Degradable Borate Glass Polyalkenoate Cements,
2014
Missouri University of Science and technology
Degradable Borate Glass Polyalkenoate Cements, L. Shen, A. Coughlan, Mark R. Towler, M. Hall
Chemical and Biochemical Engineering Faculty Research & Creative Works
Glass polyalkenoate cements (GPCs) containing aluminum-free borate glasses having the general composition Ag2O-Na2O-CaO-SrO-ZnO- TiO2-B2O3 were evaluated in this work. An initial screening study of sixteen compositions was used to identify regions of glass formation and cement compositions with promising rheological properties. The results of the screening study were used to develop four model borate glass compositions for further study. A second round of rheological experiments was used to identify a preferred GPC formulation for each model glass composition. The model borate glasses containing higher levels of TiO2 (7.5 mol %) …
Stereoselective Transformations Of Α-Trifluoromethylated Ketoximes To Optically Active Amines By Enzyme-Nanometal Cocatalysis: Synthesis Of (S)-Inhibitor Of Phenylethanolamine N-Methyltransferase,
2014
Missouri University of Science and Technology
Stereoselective Transformations Of Α-Trifluoromethylated Ketoximes To Optically Active Amines By Enzyme-Nanometal Cocatalysis: Synthesis Of (S)-Inhibitor Of Phenylethanolamine N-Methyltransferase, Guilin Cheng, Qi Wu, Zeyu Shang, Xinhua Liang, Xianfu Lin
Chemical and Biochemical Engineering Faculty Research & Creative Works
One-pot cascade synthesis of optically active α-trifluoro methylated amines directly from ketoximes was accomplished with the use of Candida antarctica lipase B and catalysts prepared by atomic layer deposition (ALD). Compared to the commercial palladium catalyst, the ALD-prepared catalysts showed much higher activity and afforded various α-trifluoro methylated amides in good yields and with high enantioselectivity. One of the enantiopure amides was further hydrolyzed into the corresponding amine, which was treated as a crucial starting material for total synthesis of (S)-inhibitor of phenyl ethanolamine N-methyltransferase without loss of chiral information. © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Synthesis Of Nano-Sized Materials Using Atomic Layer Deposition,
2014
University of Alabama in Huntsville
Synthesis Of Nano-Sized Materials Using Atomic Layer Deposition, Sara Grace Simpson
Summer Community of Scholars Posters (RCEU and HCR Combined Programs)
No abstract provided.
Developing Genetic Tools For Geobacillus,
2014
University of New Hampshire - Main Campus
Developing Genetic Tools For Geobacillus, Brittany Artale
Honors Theses and Capstones
Bacillus and Geobacillus are the primary bacterium used in biotechnology industries due to their ability to excrete extracellular materials such as proteins, enzymes and other byproducts. Bacillus subtilis, has a well-characterized competence machinery, giving way to characterized genetic tools. However, a significant problem associated with working with Bacillus is the regulation of endospore formation. An alternative to Bacillus is Geobacillus, a thermophilic bacterium. Thermophiles offer significant advantages over other bacteria as host organisms in biofuel, bioremediation, and biocatalyst processes. However, the genetic tools and competency associated with Geobacillus is still unknown. Through, genetic engineering the ability …
Information In Biological Systems And The Fluctuation Theorem,
2014
University of Nebraska-Lincoln
Information In Biological Systems And The Fluctuation Theorem, Yaşar Demirel
Department of Chemical and Biomolecular Engineering: Faculty Publications
Some critical trends in information theory, its role in living systems and utilization in fluctuation theory are discussed. The mutual information of thermodynamic coupling is incorporated into the generalized fluctuation theorem by using information theory and nonequilibrium thermodynamics. Thermodynamically coupled dissipative structures in living systems are capable of degrading more energy, and processing complex information through developmental and environmental constraints. The generalized fluctuation theorem can quantify the hysteresis observed in the amount of the irreversible work in nonequilibrium regimes in the presence of information and thermodynamic coupling.
