Biomedical Engineering and Bioengineering Commons^™

Exercise-Induced Muscle Damage As A Model For Exploring The Effects Of Pain On Gait, Sydney Savage

All Theses

Persistent gait asymmetry following anterior cruciate ligament reconstruction (ACLR) is a recognized contributor to post-traumatic knee osteoarthritis, yet the independent role of pain in driving altered movement patterns remains poorly understood due to confounding factors inherent to clinical populations. This study used exercise-induced muscle damage (EIMD) as a controlled experimental model to isolate the effects of musculoskeletal pain on gait, independent of kinesiophobia, structural damage, and proprioceptive disruption. Eighteen healthy adults underwent unilateral eccentric calf-raise protocols to induce delayed onset muscle soreness (DOMS), with gait assessed at baseline, 48 hours, and 168 hours post-exercise using bilateral inertial measurement units. Outcomes …

Design And Development Of A Perfusable Hydrogel Platform With Bioprinted Human-Endothelialized Microvascular Channels, Calvin A. Chernyatinskiy

All Theses

We developed an integrated bioprinting and perfusion platform to generate vascularized hydrogel constructs that support perfusable microchannel networks. Multiple hydrogel formulations, sacrificial ink systems, device geometries, and perfusion conditions were systematically evaluated to optimize print fidelity, mechanical stability, and cellular compatibility. Internally gelling alginate–calcium carbonate hydrogels were identified as a robust matrix, providing tunable gelation kinetics and structural stability during embedded printing. In parallel, Pluronic F-127 fugitive ink enabled reliable fabrication of continuous hollow channels due to its shear-thinning behavior and efficient post-print removal.

The finalized platform integrates stereolithographically fabricated perfusion chambers with extrusion-based bioprinting to produce three-dimensional, perfusable vascular …

Development Of Low-Cost Triaxial Force Sensor For Measurement Of Human-Exoskeleton Interaction Forces, Hamdan Khan Sarvathullah

All Theses

Contemporary research suggests that shear force is a major contributor to discomfort and pressure injury. However, the variation of shear forces during human-exoskeleton interaction dynamics is a highly unexplored field. The high cost of commercial triaxial force sensors may be a major factor in the notable lack of research in this field. Therefore, in this paper, we present a low-cost, 3D-printed triaxial force sensor designed specifically to measure the triaxial interaction forces between an exoskeleton and its user. The triaxial force sensor uses Carbon-Black/Silicone Rubber (CB/SR) strings to measure shear forces, whereas the normal force is measured with a Force …

Ihelp Foundation 2025 Uganda Medical Mission, Kade Spencer Robison

Undergraduate Honors Capstone Projects

Uganda faces significant barriers to health care access, particularly in rural communities, due to physician shortages and limited resources. As a result, care is concentrated in urban areas, leaving rural populations disproportionately affected by both communicable and noncommunicable diseases.

This Honors Capstone project focused on preparing for and supporting the iHelp Foundation’s 2025 Uganda Medical Mission. The iHelp Foundation works to reduce barriers to care in Uganda by partnering with local hospitals to provide short-term rural clinics and specialized surgical care for advanced otolaryngological conditions.

In this project, I contributed to mission preparation by training volunteers and coordinating physician licensing. …

Picc-Pal: A Support Band For Independent Picc Line Use, Kylie Luker

Honors Theses

This project presents the design and evaluation of PICC-PAL, a wearable assistive device intended to improve independence and usability for patients managing peripherally inserted central catheters (PICC lines) at home. Current at-home PICC line management often requires help due to the fine motor skills needed to connect and secure tubing. This increases reliance on caregivers and introduces potential risks such as infection and dislodgement. Through stakeholder analysis, prior art evaluation, and iterative prototyping, a device was developed to stabilize the PICC line lumen and enable one-handed connection of medical tubing. Throughout the project, multiple design concepts were explored, with the …

Quantitative Fluorescence Imaging Using A Paired Agent Approach For Improving Surgical Decision Making, Sanjana Pannem

Dartmouth College Ph.D Dissertations

Surgical resection remains to be the cornerstone of treatment for most solid tumors, where the primary objective is to remove all visible and microscopic disease. However, the extent of tumor resection is inherently limited by the surgeon’s ability to distinguish tumor from normal tissue, intraoperatively. As a result, positive surgical margins (PSM), where residual tumor remains after surgery, are a common occurrence and are associated with increased recurrence, need for adjuvant therapies, dismal patient outcomes, and high healthcare costs.

