Biomedical Engineering and Bioengineering Commons^™

Novel Incorportation Of Biomedical Engineering Algorithms (Bispectral Index Guided Or Anesthetic Concentration Guided) In Real-Time Decision Support To Prevent Intraoperative Awareness Using An Electronic Anesthesia Information Mananagement System, Amy Melanie Shanks

Wayne State University Dissertations

Background: Intraoperative awareness with explicit recall (AWR) is a feared complication of surgery that can lead to significant psychological distress. Several large prospective trials have been completed comparing two methods of monitoring anesthetic depth [minimum alveolar concentration (MAC) or electroencephalography (EEG) monitoring using the bispectral index (BIS)] for the prevention of AWR. However, these trials were conducted in high risk populations, limiting generalizability.

Research Hypothesis: Real-time decision support with Anesthesia Information Management System alerts based on a novel anesthetic concentration algorithm (incorporating the use of intravenous anesthetics) or an EEG-guided algorithm will reduce the known incidence of AWR.

Methods: First, …

Terahertz Imaging Platform To Characterize The Growth Of In-Vitro Breast Tumors, Scarlett-Marie Acklin

Inquiry: The University of Arkansas Undergraduate Research Journal

This study aimed at evaluating the ideal plating method and density for imaging with the terahertz (THz) spectrometer. In this study, different methods were used to grow in-vitro tumors using the 4T1 cell line. Here, attempts to grow breast tumors in-vitro were conducted. Results were produced in two environments, flat-bottomed plates and round-bottomed multiwell plates. The second method allowed for faster clumping and increased cell aggregation, producing tumors up to 7mm. Terahertz spectroscopy produced images that correlated well to photomicrographs taken of the in-vitro tumors. This methodology shows great promise for providing a reliable, parameter-controlled source of in-vitro breast tumors …

Du02, Center For Orthopaedic Biomechanics, Michael D. Harris, Phd, Kevin Shelburne, Phd

Natural Knee Data

No abstract provided.

Biomechanical And Biological Evaluation Of A Model Of Post-Traumatic Osteoarthritis Following Noninvasive, Traumatic Rupture Of The Anterior Cruciate Ligament, Tristan Maerz

Wayne State University Dissertations

Post-traumatic osteoarthritis (PTOA) is a prevalent condition following rupture of the anterior cruciate ligament (ACL). While numerous animal models of PTOA exist, most are based on surgical disruption of a stabilizing structure. In the rat, surgical ACL transection is the most commonly employed model, but it may introduce confounding biological factors due to surgery. The purpose of this dissertation was to utilize the tibial compression model of ACL injury to induce a noninvasive ACL rupture in the rat. First, a biomechanical characterization of four different loading protocols was undertaken, and a high-speed, high-displacement protocol was deemed optimal for inducing a …

Multiplexed Loop-Mediated Isothermal Amplification Of The 16s Rrna Gene For The Diagnosis Of Neonatal Sepsis In Resource-Limited Environments, Griffin T. Sonaty

Inquiry: The University of Arkansas Undergraduate Research Journal

Sepsis, or dysregulated inflammation caused by bacterial infection, places a disproportionately high burden on newborns in developing countries. This is due in part to a lack of diagnostic tools suitable for sustainable use in resource-limited nurseries. One potential vehicle for a new diagnostic assay is loop-mediated isothermal amplification (LAMP), a high-yield DNA amplification method. LAMP has previously been used to detect genes from single species of bacteria in blood serum samples to aid in sepsis diagnosis. LAMP could be adapted to detect a broad set of bacteria, while retaining a degree of specificity that allows clinicians to begin directed antimicrobial …

Greenhouse Gas Emissions Inventory Of The Centalized Renewable Energy System (Cres) At Nebraska Innovation Campus, Matan Gill, Adam Liska

Adam Liska Papers

The Centralized Renewable Energy System (CRES) at Nebraska Innovation Campus (NIC) is a heat-exchanger system that utilizes reclaimed, non-drinkable water from the nearby water treatment plant to heat and cool a projected 1.675 million square feet of office and lab space. A greenhouse gas emissions inventory was estimated for the CRES operating at full build-out of the campus in 2035, compared to conventional office space, being a control system with standard chiller and boiler configuration. The control system is estimated to emit 30,787 metric tons of carbon dioxide-equivalent per year (Mg CO₂e yr-1), whereas heating and cooling Nebraska …

Non-Invasive Biomedical Imaging And Radiobiology Investigations In Pre-Clinical Prostate Tumor Models, Derek A. White

