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Articles 1 - 30 of 321
Full-Text Articles in Biomedical Engineering and Bioengineering
Cellular Mechanisms Of Spinal Motoneuron Hypoexcitability Underlying Dynapenia In Aging, Ibrahim Abdul Halim
Cellular Mechanisms Of Spinal Motoneuron Hypoexcitability Underlying Dynapenia In Aging, Ibrahim Abdul Halim
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Age-related weakness remains poorly understood as the underlying mechanisms remain unclear. While synaptic input and muscular changes have been investigated with age, intrinsic motoneuron excitability alterations are often overlooked. This thesis provides the first direct assessment of intrinsic excitability and ion channel properties of spinal α-MNs from male and female mice across three ages: young, middle aged, and old. Our findings reveal a decline in intrinsic excitability of motoneurons with age in both sexes. Mechanistic analysis shows sex specific differences: female motoneurons exhibit increased dendritic size, hyperpolarized RMP, and SK channel overactivation, whereas males show only SK overactivation with age. …
Enhanced Diagnostics And Surveillance Of Enteroviruses Including Serotypes Associated With Acute Flaccid Myelitis, Denise Lynette Kramer
Enhanced Diagnostics And Surveillance Of Enteroviruses Including Serotypes Associated With Acute Flaccid Myelitis, Denise Lynette Kramer
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Prior to 2014, Enterovirus D68 infections typically caused symptoms resembling the common cold. From 2014-2018, D68 was associated with an increase in acute flaccid myelitis. However, since 2020, neurological complications have all but disappeared. We selected 1076 respiratory specimens previously determined to be positive for rhinovirus or enterovirus from Department of Defense members and their beneficiaries collected globally from October 2018 through January 2024 and underwent sequencing. Of these specimens, 93.7% were identified as rhinoviruses, while 6.3% were enteroviruses, including 30 enterovirus D68. We utilized the Nextstrain bioinformatic pipeline to reconstruct the phylogenetic relationship of these 30 D68 viruses. Twenty-two …
Vagus Nerve Stimulation Ameliorates Cognitive Impairment Caused By Hypoxia, Birendra Sharma
Vagus Nerve Stimulation Ameliorates Cognitive Impairment Caused By Hypoxia, Birendra Sharma
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Hypoxia disrupts brain function due to the high demand for oxygen, leading to significant cognitive impairments. While vagus nerve stimulation (VNS) has been shown to enhance cognition, its ability to counteract hypoxia-induced deficits remains unclear. In this study, male Sprague–Dawley rats were assigned to sham, hypoxia, or VNS + hypoxia groups, with VNS delivered during hypoxia (8% oxygen) using biphasic pulses (100 μs, 30 Hz, 0.8 mA). Cognitive performance was evaluated using multiple behavioral paradigms, and hippocampal tissue was analyzed for neurotrophin expression through quantitative PCR and immunohistochemistry. Among the behavioral measures, hypoxia specifically impaired performance on the passive avoidance …
The Role Of Trpm7 In Mouse Development And Immune Cell Function, Jananie Rockwood
The Role Of Trpm7 In Mouse Development And Immune Cell Function, Jananie Rockwood
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Transient receptor melastatin 7 (TRPM7) functions both as an ion channel and a protein kinase. TRPM7 has been implicated in Mg2+ homeostasis, embryogenesis, cardiac automaticity, and immunity. The purpose of this research was to deepen our understanding of TRPM7 channel and kinase functions. To this end, we used two transgenic mouse models: the TRPM7 gain-of-function (GOF) and TRPM7 kinase-dead (KD) mice to address the consequences of increased channel activity and kinase inactivation, respectively. Global deletion of TRPM7 or the kinase domain alone are embryonic lethal, therefore, we used the TRPM7 GOF mouse to investigate germline transmission. We examined embryo development …
Induced Reduction Of N-Glycosylation Leads To Heart Failure, Anthony M. Young
Induced Reduction Of N-Glycosylation Leads To Heart Failure, Anthony M. Young
