Biomedical Engineering and Bioengineering Commons^™

Biom 4110/6110: The Science Of Medicine (Syllabus), Bradford D. Pendley

Biomedical Engineering Syllabi Archive

Course Description: Integration of fundamental principles from physics, chemistry, biology and mathematics, and applications of these principles to solve problems in medicine.

Brassinosteroids Inhibit Autotropic Root Straightening By Modifying Filamentous-Actin Organization And Dynamics, Louise De Bang, Ana Paez-Garcia, Ashley E. Cannon, Sabrina Chin, Jaydeep Kolape, Fuqi Liao, J. Alan Sparks, Qingzhen Jiang, Elison B. Blancaflor

Nebraska Center for Biotechnology: Faculty and Staff Publications

When positioned horizontally, roots grow down toward the direction of gravity. This phenomenon, called gravitropism, is influenced by most of the major plant hormones including brassinosteroids. Epi-brassinolide (eBL) was previously shown to enhance root gravitropism, a phenomenon similar to the response of roots exposed to the actin inhibitor, latrunculin B (LatB). This led us to hypothesize that eBL might enhance root gravitropism through its effects on filamentous-actin (F-actin). This hypothesis was tested by comparing gravitropic responses of maize (Zea mays) roots treated with eBL or LatB. LatB- and eBL-treated roots displayed similar enhanced downward growth compared with controls …

Functional Characterization Of Petiolule-Like Pulvinus (Plp) Gene In Abscission Zone Development In Medicago Truncatula And Its Application To Genetic Improvement Of Alfalfa, Juan Du, Shaoyun Lu, Maofeng Chai, Chuanen Zhou, Liang Sun, Yuhong Tang, Jin Nakashima, Jaydeep Kolape, Zhaozhu Wen, Marjan Behzadirad, Tianxiu Zhong, Juan Sun, Yunwei Zhang, Zeng-Yu Wang

Nebraska Center for Biotechnology: Faculty and Staff Publications

Alfalfa (Medicago sativa L.) is one of the most important forage crops throughout the world. Maximizing leaf retention during the haymaking process is critical for achieving superior hay quality and maintaining biomass yield. Leaf abscission process affects leaf retention. Previous studies have largely focused on the molecular mechanisms of floral organ, pedicel and seed abscission but scarcely touched on leaf and petiole abscission. This study focuses on leaf and petiole abscission in the model legume Medicago truncatula and its closely related commercial species alfalfa. By analysing the petiolule-like pulvinus (plp) mutant in M. truncatula at phenotypic level (breakstrength and …

Biom 3110: Medical Physiology (Syllabus), Bradford D. Pendley

Biomedical Engineering Syllabi Archive

Course Description: Basic principles of human physiology and how these are applied in medicine and biomedical engineering problem and devices; physiological principles using appropriate mathematical and engineering models to construct an understanding of how the body works as an integrated system.

Risks And Benefits Of Using A Commercially Available Ventricular Assist Device For Failing Fontan Cavopulmonary Support: A Modeling Investigation, Masoud Farahmand, Minoo N. Kavarana, Ethan Kung

Publications

Fontan patients often develop circulatory failure and are in desperate need of a therapeutic solution. A blood pump surgically placed in the cavopulmonary pathway can substitute the function of the absent sub-pulmonary ventricle by generating a mild pressure boost. However, there is currently no commercially available device designed for the cavopulmonary application; and the risks and benefits of implanting a ventricular assist device (VAD), originally designed for the left ventricular application, on the right circulation of failing Fontan patients is not yet clear. Moreover, further research is needed to compare the hemodynamics between the two clinically-considered surgical configurations for cavopulmonary …

Comparative Performance Of The Nanoscan And The Classic Smps In Determining N95 Filtering Facepiece Efficiency Against Nanoparticles, Clothilde Brochot, Fariborz Haghighat, Ali Bahloul

Études primaires

Nanoparticles are defined as particles with at least one dimension in the range of 1–100 nm. Due to the special properties of nanoparticles, they are used in many workplaces, thus leading to occupational exposure. Filtering facepieces (FFPs) are generally used in these workplaces to reduce the exposure. Many studies have measured FFP efficiency in laboratories using a scanning mobility particle sizer (SMPS). The aim of this study was to determine whether a NanoScan could be used to measure FFP efficiency against nanoparticles in workplaces for one type of N95 FFP. The results showed that the NanoScan gave maximum penetration and …