Fluorescence guided surgery (FGS) has emerged as a promising technique to enhance intraoperative visualization of tumors and may help reduce the …

An Evaluation Of Total Navicular Implants: A Scoping Review, James Mcclure Hughes, Nicholas Belardo Obias, Amanda Killeen

School of Podiatric Medicine - Student Research

The aim of this study is to determine the efficacy and safety profile of total navicular implants based on current literature.

Navicular insults such as high-energy trauma, osteonecrosis, and Muller-Weiss syndrome may result in avascular necrosis or a critical sized bone defect, conditions that are highly difficult to manage given current treatment modalities. Total navicular implants may offer a solution to these problems. While 3D printing of implants remains investigational, its use in highly individualized cases involving the talus has had promising results with conditions like avascular necrosis, tumors, trauma, and arthritis. The navicular is unique in its attachments to …

Plant Growth Promoting Phenotypes Of Fungal Isolates From The International Space Station, Shane Doyle, Frances A. Edmonson

Ocean Engineering and Marine Sciences Student Publications

• In situ (on site) space crop production is vital for sustainability and dietary health of astronauts. 
• We hypothesize that International Space Station (ISS) derived fungal isolates will stimulate plant growth and express PGP phenotypes.
• Eleven space-viable fungi were screened via phenotypic testing to identify plant growthpromoting (PGP) activity.
• Prior research has been conducted solely with ISS derived bacteria, while ISS fungi are unexplored, which could reveal new or improved symbiotic relationships and growth factors.

C-Side: Concussion Sideline Injury Detection And Evaluation, Emily Acampora, Emma Angelo, Kyle Burden

Biomedical Engineering and Sciences Student Publications

Concussion are a form of mild traumatic brain injury (mTBI), affecting an estimated 3.8 million Americans anually. Athletes are particularly susceptible to incurring concussions. Current diagnostic methods are timeconsuming and rely primarily on subjective measures.

Biostress: An Engineered Platform For Detecting Cellular Damage Upon Mechanical Impact, Lindsay Avila, Nina Fiordaliso, Mai Tran

Biomedical Engineering and Sciences Student Publications

Mechanical impact stimuli are commonly associated with cellular damage and lower cell survival rates. However, mild impacts can promote responses that are adaptive. The heat shock protein 70 (HSP70) is a stressinducible protein that serves as an early biomarker for cellular stress. The relationship between impact severity and cellular response remains unclear.

Cardio Clarity -Wearable Cardiac Monitoring, Kaitlyn Dunn, Matthew Kotze, Emily Matheson, Caroline Moore

Biomedical Engineering and Sciences Student Publications

Purpose: Develop a low-cost wearable system for an accessible cardiac monitoring platform

Clear Aligner Overcorrection To Reduce Incisor Tipping | In Vitro, Benjamin Losch, Eddie Wawrzycki-Stein, Kylie Stong, Niko Burger

Biomedical Engineering and Sciences Student Publications

Quantify the biomechanical effects of overcorrection angles on tipping angle and periodontal moment during incisior retractions using both in vitro experiments and finite element analysis (FEA).

Biopulse: Split Hopkinson (Kolsky) Bar, Andrew Carr, Sebastian Deniz, Rachel Hizon, Stefan Paton

Biomedical Engineering and Sciences Student Publications

A Split Hopkinson (Kolsky) Bar is a device used to find a material’s mechanical response under high strain rate loading scenarios (10² – 10⁴ s⁻¹) [1]. It is commonly used to simulate vehicle crashes or ballistic impacts. The novelty of the device is its size and cost of its components compared to other SPHBs on the market. The motivation is to further the capabilities on campus by providing the first dynamic material testing device.