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Cardiovascular disease is the leading cause of death and contributes to the increasing global prevalence of heart failure (HF). N-glycosylation is a common co-/post-translational modification where branching oligosaccharides are bound to the extracellular domain of membrane proteins. This creates a diverse range of glycan structures and requires the coordination of hundreds of regulated genes. Inherited mutations in glycan synthesis frequently present with cardiomyopathies leading to HF with reduced ejection fraction (HFrEF). Additionally, gene expression studies of HFrEF patients have shown altered expression of glycosylation-related genes, including alpha-1,3-mannosyl-glycoproten 2-beta-N acetlyglucosaminyltransferase (Mgat1). This gene encodes N-acetylglucosaminyl transferase 1 (GlcNAcT1) which is required …
The Impact Of Ahr And Hs1.2 Enhancer Genetic Variations On Igh Expression And Antibody Production In Human B Cells, Mili Santosh Bhakta-Yadav
The Impact Of Ahr And Hs1.2 Enhancer Genetic Variations On Igh Expression And Antibody Production In Human B Cells, Mili Santosh Bhakta-Yadav
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Antibody production is an essential component of the immune response against pathogens. The immunoglobulin heavy chain (IgH) gene codes for the heavy chain of antibodies. The IgH constant regions Cμ, Cδ, Cγ1-4, Cα1-2, and Cε encode the five major classes of antibodies, i.e., IgM, IgD, IgG1-4, IgA1-2, and IgE, respectively. The transcription of the IgH gene and class switch from IgM to other isotypes is regulated by two 3’ IgH regulatory regions (3’IgHRRs), each of which is a cluster of three enhancer regions (hs3, hs1.2 and hs4). The genetic variations in the hs1.2 enhancer have been identified; a ~53 bp …
Evaluation And Modulation Of The Circadian Clock In Human Keratinocytes And Epidermal Skin, William Harold Cvammen Iv
Evaluation And Modulation Of The Circadian Clock In Human Keratinocytes And Epidermal Skin, William Harold Cvammen Iv
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The circadian clock is a fundamental biological mechanism that regulates various physiological processes, including DNA repair, to synchronize with the day-night cycle. In human skin, exposure to ultraviolet (UV) light poses a significant challenge, inducing DNA damage that must be efficiently repaired to maintain genomic integrity and prevent carcinogenesis. This study delved into the complex interplay between the circadian clock, UV light exposure, DNA repair, and modulation of circadian transcriptional machinery in human skin. Initially, we examined the transcriptomic profile of the circadian clock in humans through in silico-based approaches and in vivo studies, revealing that core clock gene expression …
Potential Role Of Ttt Complex In Regulating Dna Replication Checkpoint In The Fission Yeast Schizosaccharomyces Pombe, Sankhadip Bhadra
Potential Role Of Ttt Complex In Regulating Dna Replication Checkpoint In The Fission Yeast Schizosaccharomyces Pombe, Sankhadip Bhadra
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DNA replication can be perturbed by various agents that slow or stall the replication forks, causing replication stress. If undetected, stressed forks may collapse, causing mutagenic DNA damage or cell death. In response to replication stress and DNA damage, the eukaryotic cell activates the DNA replication checkpoint (DRC) and DNA damage checkpoint (DDC) pathways to promote DNA synthesis, repair, and cell survival. The two cell cycle checkpoint pathways are controlled by the protein sensor kinases Rad3 (hATR/scMec1) and Tel1 (hATM/scTel1) in fission yeast, although Tel1 plays a minimal role in checkpoint functions. Rad3 and Tel1 belong to a family of …
Novel Approaches To Treatment Of Hyperexcitability In Skeletal Muscle, Phillip Vance Walker Ii
Novel Approaches To Treatment Of Hyperexcitability In Skeletal Muscle, Phillip Vance Walker Ii