Alternative Upper Configurations During Agility-Based Movements: Part 1, Biomechanical Performance, Bradley S. Davidson, Kevin B. Shelburne, Moira Pyrhoda, Rachel Wathen, Nick Nelson, Sean Higinbotham, Jay Dicharry, Daniel Feeney, Kate Harrison

Alternative Upper Configurations During Agility-Based Movements

The objective of this research was to determine if three alternative shoe closures improve biomechanical performance measures compared to a standard lace closure in agility-based movements. NCAA Division 1 and club-level male athletes recruited from lacrosse, soccer, tennis, and rugby performed four court-based movements: Lateral Skater Jump Repeats (LSJ), Countermovement Jump Repeats (CMJ), Triangle Drop Step Drill (TDS), and Anterior-Posterior Drill (AP). Each athlete performed the movements in four shoe upper closures: Standard Closure, Lace Replacement, Y Wrap, and Tri Panel. Movement completion time, Ground contact time, peak eccentric rate of force development (RFD), peak concentric GRF, peak concentric COM …

Alternative Upper Configurations During Agility-Based Movements: Part 2, Joint-Level Biomechanics, Bradley S. Davidson, Kevin B. Shelburne, Moira Pyrhoda, Rachel Wathen, Nick Nelson, Sean Higinbotham, Jay Dicharry, Daniel Feeney, Kate Harrison

Alternative Upper Configurations During Agility-Based Movements

The objective of this research was to determine if three alternative shoe closures improve biomechanical performance measures compared to a standard lace closure in agility-based movements. NCAA Division 1 and club-level male athletes recruited from lacrosse, soccer, tennis, and rugby performed four court-based movements: Lateral Skater Jump Repeats (LSJ), Countermovement Jump Repeats (CMJ), Triangle Drop Step Drill (TDS), and Anterior-Posterior Drill (AP). Each athlete performed the movements in four shoe upper closures: Standard Closure, Lace Replacement, Y Wrap, and Tri Panel. Movement completion time, Ground contact time, peak eccentric rate of force development (RFD), peak concentric GRF, peak concentric COM …

A Series-Elastic Robot For Back-Pain Rehabilitation, Elhussein Shata

Electronic Theses and Dissertations

Robotics research has been broadly expanding into various fields during the past decades. It is widely spread and best known for solving many technical necessities in different fields. With the rise of the industrial revolution, it upgraded many factories to use industrial robots to prevent the human operator from dangerous and hazardous tasks. The rapid development of application fields and their complexity have inspired researchers in the robotics community to find innovative solutions to meet the new desired requirements of the field. Currently, the creation of new needs outside the traditional industrial robots are demanding robots to attend to the …

The Hsp90 Inhibitor, Auy-922, Ameliorates The Development Of Nitrogen Mustard-Induced Pulmonary Fibrosis And Lung Dysfunction In Mice, Pavel Solopov, Ruben M.L. Colunga Biancatelli, Margarita Marinova, Christiana Dimitropoulou, John D. Catravas

Bioelectrics Publications

Increased levels of heat shock protein 90 (HSP90) have been recently implicated in the pathogenesis of pulmonary fibrosis and the use of HSP90 inhibitors constitutes a potential therapeutic approach. Similarly, acute exposure to nitrogen mustard (NM) is related to the development of chronic lung injury driven by TNF-α, TGF-β, ERK and HSP90. Thus, we developed a murine model of NM-induced pulmonary fibrosis by instilling C57BI/6J mice with 0.625 mg/kg mechlorethamine hydrochloride. After 24 h, mice began receiving AUY-922, a second generation HSP90 inhibitor, at 1 mg/kg 2 times per week or 2 mg/kg 3 times per week, for either 10 …

Thermal Analysis Of Infrared Irradiation-Assisted Nanosecond-Pulsed Tumor Ablation, James Hornef, Chelsea M. Edelblute, Karl H. Schoenbach, Richard Heller, Siqi Guo, Chunqi Jiang

