Applications For Wearable Sensors, Brock Ferrari

Senior Honors Theses

This literature review aimed to address the limitations of rigid wearable sensors in the medical community by investigating the development of flexible materials for remote health monitoring. A keyword search was conducted on Google Scholar, PubMed, and the Jerry Falwell Library, which yielded 9,102 articles. After applying filtering techniques, the results were narrowed down to 21 articles, which were categorized into "Present Market Conditions," "Flexible Materials for Medical Use," "Applications for Wearable Sensors," and "Potential Use Cases." Discussions were held on prominent materials such as substrate, nanocomposite, and liquid metal materials, exploring their potential applications for chemical and physical sensing, …

A Look Into The Physiological Impacts Of Childhood Cancers And Modeling Of Tumor Growth Rate, Erica Steiner, Kimberly Hansen, Marissa Stanton

Honors Program: Senior Projects (Public)

Cancer is one of the deadliest diseases present in the world. Children have different reactions to diseases and treatments; thus, it is important to study those reactions specifically in children. Knowing how children are impacted by these factors can be helpful in diagnosis and treatment of cancer. I performed this study by researching the different types of cancer I was interested in and using MATLAB to code for and simulate a growth curve of a brain tumor. I found that there are many different physiological impacts of different cancers in children. As for the modeling, I was able to get …

A Comparison Of Continuous And Interval Exercise On Cognition In Young Adults, Emily C. Tagesen, Lawrence W. Judge, David M. Bellar

International Journal of Exercise Science

International Journal of Exercise Science 16(5): 458-468, 2023. Exercise stimulates the production and secretion of testosterone, cortisol, and brain-derived neurotrophic factor (BDNF) and affects cognitive performance. However, the interaction of these variables is unknown. To investigate these interactions, 21 college-aged men completed two work-matched exercise protocols: continuous (CONT) exercise and an interval protocol (INT). Blood and saliva samples were collected before and after exercise to quantify BDNF, cortisol, and testosterone. Participants completed a battery of cognitive assessments after exercise. A MANOVA analysis of condition demonstrated that no domains were significantly different after CONT and INT (p > 0.05). A repeated …

Blood Flow Restriction Attenuates Muscle Damage In Resistance Exercise Performed Until Concentric Muscle Failure., Victor Magalhães Curty, Paulo Vinicios Camuzi Zovico, Rafael Barrera Salgueiro, Leonardo Carvalho Caldas, Richard Diego Leite, Nuno Manuel Frade Souza, Lucas Guimaraes-Ferreira, Valério Garrone Barauna

International Journal of Exercise Science

International Journal of Exercise Science 16(2): 469-481, 2023. The present study aimed to evaluate whether blood flow restriction (BFR) can prevent exercise-induced muscle damage in resistance exercise (RE) performed until concentric muscle failure (CMF). Twenty healthy volunteers (25 ± 4 years, 80.4 ± 11.8 kg, 175 ± 8 cm) performed three sets of unilateral biceps curl exercise (40% of 1RM) with (RE + BFR) and without (RE) BFR until CMF. A third condition was to perform the same number of repetitions as RE + BFR without using BFR (matched). Performing fewer repetitions, RE + BFR caused muscle fatigue post-exercise as …

The Mindful Athlete Program, Joanne Bullard, Sojung Kim

Rita & Larry Salva School of Nursing and Health Professions Departmental Research

According to the spring 2020 NCAA Well-Being Study, collegiate student-athletes reported experiencing mental health concerns due to the impact of the COVID-19 pandemic. The data indicated that student-athletes were experiencing mental health concerns 150%-250% higher than historically reported (NCAA, 2020). These concerns were prevalent among all divisions. For Division III student-athletes, mental health concerns experienced during the COVID-19 pandemic included “feeling overwhelmed by all they had to do, sleep difficulties, feeling mentally exhausted, feeling very lonely, feeling a sense of loss, and feeling very lonely and sad” (NCAA, 2020). This study indicated desired resources of Division III student-athletes included elements …

Effects Of Equine Interaction On Mutual Autonomic Nervous System Responses And Interoception In A Learning Program For Older Adults, Ann L. Baldwin, Lisa Walters, Barbara K. Rector, Ann C. Alden

People and Animals: The International Journal of Research and Practice

Equine-assisted learning (EAL) may improve the health of older adults, but scientific data are sparse. This study investigated whether people aged 55 and older show increased heart rate variability (HRV) during EAL and awareness of bodily sensations that are overall pleasant. Subjects (n = 24) participated in mindful grooming during which they slowed their breathing and brushed a horse while noticing sensations in their body and watching the horse’s reactions. The subject’s and horse’s HRV were recorded simultaneously before, during, and after mindful grooming. For control, the same subjects performed mindful grooming with a plush simulation horse. During exit …

Ijes Self-Study On Participants’ Sex In Exercise Science: Sex-Data Gap And Corresponding Author Survey, Matthew J. Garver, James W. Navalta, Michel J.H. Heijnen, Dustin W. Davis, Joel D. Reece, Whitley J. Stone, Shannon R. Siegel, T. Scott Lyons