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Myotonia Congenita (MC) is a rare, inherited ion channelopathy caused by a loss-of-function mutation in the CLCN1 gene. The resulting downregulation of the skeletal muscle chloride channel (ClC-1) results in hyperexcitable skeletal muscle fibers that fire action potentials involuntarily. Patients with MC suffer from debilitating stiffness due to myotonia, described clinically as delayed muscle relaxation following voluntary contraction. Skeletal muscle is a unique system we use in this study to advance our understanding of the pathophysiology underlying MC, and other channelopathies characterized by hyperexcitable cells (i.e., forms of epilepsy and cardiac arrhythmia). Furthermore, re-assessing what makes anti-myotonic drugs such as …
A Novel In-Vitro Approach To Investigate The Molecular Interaction Between Inhaled Particles And The Human Pulmonary Surfactant System, Bryan Mayville
A Novel In-Vitro Approach To Investigate The Molecular Interaction Between Inhaled Particles And The Human Pulmonary Surfactant System, Bryan Mayville
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The deployment of military personnel to austere environments poses significant pulmonary health risks from inhalation of particulates including sand, dust, pollution, and heavy machinery exhaust. When particles are less than 10 µm in diameter, they can penetrate deep within the alveoli and embed within the protective lung surfactant monolayer. Here, absorption of surfactant lipids to the particle surface disrupts the essential monolayer configuration needed to reduce surface tension and prevent atelectasis, thus leading to disease. Currently, there are no in vitro surfactant-producing lung cell models capable of studying the effects of inhaled particles on the human pulmonary surfactant system. A549 …
Insights Into Hyperkalemic Periodic Paralysis: Novel Mechanisms And Treatments, Christopher Dupont
Insights Into Hyperkalemic Periodic Paralysis: Novel Mechanisms And Treatments, Christopher Dupont
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Hyperkalemic Periodic Paralysis (hyperKPP) is an inherited channelopathy that leads to incapacitating episodes marked by severe skeletal muscle weakness or total paralysis, often accompanied by muscular stiffness (myotonia). The periods of muscle dysfunction are thought to be caused by the elevation in extracellular potassium (K). This autosomal dominant disorder is associated with mutations in the skeletal muscle voltage-gated sodium channel (Nav1.4). A multitude of inciting factors have been documented, including rest post-exertion, a potassium-rich diet, exposure to cold temperatures, psychological stressors, and fatigue. Given the variability of the triggers and the debilitating manifestation of symptoms, individuals afflicted by hyperKPP have …
Comparative Analysis Of Motoneuronal C-Bouton Structural Alterations In Als And Aging, Shelby Nicole Ward
Comparative Analysis Of Motoneuronal C-Bouton Structural Alterations In Als And Aging, Shelby Nicole Ward
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Amyotrophic Lateral Sclerosis (ALS) is a neurodegenerative disease characterized by motor neuron (MN) death resulting in paralysis and eventually death. ALS has greater prevalence in older populations sharing characteristics with aging like muscle weakness and MN type specific degeneration. MNs innervate skeletal muscles and control muscle contraction through their excitability which is altered in both conditions. C-Boutons are a cholinergic, excitatory synaptic input to MNs and have been studied in ALS and aging but have produced inconsistent findings and undesired gaps. We used immunohistochemistry to label mouse lumbar spinal cord and separate MN types. 60x imaging and automated analysis was …
Sex-Driven Alterations In Aging Alpha Motoneurons: Exploring Size, Type, Density, And Kv2.1 Channel Expression, Kalin R. Gerber
Sex-Driven Alterations In Aging Alpha Motoneurons: Exploring Size, Type, Density, And Kv2.1 Channel Expression, Kalin R. Gerber
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This research explores how motor neurons (MNs) and Kv2.1 clustering change with age, emphasizing sex differences and MN subtypes. We found that MN density decreases with age in both sexes, while soma size increases in male mice. FF MNs were the most affected, and old weak mice had smaller MNs than their stronger counterparts, underscoring FF MN vulnerability. Baseline studies revealed that FF and FI MNs have larger Kv2.1 clusters compared to FR and S MNs. Female mice had smaller, denser Kv2.1 clusters than male mice, suggesting less clustering in females. With age, Kv2.1 clusters grew larger but became less …