Bioengineering Dissertations - Archive

Oxygen deficiency (hypoxia) in prostate tumors can hinder the biological effectiveness of radiotherapy. Therefore the ability to assess tumor hypoxia non-invasively in vivo in man could significantly improve therapy outcome. Magnetic resonance (MR) imaging is increasingly applied in clinical evaluation of prostate cancer. Therefore, an oxygen sensitive technique would be very attractive and the utility of oxygen-enhanced MRI (OE-MRI) has shown promise for predicting tumor growth delay in syngeneic rat prostate tumors following radiotherapy. In this dissertation, the overall goal was to investigate a potential imaging biomarker for predicting tumor response to image-guided radiotherapy (IGRT). First, I used in vivo …

Development Of Atlas-Guided Diffuse Optical Tomography To Investigate Age-Dependent Human Cognitive Functions Under Risk Decision Making, Lin Li

Bioengineering Dissertations - Archive

To better understand the age effect on neural correlates under risk decision-making stimulations, studies using advanced neuroimaging with a sufficient statistical power are desired. Diffuse optical tomography (DOT) of human brain functions is an emerging non-invasive neuroimaging technology. Compared to magnetic resonance imaging (MRI), DOT is more cost-effective, more portable, and easier to conduct studies targeting on different age groups. However, current DOT is limited by its low spatial resolution and depth accuracy. It is thus imperative to develop a technique that can improve imaging quality of DOT and be used to investigate age-dependent human brain functions under risk decision …

An Investigation Of The Effect Of Obstructive Sleep Apnea On Cerebral Hemodynamics In Relation With Systemic Hemodynamics, Raichel Mary Alex

Bioengineering Dissertations - Archive

Obstructive Sleep Apnea (OSA) is a major sleep disorder affecting approximately 18 million adults in the US. Recent studies have observed cognitive impairments and brain structural changes in OSA subjects where these deficits were related to peripheral hypoxia and sleep fragmentation. Nonetheless, underlying cerebral hemodynamics and cerebral oxygenation might play an important role in the development of these impairments. Hence, in this study it is hypothesized that 1) OSA induces significant variations in cerebral hemodynamics, and 2) level of variations in cerebral hemodynamics can be related to the changes in systemic hemodynamics. To test these hypotheses, 8 hours of nocturnal …

Computer Aided Diagnosis Of Oral Cancer: Using Time-Step Ct Images, Jonathan T. Scott

Masters Theses

"In medical imaging it is a very common practice to use a technique known as Time-Step imaging in patients who might develop cancer. Time-Step imaging it a very powerful technique, however it can lead to unmanageable amounts of image data. Previously the only way to search all of this data was to manually look through all of the files. This had to be done by trained professionals who knew what to look for within the images and make a judgment about the patient based on the images. This paper discusses the development of an algorithm to have a computer search …

Freeform Extrusion Fabrication Of Titanium Fiber Reinforced 13-93 Bioactive Glass Scaffolds, Albin Thomas

Masters Theses

"Although implants made with bioactive glass have shown promising results for bone repair, their application in repairing load-bearing long bones is limited due to their poor mechanical properties as compared to human bones. This thesis study is on freeform extrusion fabrication of silicate based 13-93 bioactive glass scaffolds reinforced with titanium fibers. A composite paste was prepared with 13-93 bioactive glass filled with titanium fibers (~16 µm in diameter and aspect ratio of ~250) having 0.1 to 0.4 vol. % of the bioactive glass scaffold. This paste was then filled into a syringe manually, and then extruded through a nozzle …

Hemodynamic Responses To Thermal Stimulation In The Prefrontal Cortex Of The Brain Measured By Fnirs, Koumudi Chari

Bioengineering Theses - Archive

Although FMRI has marked its importance in the neurological research by understanding the brain activities, FNIRS has also set a new standard in the brain imaging study research with non-invasive and easy to use technology. FNIRS is a portable, inexpensive optical imaging method that measures the changes in the oxygenated and de-oxygenated hemoglobin of the brain that results from the neurological activity. In this study, FNIRS has been used to study the pain processing in humans by measuring the pre-frontal cortex area of the brain. Eight (n=8) healthy subjects were induced with pain using a thermal stimulator device with temperatures …

An Investigation Of The Covariations Between Variations In Exhaled Carbon Dioxide And Cerebral Blood Flow Levels During Apnea, Varun Ajay Kanal