Bioelectrics Publications

Nanosecond Pulsed Electric Fields (nsPEF) have the potential to treat a variety of cancer types including melanoma, pancreatic and lung squamous cancers. Recent studies show that nsPEF-based cancer therapy may be improved further with the assistance of moderate heating of the target. A feedbacklooped heating system, utilizing a 980-nm fiber optic laser, was integrated into nsPEF electrodes for tumor ablation. The laser beam profile was determined to be Gaussian using a knife-edge technique. Thermal properties of the biological target were evaluated based on the treatment area, penetration depth and thermal distribution due to laser irradiation with or without nsPEF. Synergistic …

Early Acid/Base And Electrolyte Changes In Permanent Middle Cerebral Artery Occlusion: Aged Male And Female Rats, Sarah R. Martha, Lisa A. Collier, Stephanie M. Davis, Sarah J. Goodwin, David Powell, Doug Lukins, Justin F. Fraser, Keith R. Pennypacker

Neurosurgery Faculty Publications

BACKGROUND: Early changes in acid/base and electrolyte concentrations could provide insights into the development of neuropathology at the onset of stroke. We evaluated associations between acid/base and electrolyte concentrations, and outcomes in permanent middle cerebral artery occlusion (pMCAO) model.

METHODS: 18-month-old male and female Sprague-Dawley rats underwent pMCAO. Pre-, post- (7 min after occlusion), and at 72 hr of pMCAO venous blood samples provided pH, carbon dioxide, oxygen, glucose, hematocrit, hemoglobin, and electrolyte values of ionized calcium, potassium, and sodium. Multiple linear regression determined predictors of infarct and edema volumes from these values, Kaplan-Meier curve analyzed morality between males and …

Investigation On Nanoparticle Based Combination Therapy For Targeted Cancer Treatment, Muhammad Raisul Abedin

Doctoral Dissertations

“The current treatment methods in cancer are associated with toxicity in healthy tissues, partial therapeutic response, drug resistance and finally recurrence of the disease. The cancer drugs are challenged by non-specific binding, undesired toxicity in healthy cells, low therapeutic index and finally poor therapeutic outcome. In this work, a targeted nanoscale therapeutic system Antibody Drug Nanoparticle (ADN) was engineered to selectively inhibit the breast cancer cell growth with reduced toxicity in healthy cells. The ADNs were designed by synthesizing rod shaped anoparticles using pure chemotherapeutic drug and covalently conjugating a therapeutic monoclonal antibody (mAb) on the surface of the drug …

Deep Learning For Digitized Histology Image Analysis, Sudhir Sornapudi

Doctoral Dissertations

“Cervical cancer is the fourth most frequent cancer that affects women worldwide. Assessment of cervical intraepithelial neoplasia (CIN) through histopathology remains as the standard for absolute determination of cancer. The examination of tissue samples under a microscope requires considerable time and effort from expert pathologists. There is a need to design an automated tool to assist pathologists for digitized histology slide analysis. Pre-cervical cancer is generally determined by examining the CIN which is the growth of atypical cells from the basement membrane (bottom) to the top of the epithelium. It has four grades, including: Normal, CIN1, CIN2, and CIN3. In …

Design Of X-Ray Source For Real-Time Computed Tomography, Wesley William Tucker

Doctoral Dissertations

"The reduction of motion blur in computed tomography (CT) drives the current research for multisource CT. Due to their compact nature, the current multisource systems utilize stationary angled anodes. Unfortunately, these configurations neither simplify the imaging geometry, nor satisfy the need for managing the high thermal loads demanded by real-time CT (30 acquisition frames per second). To add to the current field of knowledge, two x-ray tube concepts are presented in this dissertation. First, a simulation of transient thermal analysis was performed on a compact transmission-type x-ray tube anode operating in pulse-mode. A correlation was found between deposited beam power …

ระบบแบบสวมใส่สำหรับประเมินฟุเกิลเมเยอร์ของรยางค์ส่วนบนในผู้ป่วยโรคหลอดเลือดสมอง, วรพงษ์ ณรงค์วงศ์วัฒนา

Chulalongkorn University Theses and Dissertations (Chula ETD)

