Biomedical Engineering and Bioengineering Commons^™

Contact Analysis For Coupling Of Plates And Screws In Fracture Fixation Of Cortical Bone, Gaffar Gailani, Rachid Moumni, Malek Brahimi

Publications and Research

Internal fixation is a common treatment for bone fracture. Bone fracture occurs due to different reasons such as motor vehicle accidents, falling,…etc. The treatment is performed by fixing plate and screws to the fracture site. Lack of stability of the implants (plates and screws) may lead to delay in healing or failure of treatment. Micro-motion between the implant and the bone may cause formation of fibrous tissue around the screw which will lead to implant loosening. On the other hands, firm fixing of the conventional implants (Dynamic Compression Plates) may lead to delay resorption and delay in healing. Recently, Locked …

A Device For The Objective Assessment Of Adhd Using Eye Movements, Ankita Dosaj, Jefferson Overlin, Cassie Turnage

Capstone Design Expo Posters

Attention deficit hyperactivity disorder (ADHD) is a commonly diagnosed psychiatric disorder characterized by lack of focus, self-control,and hyperactivity. ADHD is difficult to diagnose without extensive observation by an expert, and even then is often misdiagnosed. Current methods of pediatric diagnosis rely on subjective measures of activity and behavior relative to other children [3]. Proper diagnosis is critical in preventing unnecessary prescription of the powerful, habit-forming nature of the drugs used to manage ADHD, such as Adderall and Ritalin [1][5]. Research has shown that patients with ADHD show abnormalities in reading tests and antisaccade tests, as these tests gauge ability to …

Non-Invasive Blood Glucose Monitoring System, Brittany Martinez, Brittany Noah, David Decker

Capstone Design Expo Posters

The objective of this project is to create a non-invasive hypoglycemic alert system that will detect a drop in blood sugar in type 1 diabetics during sleep. This will be achieved by creating an algorithm that couples heart rate variability with skin conductance to increase the accuracy of hypoglycemia detection. The device will be housed in a torso strap that will include: electrodes located over the user’s rib cage, a skin conductance sensor placed in the user’s armpit, a microcontroller to collect and process the data, and vibrating motors that will awaken the patient if hypoglycemia is detected. Integrating the …

A Non-Contact System For Measuring Wrist And Carpal Kinematics, Shruthi Muralidharan, Kristina Hendel, Joseph Newton, Vivek Patel

Capstone Design Expo Posters

Ligamentous and bone injuries in the wrist affect tens of thousands of adults per year and leads to abnormal function. Surgical procedures as well as physical therapy intended to restorefunction have room for improvement. Measuring wrist kinematics of the small carpal bones is necessary to understand the effect of ligamentous injury during normal motion.Currently there are motion analysis systems that are used to track large scale movementfor total body kinematics such as gait analysis. The accuracy of these systems is catered toward capturing gross movement and cannot precisely measure on the order of millimeters necessary for carpal kinematics. There are …

Development And Validation Of A Robust, Adjustable Hippotherapy Simulator, Melissa Montgomery

Graduate Theses - Biology & Biomedical Engineering

This thesis describes all aspects of development, testing, refinement, and validation of a robust, adjustable hippotherapy simulator. This simulator primarily focuses on physical therapy; however, emotional benefits can be realized. It uniquely innovates on an effective design that has only partially been addressed in other simulators. Using a variable drive for adjustable speed, it incorporates reinforcements to increase load capacity along with removable camshafts that adjust the throw heights in the device’s simulated hips and shoulders. For testing and validation, Qualisys software and motion capture supported analysis of the device’s motion paths and speeds. Riders weighing approximately 135-300 pounds successfully …

Time And Temperature Dependent Surface Tension Measurements Of Responsive Protein-Based Polymer Surfactant Solutions, Hakan Celik

ETD Archive

A three-armed star elastin-like polypeptide (ELP-foldon) has thermoreversible character which exhibits phase separation above a transition temperature (Tt) in physiologic salt concentrations. At lower salt concentration, the ELP-foldon behaves like a thermoresponsive surfactant, exhibiting micelle formation above its Tt. The purpose of this study is characterize the surfactant behavior of the ELP-foldon at air-liquid interface by measuring the surface tension. The surface tension is measured as a function of time for different ELP concentrations from 10 nM to 50 ℗æM and over range of temperatures from 25 to 35 ℗¿ using the axisymmetric drop shape analysis (ADSA). The ADSA is …

Solute Partitioning In Elastin-Like Polypeptides: A Foundation For Drug Delivery Applications, Eric Helm

ETD Archive

No abstract provided.