Bioengineering Theses - Archive

Sleep apnea is a breathing disorder characterized by repetitive reduction or cessation of breathing during sleep. It is estimated that that around 17% of adults suffer from mild to severe sleep disordered breathing. The aim of this study was to investigate the level of correlation between variations in exhaled CO2 and cerebral blood flow (CBF) during apnea. It is difficult to measure the CBF during sleep. This relationship was found in an effort to substitute the measurement of the changes in CBF with the changes in the CO2. The relationship between these two physiological parameters was first studied in healthy …

An Investigation Of The Relationship Between Axonal Injury, Biomarker Expression And Mechanical Response In A Rodent Head Impact Acceleration Model, Yan Li

Wayne State University Dissertations

In the United States 1.4 million people sustain traumatic brain injury (TBI) each year, resulting in 235,000 hospitalizations and 50,000 fatalities annually. Traumatic axonal injury (TAI) is a serious outcome of TBI that accounts for 40-50% of hospitalizations due to head injury and one third of the mortality due to TBI, and it is difficult to diagnose and evaluate. The purpose of this dissertation is to determine mechanical injury predictors for TAI and identify potential biomarkers to evaluate TAI.

In this dissertation, a modified Marmarou impact acceleration injury model was developed to allow the monitoring of velocity of the impactor …

Quantifying Magnetic Moments And Susceptibilities Of Small Cylindrical And Spherical Objects In Mri, Ching-Yi Hsieh

Wayne State University Dissertations

Purpose: The purpose of this PhD work is to develop a method for accurately quantifying effective magnetic moments and susceptibility of either cylindrical or spherical-like small objects from magnetic resonance imaging (MRI). A standard 3D gradient echo sequence with only one echo time is intended for our approach to measure the effective magnetic moment of a given object of interest. For the quantification of the susceptibility in the cylindrical objects at different orientations, a standard 3D gradient echo sequence with only one or two echo times is needed.

Methods: Our method is to sum over complex MR signals around the …

Biom 4110/6110: The Science Of Medicine, Bradford D. Pendley

Biomedical Engineering Syllabi Archive

Course Description: Integration of fundamental principles from physics, chemistry, biology and mathematics, and applications of these principles to solve problems in medicine.

Biomimetic Oral Mucin From Polymer Micelle Networks, Sundar Prasanth Authimoolam

Theses and Dissertations--Chemical and Materials Engineering

Mucin networks are formed by the complexation of bottlebrush-like mucin glycoprotein with other small molecule glycoproteins. These glycoproteins create nanoscale strands that then arrange into a nanoporous mesh. These networks play an important role in ensuring surface hydration, lubricity and barrier protection. In order to understand the functional behavior in mucin networks, it is important to decouple their chemical and physical effects responsible for generating the fundamental property-function relationship. To achieve this goal, we propose to develop a synthetic biomimetic mucin using a layer-by-layer (LBL) deposition approach. In this work, a hierarchical 3-dimensional structures resembling natural mucin networks was generated …

Noncontact Diffuse Correlation Tomography Of Breast Tumor, Lian He

Theses and Dissertations--Biomedical Engineering

Since aggressive cancers are frequently hypermetabolic with angiogenic vessels, quantification of blood flow (BF) can be vital for cancer diagnosis. Our laboratory has developed a noncontact diffuse correlation tomography (ncDCT) system for 3-D imaging of BF distribution in deep tissues (up to centimeters). The ncDCT system employs two sets of optical lenses to project source and detector fibers respectively onto the tissue surface, and applies finite element framework to model light transportation in complex tissue geometries. This thesis reports our first step to adapt the ncDCT system for 3-D imaging of BF contrasts in human breast tumors. A commercial 3-D …

Layered, Flexible Drug Delivery Films For The Prevention Of Fibrotic Scar Tissue Formation, Cheryl L. Rabek

Theses and Dissertations--Biomedical Engineering

Open wounds account for about 50% of military injuries and 10% of non‐fatal traffic injuries. Scar tissue formation in these wounds may be reduced or prevented if treated with a combination of molecules whose release is tuned to the healing phases. The goal of this research was to develop flexible, layered drug delivery films for sequential, localized release of anti‐inflammatory, anti‐oxidant, and anti‐fibrotic molecules to soft tissue.

Films were composed of cellulose acetate phthalate (CAP) and Pluronic F‐127 (Pluronic). To impart flexibility, plasticizers, triethyl citrate (TEC) or tributyl citrate (TBC), were added. Mechanical analysis was performed on films as prepared …

Du06, Center For Orthopaedic Biomechanics, Michael D. Harris, Phd, Kevin Shelburne, Phd

Natural Knee Data

No abstract provided.