An Indigoidine Biosynthetic Gene Cluster From Streptomyces Chromofuscus Atcc 49982 Contains An Unusual Indb Homologue,
2012
Utah State University
An Indigoidine Biosynthetic Gene Cluster From Streptomyces Chromofuscus Atcc 49982 Contains An Unusual Indb Homologue, Dayu Yu, Fuchao Xu, Jonathan Valiente, Siyuan Wang, Jixun Zhan
Biological Engineering Faculty Publications
A putative indigoidine biosynthetic gene cluster was located in the genome of Streptomyces chromofuscus ATCC 49982. The silent 9.4-kb gene cluster consists of five open reading frames, named orf1, Sc-indC, Sc-indA, Sc-indB, and orf2, respectively. Sc-IndC was functionally characterized as an indigoidine synthase through heterologous expression of the enzyme in both Streptomyces coelicolor CH999 and Escherichia coli BAP1. The yield of indigoidine in E. coli BAP1 reached 2.78 g/l under the optimized conditions. The predicted protein product of Sc-indB is unusual and much larger than any other reported IndB-like protein. The N-terminal portion of this enzyme resembles IdgB and the …
Toe Brace Designs,
2012
Wright State University - Main Campus
Toe Brace Designs, Tarun Goswami, Allison L. Van Horn, Alexander O. Sheets
Biomedical, Industrial & Human Factors Engineering Faculty Publications
In various embodiments, provided are braces for use in supporting the metatarophalangeal joint, reducing or maintaining the intermetatarsal angle, enhancing or maintaining alignment of the hallux, or combinations thereof in a subject having hallux valgus.
An Information Architecture For Icme,
2012
Granta Design
An Information Architecture For Icme, William Marsden
Harnessing The Materials Genome: Accelerated Materials Development via Computational and Experimental Tools
No abstract provided.
Multiscale Modeling For Material Design Of Solid Oxide Fuel Cell Electrode,
2012
The University of Tokyo
Multiscale Modeling For Material Design Of Solid Oxide Fuel Cell Electrode, Y. Umeno, S. Hara, T. Tada, N. Shikazono
Harnessing The Materials Genome: Accelerated Materials Development via Computational and Experimental Tools
No abstract provided.
Some (Other) Uses Of Diffusion Couples In Metallurgy: Model Calibration And Mapping Transitions In Mechanisms,
2012
Department of Materials Engineering, Monash University
Some (Other) Uses Of Diffusion Couples In Metallurgy: Model Calibration And Mapping Transitions In Mechanisms, Christopher Hutchinson
Harnessing The Materials Genome: Accelerated Materials Development via Computational and Experimental Tools
No abstract provided.
From Genome To Flying Cyberalloys: The First Half Century,
2012
Northwestern University
From Genome To Flying Cyberalloys: The First Half Century, G. B. Olson
Harnessing The Materials Genome: Accelerated Materials Development via Computational and Experimental Tools
No abstract provided.
A Hybrid Computational-Experimental Approach For Automated Crystal Structure Solution,
2012
Northwestern University
A Hybrid Computational-Experimental Approach For Automated Crystal Structure Solution, Bryce Meredig, Scott Kirklin, Chris Wolverton
Harnessing The Materials Genome: Accelerated Materials Development via Computational and Experimental Tools
No abstract provided.
Predicting Microstructure-Property Relationships In Structural Materials Via Multiscale Models Validated By In-Situ Synchrotron Observation,
2012
Manchester X-ray Imaging Facility
Predicting Microstructure-Property Relationships In Structural Materials Via Multiscale Models Validated By In-Situ Synchrotron Observation, Peter D. Lee, Lang Yuan, Chedtha Puncreobutr, S. Karagadde
Harnessing The Materials Genome: Accelerated Materials Development via Computational and Experimental Tools
No abstract provided.
Nist Databases For Materials Research,
2012
National Institute of Standards & Technology
Nist Databases For Materials Research, T. Vanderah, Vicky Karen, Peter Linstrom, Donald Burgess
Harnessing The Materials Genome: Accelerated Materials Development via Computational and Experimental Tools
No abstract provided.
The Materials Project – A Public Materials Design Platform,
2012
Lawrence Berkeley National Laboratory
The Materials Project – A Public Materials Design Platform, Kristin Persson
Harnessing The Materials Genome: Accelerated Materials Development via Computational and Experimental Tools
No abstract provided.
New Stage Of Matnavi, Materials Database At Nims,
2012
National Institute for Materials Science
New Stage Of Matnavi, Materials Database At Nims, Toshio Ogata, Masayoshi Yamazaki
Harnessing The Materials Genome: Accelerated Materials Development via Computational and Experimental Tools
No abstract provided.
