Biomedical Commons^™

Eyecom: An Innovative Approach For Computer Interaction, Anam Mazhar

Theses, Dissertations and Capstones

The world is innovating rapidly, and there is a need for continuous interaction with the technology. Sadly, there do not exist promising options for paralyzed people to interact with the machines i.e., laptops, smartphones, and tabs. A few commercial solutions such as Google Glasses are costly and cannot be afforded by every paralyzed person for such interaction. Towards this end, the thesis proposes a retina-controlled device called EYECOM. The proposed device is constructed from off-the-shelf cost-effective yet robust IoT devices (i.e., Arduino microcontrollers, Xbee wireless sensors, IR diodes, and accelerometer). The device can easily be mounted on to the glasses; …

Novel Computational Approaches For Multidimensional Brain Image Analysis, Harish Raviprakash

Electronic Theses and Dissertations, 2020-2023

The overall goal of this dissertation is focused on addressing challenging problems in 1D, 2D/3D and 4D neuroimaging by developing novel algorithms that combine signal processing and machine learning techniques. One of these challenging tasks is the accurate localization of the eloquent language cortex in brain resection pre-surgery patients. This is especially important since inaccurate localization can lead to diminshed functionalities and thus, a poor quality of life for the patient. The first part of this dissertation addresses this problem in the case of drug-resistant epileptic patients. We propose a novel machine learning based algorithm to establish an alternate electrical …

Effects Of Plasma-Activated Water On Skin Wound Healing In Mice, Dehui Xu, Shuai Wang, Bing Li, Miao Qi, Rui Feng, Qiaosong Li, Hao Zhang, Hailan Chen, Michael G. Kong

Bioelectrics Publications

Cold atmospheric plasma (CAP) has been widely used in biomedicine during the last two decades. While direct plasma treatment has been reported to promote wound healing, its application can be uneven and inconvenient. In this study, we first activated water with a portable dielectric barrier discharge plasma device and evaluated the inactivation effect of plasma-activated water (PAW) on several kinds of bacteria that commonly infect wounds. The results show that PAW can effectively inactivate these bacteria. Then, we activated tap water and examined the efficacy of PAW on wound healing in a mouse model of full-thickness skin wounds. We found …

Quadrupoles For Remote Electrostimulation Incorporating Bipolar Cancellation, Shu Xiao, Ryo Yamada, Carol Zhou

Bioelectrics Publications

Introduction: A method that utilizes nanosecond bipolar cancellation (BPC) near a quadrupole electrodes to suppress a biological response but cancels the distal BPC at the quadrupole center, i.e., cancellation of cancellation (CANCAN), may allow for a remote focused stimulation at the quadrupole center.

Objectives: The primary object of this study was to outline the requirement of the CANCAN implementation and select an effective quadrupole configuration.

Results: We have studied three quadrupole electrode configurations, a rod quadrupole, a plate quadrupole (Plate-Q), and a resistor quadrupole. The pulse shapes of electric fields include monophasic pulses, cancellation pulses, and additive pulses. The Plate-Q …

Development Of An Anatomically And Electrically Conductive Brain Phantom For Transcranial Magnetic Stimulation, Hamzah A. Magsood

Theses and Dissertations

Transcranial Magnetic Stimulation (TMS) is a non-invasive technique for diagnostics, prognostic, and treatments of various neurological diseases. However, the lack of anatomically realistic brain phantoms has made the experimental verification of stimulation strength in the form of induced electric fields/voltages in the brain tissues an impediment to developing new TMS coils, stimulators, and treatment protocols. There are significant technological, safety, and ethical limitations to test the potential TMS treatment procedures or develop enhancements and refine them on humans or animals. This work aims to bridge the gap by introducing and developing an innovative manufacturing and fabrications process to produce a …

Design, Construction, And Characterization Of A Combined Mini-Co₂/Voc Sensor And Gas Chromatograph For Field Research, Rishi Basdeo, Michael Hampton

Digital Repository: Showcase of Undergraduate Research Excellence

No abstract provided.

To Or Through The Skin: A Rational Design Of Transdermal Drug Delivery, Isaac Giovanni Deaguero

Open Access Theses & Dissertations

The skin is the largest organ in the body and plays many crucial roles through diverse functions ranging from protection, temperature regulation, energy storage via fat deposits, and is used to communicate with our surroundings. Various methods have been attempted to deliver drugs to target areas of the skin in effective dosages by a variety of means with limited success. Recently, advances in transdermal drug delivery have offered avenues previously unattainable through conventional means. Some of these new delivery methods have been reviewed, explored and offer promising results with the potential to carve a new avenue in the way therapeutic …

Design And Characterization Of Thermal Inkjet Bioprinted Constructs For The Treatment Of Diabetic Foot Ulcers And Other Wound Healing Impaired Conditions, Luis Horacio Solis

Open Access Theses & Dissertations

Tissue engineering (TE) is a multidisciplinary practice focused on developing patient-specific constructs to repair, regenerate, or replace injured tissues and organs. One biofabrication process that has gained tremendous momentum in this field is bioprinting. Most, if not all bioprinting modalities embody the same principles of heat and shear due to mechanical forces or friction as cells are forced through narrow orifices. While it is important to examine the interaction between host and implanted constructs, it is also crucial to understand the direct effects that these bioprinting technologies have on cells before embedding them into TE applications.