One-Step Production Of Long-Chain Hydrocarbons From Waste-Biomass-Derived Chemicals Using Bi-Functional Heterogeneous Catalysts,
2014
University of South Carolina - Columbia
One-Step Production Of Long-Chain Hydrocarbons From Waste-Biomass-Derived Chemicals Using Bi-Functional Heterogeneous Catalysts, Cun Wen, Elizabeth A. Barrow, Jason R. Hattrick-Simpers, Jochen A. Lauterbach
Faculty Publications
n this study, we demonstrate the production of long-chain hydrocarbons (C8+) from 2-methylfuran (2MF) and butanal in a single step reactive process by utilizing a bi-functional catalyst with both acid and metallic sites. Our approach utilizes a solid acid for the hydroalkylation function and as a support as well as a transition metal as hydrodeoxygenation catalyst. A series of solid acids was screened, among which MCM-41 demonstrated the best combination of activity and stability. Platinum nanoparticles were then incorporated into the MCM-41. The Pt/MCM-41 catalyst showed 96% yield for C8+ hydrocarbons and the catalytic performance was stable …
Quartz Crystal Microbalance Investigation Of Cellulosome Activity From Clostridium Thermocellum On Model Cellulose Films,
2014
University of Kentucky
Quartz Crystal Microbalance Investigation Of Cellulosome Activity From Clostridium Thermocellum On Model Cellulose Films, Shanshan Zhou
Theses and Dissertations--Chemical and Materials Engineering
The cost of deconstructing cellulose into soluble sugars is a key impediment to the commercial production of lignocellulosic biofuels. The use of the quartz crystal microbalance (QCM) to investigate reaction variables critical to enzymatic cellulose hydrolysis is investigated here, extending previous studies of fungal cellulase activity for the first time to whole cell cellulases. Specifically, the activity of the cellulases of Clostridium thermocellum, which are in the form of cellulosomes, was investigated. To clearly differentiate the activity of free cellulosome and cell-bound cellulosome, the distribution of free cellulosome and cell-bound cellulosome in crude cell broth at different growth stages …
Characteristics Of Glass Ionomer Cements Composed Of Glass Powders In Cao-Sro-Zno-Sio2 System Prepared By Two Different Synthetic Routes,
2013
Missouri University of Science and Technology
Characteristics Of Glass Ionomer Cements Composed Of Glass Powders In Cao-Sro-Zno-Sio2 System Prepared By Two Different Synthetic Routes, Ill Yong Kim, Chikara Ohtsuki, Aisling Coughlan, Lana Placek, Anthony W. Wren, Mark R. Towler
Chemical and Biochemical Engineering Faculty Research & Creative Works
Glass ionomer cements (GICs) are composed of an acid degradable glass, polyacrylic acid and water. Sol-gel processing to prepare the glass phase has certain advantages, such as the ability to employ lower synthesis temperatures than melt quenching and glasses that are reported to have higher purity. A previous study reported the effects of glass synthesis route on GIC fabrication. However, in that study, the sol-gel derived glass exhibited a reduced concentration of cations. This study investigates increasing the cation content of a sol-gel derived glass, 12CaO·4SrO·36ZnO·48SiO2 (molar ratio) by heating before aging to reduce dissolution of cations. This glass …
An Experimental And Computational Evaluation Of The Importance Of Molecular Diffusion In Gas Gravity Currents,
2013
University of Arkansas, Fayetteville
An Experimental And Computational Evaluation Of The Importance Of Molecular Diffusion In Gas Gravity Currents, Jeremy Jac Herman
Graduate Theses and Dissertations
The accidental release of hazardous, denser-than-air gases during their transport or manufacture is a vital area of study for process safety researchers. This project examines the importance of molecular diffusion on the developing concentration field of a gas gravity current released into a calm environment. Questions which arose from the unexpectedly severe explosion in 2005 at Buncefield, England were of particular interest. The accidental overfilling of a large tank with gasoline on a completely calm morning led to a massive open air explosion. Forensic evidence showed that at the time of ignition, a vapor cloud, most of which now appears …
Reassessment Of Biowish Activation Procedure For Denitrification,
2013
California Polytechnic State University, San Luis Obispo
Reassessment Of Biowish Activation Procedure For Denitrification, William Wah Yee
Master's Theses
BiOWiSHTM – Aqua is a blend of preserved multi-bacteria culture with the capability of denitrification. If an anaerobic nitrate rich activation procedure is used instead of the standard aerobic activation procedure, the denitrification rate is increased by 28 percent under the conditions of 30°C, 1C:1N, 200mg/L of carbon, and 200mg/L nitrogen.