Sarcopenia Is Associated With Osteopenia And Impaired Quality Of Life In Children With Genetic Intrahepatic Cholestatic Liver Disease, Julia Boster, Nathan P. Goodrich, Cathie Spino, Kathleen M. Loomes, Estella M. Alonso, Binita M. Kamath, Ronald J. Sokol, Saul J. Karpen, Alexander Miethke, Benjamin L. Shneider, Jean P. Molleston, Rohit Kohli, Simon P. Horslen, Philip Rosenthal, Pamela L. Valentino, Jeffrey Teckman, Thomas N. Hangartner, Sundaram Shikha
Sarcopenia Is Associated With Osteopenia And Impaired Quality Of Life In Children With Genetic Intrahepatic Cholestatic Liver Disease, Julia Boster, Nathan P. Goodrich, Cathie Spino, Kathleen M. Loomes, Estella M. Alonso, Binita M. Kamath, Ronald J. Sokol, Saul J. Karpen, Alexander Miethke, Benjamin L. Shneider, Jean P. Molleston, Rohit Kohli, Simon P. Horslen, Philip Rosenthal, Pamela L. Valentino, Jeffrey Teckman, Thomas N. Hangartner, Sundaram Shikha
Biomedical, Industrial & Human Factors Engineering Faculty Publications
Background:
Sarcopenia occurs in pediatric chronic liver disease, although the prevalence and contributing factors in genetic intrahepatic cholestasis are not well-described. The objective of this study was to measure muscle mass in school-aged children with genetic intrahepatic cholestasis and assess relationships between sarcopenia, clinical variables, and outcomes.
Methods:
Estimated skeletal muscle mass (eSMM) was calculated on dual-energy x-ray absorptiometry obtained in a Childhood Liver Disease Research Network study of children with bile acid synthesis disorders(BASD) alpha-1 antitrypsin deficiency (a1ATd), chronic intrahepatic cholestasis (CIC), and Alagille syndrome (ALGS). Relationships between eSMM, liver disease, and transplant-free survival were assessed.
Results:
eSMM was …
Friend Or Foe? The Role Of Transforming Growth Factor-Β (Tgfβ) Signaling In Calcineurin Inhibitor-Induced Renal Damage, Adaku Uwe
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With its incorporation into clinical practice in the early 1980s, the class of pharmacological agents known as calcineurin inhibitors (CNIs) quickly became the cornerstone of immunosuppressive therapy post-organ transplantation. However, its use is limited by irreversible kidney damage in the form of renal fibrosis. The molecular mechanism by which CNIs induce renal fibrosis remains to be better understood, and to date, there are no specific therapeutic strategies to mitigate this damage. This dilemma presents a critical need to explain mechanisms by which CNIs cause renal damage. Kidneys of patients on chronic CNI therapy show increased expression of the proinflammatory cytokine …
Lipin1 Overexpression Ameliorates The Dystrophic Phenotype In Mdx Mice By Enhancing Myofiber Membrane Integrity, Abdullah Alshudukhi
Lipin1 Overexpression Ameliorates The Dystrophic Phenotype In Mdx Mice By Enhancing Myofiber Membrane Integrity, Abdullah Alshudukhi
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Duchenne muscular dystrophy (DMD) is a severe disease characterized by a progressive muscle fiber loss. DMD affects approximately 1 in 3500 male births worldwide. Patients die at early ages due to failure of respiratory and cardiac functions. DMD is caused by mutations in dystrophin gene. Loss of dystrophin leads to disruption of the membrane integrity and necroptosis in skeletal muscles of DMD patients contributing to muscle fiber loss. Currently, effective therapies for DMD have not been established. The goal of this project is to find mechanisms that may improve muscle function/structure despite dystrophin deficiency. Our data show that the expression …
Unfolding The Link Between The Axon Initial Segment, Endoplasmic Reticulum Stress, And Cognitive Impairment In Type 2 Diabetes, Jennae Shelby
Unfolding The Link Between The Axon Initial Segment, Endoplasmic Reticulum Stress, And Cognitive Impairment In Type 2 Diabetes, Jennae Shelby