International Journal of Exercise Science

International Journal of Exercise Science 16(6): 364-376, 2023. A sex-data gap exists between females and males within the sport and exercise science literature, and implications are far-reaching. The purpose of this work was to (a) heed recent calls and scrutinize data from within IJES to address the gap and (b) gain insight on self-identified sex of IJES corresponding authors. The present self-study included all published manuscripts from 2008 through 2021. A total of 851 publications were included, and 806 (94.7%) reported data on participant sex. There was a difference between publications that included only females (n = 132) versus …

Directing Attention Externally Produces Consistent Vertical Jump Assessment Results, Logan T. Markwell, Hubert Makaruk, Vanessa Frost-Piedrahita, Jared M. Porter

International Journal of Exercise Science

International Journal of Exercise Science 16(5): 448-457, 2023. Recent research has demonstrated that consistent external attentional focus instructions produce more reliable jumping measurements compared to non-consistent focus of attention instructions. While previous research has examined the effects of different external attentional focus instructions, less is known about different external focus of attention instruction effects during a vertical jump. Given that previous work has demonstrated that consistent external focus of attention instructions produced reliable jumping estimations, we hypothesized that using multiple methods to direct attention externally would produce consistent vertical jump results. Using a within-participant design, college aged students (n …

Reliability Of A Novel Automated Ultrasound Technology For Body Composition Assessment And Comparisons With Dual Energy X-Ray Absorptiometry, Adam Bradley, Lukus Klawitter, Emma Carver, Zach Johnson, Ryan Mcgrath, Sherri Stastny, Bryan Christensen, Kyle Hackney

International Journal of Exercise Science

International Journal of Exercise Science 16(4): 393-401, 2023. Body composition tools vary in reliability, portability, and accessibility. The purpose of this study was to evaluate test-retest reliability of MuscleSound® (MS) and dual-energy x-ray absorptiometry (DXA) for both two compartment (region) and three compartment (tissue) models. A secondary aim was to compare body composition values produced by both devices. Fifty participants (n = 25 male, n = 25 female) aged 18-39 years completed two body composition assessments, twice in a single session. Participants arrived at the lab after a 12-hour fast. DXA required participants to lay supine for 10-15 minutes …

Effects Of Different Percentages Of Blood Flow Restriction On Muscle Oxygen Saturation While Walking, Clayton Shriver, Yvette Figueroa, Jayson R. Gifford, Patrick Davis

International Journal of Exercise Science

International Journal of Exercise Science 16(2): 411-428, 2023. The purpose of this investigation was to determine the effect of different relative pressures of blood flow restriction (BFR) on muscle oxygen saturation (SmO₂) while walking at 3.0 mph (4.83 kph). Fifteen physically active healthy adults performed seven 5-minute stages of walking at 3.0 mph with a blood flow restriction cuff applied to the proximal portion of the left or right leg while bilateral SmO₂ changes were measured using near infra-red spectroscopy (NIRS) on the medial head of the gastrocnemius (GM) and vastus lateralis (VL) muscles. Other measurements including …

Arch Stiffness Does Not Determine Running Economy In Recreational Runners, Ian Bradford, Padraig Kirkwood, Jared Eddy, Phillip Essenmacher, Jean L. Mccrory, Brian K. Leary

International Journal of Exercise Science

International Journal of Exercise Science 16(2): 402-410, 2023. The primary purpose of this study was to determine the relationship between foot length, arch stiffness, and running economy in recreational runner at low running velocities. Sixteen trained endurance (age 20.5 ± 0.4 yrs, height 172 ± 1.8 cm, and mass 68.53 ± 2.40 kg) athletes had their foot anthropometrics and running economy measured. Foot anthropometrics including Foot Length (FL), Arch Stiffness Index (ASI), and Achilles Tendon Moment Arm Length (ATML) were assessed. Subjects then completed a maximal oxygen consumption (VO_2max) test and running economy (RE) assessment. RE was measured …

Training Status Impacts Metabolic Response To A High-Protein Weight Loss Diet In Recreationally Resistance-Trained Females., Alyssa A. Olenick, Regis C. Pearson, Nathan T. Jenkins

International Journal of Exercise Science

International Journal of Exercise Science 16(2): 377-392, 2023. This study investigated the effects of a novel high-protein diet template on postprandial metabolism and body composition (e.g., waist and hip circumference, body fat (%), fat mass, fat-free mass) in recreationally resistance-trained females. Fifteen females adhered to an eight-week high-protein dietary intervention (~1.5-1.6 g·kg^-1·day^-1) administered via template format. Pre- and post-intervention visits included anthropometrics, measurement of body composition, and an acute high-fat meal challenge. The high-fat meal challenge (61% fat) consisted of fasting postprandial blood glucose, resting metabolic rate (RMR), fat and carbohydrate oxidation assessed at 60-, 120-, …

