Biomedical Engineering and Bioengineering Commons^™

Improving Optical Contact For Functional Near-Infrared Brain Spectroscopy And Imaging With Brush Optodes, Bilal Khan, Chester Wildey, Robert Francis, Fenghua Tian, Mauricio R. Delgado, Hanli Liu, Duncan Macfarlane, George Alexandrakis

Bioengineering Faculty Publications - Archive

A novel brush optode was designed and demonstrated to overcome poor optical contact with the scalp that can occur during functional near infrared spectroscopy (fNIRS) and imaging due to light obstruction by hair. The brush optodes were implemented as an attachment to existing commercial flat-faced (conventional) fiber bundle optodes. The goal was that the brush optodes would thread through hair and improve optical contact on subjects with dense hair. Simulations and experiments were performed to assess the magnitude of these improvements. FNIRS measurements on 17 subjects with varying hair colors (blonde, brown, and black) and hair densities (0–2.96 hairs/mm2 ) …

Sparsity Enhanced Spatial Resolution And Depth Localization In Diffuse Optical Tomography, Venkaiah C. Kavuri, Zi-Jing Lin, Fenghua Tian, Hanli Liu

Bioengineering Faculty Publications - Archive

No abstract provided.

Bioengineering Approach To Understanding Tmj Pathobiology, Jonathan Kuo

All Dissertations

The temporomandibular joint (TMJ) is a load-bearing joint consisting of the condyle of the mandibular bone, the fossa eminence of the temporal bone, and a fibrocartilaginous disc held in between the bone surfaces by ligaments. The TMJ disc serves to distribute stress, lubricate movement, and protect the articular surfaces of the joint. Over ten million Americans suffer from TMJ disorders (TMD) that affect the movement and function of the joint, making everyday tasks like talking and eating difficult and painful. A wide variety of treatments and surgeries have been proposed and undertaken with limited success based on the varying degree …

The Effects Of Coated Gold Nanorods On Porcine Atrioventricular Valve Tissues Using Atomic Force Microscopy, Heather L'Ecuyer

All Theses

In this Master's thesis we examine the effect of surface modified gold nanorods (AuNRs) coated with polyelectrolyte multilayers (PEMs) on the mechanical properties of porcine mitral valve tissue ex vivo. The presence of healthy mitral valve tissue in the body is important to ensuring unidirectional flow of blood through the systemic circuit. Unfortunately, due to its anatomic complexity and unique mechanical behavior, pathological mitral valve tissue remains difficult to treat with conventional methods. We hope that the knowledge gleaned from these studies could be useful for developing new and novel treatments treating pathological mitral valve mechanical properties.
Specifically, we examine …

Silver Coated Bioactive Glass Particles For Wound Healing Applications, A. W. Wren, A. Coughlan, P. Hassanzadeh, Mark R. Towler

Chemical and Biochemical Engineering Faculty Research & Creative Works

Bioactive glass particles (0.42SiO₂-0.15CaO-0.23Na ₂O-0.20ZnO) of varying size (<90 >μm and 425-850 μm) were synthesized and coated with silver (Ag) to produce Ag coated particles (PAg). These were compared against the uncoated analogous particles (Pcon.). Surface area analysis determined that Ag coating of the glass particles resulted in increased the surface area from 2.90 to 9.12 m²/g (90 μm) and 1.09-7.71 m²/g (425-850 μm). Scanning electron microscopy determined that the Ag coating remained at the surface and there was little diffusion through the bulk. Antibacterial (Escherichia coli - 13 mm and Staphylococcus epidermidis …

Engineering Design Of A Prototype Ammonia Absorption Tower, Andrew Warren Calogero

Honors Capstones

No abstract provided.

Aptamer-Based Spr Biosensor For Detection Of Avian Influenza Virus, Hua Bai

Graduate Theses and Dissertations

Rapid and specific detection of avian influenza (AI) virus is urgently needed with the concerns over the outbreaks of highly pathogenic H5N1 avian influenza in animal and human infection. Aptamers are artificial oligonucleic acid that can specifically bind to target molecules. They show comparable affinity for target virus and better thermal stability than monoclonal antibodies. Those advantages make aptamers promising candidates in diagnostic and detection applications. The goal of this research was to use DNA&ndashaptamer as the specific recognition element in a portable surface plasmon resonance (SPR) biosensor for detection of AI H5N1 virus in poultry.