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Dementia and mild cognitive impairment are well recognized comorbidities of type 2 diabetes, termed diabetic encephalopathy, that lack in course modifying treatment options. The axon initial segment (AIS) is a critical mediator of neuronal output. Shortening of AIS length has been shown to decrease neuronal excitability and is implicated in diabetic encephalopathy. AIS shortening may be reversible, hence investigating the mechanism responsible could address this significant gap in patient care by providing new therapeutic targets. Endoplasmic reticulum (ER) stress, a cellular condition that activates the unfolded protein response has been implicated in diabetic encephalopathy. Here, using immunocytochemistry in primary mouse …
Identifying A Novel Ferrocene Derivative As A K-Ras Inhibitor, Kristen Marie Rehl
Identifying A Novel Ferrocene Derivative As A K-Ras Inhibitor, Kristen Marie Rehl
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Ras proteins are small GTPases that regulate cell proliferation, differentiation and survival at the plasma membrane (PM). There are three Ras isoforms ubiquitously expressed in mammalian cells: H-, N- and K-Ras. Constitutively active Ras mutations are found in ~19% of all human cancers, with ~75% of those being in K-Ras. There are K-Ras inhibitors in clinic but they only target the oncogenic K-RasG12C mutant, which only makes up a small sub-set of K-Ras-driven cancers. Thus, there still exists a need for a pan anti-K-Ras drug. Ferrocene derivatives are a class of compounds that have been shown to inhibit the growth …
Brain Morphometry From Neuroimaging As A Biomarker For Alzheimer's Disease, Nonyelum Benedicta Aniebo
Brain Morphometry From Neuroimaging As A Biomarker For Alzheimer's Disease, Nonyelum Benedicta Aniebo
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Alzheimer’s disease (AD) is the seventh leading cause of death globally with an estimated 6.5 million Americans aged 65 and above living with Alzheimer’s dementia in 2022 and at a projected national cost of $321 billion. AD is characterized by a progressive and irreversible neurodegenerative dysfunction with clinical symptoms such as deterioration in cognition and memory loss. The Alzheimer’s Disease Neuroimaging Initiative (ADNI) is a multi-site, public-private global research initiative that supports both investigation and development of treatments that slow or terminate AD progression. The study included 60 participants, comprising 30 AD and 30 control cohorts respectively. All participants were …
Calpains In The Peripheral Nerve And During Demyelination And Degeneration In Rodents, John A. Miller
Calpains In The Peripheral Nerve And During Demyelination And Degeneration In Rodents, John A. Miller
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Myelin formed around axons ensures rapid and efficient action potential propagation. Disruption of myelinated axons in the peripheral nervous system (PNS) often causes nerve conduction failure, neurological symptoms and can lead to long-term disability. Calpains are calcium dependent cysteine proteases that play many roles during both normal physiology and pathogenesis. Calpain-1 (CAPN1) and calpain-2 (CAPN2) are key calpain paralogs found in the nervous system and potentially have opposing roles, with CAPN2 having a more neurodegenerative function. In the central nervous system (CNS), calpains have a role in developmental myelination as well as in the pathological demyelination of multiple sclerosis and …
Kv2.1 Dysfunction Underlies The Onset Of Symptoms In Sod1-G93a Mouse Model Of Als, Andrew J. Deutsch
Kv2.1 Dysfunction Underlies The Onset Of Symptoms In Sod1-G93a Mouse Model Of Als, Andrew J. Deutsch
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Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease which targets motoneurons (MNs), yet underlying disease mechanisms are not well understood. Evaluating the intrinsic excitability of MNs in ALS could lead to a better understanding of mechanisms causing neurodegeneration. The SOD1-G93A (SOD) model is the most commonly studied animal model of ALS. However, past studies have shown highly conflicting results on SOD MN excitability. Interestingly, I show that depending on the level of membrane depolarization, SOD MNs show opposite results of both hyper- and hypo-excitability. This reveals that differences in the methodology of measuring excitability can heavily impact the study results. …
Lipin1 Improves Membrane Integrity In Dystrophic Muscles Of Mdx Mice, Abdulrahman Jama
Lipin1 Improves Membrane Integrity In Dystrophic Muscles Of Mdx Mice, Abdulrahman Jama