แบบประเมินฟุเกิลเมเยอร์ เป็นแบบประเมินผู้ป่วยโรคหลอดเลือดสมองที่เป็นที่ยอมรับกันในสากล เนื่องจากแบบประเมินมีความน่าเชื่อถือและครอบคลุมผู้ป่วยทุกระดับอาการ อย่างไรก็ตามแบบประเมินดังกล่าวนั้นใช้เวลาในการประเมินนาน และผู้ประเมินต้องมีความเชี่ยวชาญสูง ทางผู้วิจัยจึงได้สร้างระบบประเมินแบบใหม่ขึ้น โดยระบบสามารถประเมินผู้ป่วยโรคหลอดเลือดสมองอ้างอิงตามแบบประเมิน ส่วนการสั่งการ ของฟุเกิลเมเยอร์รยางค์บน งานวิจัยได้ทดสอบความแม่นยำในการตรวจวัดมุมการเคลื่อนที่ ให้ค่าความคลาดเคลื่อนเฉลี่ยที่ ± 2.24 องศา จากนั้นทดสอบการใช้งานระบบประเมินกับคนสุขภาพดี มีความแม่นยำในการประเมินคะแนนตามฟุเกิลเมเยอร์อยู่ที่ 96% และได้ทดสอบเปรียบเทียบกันระหว่าง การประเมินคะแนนฟุเกิลเมเยอร์ด้วยนักกิจกรรมบำบัด กับการประเมินด้วยระบบประเมินที่ออกแบบนี้ ในผู้ป่วยโรคหลอดเลือดสมอง จำนวน 20 ราย พบว่าให้ผล R=0.888 ที่ P=0.001 , นักกิจกรรมบำบัดใช้เวลาในการประเมินเฉลี่ย 6.25±1.57 นาที/ราย ในขณะที่ระบบประเมินนี้ใช้ระยะเวลา 9.25±1.50 นาที/ราย จากผลการทดลองพบว่ามีค่าคลาดเคลื่อนสูงสุดอยู่ที่ 5.9 องศาซึ่งความเห็นของแพทย์เชี่ยวชาญถือว่ายอมรับได้ ในขณะที่ผลการทดสอบในผู้ป่วยพบว่าระบบสามารถประเมินคะแนนเปรียบเทียบกับแบบประเมินฟุเกิลเมเยอร์ มีความสัมพันธ์กันอย่างมีนัยสำคัญ สามารถใช้ระบบประเมินได้อย่างอัตโนมัติทั้งระบบ 27 กิจกรรมย่อย จากทั้งหมด 33 กิจกรรมย่อย ทำให้ผู้ป่วยสามารถเข้าถึงการประเมินได้ง่ายยิ่งขึ้น

Development Of A Single Use Device Intended To Wash Blood Clot Debris From A Stent Retriever In The Operating Room, Shane Diller

Theses and Dissertations

Ischemic stroke is a life-threatening condition that requires immediate surgical intervention to remove the blood clot that is lodged in the blood vessels of the brain. Mechanical thrombectomy, performed by an endovascular surgeon, involves inserting a stent retriever, which deploys distally and attempts to capture the clot when dragged backwards. A complication prevalent in 50% - 67% of cases is that the blood clot is only partially removed and clings to the mesh framework of the stent. The operating surgeon must either clean the debris from the stent retriever, to be reinserted or throw the stent retriever away and open …

Surface Modification Of Titanium For Orthopedic And Drug Delivery Applications, Prantik Roy Chowdhury

Graduate Research Theses & Dissertations

Titanium is one of the most attractive metal used in orthopedic and drug delivery applications because of its excellent mechanical properties, biocompatibility and high corrosion resistance. However, due to its bio-inertness, fibrous tissue forms between the bone and implant which causes loosening of implant. Surface modification can play an important role to enhance interaction between implant and the surrounding tissues which reduces the implant failure. The aim of this study is to a) incorporate magnesium (Mg) into modified titanium surface by different deposition methods for bone-implant interaction, b) modify the surface of titanium by alkali treatment, and c) investigate the …

Physical And Mechanical Properteis Of Magnesium-Incorporated Bone Substitute Materials, Sarah E. Fleck

Graduate Research Theses & Dissertations

Calcium phosphate (CaP) ceramics have become popular as bone substitutes due to their biocompatibility and similarity to natural bone. Although they are widely used, the mechanical and biological properties of these CaP ceramics can be improved by various methods such as combining them with polymers or ionic substitution in their crystal structure. In current research, we have used carboxymethyl cellulose (CMC) and magnesium (Mg) to modify the physical and mechanical properties of CaP. CMC is a derivative of cellulose which is hydrophilic, biodegradable, and biocompatible. Presence of Mg, a trace element naturally found in the body, is linked to bone …