Vitasense: Noninvasive Physiological Signal Measurement From Video Data, Ava Dorow, Justin Mcparland, Ashley Schindler

Biomedical Engineering and Sciences Student Publications

• Heart rate monitoring enables proactive patient care
• Imaging Photoplethysmography (iPPG) enables noncontact measurement 
• Improves access to remote and virtual care

Cardiosync: Real-Time Pid Control Of Lvad Hemodynamics, Brendan Bouchard, Morgan Brenner, Panagiotis Vasileiadis, Michaela Wittman

Biomedical Engineering and Sciences Student Publications

Goals:

Develop a real-time, closed-loop control system for autonomous LVAD RPM adjustment. Minimize clinician reliance, reducing hospital visits and healthcare costs. Improve patient independence and quality of life. Maintain stable hemodynamic performance and reduce complications. Reduce patient mortality

Ocusensus: Real-Time Force Detection Strabismus Hook, Asa Barnhart, Niko Burger, Patricia Carrelo-Creque, Kristie Fonseca

Biomedical Engineering and Sciences Student Publications

Strabismus affects approximately 2–5% of the general population [1]. Primary treatment is (strabismus) surgery but current methods result in approximately 36% of patients undergoing reoperation within 5 years [2]. One factor proposed to contribute towards reoperation is insufficient force applied to extraocular muscles during surgery. Excessive force triggers the oculocardiac reflex (OCR) which lowers heart rate by >20%[3]

A Treatise On Tool Development: The Arthroscope’S Cultural, Technological, And Metascientific Translation, Montgomery F. Waterer

Honors Theses

The arthroscope was a revolutionary development in the fields of medicine, engineering, and ethics. There are many valuable lessons to be learned from the story of its development and translation that are relevant to the future of medicine and society. Beginning with a brief description of the tool’s design, this paper will examine a period within the history of the arthroscope. This window contains multiple innovators and ends with the life and work of Dr. Robert Jackson. In examining the relevant historical facts of its development, this paper will then briefly address the importance of sports medicine in the development …

Opportunistic Breast Cancer Detection With Photon-Counting Ct: A Quantitative Pilot Study Of Reconstruction-Dependent Image Quality, Graham Hannon

McKelvey School of Engineering Graduate Student Theses & Dissertations

Photon-counting computed tomography (PCCT) has emerged as a promising imaging modality with improved spatial resolution and contrast capabilities compared to conventional energy-integrating detector systems. These advantages present an opportunity for opportunistic detection of breast cancer in routine thoracic CT scans that include breast tissue. In this pilot study, we evaluated the feasibility of opportunistic breast cancer detection using clinical PCCT data through quantitative image analysis. Two patients with confirmed breast malignancies and corresponding thoracic PCCT scans were retrospectively analyzed. Dedicated reconstructions were performed with varying convolution kernels, field-of-view sizes, and virtual monoenergetic spectra. Image quality was assessed using signal-to-noise ratio …

Erk Builds A Population Of Short-Lived Nascent Adhesions That Produce Persistent Edge Protrusion And Cell Migration, Andrew P. Shepherd, Keith R. Carney, Majid Rostami, Jakaria Shawon, Andrew Elliott, Shiela C. Samson, Sangyoon J. Han, Michelle C. Mendoza

Michigan Tech Publications

Cell migration is realized through the fast and persistent protrusion of a leading edge in the direction of movement. The actin and adhesion structures that build edge protrusions are integrated such that pro-migration signaling pathways must control both assemblies to induce protrusion. Understanding the contribution of adhesion regulation has been complicated by the inability to selectively assay the nascent adhesions that promote edge protrusion. Here, we dissect how the core RAS → RAF → MEK → ERK pathway’s control of nascent adhesions contributes to edge protrusion and cell migration by targeting an ERK FRET biosensor to adhesions and quantifying ERK’s …

Spatial Computing With The Apple Vision Pro In Minimally Invasive Procedure Simulation: A Randomized Crossover Feasibility Study, Sydney Cooper, Aaron Kyle Jones, Rahul Anil Sheth, Koustav Pal, Bruno Odisio, Mark Blaylock, Shelita Kimble, Justin Bird, David Rice, Daniel Shoenthal, Emil Patel, Vipin Kamath, Sanjay Gupta, Jeffrey Siewerdsen, Joshua Kuban

Advances in Cancer Education and Quality Improvement

Purpose: This study aimed to evaluate the feasibility of wearing the Apple Vision Pro (AVP), a mixed-reality headset that integrates augmented and virtual reality, while performing minimally invasive procedures. While studies have demonstrated that spatial computing technology can improve surgical precision and reduce the risks of surgical complications, to our knowledge, no studies have specifically addressed the impact of the AVP on task performance during simulated image-guided procedures.