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Duchenne muscular dystrophy (DMD) is an X-linked genetic disorder that affects 1 in 3500 male births worldwide. It is characterized by mutations in the dystrophin gene that results in the loss of functional dystrophin. Dystrophin deficiency leads to instability of the sarcolemma alongside increased inflammation, necrosis and fibrosis resulting in membrane rupture and eventual muscle fiber death. There are currently no effective treatments for DMD. Here we show that Lipin1 expression is significantly downregulated at the mRNA and protein levels in gastrocnemius muscle of mdx mice, the DMD mouse model. Lipin1 has a dual function as a phosphatidic acid phosphatase …
Dna Instability At (Attct) Microsatellites In Human Cells, Venicia Alhawach
Dna Instability At (Attct) Microsatellites In Human Cells, Venicia Alhawach
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Microsatellites are short tandem repeats of DNA (1-9 nucleotides) that are unstable in the genome. They can expand and contract which leads to mutations and rearrangements that jeopardize genomic integrity. When encountered by a replication fork, repeats of these microsatellites can form non-B DNA structures which cause replication forks to stall and collapse eventually leading to double stranded breaks (DSBs) and replication stress. One form of repair of replication dependent DSBs happens via break induced replication (BIR), a highly mutagenic repair pathway. The main objective of this study is to understand how ATTCT pentanucleotide repeats affect replication and chromosomal instability …
Microsatellite Induced Genomic Instability And Mutagenesis Through Break Induced Replication, Rujuta Yashodhan Gadgil
Microsatellite Induced Genomic Instability And Mutagenesis Through Break Induced Replication, Rujuta Yashodhan Gadgil
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Faithful DNA replication is essential to maintain genomic integrity. Compromises in this process are among the prime causes of cancer and other genetic disorders. Among several factors that can interfere with error-free DNA replication, the formation of non-B DNA structures by microsatellite sequences is critical. Microsatellites are 1-9 bp long tandem repetitive regions that can form secondary structures like hairpins, triplex, Gquadruplex etc. and undergo expansions due to replication fork stalling to cause several diseases. Hairpin forming microsatellites have been shown to induce DNA DSBs and lead to genetic instability and mutagenesis. The goal of this study is to understand …
Hierarchical Structure And Properties Of The Bone At Nano Level, Farah Hamandi, Tarun Goswami
Hierarchical Structure And Properties Of The Bone At Nano Level, Farah Hamandi, Tarun Goswami
Biomedical, Industrial & Human Factors Engineering Faculty Publications
Bone is a highly hierarchical complex structure that consists of organic and mineral components represented by collagen molecules (CM) and hydroxyapatite crystals (HAC), respectively. The nanostructure of bone can significantly affect its mechanical properties. There is a lack of understanding how collagen fibrils (CF) in different orientations may affect the mechanical properties of the bone. The objective of this study is to investigate the effect of interaction, orientation, and hydration on atomic models of the bone composed of collagen helix (CH) and HAC, using molecular dynamics simulations and therefrom bone-related disease origins. The results demonstrate that the mechanical properties of …
Residual Properties Of Silicone (Med-4719) Lead With Leads From Retrieved Devices, Anmar Salih, Tarun Goswami
Residual Properties Of Silicone (Med-4719) Lead With Leads From Retrieved Devices, Anmar Salih, Tarun Goswami
Biomedical, Industrial & Human Factors Engineering Faculty Publications
Leads are designed for in vivo applications, however, for a definite period of time. In-vivo environment affects the mechanical behavior of implantable devices, therefore, there is a need to evaluate the residual properties of implantable leads used with pacemakers, defibrillator and neuro-stimulators. Silicone (MED-4719) lead is widely used in cardiac implantable electronic devices made by different manufacturers. . We collected 150 devices (with or without leads) from Anatomical Gift Program of the Wright State University. The objective of this study was to investigate the residual properties of Silicone (MED-4719) lead with different in vivo exposure time and compare the properties …