Method And Apparatus For Utilizing Amplitude-Modulated Pulse-Width Modulation Signals For Neurostimulation And Treatment Of Neurological Disorders Using Electrical Stimulation,
2012
Kettering University
Method And Apparatus For Utilizing Amplitude-Modulated Pulse-Width Modulation Signals For Neurostimulation And Treatment Of Neurological Disorders Using Electrical Stimulation, Jeffrey Hargrove, Theodore Stokes, Mary L. Esty
Mechanical Engineering Patents
A computing device-controlled system is described for the generation of amplitude-modulated pulse-width modulation (AMPWM) signals for use in treating neurological dysfunction via cranial neurostimulation, where the AMPWM signal is specifically designed to minimize the electrical impedance of the tissues of the head. A low-frequency carrier signal is determined for the AMPWM signal by measuring EEG activity at a reference site or sites, generally corresponding with the location of suspected brain dysfunction. Carrier signal frequency is variably related to critical frequency components of the EEG power spectral density, determined from statistical analysis of amplitudes and variability, and dynamically changed as a …
Designing For Success: Developing Engineers Who Consider Universal Design Principles,
2012
University of Dayton
Designing For Success: Developing Engineers Who Consider Universal Design Principles, Kimberly Edginton Bigelow
Mechanical and Aerospace Engineering Faculty Publications
Engineers must design for a diverse group of potential users of their products; however, engineering curricula rarely include an emphasis on universal design principles. This research article details the effectiveness of a design project implemented in a first-year engineering course in an effort to raise awareness of the need for engineers to be more inclusive when designing. Students were asked to apply universal design principles to redesign an engineering laboratory to make it more usable to all, including individuals with disabilities who use the room. A representative from the university’s disability services staff, as well as individuals with first-hand experience …
Materials Design Based On Ab Initio Thermodynamics,
2012
Max Planck Institut
Materials Design Based On Ab Initio Thermodynamics, Jorg Neugebauer, Fritz Kormann, Blazej Grabowski, Tilmann Hickel, Dierk Raabe
Harnessing The Materials Genome: Accelerated Materials Development via Computational and Experimental Tools
No abstract provided.
Materials Property Microscopy Tools For The Materials Genome Initiative,
2012
The Ohio State University
Materials Property Microscopy Tools For The Materials Genome Initiative, J. C. Zhao, David Cahill
Harnessing The Materials Genome: Accelerated Materials Development via Computational and Experimental Tools
No abstract provided.
High-Throughput Synthesis And Analysis For Searching New Permanent Magnet Materials,
2012
Materials Research Institute, Aalen University
High-Throughput Synthesis And Analysis For Searching New Permanent Magnet Materials, Gerhard Schneider, Dagmar Goll, Ralf Loffller, Roman Karimi
Harnessing The Materials Genome: Accelerated Materials Development via Computational and Experimental Tools
No abstract provided.
A Software Framework For Designing Material,
2012
University of Cambridge
A Software Framework For Designing Material, David Cebon, Mike Ashby
Harnessing The Materials Genome: Accelerated Materials Development via Computational and Experimental Tools
No abstract provided.
Rapid Temporal Changes In The Expression Of A Set Of Neuromodulatory Genes During Alcohol Withdrawal In The Dorsal Vagal Complex: Molecular Evidence Of Homeostatic Disturbance.,
2012
Rowan University
Rapid Temporal Changes In The Expression Of A Set Of Neuromodulatory Genes During Alcohol Withdrawal In The Dorsal Vagal Complex: Molecular Evidence Of Homeostatic Disturbance., Kate Freeman, Mary M. Staehle, Zeynep H Gümüş, Rajanikanth Vadigepalli, Gregory E Gonye, Carmen N Nichols, Babatunde A Ogunnaike, Jan B Hoek, James S Schwaber
College of Science & Mathematics Departmental Research
BACKGROUND: Chronic alcohol exposure produces neuroadaptation, which increases the risk of cellular excitotoxicity and autonomic dysfunction during withdrawal. The temporal progression and regulation of the gene expression that contributes to this physiologic and behavioral phenotype is poorly understood early in the withdrawal period. Further, it is unexplored in the dorsal vagal complex (DVC), a brainstem autonomic regulatory structure.
METHODS: We use a quantitative polymerase chain reaction platform to precisely and simultaneously measure the expression of 145 neuromodulatory genes in more than 100 rat DVC samples from control, chronically alcohol-exposed, and withdrawn rats. To gain insight into the dynamic progression and …
Quantitation And Identification Of Protein S-Nitrosylation: Implication For The Progression Of Alzheimer's Disease,
2012
Louisiana Tech University
Quantitation And Identification Of Protein S-Nitrosylation: Implication For The Progression Of Alzheimer's Disease, Siyang Wang
Doctoral Dissertations
Protein S-nitrosylation, the covalent modification of a cysteine sulfhydryl group by nitric oxide (NO), plays a critical role in post-translational modification (PTM) that regulates a large variety of cellular functions and signalling events. The nitrosylation state changes with oxidative damage and is involved in variety of cancers and neurodegeneration diseases.
Three technologies were developed for nitrosylated protein detection and identification. Capillary gel electrophoresis with laser induced fluorescence (CGE-LIF) detection was used for the detection and quantitation of nitrosylated proteins. A two-dimensional micro-electrophoresis (2D μ-CE) separations system was also built to detect nitrosylated proteins via poly (methylmethacrylate) microchips. Proteomics following nitrosylated …
The Contribution Of Oxidative Stress In The Protein Damage And Dna Lesion In Alzheimer's Disease Neuropathology,
2012
Louisiana Tech University
The Contribution Of Oxidative Stress In The Protein Damage And Dna Lesion In Alzheimer's Disease Neuropathology, Cheng Zhang
Doctoral Dissertations
Glutathione (GSH) plays an essential role in the intracellular antioxidant defense against the oxidant radicals, especially the ·OH radical. To understand the early and progressive cellular changes in Alzheimer's disease (AD) development, we investigated reduced glutathione/oxidized glutathione (GSH/GSSG) status in a double mutated AD transgenic mouse model (B6.Cg-Tg), which carries Swedish amyloid precursor protein mutation (APPswe) and exon 9 deletion of the PSEN1 gene. Likewise, S-glutathionylation (Pr-SSG) is a specific post-translational modification (PTM) of cysteine residues by the addition of glutathione. S-glutathionylated proteins induced by oxidative stress play an essential role in understanding the pathogenesis of the aging …