Materials and Methods: Thirteen diagnostic and interventional radiology residents performed image-guided central venous catheter placement, thoracentesis, and paracentesis on simulation models. Each participant completed a non-timed practice followed by the procedures once …

Uptake And Fate Of Silver And Zinc Engineered Nanoparticles In Maize Under Single And Binary Dosing Soil Ecosystems, Lei Xu, Qingbo Yang, Xingmao Ma, Honglan Shi, John Yang, Hu Yang, Samira Mahdi, Ying Wang, Young Shin Jun

Chemistry Faculty Research & Creative Works

Recent agricultural applications of engineered metallic nanoparticles (ENPs) have raised concerns about their uptake and fate in plants. To understand this critical issue, this study investigated the fate and uptake of silver (Ag) and zinc oxide (ZnO) ENPs in maize (Zea mays L.) after single or binary ENP exposure in soil. Results indicated that both Zn and Ag elemental concentrations in roots increased with increasing ENP dosage. Ag NPs in the tissues were detected, but not Zn NPs. Ag NP concentration was 3 times higher in the roots than in the shoots at low Ag NP dosing, while Ag NP …

Robust Non-Invasive Cardiac Index Prediction Via Feature Integration And Data-Augmented Neural Networks, Chih-Hao Chang, Mei-Ling Chan, Yu-Hung Fang, Po-Lin Huang, Tsung-Yi Chen, Tsun-Kuang Chi, I Elizabeth Cha, Tzong-Rong Ger, Kuo-Chen Li, Shih-Lun Chen, Liang-Hung Wang, Jia-Ching Wang, Patricia Angela R. Abu

Department of Information Systems & Computer Science Faculty Publications

Concurrent with the rising consumption of ultra-processed, high-calorie diets and the decline in physical activity, obesity and related cardiovascular conditions among young adults have continued to increase, becoming an important global public health concern. This study integrates non-invasive Internet of Things (IoT) sensing devices, including the TERUMO ES-P2000 blood pressure monitor (Terumo Corp., Tokyo, Japan) and the PhysioFlow PF07 Enduro cardiac hemodynamic analyzer (Manatec Biomedical, Poissy, France), with an artificial neural network (ANN) for cardiac index (CI) prediction. Through appropriate data preprocessing and model training strategies, the generalization ability and stability of the proposed CI prediction model were significantly enhanced. …

Implantable, Sensor-Embedded Vascular Graft Towards Wireless Monitoring Of Stenosis, Nnamdi Dike

LSU Master's Theses

Arteriovenous (AV) grafts are commonly used to provide vascular access for hemodialysis in patients with end-stage renal disease. Despite their widespread use, AV grafts are prone to complications such as stenosis and thrombosis. Early detection of these conditions remains challenging with current monitoring methods too costly or insufficient. This work presents the design, fabrication, and validation of an LC pressure sensor embedded within a model AV graft to enable real-time monitoring. The proposed system integrates a parallel-plate capacitive pressure sensor with a spiral inductor to form an LC circuit embedded within an elastomeric graft wall. The Ecoflex 00-30 dielectric layer …

Mathematical Modelling And Optimisation Of The Reactor For The Esterification Process Of Safflower Oil With N-Butyl Alcohol, Sadritdin Makhamatdinovich Turabdjanov Academician, Hasan Sadriddin Ugli Fozilov, Ozoda Bakhronovna Axmedova, Sadriddin Fayzullayevich Fozilov

Technical science and innovation

This study addresses the mathematical modelling and optimisation of a reactor for the esterification of safflower oil with n-butyl alcohol. To improve process controllability and reduce the need for numerous pilot-scale trials, an ideal-mixing continuous stirred-tank reactor (CSTR) model was adopted. Incorporating reaction kinetics, the effect of contact time on the relative viscosity of the product mixture was analysed. The modelling results indicate that achieving an acceptable degree of feedstock conversion is difficult when a single ideal-mixing reactor is used. Therefore, a CSTR cascade was proposed, and the configuration with N = 2 reactors was selected as the most appropriate …

Development Of New Methods For Calculating Pressure And Energy Losses For Pumping Station Water Intakes, Faxriddin Jaylovovich Nosirov, Oleg Yakovlevich Glovatsky, Jurabek Abdyrahmon O'G'Li Urolov, Abduqodirkhon Samatkhonovich Abdullakhaev, Anvar Mamur Ugli Uzokov

Technical science and innovation

The aim of this study is to improve the efficiency of water resource management methods. Improvements to the water intake of the Karshi Main Canal are considered using calculations of pressure losses at the entry and exit of liquid into the flow, which differ from pressure losses in a stationary medium. The article considers some of the methods for using renewable energy sources, where the change in gravitational potential energy does not depend on the way of using energy and the operating scheme is a gravitational energy pump. The implementation of control and monitoring systems is necessary to ensure optimal …