Characterization Of Highly Concentrated Elastin-Like Polypeptide Solutions: Rheometric Properties And Phase Separation Analysis, Kevin Michael Otto

ETD Archive

Elastin-like polypeptides (ELPs) are environmentally responsive biopolymers. These protein based polymers are specific in that they exhibit phase separation in response to a number of stimuli. Some of these stimuli include temperature, light, and pH. There are a large number of factors to consider when designing ELP constructs that allow for control of the transitioning behavior, some of which include amino acid sequences, protein concentration, salt concentration, and the polymer chain length. Elastin-like polypeptides are soluble in water at low temperatures, however, upon an increase in temperature, the proteins become insoluble in water and phase separate. This point of temperature …

Flow-Cytometry Machine For The Developing World, Paul Howell, Jewel Nkwocha, Jaynie Laverty

Capstone Design Expo Posters

Flow cytometry provides critical diagnostic, measurement, and research applications across many healthcare and biological disciplines. Its use in the detection of blood-cancers, HIV/AIDS, cell differentiation, and viral detection is unique and unparalleled. Despite flow cytometry’s vast array of applications, its use is limited by expense. Rather than individual labs being able to afford a dedicated machine, core facilities are developed and the research is exported. In addition, flow cytometry’s high costs create a barrier to its implementation in developing nations.

There were 35 million people living with HIV in 2013, nearly 1% of the world’s population. There are more than …

Independent Exercise Assistive Device For Individuals With Visual Impairments, Ashley Duke, Megan Goldberg, Lindsay Schnur

Capstone Design Expo Posters

Physical exercise is challenging for individuals who are blind because they lack the spatial awareness necessary to imitate described motions for exercises, and additionally require physical guidance. The current solutions involve tactile equipment to assist in body placement, but a person with low vision cannot compare their own position to the correct position and adjust properly. The proposed solution is an instructional yoga program that will give feedback to the user based on her exercise performance, allowing people who are blind to be able to perform these exercises independently at home. The design will incorporate the Skeletal Tracking program of …

Effect Of Four Approaches To Oral Feeding Progression On Clinical Outcomes In Preterm Infants, Rita H. Pickler, Barbara A. Reyna, Paul A. Wetzel, Mary Lewis

Biomedical Engineering Publications

Background. The purpose of this study of preterm infants was to test the effect of four approaches to the time of transition from gavage to full oral feedings, time to discharge, and weight gain during the transition.Methods. A randomized experimental design was used with four intervention groups: early start (32 weeks' postmenstrual age)/slow progressing experience (gradually increasing oral feedings offered per day); early start/maximum experience (oral feedings offered at every feeding opportunity); late start (34 weeks' postmenstrual age)/slow progressing experience; and late start/maximum experience. Results. The analysis included 86 preterm infants. Once oral feedings were initiated, …

Regulation Of Osteoblast Differentiation By Acid-Etched And/Or Grit-Blasted Titanium Substrate Topography Is Enhanced By 1,25(Oh)2d3 In A Sex-Dependent Manner, Rene Olivares-Navarrete, Sharon L. Hyzy, Barbara D. Boyan, Zvi Schwartz

Biomedical Engineering Publications

This study assessed contributions of micron-scale topography on clinically relevant titanium (Ti) to differentiation of osteoprogenitor cells and osteoblasts; the interaction of this effect with 1𝛼,25-dihydroxyvitamin D₃ (1𝛼,25(OH)₂D₃); and if the effects are sex-dependent. Male and female rat bone marrow cells (BMCs) were cultured on acid-etched (A, 𝑅_𝑎 = 0.87 𝜇m), grit-blasted (GB, 𝑅_𝑎 = 3.90 𝜇m), or grit-blasted/acid-etched (SLA, 𝑅_𝑎 = 3.22 𝜇m) Ti. BMCs were sensitive to surface topography and underwent osteoblast differentiation. This was greatest on SLA; acid etching and grit blasting contributed additively. Primary osteoblasts were also sensitive …

Frontal Cryosectioning: An Improved Protocol For Sectioning Large Areas Of Fibrous Scaffolds, Casey Grey, David G. Simpson

Biomedical Engineering Publications

Fibrous tissue engineering scaffolds, such as those produced by electrospinning, cannot achieve their clinical potential until deep cell-scaffold interactions are understood. Even the most advanced imaging techniques are limited to capturing data at depths of 100 µm due to light scatter associated with the fibers that compose these scaffolds. Conventional cross-sectional analysis provides information on relatively small volumes of space and frontal sections are difficult to generate. Current understanding of cellular penetration into fibrous scaffolds is limited predominantly to the scaffold surface. Although some information is available from cross-sections, sections vary in quality, can distort spatial scaffold properties, and offer …

Osteogenic Embryoid Body-Derived Material Induces Bone Formation In Vivo, Ken Sutha, Zvi Schwartz, Yun Wang, Sharon Hyzy, Barbara D. Boyan, Todd C. Mcdevitt