Anthropometric Predictors Of Conventional Deadlift Kinematics And Kinetics: A Preliminary Study, Dale S. Keith, Daniel Scherrer, Brandon Nunley, Jake R. Boykin, Jacob J. Green, Madelin R. Siedler, Christian Rodriguez, Patrick S. Harty, Matthew T. Stratton, John R. Harry, Grant M. Tinsley

International Journal of Exercise Science

International Journal of Exercise Science 16(1): 429-447, 2023. The purpose of this preliminary analysis was to determine if there are relationships between anthropometric characteristics (arm length, torso length, thigh length, and shank length) and conventional deadlift (CDL) kinematics and kinetics during a 5 sets of 5 repetitions (5 x 5) CDL routine in resistance-trained males. Eleven males who had experience with the deadlift exercise were included in this analysis (age: 21.5 ± 1.4 y; height: 180.7 ± 5.7 cm; body mass: 89.9 ± 16.0 kg). Anthropometrics were measured by a 3-dimensional optical scanner. The participants underwent a 5 x 5 …

Endothelial Cell Nrf2-Ko Attenuates Endothelial Function And Skeletal Muscle Antioxidant Capacity, Elizabeth J. Pekas, Cody P. Anderson, Michael F. Allen, Kollyn B. Jallen, Dong Gun Jin, Andres Benitez-Albiter, Christian D. Sanchez Tato, Lie Gao, Neha Dhyani, Tara L. Rudebush, Irving H. Zucker, Song-Young Park

UNO Student Research and Creative Activity Fair

INTRODUCTION: Endothelial cells line the inner surface of blood vessels and play a major role in modulating blood flow and gas exchange. Endothelial dysfunction is thought to be a contributor to cardiovascular disease development, and it is well-accepted that excessive reactive oxygen species (harmful molecules) likely contribute to endothelial dysfunction. The transcription factor nuclear factor erythroid 2-related factor 2 (Nrf2) is considered the master regulator of cellular protection in response to elevated reactive oxygen species. Therefore, Nrf2 may be a potential therapeutic target to protect against endothelial dysfunction. However, the roles of endothelial cell-specific Nrf2 on endothelial function are not …

Impaired Hydrogen Sulfide Protein Expression In Patients With Peripheral Artery Disease, Dong Gun Jin, Kollyn B. Jallen, Liz Pekas, Song-Young Park

UNO Student Research and Creative Activity Fair

INTRODUCTION: Hydrogen sulfide (H₂S) is a gaseous signaling molecule that serves various roles in the vasculature, such as upregulating angiogenesis, vascular smooth muscle relaxation, protecting endothelial function, and regulating redox balance. Despite H₂S’s positive impacts on vascular homeostasis, it is important to note that its actions depend on its concentrations. At high concentrations, H₂S has been reported to increase oxidative stress damage, such as oxidation of cysteine residues and lipid peroxidation. This may indicate that H₂S may act as a ‘double-edged sword’ in the field of vascular physiology. Peripheral artery disease (PAD) …

Thymic Stromal Lymphopoietin Participates In The Host Response To Intra-Amniotic Inflammation Leading To Preterm Labor And Birth, Tomi Kanninen, Li Tao, Roberto Romero, Yi Xu, Marcia Arenas-Hernandez, Jose Galaz, Zhenjie Liu, Derek Miller, Dustyn Levenson, Jonathan M. Greenberg, Jonathan Panzer, Justin Padron, Kevin Theis, Nardhy Gomez-Lopez Phd

Medical Student Research Symposium

Objective: To determine if bacteria (Ureaplasma parvum and Sneathia spp.) associated with intra-amniotic infection can trigger the induction of cytokine Thymic stromal lymphopoietin (TSLP) in human amnion epithelial cells (hAECs) in vitro.

Material or subjects: Amniotic fluid and chorioamniotic membrane (CAM) were collected from women with sPTL who delivered at term (n=30) or preterm without intra-amniotic inflammation (n=34), with sterile intra-amniotic inflammation (SIAI, n=27), or with intra-amniotic infection (IAI, n=17). Amnion epithelial cells (AECs), Ureaplasma parvum, and Sneathia spp. were also utilized.

Methods: The expression of TSLP, TSLPR, and IL-7Rα was evaluated in amniotic fluid or CAM by …

Movement, Behavior, And Trophic Ecology Of A Pelagic Predator Guild In The Eastern Tropical Pacific Ocean, Ryan Keith Logan

All HCAS Student Capstones, Theses, and Dissertations

Pelagic apex predators exert strong influences on ecological communities, and often support valuable commercial or recreational fisheries worldwide. Yet, due to their rarity and pelagic lifestyle, many species, such as billfishes, have proven particularly difficult to study at resolutions necessary to define dynamics of recovery from fishery interaction, physical interaction with environmental features and prey exploitation, and competitive interactions among other billfish predators. This leads to a paucity of knowledge on billfish ecology and habitat use, and hinders management efforts. With the ever-improving and miniaturization of technology and oceanographic datasets, the ability to define and quantify these interactions of fish …