Regulation Of Δnp63Α By Tip60 Promotes Cellular Proliferation, Andrew Jared Stacy

Browse all Theses and Dissertations

ΔNp63α is a p53 transcription factor family member that promotes cellular proliferation and survival. In squamous cell carcinoma (SCC), ΔNp63α overexpression is associated with poor prognosis and survival, implicating it as a proto-oncogene. Despite its importance in SCC, the mechanisms regulating ΔNp63α expression are poorly understood. We have identified the acetyltransferase TIP60 as a novel upstream regulator of ΔNp63α levels. We discovered that TIP60 regulates ΔNp63α via two mechanisms. First, TIP60 upregulates ΔNp63α mRNA levels. Moreover, pharmacological inhibition of TIP60 activity reduces ΔNp63α transcript levels, indicating that TIP60-cataltyic activity is vital to amplified transcription of ΔNp63α. Second, we have demonstrated …

Host-Parasite Interactions: Comparative Analyses Of Population Genomics, Disease-Associated Genomic Regions, And Host Use, Sara Rose Seibert

Browse all Theses and Dissertations

Birds are major vectors and reservoir hosts of pathogens across our globe. Pathogens can be spread through the dispersal and seasonal movements of migratory and resident wild birds. Although biogeographic barriers have the potential to restrict completely or in part gene flow in wild birds, variation in ecological drivers of dispersal likely influences the effectiveness of these barriers amongst different species. This dissertation seeks to enhance our knowledge of Southern Hemisphere waterfowl species’ dispersal, population genomics, and disease ecology using population genomic techniques (double-digest restriction-site associated DNA sequencing (ddRADseq)) and multi-variate statistics. First, we investigated the roles of dispersal behavior …

Development Of Cellulose Acetate-Based Scaffold For Bone Tissue Engineering Applications, Ruhit Sinha

Electronic Theses and Dissertations

Cellulose Acetate (CA) based biomaterials are being used as substrates for bone ingrowth applications due to their nontoxic and nonirritant nature coupled with optimum morphology and stiffness. Electrospinning with additives and/or post-treatment has emerged as a viable protocol to further improve mechanical properties of CA and expand its utility. Herein, we highlight the role of potassium chloride (KCl) in association with airdrying to enhance the elastic modulus and tensile strengths of CA fibers. Salt aggregation in between fibers is observed through Scanning Electron Microscopy (SEM), however, Fourier-transform infrared (FTIR) analysis signifies the interactions between K+ ions and acetyl groups. The …

Comparison Of Hybridizing Options For Solar Heat, Biomass And Heat Storage For Electricity Generation In Spain, Cm Iftekhar Hussain, Brian Norton, Aidan Duffy

Articles

Diurnal and seasonal variations of direct solar energy circumscribe locations suitable for sole use of concentrated solar power for electricity generation, whereas to generate electricity at night and during winter months, biomass systems can be used that incur fuel expenditures and may encounter fuel supply discontinuities. Combining solar heat, biomass conversion and heat storage in a hybrid electricity generation plant may overcome the limitations of sole use of any one of these energy sources in specific geographic and/or economic conditions. In this work standalone biomass, hybrid concentrated solar power-biomass and hybrid concentrated solar power-biomass-thermal energy storage power generation systems are …

Increasing Performance Of Classifiers For Ssvep-Based Brain-Computer Interfaces Using Extension Methods, Ethan Douglas Webster

Legacy Theses & Dissertations (2009 - 2024)

Brain-computer interfaces (BCI) provide an alternative communication method that does not require standard physical mediums (speech, typing, etc.). These systems have been implemented to provide additional communication and control options for people with certain motor disabilities. Classification is an important part of BCI systems and consists of inferring user commands from brain activity. Supervised classification methods often achieve higher accuracy, but unsupervised classification methods are useful when training is not practical for the user. This thesis focuses on unsupervised classification algorithms used for a BCI speller application and presents extensions for two existing classifiers that improve classification accuracy and thus …