Refinement Of Wind Speed Estimation At Turbine Hub Height Using Satellite Data And Regression Analysis Under Complex Terrain Conditions, Isroil Abriyevich Yuldoshev, Tulqin Rustamovich Jamolov, Sa'dullo Sayfiddin Ugli Fazliddinov, Jumanazar Farhodjon OʻGʻL Abdurashidov

Technical science and innovation

Reliable assessment of wind energy potential in regions characterized by complex terrain is often constrained by the limited availability of ground-based meteorological measurements. This study proposes an improved regression-based approach for refining wind speed estimates at the wind turbine hub height of 65 m using satellite-derived data from the NASA POWER database combined with a logarithmic vertical wind profile. The proposed methodology is validated using real operational data from a 750 kW wind power plant located in the mountainous Bostanlyk district of Uzbekistan for the period 2018–2021. The regression analysis demonstrates a strong linear relationship between the extrapolated wind speed …

Theoretical And Practical Foundations Of Healthcare System Digitalization, Sanjarbek Bekturdiev Sharifboyevich Phd, Muxlisa G‘Ulom Qizi G‘Ofurova

Technical science and innovation

The digital transformation of healthcare represents a key direction in improving the accessibility, quality, and efficiency of medical services. This study examines the main components of eHealth, including telemedicine, electronic health records, cloud technologies, and mobile applications, as well as the role of international organizations in promoting national digital health strategies. Particular attention is given to the current state of digital healthcare in the Republic of Uzbekistan, where significant progress has been made in developing infrastructure and implementing information systems, although challenges related to integration, standardization, and regulatory support remain. The work identifies the main trends in the development of …

Analysis Of The Effects Of Magnetic Field, Heat Transfer, And Thermal Radiation On Blood Flow Through Bifurcated Artery To Enhance Tumor Treatments, Abdullahi Isah, Dauda Gulibur Yakubu, Ali Musa

Tanzania Journal of Science

The work presents the effects of some pertinent parameters on blood flow through bifurcated artery to enhance tumor treatments. Combining appropriately the basic equations, together with the fractionalized Maxwell fluid model allow us to determine the velocity, temperature and concentration of blood flow through bifurcated artery. The study adopted the Atangana-Baleanu fractional time derivative on fluid model to describe the non-Newtonian behavior of blood flow. The numerical simulations were performed using the combined Laplace transform and the method of undetermined coefficients and the results obtained with the aid of Mathcad software were simulated and presented graphically. From the graphical results, …

Development Of Chitosan Encapsulated Ag/Zno Ternary Nanocomposites For Multifunctional Activity: Synthesis And Characterization, Latifa Ali Al Yabhouni Al Dhaheri

Thesis/ Dissertation Defenses

Nanocomposites of polymers combined with metal oxide nanoparticles have gained much attention due to their synergistic properties leading to enhanced functional ability. Herein, we report the synthesis of a nanocomposite composed of chitosan (CS) with Ag/ZnO nanoparticles produced via a wet chemistry route and fabrication of a pure CS and CS/Ag/ZnO thin films while varying the concentration of ZnO for each sample using a sol-gel transformation method. The CS/Ag/ZnO nanocomposite was characterized to study its crystal structure, morphology, thermal, and chemical properties. Morphological studies revealed uniform deposition of Ag NPs (with size range of 20-50 nm) and ZnO nanoparticles (with …

Ai Method For Classification Of Diagnosis Of Near-Infrared Breast Lesion Images, Kaiquan Chen, Fangyang Shen, Honggang Wang, Zhengchao Dong, Jizhong Xiao, Ming Ma, Afroza Aktar, Christopher Chow, Wenxiong Zhang

Publications and Research

In near-infrared optical breast lesion screening and diagnosis systems, high-speed four-dimensional scanners can dynamically acquire tens of thousands of lesion images within a five-minute period. Currently, manual computer annotation is required to generate standard samples from these scanned breast lesion images, a process that depends heavily on physicians with clinical expertise. On average, a single physician can annotate only approximately ten samples per working day. As a result, this process is time-consuming and labor-intensive, and the collected samples often suffer from low accuracy, large variability, and limited diagnostic reliability. Several AI-based annotation tools, such as QuPath, HALO AI™, and X-AnyLabeling, …