The purpose of this …

Mitochondrial Utilization Of Competing Fuels Is Altered In Insulin Resistant Skeletal Muscle Of Non-Obese Rats (Goto-Kakizaki), Nicola Lai, Ciarán E. Fealy, Chinna M. Kummitha, Silvia Cabras, John P. Kirwan, Charles L. Hoppel

Electrical & Computer Engineering Faculty Publications

Aim: Insulin-resistant skeletal muscle is characterized by metabolic inflexibility with associated alterations in substrate selection, mediated by peroxisome-proliferator activated receptor 𝜹 (PPAR𝜹). Although it is established that PPAR𝜹 contributes to the alteration of energy metabolism, it is not clear whether it plays a role in mitochondrial fuel competition. While nutrient overload may impair metabolic flexibility by fuel congestion within mitochondria, in absence of obesity defects at a mitochondrial level have not yet been excluded. We sought to determine whether reduced PPAR𝜹 content in insulin-resistant rat skeletal muscle of a non-obese rat model of T2DM (Goto-Kakizaki, GK) ameliorate the inhibitory effect …

Characterization Of Left Ventricular Volumes And Ejection Fraction In Patients With A Left Ventricular Assist Device, Viswajith Siruvallur Vasudevan

Electronic Theses and Dissertations, 2020-2023

In the treatment of heart patients, as a bridge to recovery, the challenge currently in using a continuous-flow left ventricular assist device (LVAD), is to provide a method to monitor the recovery of the heart. This dissertation addresses the hypothesis that continuous monitoring of the ejection fraction of a patient implanted with an LVAD should be to examine the progress of the patient without the need for excessive in vivo measurements. Also, the ejection fraction can be used to provide a control mechanism for the pump depending on the requirements of each patient. In this dissertation, the left ventricle, in …

The Study Of Non-Permanent Tattoo Ink Using Nano Silver Compounds And Untact 3d Printing Technology, Jisu Lee

Open Access Theses & Dissertations

Due to a recent epidemic of COVID 19, the possibility of 3D tattoo printing technology using the Internet of Things (IoT) control system developed in a non-face-to-face contact process was identified. A non-surgical tattoo process and hygiene safety differentiated with silver tattoo ink was used to solve the health problems arising from the surgical tattoo process and to identify 3D tattoo printing techniques through a non-personal contact concept. During the tattoo processing, the image selected by the customer is sent to a designated printer via an IoT control system in a separate location. A piston-type extruder (PTE) printing technique was …

Developing Machine Learning Algorithms For Behavior Recognition From Deep Brain Signals, Hosein Golshan Mojdehi

Electronic Theses and Dissertations

Parkinson’s disease (PD) is a neurodegenerative condition and movement disorder that appears with symptoms such as tremor, rigidity of muscles and slowness of movements. Deep brain stimulation (DBS) is an FDA-approved surgical therapy for essential tremor and PD. Despite the fact that DBS substantially alleviates the motor signs of PD, it can cause cognitive side effects and speech malfunction mainly due to the lack of adaptivity and optimality of the stimulation signal to the patients’ current state. A behavior-adapted closed-loop DBS system may reduce the side effects and power consumption by adjusting the stimulation parameters to patients’ need.

Behavior recognition …

Accurate Replication Of An Ear Pinnae Geometry For Use In Acoustic Testing Of Spatial Cues And Sound Localization, Alejandra Belmont

Open Access Theses & Dissertations

Additive manufacturing (AM) enables freedom of design as well as fabrication of complex objects such as the human hear. In medical modeling there is a need for patient-specific customizable parts. The outer human ear consists of these main parts: the pinna, which naturally filters sound, and the ear canal, which is the point at which sound enters before being moved up to the tympanic membrane, otherwise known as the eardrum. In an attempt to accurately replicate ear models, the use of scanning and reverse engineering methods was used. A comparison of 3D laser scanning systems was performed to determine their …

Impact Of Cryptococcus Neoformans Polysaccharide Capsule On Astrocytes, Yeon Hwa Woo

Open Access Theses & Dissertations

Cryptococcus neoformans is a neurotropic, opportunistic, encapsulated, yeast-like fungus that causes life-threatening meningoencephalitis in both healthy and immunocompromised individuals. C. neoformans infects 1,000,000 people and causes 210,000 deaths worldwide annually, mostly in sub-Saharan Africa. The polysaccharide capsule of C. neoformans is the fungus major virulent factor. Glucuronoxylomannan (GXM), the main component of the capsule is abundantly released into brain tissue during C. neoformans infection, causing immunosuppressive defects in the host. C. neoformans is inhaled from the environment, disseminate via bloodstream, and crosses the blood brain barrier (BBB) to cause cryptococcal meningoencephalitis (CM). Although CM causes significant mortality in HIV/AIDS patients, …