Biomedical Engineering Publications

The progressive loss of endogenous regenerative capacity that accompanies mammalian aging has been attributed at least in part to alterations in the extracellular matrix (ECM) composition of adult tissues. Thus, creation of a more regenerative microenvironment, analogous to embryonic morphogenesis, may be achieved via pluripotent embryonic stem cell (ESC) differentiation and derivation of devitalized materials as an alternative to decellularized adult tissues, such as demineralized bone matrix (DBM). Transplantation of devitalized ESC materials represents a novel approach to promote functional tissue regeneration and reduce the inherent batch-to-batch variability of allograft-derived materials. In this study, the osteoinductivity of embryoid body-derived material …

Patterned Feeding Experience For Preterm Infants: Study Protocol For A Randomized Controlled Trial, Rita H. Pickler, Paul A. Wetzel, Jareen Meinzen-Derr, Heather L. Tubbs-Cooley, Margo Moore

Biomedical Engineering Publications

Background

Neurobehavioral disabilities occur in 5–15 % of preterm infants with an estimated 50–70 % of very low birth weight preterm infants experiencing later dysfunction, including cognitive, behavioral, and social delays that often persist into adulthood. Factors implicated in poor neurobehavioral and developmental outcomes are hospitalization in the neonatal intensive care unit (NICU) and inconsistent caregiving patterns. Although much underlying brain damage occurs in utero or shortly after birth, neuroprotective strategies can stop lesions from progressing, particularly when these strategies are used during the most sensitive periods of neural plasticity occurring months before term age. The purpose of this randomized …

Dual Effects Of Β-Cyclodextrin-Stabilised Silver Nanoparticles: Enhanced Biofilm Inhibition And Reduced Cytotoxicity, Swarna Jaiswal

Articles

No abstract provided.

Measuring Pulse Rate Variability During Motion Artifact With A Non-Contact, Multi-Imager Photoplethysmography System, Zachary Adam Kiehl

Browse all Theses and Dissertations

Non-contact imaging photoplethysmography is an exciting new field based on the principles of traditional photoplethysmography where viable signals can now be acquired without the use of contact equipment. Recent advances regarding non-contact imaging photoplethysmography have permitted a wide range of new possibilities focused on sensing the cardiopulmonary system. Physiological metrics such as pulse rate, respiration rate, and pulse rate variability can be obtained by current photoplethysmographic imaging methods. Although previous systems were challenged by head-motion artifacts, the mitigation of rigid head-motion artifacts has been demonstrated with a multi-imager design. This study investigated the feasibility and accuracy of pulse rate variability …

Liver Sinusoid On A Chip: Long-Term Layered Co-Culture Of Primary Rat Hepatocytes And Endothelial Cells In Microfluidic Platforms, Young Bok (Abraham) Kang, Temitope R. Sodunke, Jason Lamontagne, Joseph Cirillo, Caroline Rajiv, Michael J. Bouchard, Moses Noh

Faculty Publications - Biomedical, Mechanical, and Civil Engineering

We describe the generation of microfluidic platforms for the co-culture of primary hepatocytes and endothelial cells; these platforms mimic the architecture of a liver sinusoid. This paper describes a progressional study of creating such a liver sinusoid on a chip system. Primary rat hepatocytes (PRHs) were co-cultured with primary or established endothelial cells in layers in single and dual microchannel configurations with or without continuous perfusion. Cell viability and maintenance of hepatocyte functions were monitored and compared for diverse experimental conditions. When primary rat hepatocytes were co-cultured with immortalized bovine aortic endothelial cells (BAECs) in a dual microchannel with continuous …

Collagen Crosslinking Reagent Utilized To Modify The Mechanical Properties Of The Soft Palate In Equine Snoring And Apnea Applications, Stephanie L. Hunt

Theses and Dissertations--Biomedical Engineering

Snoring is a sleep disruption that can lead to obstructive sleep apnea (OSA), which interrupts breathing by obstructing the airway. Injecting a protein crosslinker, such as genipin, into the soft palate could decrease the severity of snoring and OSA by stiffening the soft palate. Equine soft palates modeled human palates due to a high incidence of awake snoring and apnea.

The pilot in vivo study treated six horses with two 100 mM injections of the buffered genipin reagent. The efficacy phase horses underwent respiratory audio recordings to document snoring changes using Matlab and ImageJ in the time and frequency domains. …

3-D Culture Systemfor Rapid Expansion Of Human Neural Stem Cells, Waleed Ilyas, Jeeyun Park, Dan Reep, Lawrence Talej

Capstone Design Expo Posters

Research into stem cells is a growing field of contemporary biology due to their extraordinary potential to develop into myriad cell types for use in regenerative medicine and research applications. Stem cells can vary from adult stem cells, embryonic stem cells, or induced pluripotent stem cells, or iPS. Due to the high potential for therapeutic applications, or individualized medicine, there is an increasing demand for stem cell quantities since a critical cell count must be met to demonstrate any therapeutic effect. The problem lies in the amount of time it takes to culture this critical cell count. Isolating fibroblasts in …