A SPR biosensor was …

Improving Health Care Quality And Safety: The Development And Assessment Of Laparoscopic Surgery Instrumentation, Practices And Procedures, Bernadette Mccrory

Department of Mechanical and Materials Engineering: Dissertations, Theses, and Student Research

Adverse events due to medical errors are a leading cause of death in the United States exceeding the mortality rates of motor vehicle accidents, breast cancer and AIDS. Improvements can and should be made to reduce the rates of preventable surgical errors since they account for nearly half of all adverse events within hospitals. Although minimally invasive surgery has proven patient benefits such as reduced postoperative pain and hospital stay, its operative environment imposes substantial physical and cognitive strain on the surgeon increasing the risk of error. In order to mitigate errors and protect patients, a multidisciplinary approach was taken …

Design And Implementation Of A Shoulder Simulator, Chelsea Lynn Kowal

Renée Crown University Honors Thesis Projects - All

The main objective of this thesis project is to build a shoulder simulator to be able to understand the mechanics of the shoulder, specifically the rotator cuff and deltoid muscles. The shoulder simulator should be able to mimic the important motions of the human shoulder by pulling on tendons of cadaver shoulders and moving the shoulder in various specified motions. In my thesis project, I worked on creating a shoulder simulator that would control the rotator cuff muscles along with the three deltoid muscles. In order to do this, I needed to design and test the shoulder simulator using cadaver …

Escherichia Coli Hm22 Biofilm Viability When In Contact With Implant-Grade, Titanium-6aluminum-4-Vanadium Alloy Under Varied Electrochemical Conditions, Alexander Ross Weiss

Renée Crown University Honors Thesis Projects - All

No abstract provided.

Simulation Of Lower Limb Axial Arterial Length Change During Locomotion, Melissa D. Young, Matthew C. Streicher, Richard J. Beck, Antonie J. Van Den Bogert, Azita Tajaddini, Brian L. Davis

Mechanical Engineering Faculty Publications

The effect of external forces on axial arterial wall mechanics has conventionally been regarded as secondary to hemodynamic influences. However, arteries are similar to muscles in terms of the manner in which they traverse joints, and their three-dimensional geometrical requirements for joint motion. This study considers axial arterial shortening and elongation due to motion of the lower extremity during gait, ascending stairs, and sitting-to-standing motion. Arterial length change was simulated by means of a graphics based anatomic and kinematic model of the lower extremity. This model estimated the axial shortening to be as much as 23% for the femoropopliteal arterial …

Electrospun Polycaprolactone Nanofiber Scaffolds For Tissue Engineering, Andreas Haukas

Graduate Theses and Dissertations

Stem cell and tissue engineering offer us with a unique opportunity to research and develop new therapies for treating various diseases that are otherwise incurable using traditional medicines. However, development of these new therapies replies upon the establishment of in vitro cell culture and differentiation systems that mimic in vivo microenvironments required for cell-cell and cell-ECM interaction. The development of these cell culture systems depends upon the identification of appropriate biomaterials and cell sources. Biomaterials should be carefully selected and fabricated into scaffolds for supporting cell growth and differentiation. In this study, we explored the fabrication of 3D electrospun nanofiber …

Development Of A Microfluidic Device Coupled To Microdialysis Sampling For The Pre-Concentration Of Cytokines, Randy Francisco Espinal Cabrera

Graduate Theses and Dissertations

A proof-of-concept microfluidic device combined with heparin-immobilized magnetic beads was created to concentrate cytokine proteins collected from microdialysis samples. Cytokines are known to be related to several diseases such as cancer, and Parkinson's diseases, so to be able to develop more effective diseases treatments their interactions have to be well understood. Amine-functionalized polystyrene and carboxyl-functionalized magnetic microspheres of ~6.0 ìm in diameter were used to immobilize heparin. The amount of heparin immobilized on polystyrene beads was 5.82 x 10-8 ± 0.36 x 10-8 M per 1.0 x 106 beads and for magnetic beads was 0.64 x 10-8 ± 0.01 x …

Within-Subject Joint Independent Component Analysis Of Simultaneous Fmri/Erp In An Auditory Oddball Paradigm, Jain Mangalathu-Arumana, Scott A. Beardsley, E. Liebenthal

Biomedical Engineering Faculty Research and Publications

The integration of event-related potential (ERP) and functional magnetic resonance imaging (fMRI) can contribute to characterizing neural networks with high temporal and spatial resolution. This research aimed to determine the sensitivity and limitations of applying joint independent component analysis (jICA) within-subjects, for ERP and fMRI data collected simultaneously in a parametric auditory frequency oddball paradigm. In a group of 20 subjects, an increase in ERP peak amplitude ranging 1–8 μV in the time window of the P300 (350–700 ms), and a correlated increase in fMRI signal in a network of regions including the right superior temporal and supramarginal gyri, was …