Early Detection Of Asthma Via Enhanced Resolution Of Small Airways Using Ultra-Low Frequency Impulse Oscillometry, Christopher M. Aguilar

Open Access Theses & Dissertations

Examination of lung function for diagnosis and monitoring of diseases such as chronic obstructive pulmonary disease (COPD) and asthma can be performed with a variety of pulmonary function testing (PFT) techniques. The most commonly prescribed of these procedures are spirometry and whole-body plethysmography. However, these active participation tests depend on forced breathing maneuvers, may be physically exhausting, might not produce enough information, and are susceptible to being subject-dependent. In contrast, passive PFT approaches such as the forced oscillation technique (FOT) and the impulse oscillometry system (IOS) are increasingly being utilized for measuring lung mechanics because they require only minimal participation, …

Supercritical Processed Decellularized Extracellualr Matrix As Regeneration Therapeutics Applying 3d Printing, Seungwon Chung

Open Access Theses & Dissertations

Extracellular matrix has been broadly applied and show great promise in medical applications and tissue engineering. Product of extracellular matrix (ECM) should be treated with decellularization and purification process. Supercritical carbon dioxide treatment is of particular interest for purifying ECM because of its medically available and rapid speed of process. However, it is not fully researched in treatment of biomaterials for tissue engineering. Therefore, we investigated optimal conditions of supercritical carbon dioxide processing in different extracting parameters from porcine adipose tissue. The 3-day, dual treatment including enzymatic decellularization and supercritical fluid extraction of pork adipose tissue were performed. Two types …

3d Printed Alginate-Based Zinc Oxide Nanoparticle Scaffolds For Wound Healing, Carol Cleetus

Open Access Theses & Dissertations

Effective treatment of chronic wounds is essential for the prevention of infection and scar tissue formation, requiring a novel approach to address the limitations of existing options. This study utilizes Calcium Chloride (CaCl2) crosslinked alginate, a common biomaterial widely used in wound dressing, and UV activated Zinc Oxide (ZnO) nanoparticles (NPs) for their potential hydroxyl radical mediated antibacterial applications. ZnO NPs were synthesized by combustion method from Zinc Nitrate Hexahydrate and Sucrose. Scanning Electron Microscopy (SEM) and X-Ray Diffraction (XRD) characterization were used to verify composition and NP size. Terephthalic Acid, used as a fluorescent probe, confirmed the generation of …

The Study Of The Mouse Schlafen Family Members As Mediators Of Antiviral Activity, Julia Fernanda Hernandez

Open Access Theses & Dissertations

The Schlafen family of proteins was first characterized in 1988, and since then evidence of their relevance in different physiological and pathological situations have been accumulating although at a slow pace. Hence, the biological roles of these proteins remain ill-defined. The expression of these proteins is positively regulated by type 1 interferons, constituting a component of the innate immune response. Functions of these proteins vary from regulation of cell proliferation to restriction of viral infections. Recent studies have implicated SLFN11 and SLFN13 as inhibitors of HIV-1 infection2-4. The mechanism of action of SLFN11 resides in its capacity to regulate the …

Fabrication, Development, And Characterization Of Hipco Swcnt - Alginate Hydrogel Composites For Cellular Product Applications, Fabian Armando Alvarez-Primo

Open Access Theses & Dissertations

In this study, we designed, synthesized, and characterized ultrahigh purity single-walled carbon nanotube (SWCNT)-alginate hydrogel composites. Among the parameters of importance in the formation of an alginate-based hydrogel composite with single-walled carbon nanotubes, are their varying degrees of purity, their particulate agglomeration and their dose-dependent correlation to cell viability, all of which have an impact on the resultant compositeâ??s efficiency and effectiveness towards biomedical applications. To promote their homogenous dispersion by preventing agglomeration of the SWCNT, at first, we used three different surfactants-sodium dodecyl sulfate (SDS-anionic), cetyltrimethylammonium bromide (CTAB-cationic), and Pluronic F108 (nonionic). After experimentation and corroboration through evidence obtained …

Formulation Strategies To Enhance Solubility And Permeability Of Small Molecules For Drug Delivery Applications, Pradeep Kumar Bolla

Open Access Theses & Dissertations

All the new chemical entities/drug molecules intended for therapeutic use must be administered using an appropriate delivery system/dosage form to achieve maximum bioavailability. However, designing a drug delivery system is complex as several factors such as lipophilicity, molecular mass, crystallinity, ionic charge, polymorphic forms and hydrogen bonding) affect the solubility and permeability of these molecules. Biopharmaceutics drug classification system (BCS) categorizes the existing drugs into four classes based on the aqueous solubility and membrane permeability and it is reported that >70% of the drugs are poorly soluble and belong to BCS class II and BCS class IV. Several physical, chemical …