The Brain's Large-Scale Electrophysiological Signals : Fundamental Attributes And Neurosurgical Applications, Mohammad Amin N/A Nourmohammadi

Legacy Theses & Dissertations (2009 - 2024)

Brain’s electrophysiological signals are most certainly the ultimate source for studying the sophisticated neural network inside our cranium. The unparalleled complexity of these biosignalsis the quintessential manifestation of their underlying complicated neurophysiological processes. Studying brain signals on the cellular level provides valuable information regarding the brain’s electrophysiology on the small-scale. However, it is the remarkable network in the large-scale that gives rise to the brain’s extraordinary attributes and exceptional capabilities—perception, cognition, computation, and consciousness are all the emergent byproducts of the dynamic neuronal interactions on the network level. In this sense, the large-scale electrophysiological signals, recorded from the surface of …

Modeling, Designing And Applying Machine Learning Algorithms For Driver Drowsiness Detection, Mohsen Babaeian

CGU Theses & Dissertations

Driver drowsiness has been a significant hazard resulting in various traffic accidents. Therefore, monitoring this condition is crucial not only in alerting drivers, but also in avoiding fatal accidents. Many research studies propose new systems to reduce the number of drowsiness-related injuries and fatalities. The ultimate goal for a drowsiness detection system is to detect the drowsiness on time and minimize the system or environment errors to avoid false readings, such as studying physiological signal processing patterns. These potentially life-saving systems must operate in a timely manner with the highest precision. Researchers proposed various methods based on driving pattern changes, …

In Vivo Data Capture Using Hssr For Calibration Of Computational Models, Thor Erik Andreassen

Electronic Theses and Dissertations

Computational modeling is a vital tool for understanding and evaluating healthy and unhealthy function of the musculoskeletal aspects of the human body. However, the accuracy of the musculoskeletal models depends significantly on the accuracy of the input data used to calibrate various behavioral parameters of the model. To date, most computational models have been built using generic in vitro data, mostly because of a lack of accurate and meaningful datasets from in vivo testing. The next major step in computational modeling is to create subject-specific computational models using calibration data taken from in vivo testing. The overall goal was to …

Development Of A Clinical Marker-Less Motion Capture System For Patient Monitoring, Abigail Eustace

Electronic Theses and Dissertations

The ability to understand human movement is beneficial for deciding surgical procedures, tracking disease progression over time and helping with patient rehabilitation. The current gold-standard for collecting human movement is the use of 3-dimensional marker-based systems. Several studies have presented the many limitations to the current gold-standard that reduces the number of people who are able to benefit from a gait analysis. Those limitations in the current gold-standard include the requirements of large laboratory space, costly equipment, long instrumentation and collection time, and the potential for motion artifact from markers being placed on the skin. The purpose of this study …

Developing Machine Learning Algorithms For Behavior Recognition From Deep Brain Signals, Hosein Golshan Mojdehi

Electronic Theses and Dissertations

Parkinson’s disease (PD) is a neurodegenerative condition and movement disorder that appears with symptoms such as tremor, rigidity of muscles and slowness of movements. Deep brain stimulation (DBS) is an FDA-approved surgical therapy for essential tremor and PD. Despite the fact that DBS substantially alleviates the motor signs of PD, it can cause cognitive side effects and speech malfunction mainly due to the lack of adaptivity and optimality of the stimulation signal to the patients’ current state. A behavior-adapted closed-loop DBS system may reduce the side effects and power consumption by adjusting the stimulation parameters to patients’ need.

Behavior recognition …

A Longitudinal Examination Of Biomechanical Balance And Quantitative Multidomain Assessments During Recovery Following Sport-Related Concussion, Moira Kate Pyrhoda

Electronic Theses and Dissertations

Sport-related concussion is an inherent risk to athlete health in contact and collision sports. Both short- and long-term risks are associated with the injury. Short-term, athletes may develop post-concussion syndrome (PCS), the persistence of cognitive, physical, and emotional symptoms for weeks or months after injury. Athletes who return to play (RTP) prematurely are at increased risk for lower extremity injury and repeated concussion injuries. Long-term, history of multiple concussions have been linked to neurodegenerative diseases. Due to these risks, concussion assessments must be sensitive to the injury and useful in the diagnosis, recovery, and RTP phases of the injury.

Sideline …