Relating Ph And Ion Release From Ga2o3-Na 2o-Cao-Zno-Sio2 Bioactive Glasses,
2013
Missouri University of Science and Technology
Relating Ph And Ion Release From Ga2o3-Na 2o-Cao-Zno-Sio2 Bioactive Glasses, T. J. Keenan, A. W. Wren, A. Coughlan, Mark R. Towler, M. M. Hall
Chemical and Biochemical Engineering Faculty Research & Creative Works
Three glasses were designed for this study, including one Ga-free glass (Control), and two Ga-containing glasses (TGa-1, TGa-2). In the Ga-containing glasses, Ga2O3 is included at the expense of ZnO. This study focuses on the relation between pH and ion concentration present in solution in which these bioactive glasses have been submerged for periods of 1, 7, and 14 days. © 2013 IEEE.
Gallium Containing Glass Polyalkenoate Bone Cements: Ion Release And E. Coli Inhibition,
2013
Missouri University of Science and Technology
Gallium Containing Glass Polyalkenoate Bone Cements: Ion Release And E. Coli Inhibition, L. Placek, A. W. Wren, A. Coughlan, Mark R. Towler
Chemical and Biochemical Engineering Faculty Research & Creative Works
The Glass Polyalkenoate Cement (GPC) series (LCon., LGa-1 and LGa-2) containing gallium (Ga) and a 50 wt% addition of E11 polyacrylic acid (PAA), previously developed, was evaluated for ion release, specifically Si, Ca, Zn and Ga, and E. coli inhibition. The maximum inhibition was observed in the t = 0 samples and was 0.35 mm for LCon. and 0.65 mm for LGa-1 and LGa-2. © 2013 IEEE.
Biocompatibility Of Cao-Na2o-Sio2/Tio2 Glass Ceramic Scaffolds For Orthopaedic Applications,
2013
Missouri University of Science and Technology
Biocompatibility Of Cao-Na2o-Sio2/Tio2 Glass Ceramic Scaffolds For Orthopaedic Applications, A. W. Wren, A. Coughlan, K. E. Smale, S. T. Misture, B. P. Mahon, O. M. Clarkin, Mark R. Towler
Chemical and Biochemical Engineering Faculty Research & Creative Works
This work aims to determine the effect of substituting TiO2 for SiO2 in a 0.62SiO2-Na2O-0.24CaO based glass-ceramic scaffold. High temperature X-ray Diffraction (HT-XRD) was used to determine the sintering temperature (700oC). Both optical microscopy and x-ray micotomography was used to determine the average pore size (540-680ìm) of each scaffold. Cytocompatibility of each scaffold was conducted using murine mesenchymal stem cells. © 2013 IEEE.
An Investigation Into The Structure And Properties Of Cao-Zno-Sio 2-Tio2-Na2o Bioactive Glass/Hydroxyapatite Composite,
2013
Missouri University of Science and Technology
An Investigation Into The Structure And Properties Of Cao-Zno-Sio 2-Tio2-Na2o Bioactive Glass/Hydroxyapatite Composite, Chokchai Yatongchai, Mark R. Towler, Anthony W. Wren
Chemical and Biochemical Engineering Faculty Research & Creative Works
Effect of the addition of CaO-ZnO-SiO2-TiO2-Na2O glass as a reinforcing phase on properties of hydroxyapatite/glass composites was investigated. The addition of the glass caused the decomposition of HA phase to tricalcium phosphate, inhibiting densification in the HA/glass composites. However, depending on the glass concentration, some of the glass can act as a sintering aid enhancing the densification in the composites. © 2013 IEEE.