Fluidized-Bed Gasification Of Dairy Manure By Box–Behnken Design, Hanjing Wu, Milford A. Hanna, David D. Jones

Department of Agricultural and Biological Systems Engineering: Faculty Publications

Application of excessive animal manure to the land may cause some environmental problems such as eutrophication of surface waters, degradation of ground water quality, and threats to human health. This paper reports an experimental study on the technology of biomass gasification to treat animal waste by analyzing the effects of key operating parameters on gasification. In this research, dairy manure from the University of Nebraska dairy farm was first collected and dried, and then gasified in a fluidized-bed, laboratory-scale gasifier to generate syngas. The effects of three parameters, namely temperature, steam to biomass ratio (SBR) and the equivalence ratio (ER), …

Novel Phantoms And Post-Processing For Diffusion Spectrum Imaging, Vaibhav Juneja

Dissertations and Theses (Open Access)

High Angular Resolution Diffusion Imaging (HARDI) techniques, including Diffusion Spectrum Imaging (DSI), have been proposed to resolve crossing and other complex fiber architecture in the human brain white matter. In these methods, directional information of diffusion is inferred from the peaks in the orientation distribution function (ODF). Extensive studies using histology on macaque brain, cat cerebellum, rat hippocampus and optic tracts, and bovine tongue are qualitatively in agreement with the DSI-derived ODFs and tractography. However, there are only two studies in the literature which validated the DSI results using physical phantoms and both these studies were not performed on a …

Electrochemical Capacitance Measurements To Study Molecular Surface Interactions, Nrutya Madduri

All Theses

The behavior of biological molecules such as proteins at the electrode/electrolyte has been of considerable interest for the development of biosensors. Several investigative techniques including Potentiometry, Voltammetry, Amperometry, and Electrochemical Impedance Spectroscopy are being employed to study and analyze these molecular surface interactions. Investigative techniques such as cyclic voltammetry involve the application of a large potential to probe the electrode characteristics and capture the bulk membranous events to obtain the required measurements. This study looks to achieve two major objectives through the use of a novel technique, namely, the double layer capacitive method: 1) to analyze the electrochemical behavior of …

Development Of A Lower Extremity Mobility Assessment Methodology For Motor Vehicle Operation And Initial Validation, Justin Arnosky

All Theses

Limited quantifiable data exists on lower extremity mobility and function during driving. To date, the most appropriate existing measures of successful driving function are assessed by a driving rehabilitation specialist during an on-road evaluation. Establishing the kinematic chain- or the order and magnitude in which joints are moved- during driving may prove to be a useful tool in lower extremity function assessment in drivers. To this end, a study was conducted instrumenting both the left and right legs of healthy licensed male drivers (18-26 years old) with a system of angle measuring goniometers (Biometrics, Ltd.) in a driving simulator (DriveSafety …

Effects Of Different Microenvironmental Conditions On The Growth And Differentiation Of Dental Pulp Stem Cells, Matthew Cupelli

All Theses

Human teeth are very complex structures that are susceptible to many different pathologies due to poor dental health. Currently, there are many restorative methods to reestablish some of the function that teeth have, but the materials used in these methods all have drawbacks and cannot fully mimic the native teeth. Tissue engineering research groups have begun to explore regenerating bone or dental tissue using mesenchymal stem cells derived from the bone marrow. However, our group focuses on regenerating dental tissues using multipotent stem cells from dental pulp.
Dental pulp stem cells (DPSCs) have shown similarities to bone marrow stem cells …

Evaluation Of A Bisphosphonate Enriched Ultra-High Molecular Weight Polyethylene For Enhanced Total Joint Replacement Bearing Surface Functionality, Cassandra Wright-Walker

All Dissertations

Each year in the United States there is an increasing trend of patients receiving total joint replacement (TJR) procedures. Approximately a half million total knee replacements (TKRs) are performed annually in the United States with increasing prevalence attributed to baby-boomers, obesity, older, and younger patients. This trend is also seen for total hip replacements (THRs) as well. The use of ultra high molecular weight polyethylene (UHMWPE) inserts in TJRs results in wear particle-induced osteolysis, which is the predominant cause for prosthesis failure and revision surgery. Sub-micron size particle generation is inevitable despite the numerous efforts in improving this bearing material. …