Low Intensity Vibration Protects The Weight Bearing Skeleton And Suppresses Fracture Incidence In Boys With Duchenne Muscular Dystrophy, Maria Luisa Bianchi, Silvia Vai, Giovanni Baranello, Francesca Broggi, Stefan Judex, Thomas N. Hangartner, Clinton Rubin
Low Intensity Vibration Protects The Weight Bearing Skeleton And Suppresses Fracture Incidence In Boys With Duchenne Muscular Dystrophy, Maria Luisa Bianchi, Silvia Vai, Giovanni Baranello, Francesca Broggi, Stefan Judex, Thomas N. Hangartner, Clinton Rubin
Biomedical, Industrial & Human Factors Engineering Faculty Publications
The ability of low intensity vibration (LIV) to combat skeletal decline in Duchenne Muscular Dystrophy (DMD) was evaluated in a randomized controlled trial. Twenty DMD boys were enrolled, all ambulant and treated with glucocorticoids (mean age 7.6, height adjusted Z scores [HAZ] of hip bone mineral density [BMD] −2.3). Ten DMD boys were assigned to stand for 10 min/d on an active LIV platform (0.4 g at 30 Hz), while 10 stood on a placebo device. Baseline and 14 month bone mineral content (BMC) and BMD of spine, hip, and total body were measured with DXA, and trabecular bone density …
Traumatic Brain Injury Biomarkers, Simulations And Kinetics, Celeste Hicks, Akshima Dhiman, Chauntel Barrymore, Tarun Goswami
Traumatic Brain Injury Biomarkers, Simulations And Kinetics, Celeste Hicks, Akshima Dhiman, Chauntel Barrymore, Tarun Goswami
Biomedical, Industrial & Human Factors Engineering Faculty Publications
This paper reviews the predictive capabilities of blood-based biomarkers to quantify traumatic brain injury (TBI). Biomarkers for concussive conditions also known as mild, to moderate and severe TBI identified along with post-traumatic stress disorder (PTSD) and chronic traumatic encephalopathy (CTE) that occur due to repeated blows to the head during one’s lifetime. Since the pathways of these biomarkers into the blood are not fully understood whether there is disruption in the blood–brain barrier (BBB) and the time it takes after injury for the expression of the biomarkers to be able to predict the injury effectively, there is a need to …
Therapeutic Efficacies Of Nano Carriers In Delivering Drugs, Bailey Krueger, Taylor Frazier, Sheila Galbreath, Tarun Goswami
Therapeutic Efficacies Of Nano Carriers In Delivering Drugs, Bailey Krueger, Taylor Frazier, Sheila Galbreath, Tarun Goswami
Biomedical, Industrial & Human Factors Engineering Faculty Publications
The drug release rates of poorly soluble medications such as doxorubicin has been investigated in this paper. Since the drug was fixed, different carriers used to deliver it and their release rates compiled from literature were evaluated in this paper. Even though targeting of drugs is very important in drug delivery, it is not within the scope of this paper. However, functionalization of the carrier may provide this benefit, those constructs are included for comparison in terms of hybrid constructs. Dendrimer, micelles and hybrid constructs used in the delivery of doxorubicin compared in this paper with respect to carrier size …
Therapeutic Efficacies Of Nano Carriers In Delivering Drugs, Bailey Krueger, Taylor Frazier, Sheila Galbreath, Tarun Goswami
Therapeutic Efficacies Of Nano Carriers In Delivering Drugs, Bailey Krueger, Taylor Frazier, Sheila Galbreath, Tarun Goswami
Biomedical, Industrial & Human Factors Engineering Faculty Publications
The drug release rates of poorly soluble medications such as doxorubicin has been investigated in this paper. Since the drug was fixed, different carriers used to deliver it and their release rates compiled from literature were evaluated in this paper. Even though targeting of drugs is very important in drug delivery, it is not within the scope of this paper. However, functionalization of the carrier may provide this benefit, those constructs are included for comparison in terms of hybrid constructs. Dendrimer, micelles and hybrid constructs used in the delivery of doxorubicin compared in this paper with respect to carrier size …