Dna Based Carbon Nanotube Porphyrin Nanohybrids Molecular Recognization And Regeneration,
2013
Purdue University
Dna Based Carbon Nanotube Porphyrin Nanohybrids Molecular Recognization And Regeneration, Molly M. Riccitelli, Hanyu Zhang, Jong Hyun Choi
The Summer Undergraduate Research Fellowship (SURF) Symposium
In the search to improve solar cells, scientists are exploring new materials that will provide better current transfer. One material that has emerged as a strong contender is the single walled carbon nanotube (SWNT). Current DNA-SWNT based films combined with chromophores have poor operational lifetimes compared to commercial solar cells. Once exposed to light the chromophore begins to degrade, eventually rendering the solar cell unusable. To solve this problem, we used a method involving multiple steps. First we found which DNA sequences formed structures around the SWNT that could hold the most chromophores by using a spectrophotometer to test the …
Multi-Factorial Stability Study Of Metabolites,
2013
Purdue University
Multi-Factorial Stability Study Of Metabolites, Ruijun Zheng, John A. Morgan
The Summer Undergraduate Research Fellowship (SURF) Symposium
Previous research done on metabolites has found that high energy compounds like adenosine triphosphate(ATP), nicotinamide adenine dinucleotide phosphate reduced (NADPH) or nicotinamide adenine dinucleotide reduced (NADH) are unstable in cell extracts at relatively high temperature and acidic condition. The multifactorial stability study of metabolites enables us to verify the best condition of storage for these energy compounds and sugar phosphates, as well as to strengthen the understanding of metabolism in biological study. As the most solvents for high performance liquid chromatography (HPLC) are acidic and unfavorable for these energy compounds, it is necessary to perform a detailed study about …
Tobacco Mosaic Virus Implemented As An Interfacial Layer In Organic Photovoltaic Cells,
2013
Purdue University
Tobacco Mosaic Virus Implemented As An Interfacial Layer In Organic Photovoltaic Cells, Monica D. Del Real, Bryan Boudouris
The Summer Undergraduate Research Fellowship (SURF) Symposium
Organic photovoltaics (OPVs) are flexible, light weight, and economical to produce due to low processing temperatures, solution processing, and print fabrication. This makes them optimal for a wide range of applications. However, the efficiencies of OPVs are currently not high enough for them to be viable in the market or to be able to compete with inorganic photovoltaics. Therefore the integration of new materials and methods into OPVs in order to increase their efficiency is a vital field. One way to increase the efficiency of OPVs is to increase the surface area in-between layers to allow for enhanced electron transport. …
Biomarkers For Vincristine-Induced Neuropathy,
2013
Purdue University
Biomarkers For Vincristine-Induced Neuropathy, Danni Li, Jayachandran Devaraj, Doraiswami Ramkrishna
The Summer Undergraduate Research Fellowship (SURF) Symposium
Vincristine is a vinca alkaloid, a commonly used chemotherapy drug for treating leukemia, lymphoma, multiple myeloma and some pediatric cancers. Its major dose-limiting side effect is peripheral neuropathy. The current dosing of “standard-dose-for-all” ignores the genetic and phenotypic variations among different patients, and causes severe neuropathy in some patients while ineffectively treats the others. In the present study, we aim to discover novel biomarkers involved in vincristine-induced neuropathy and identify patients with varied metabolic characteristics. Thus treatment can be tailored accordingly to improve outcomes of vincristine treatment. Pre-dose and post-dose serum samples were collected from two groups of patients (low …
Adhesive Elastomeric Proteins,
2013
Purdue University
Adhesive Elastomeric Proteins, Haefa Mansour, Julie Liu
The Summer Undergraduate Research Fellowship (SURF) Symposium
Sutures and staples commonly used to close surgical wounds tend to be much stiffer than the surrounding tissue, often resulting in external tissue damage. Surgical adhesives provide a promising alternative to these sutures and staples. Ideal surgical adhesives are biocompatible, able to set well and remain sticky in moist conditions, possess strong adhesive and cohesive properties, and exhibit mechanical properties that mimic those of the surrounding tissue. Unfortunately, the adhesives available today are unable to satisfactorily meet all of these criteria. We are utilizing protein engineering techniques to design, create, and test a new surgical adhesive that combines the adhesive …
Bacteriorhodopsin-Based Sensors,
2013
Michigan Technological University
Bacteriorhodopsin-Based Sensors, Craig Friedrich, Donald Lueking, Mark Griep
Michigan Tech Patents
A sensor comprising a membrane containing bacteriorhodopsin. In one embodiment, the sensor comprises a layer of purple membrane between a first and a second electrode, wherein the electrodes are connected to a circuit such that a signal is produced when a charge is transferred across the membrane. In another embodiment, the sensor comprises a field effect transistor with a layer of purple membrane deposited on the gate. The layer of purple membrane may be further functionalized by adding fluorophores to the layer of purple membrane. The fluorophores may be deposited adjacent to the layer of purple membrane, or the fluorophores …
